Publications by authors named "S Hamzaoui"

54 Publications

Pheochromocytoma presenting as an authentic small vessel vasculitis and complicated with pulmonary embolism: An original presentation.

Ann Cardiol Angeiol (Paris) 2021 Jun 4;70(3):168-170. Epub 2021 May 4.

Service de médecine interne, Hôpital Mongi Slim La Marsa, Tunis, Tunisia.

Diagnosis of pheochromocytoma can be simple when classic manifestations are present. It can also be challenging and complicated in some cases because of its wide array of faces and presentations. We present a case of a 30-year-old female patient who came with acute respiratory distress, chest pain, hemoptysis, asthenia, anorexia, weight loss of 20kg, and paresthesia in her lower limbs. Clinical examination found high blood pressure, accelerated heart and respiratory rates, signs of acute right heart failure with jugular venous distention and ankle edema, reticularis livedo in the four limbs, ulcers in both knees and in the 3rd metacarpo-phalangeal articulations and necrotic lesions in both calcaneal tendons and in the right toes. Further investigations concluded on myocarditis associated with alveolar hemorrhage, pericardic and pleuritic effusions and a segmental pulmonary embolism of the right inferior lobe. Neuro-muscular biopsy was suggestive of myositis. Cutaneous biopsy found nonspecific chronic dermatitis. ANCA antibodies were tested twice and were negative. Cryoglobulinemia was also negative. Thoraco-abdomino-pelvic scan was performed showing a large right adrenal mass suggestive of pheochromocytoma. Diagnosis of right adrenal pheochromocytoma was confirmed by MIBG-I123 hyperfixation findings and urinary normetanephrin levels. The patient was treated surgically. Postoperative outcomes were remarkably favorable with a complete regression of the cutaneous lesions and normalization of the blood pressure. Paresthesia significantly decreased. Control echocardiography at 3 months showed an improved heart function with a persistent apical and septal akinesis.
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http://dx.doi.org/10.1016/j.ancard.2021.04.006DOI Listing
June 2021

Structural, Magnetic, Dielectric and Piezoelectric Properties of Multiferroic PbTiFeO Ceramics.

Materials (Basel) 2021 Feb 16;14(4). Epub 2021 Feb 16.

Laboratoire de Microscopie Electronique & Sciences des Matériaux, Université des Sciences et de Technologie d'Oran (USTO), BP 1505, El M'Naouer, Oran 31000, Algeria.

PbTiFeO ( = 0, 0.3, 0.5, and 0.7) ceramics were prepared using the classical solid-state reaction method. The investigated system presented properties that were derived from composition, microstructure, and oxygen deficiency. The phase investigations indicated that all of the samples were well crystallized, and the formation of a cubic structure with small traces of impurities was promoted, in addition to a tetragonal structure, as Fe concentration increased. The scanning electron microscopy (SEM) images for PbTiFeO ceramics revealed microstructures that were inhomogeneous with an intergranular porosity. The dielectric permittivity increased systematically with Fe concentration, increasing up to = 0.7. A complex impedance analysis revealed the presence of multiple semicircles in the spectra, demonstrating a local electrical inhomogeneity due the different microstructures and amounts of oxygen vacancies distributed within the sample. The increase of the substitution with Fe ions onto Ti sites led to the improvement of the magnetic properties due to the gradual increase in the interactions between Fe ions, which were mediated by the presence of oxygen vacancies. The PbTiFeO became a multifunctional system with reasonable dielectric, piezoelectric, and magnetic characteristics, making it suitable for application in magnetoelectric devices.
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http://dx.doi.org/10.3390/ma14040927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919785PMC
February 2021

[Characteristics of cardiac involvement in eosinophilic granulomatosis with polyangiitis].

Ann Cardiol Angeiol (Paris) 2021 Feb 23. Epub 2021 Feb 23.

Service de médecine interne, centre hospitalier universitaire Mongi-Slim, 2070 La Marsa, Tunisie.

Aim Of The Study: Our study aimed to identify the characteristics of cardiac involvement in eosinophilic granulomatosis with polyangiitis (EGPA).

Methods: We conducted a retrospective analytic study including EGPA cases diagnosed between 2000 and 2019 in an internal medicine department. Diagnosis was made according to the 1990 American College of Rheumatology criteria and the 2012 Chapel Hill Concensus.

Results: Eleven EGPA cases were included, 64% of patients were female. Median age at diagnosis was 52 years [42-58]. Heart damage revealed EGPA in 55% of cases with a significant predominance of women (p=0.015). The main cardiac manifestations were myocarditis, ischemic cardiomyopathy due to small vessel vasculitis, cardiac tamponade and intracardiac thrombus. Cardiac magnetic resonance imaging (MRI) mainly showed subendocardial hyposignal in early infusion and late enhancement in the same areas, nodular by locations, associated with impaired left ventricle function and micro-infarctions by distal vasculitis. Cardiac damage was associated to ANCA negativity in 83.3% of cases. The median Birmingham Vasculitis Activity Score version3 (BVAS v3) was 16 [10-17]. Under conventional treatment, no relapses had occurred. The median vasculitis damage index (VDI) was 2 [1-2.3] and the mortality rate was zero after a mean follow-up of 43 months.

Conclusion: Cardiomyopathy is a frequent revealing mode of EGPA. A late onset asthma and hypereosinophilia should guide the diagnosis. As ANCA research often turns out to be negative, histological evidence is recommended in this context. The contribution of cardiac MRI in the diagnosis of EGPA remains to be defined.
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http://dx.doi.org/10.1016/j.ancard.2020.12.002DOI Listing
February 2021

Effect of Soybean Oil Supplementation on Milk Production, Digestibility, and Metabolism in Dairy Goats under Thermoneutral and Heat Stress Conditions.

Animals (Basel) 2021 Jan 30;11(2). Epub 2021 Jan 30.

Group of Research in Ruminants (G2R), Animal and Food Science Department, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.

In a previous work, we observed that heat-stressed goats suffer reductions in milk yield and its contents of fat and protein. Supplementation with soybean oil (SBO) may be a useful strategy to enhance milk quality. In total, eight multiparous Murciano-Granadina dairy goats (42.8 ± 1.3 kg body weight; 99 ± 1 days of lactation) were used in a replicated 4 × 4 Latin square design with four periods; 21 d each (14 d adaptation, 5 d for measurements and 2 d transition between periods). Goats were allocated to one of four treatments in a 2 × 2 factorial arrangement. Factors were no oil (CON) or 4% of soybean oil (SBO), and controlled thermal neutral (TN; 15 to 20 °C) or heat stress (HS; 12 h/d at 37 °C and 12 h/d at 30 °C) conditions. This resulted in four treatment combinations: TN-CON, TN-SBO, HS-CON, and HS-SBO. Compared to TN, HS goats experienced lower ( < 0.05) feed intake, body weight, N retention, milk yield, and milk protein and lactose contents. However, goats in HS conditions had greater ( < 0.05) digestibility coefficients (+5.1, +5.2, +4.6, +7.0, and +8.9 points for dry matter, organic matter, crude protein, neutral detergent fiber, and acid detergent fiber, respectively) than TN goats. The response to SBO had the same magnitude in TN and HS conditions. Supplementation with SBO had no effects on feed intake, milk yield, or milk protein content. However, SBO supplementation increased ( < 0.05) blood non-esterified fatty acids by 50%, milk fat by 29%, and conjugated linoleic acid by 360%. In conclusion, feeding 4% SBO to dairy goats was a useful strategy to increase milk fat and conjugated linoleic acid without any negative effects on intake, milk yield, or milk protein content. These beneficial effects were obtained regardless goats were in TN or HS conditions.
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http://dx.doi.org/10.3390/ani11020350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911429PMC
January 2021

Milk Production and Energetic Metabolism of Heat-Stressed Dairy Goats Supplemented with Propylene Glycol.

Animals (Basel) 2020 Dec 21;10(12). Epub 2020 Dec 21.

Group of Research in Ruminants (G2R), Animal and Food Sciences Department, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.

Heat-stressed dairy animals increase their reliance on glucose. This elevated glucose demand is partially met by increasing the conversion of glucogenic amino acids (AA) in the liver. Propylene glycol (PG) is a glucogenic precursor and was not tested in dairy goats under thermoneutral (TN) and heat stress (HS) conditions simultaneously. We hypothesize that if HS-goats are fed with PG, they would get more glucose and consequently spare more glucogenic AA for milk protein synthesis rather than gluconeogenesis. Eight multiparous dairy goats (40.8 ± 1.1 kg body weight; 84 ± 1 days in milk) were used in a replicated 4 × 4 Latin square design of 4 periods; 21 d each (14 d adaptation, 5 d for measurements, and 2 d of transition). Goats were allocated to one of 4 treatments in a 2 × 2 factorial arrangement. Factors were control (CO) without PG or 5% of PG, and thermoneutral (TN; 15 to 20 °C) or heat stress (HS; 12 h/d at 37 °C and 12 h/d at 30 °C) conditions. Feed intake, rectal temperature, respiratory rate, milk yield, milk composition, and blood metabolites were measured. Compared to TN, HS goats had lower ( < 0.01) feed intake (-34%), fat-corrected milk (-15%), and milk fat (-15%). Heat-stressed goats also tended ( < 0.10) to produce milk with lower protein (-11%) and lactose (-4%) contents. Propylene glycol increased blood glucose (+7%; < 0.05), blood insulin (+37%; < 0.10), and body weight gain (+68%; < 0.05), but decreased feed intake (-9%; < 0.10) and milk fat content (-23%; < 0.01). Furthermore, blood non-esterified fatty acids (-49%) and β-hydroxybutyrate (-32%) decreased ( < 0.05) by PG. In conclusion, supplementation of heat-stressed dairy goats with propylene glycol caused milk fat depression syndrome, but reduced body weight loss that is typically observed under HS conditions. Supplementation with lower doses of PG would avoid the reduced feed intake and milk fat depression, but this should be tested.
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http://dx.doi.org/10.3390/ani10122449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766538PMC
December 2020