Publications by authors named "S K������kkaya Eren"

281 Publications

Emergency service results of central venous catheters: Single center, 1042 patients, 10-year experience.

World J Crit Care Med 2021 Jul 9;10(4):120-131. Epub 2021 Jul 9.

Department of Emergency, Gaziantep University Medical Faculty, Gaziantep 27410, Turkey.

Background: Central venous catheterization is currently an important procedure in critical care. Central catheterization has important advantages in many clinical situations. It can also lead to different complications such as infection, hemorrhage, and thrombosis. It is important to investigate critically ill patients undergoing catheterization.

Aim: To evaluate the characteristics, such as hospitalization, demographic characteristics, post-catheterization complications, and mortality relationships, of patients in whom a central venous catheter was placed in the emergency room.

Methods: A total of 1042 patients over the age of 18 who presented to the emergency department between January 2005 and December 2015 were analyzed retrospectively. The patients were divided into three groups, jugular, subclavian, and femoral, according to the area where the catheter was inserted. Complications related to catheterization were determined as pneumothorax, guidewire problems, bleeding, catheter site infection, arterial intervention, and sepsis. Considering the treatment follow-up of the patients, three groups were formed as outpatient treatment, hospitalization, and death.

Results: The mean age of the patients was 60.99 ± 19.85 years; 423 (40.6%) of them were women. Hospitalization time was 11.89 ± 16.38 d. There was a significant correlation between the inserted catheters with gender ( = 0.009) and hospitalization time ( = 0.040). Also, blood glucose, blood urea nitrogen, creatinine, and serum potassium values among the biochemical values of the patients who were catheterized were significant. A significant association was observed in the analysis of patients with complications that develop according to the catheter region ( = 0.001) and the outcome stage ( = 0.001). In receiver operating characteristic curve analysis of hospitalization time and mortality area under curve was 0.575, the 95% confidence interval was 0.496-0.653, the sensitivity was 71%, and the specificity was 89% ( = 0.040).

Conclusion: Catheter location and length of stay are important risk factors for catheter-borne infections. Because the risk of infection was lower than other catheters, jugular catheters should be preferred at entry points, and preventive measures should be taken by monitoring patients closely to reduce hospitalization infections.
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http://dx.doi.org/10.5492/wjccm.v10.i4.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291001PMC
July 2021

Two-handed endoscopic ear surgery: Feasibility for stapes surgery.

Am J Otolaryngol 2021 Jun 18;42(6):103111. Epub 2021 Jun 18.

Bezmialem Vakif University, Department of Otorhinolaryngology, Fatih, Istanbul, Turkey.

Objective: Endoscopic ear surgery is becoming an increasingly popular approach. Our aim in this study is to evaluate the feasibility of the two-handed endoscopic technique for stapes surgery, which has its own unique steps.

Methods: Patients who underwent two-handed endoscopic stapes surgery between September 2017 and February 2018 were included in this study. Preoperative and postoperative pure tone averages and air bone gaps, intraoperative complications were recorded. All procedures were performed under hypotensive general anesthesia by the same surgeon using 0° rigid endoscopes of 2.7-mm diameter, 14-cm length with an endoscope holder.

Results: Seven endoscopic two-handed stapes surgery were performed between September 2017 and February 2018. Of these, six patients were operated entirely endoscopically because one patient was found to has perilymph gusher and converted to microscopic surgery. There were no intraoperative tympanic membrane injuries, facial nerve paresis or sensorineural hearing losses. The average preoperative ABG of patients who underwent fully endoscopic surgery was 31.3 dB, and the postoperative ABG closed up to 9.6 dB.

Conclusions: Adoption of the two-handed technique during endoscopic stapes surgery ensures the surgeon benefits from the advantages of endoscopy while overcoming the disadvantages of the one-handed technique.
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http://dx.doi.org/10.1016/j.amjoto.2021.103111DOI Listing
June 2021

Effect of allergic rhinitis on the outcomes of diode laser dacryocystorhinostomy.

Am J Otolaryngol 2021 Jun 19;42(6):103127. Epub 2021 Jun 19.

Bezmialem Vakif University, Department of Otorhinolaryngology, Fatih, Istanbul, Turkey.

Purpose: Studies on patients with nasolacrimal duct obstruction have suggested the presence of comorbid allergic rhinitis. This study aimed to investigate the role of allergic rhinitis in the long-term surgical failure of diode laser dacryocystorhinostomy.

Materials And Methods: A total of 153 patients undergoing diode laser dacryocystorhinostomy between 2013 and 2017 were included in the study. In the consultation and follow-up, a skin prick test, endoscopic nasal examination, and nasal symptom scoring were performed.

Results: A total of 137 patients participated in the follow-up. The nasolacrimal obstruction complaints were completely resolved in 112 patients (81.8%). Of these, eight (7.1%) had positive skin prick tests. The preoperative complaints continued postoperatively in 25 (18.2%) patients. Nasal endoscopy revealed synechiae in one of these patients, whereas no anatomic deformities were observed in the other 24 patients. Of the 25 patients, 21 (84%) had positive skin prick tests. Those patients had signs of allergic rhinitis on endoscopic examination and high nasal symptom scores. There were significant differences in skin prick test results and nasal symptom scores between the two groups (p < 0.05).

Conclusion: Allergic rhinitis may affect the success of dacryocystorhinostomy in patients with nasolacrimal duct obstruction. To increase the chances of surgical success, besides choosing the appropriate surgical procedure, it may be useful to treat allergic rhinitis pre- and postoperatively.
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http://dx.doi.org/10.1016/j.amjoto.2021.103127DOI Listing
June 2021

Water-bottle heart.

Anatol J Cardiol 2021 Jun;25(6):E24-E25

Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital; İstanbul-Turkey.

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http://dx.doi.org/10.5152/AnatolJCardiol.2021.25274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210931PMC
June 2021

Meckel-Gruber Syndrome: Clinical and Molecular Genetic Profiles in Two Fetuses and Review of the Current Literature.

Genet Test Mol Biomarkers 2021 Jun 4;25(6):445-451. Epub 2021 Jun 4.

Department of Medical Genetics, School of Medicine, Marmara University, Istanbul, Turkey.

Meckel-Gruber syndrome (MKS; OMIM No. 249000) is a rare, lethal disease characterized by occipital encephalocele, polycystic kidneys, and polydactyly. In this study, two fetuses diagnosed as having MKS in the prenatal period were evaluated on the basis of ultrasonographic findings, postmortem autopsy findings, and molecular genetic analyses. Using exome sequencing analyses a novel homozygous frameshift variant (NM_015631: c.530delA, p.Lys177Argfs*47) was detected at exon 4 of gene in case 1, and a novel homozygous synonymous variant (NM_025114: c.180G>A, p Lys60Lys) was detected at exon 3 of gene in case 2. Case 1 is the first reported case in the literature, which showed the typical MKS clinical feature with a novel frameshift variation in the gene. The variant in case 2 is the first reported synonymous variant of gene in the literature, which has been shown to affect splicing in a functional study at the RNA level. gene variants that were rarely associated with the typical MKS phenotype and all cases with these variations have been discussed in the context of genotype-phenotype. The detection of the first synonymous variant of gene and the demonstration of its effect on splicing by a functional study are likely to contribute to the molecular etiology of MKS.
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http://dx.doi.org/10.1089/gtmb.2020.0311DOI Listing
June 2021
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