Steve Gerondakis

Steve Gerondakis

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Steve Gerondakis

Steve Gerondakis

Publications by authors named "Steve Gerondakis"

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Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.

Cell Metab 2018 May 19;27(5):1096-1110.e5. Epub 2018 Apr 19.

Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia; Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia; Faculty of Medicine, St Vincent's Clinical School, Faculty of Medicine, University of NSW, Sydney, NSW 2010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.03.014DOI Listing
May 2018

The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8 Thymocyte Selection.

J Immunol 2017 04 15;198(7):2649-2660. Epub 2017 Feb 15.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037;

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http://dx.doi.org/10.4049/jimmunol.1601462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360474PMC
April 2017

Understanding the Roles of the NF-κB Pathway in Regulatory T Cell Development, Differentiation and Function.

Prog Mol Biol Transl Sci 2015 3;136:57-67. Epub 2015 Sep 3.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2015.08.002DOI Listing
November 2016

The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3(+) regulatory T cells.

J Autoimmun 2016 06 7;70:52-62. Epub 2016 Apr 7.

Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.03.017DOI Listing
June 2016

The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.

PLoS One 2014 6;9(11):e111524. Epub 2014 Nov 6.

The Australian Centre for Blood Diseases and Department of Clinical Hematology, Monash University Central Clinical School, Melbourne, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111524PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222916PMC
July 2015

The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.

Nat Commun 2015 Apr 13;6:6795. Epub 2015 Apr 13.

1] Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria 3168, Australia [2] Department of Molecular and Translational Science, Monash University, Melbourne, Victoria 3168, Australia [3] Institute of Ageing Research, Hangzhou Normal University School of Medicine, 1378 Wenyi Road West, Hangzhou, Zhejiang 311121, China.

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http://dx.doi.org/10.1038/ncomms7795DOI Listing
April 2015

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.

Proc Natl Acad Sci U S A 2015 Feb 20;112(5):1535-40. Epub 2015 Jan 20.

MIMR-PHI Institute of Medical Research, Clayton, Victoria 3168, Australia; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3168, Australia; Institute of Ageing Research, Hangzhou Normal University School of Medicine, Hangzhou, Zhejiang 311121, China;

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http://dx.doi.org/10.1073/pnas.1409728112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321291PMC
February 2015

c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells.

J Biol Chem 2014 Nov 29;289(46):31693-707. Epub 2014 Sep 29.

From the School of Biological Sciences, College of Science, Nanyang Technological University, Singapore 637551, Republic of Singapore and

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http://dx.doi.org/10.1074/jbc.M114.574517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231650PMC
November 2014

NF-κB control of T cell development.

Nat Immunol 2014 Jan;15(1):15-25

The Australian Centre for Blood Diseases and Department of Clinical Hematology, Monash University Central Clinical School, Melbourne, Victoria, Australia.

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http://www.nature.com/articles/ni.2785
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http://dx.doi.org/10.1038/ni.2785DOI Listing
January 2014

c-Rel: shaping CD4 regulatory T cell development in unexpected ways.

Transcription 2012 Sep-Oct;3(5):245-9. Epub 2012 Sep 1.

The Australian Centre for Blood Diseases and Department of Clinical Hematology; Monash University Central Clinical School, Melbourne, VIC, Australia.

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http://www.tandfonline.com/doi/abs/10.4161/trns.21309
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http://dx.doi.org/10.4161/trns.21309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632621PMC
November 2013

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein.

EMBO Rep 2013 Nov 24;14(11):992-8. Epub 2013 Sep 24.

1] The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia [2] Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/embor.2013.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818073PMC
November 2013

The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death.

Immunity 2013 Sep 5;39(3):573-83. Epub 2013 Sep 5.

Department of Immunology, Monash University, Melbourne, VIC 3004, Australia; Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.immuni.2013.05.019DOI Listing
September 2013

The NF-κB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis.

J Immunol 2011 Nov 21;187(9):4483-91. Epub 2011 Sep 21.

Gene Expression and Epigenomics Laboratory, Department of Genome Biology, The John Curtin School of Medical Research, Australian National University, Canberra 2600, Australia.

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http://dx.doi.org/10.4049/jimmunol.1101757DOI Listing
November 2011

Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation.

J Immunol 2011 Oct 7;187(8):4018-30. Epub 2011 Sep 7.

University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.

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http://dx.doi.org/10.4049/jimmunol.1101727DOI Listing
October 2011

The c-Rel Transcription Factor in Development and Disease.

Genes Cancer 2011 Jul;2(7):695-711

Boston University, Biology Department, Boston, MA, USA.

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http://dx.doi.org/10.1177/1947601911421925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218406PMC
July 2011

Critical role of cRel subunit of NF-κB in sepsis survival.

Infect Immun 2011 May 22;79(5):1848-54. Epub 2011 Feb 22.

Département de Biologie Cellulaire des Interactions Hôte-Pathogène, Institut Cochin, Paris, France.

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http://dx.doi.org/10.1128/IAI.00021-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088128PMC
May 2011

Differentiation of inflammatory dendritic cells is mediated by NF-κB1-dependent GM-CSF production in CD4 T cells.

J Immunol 2011 May 18;186(9):5468-77. Epub 2011 Mar 18.

Reid Rheumatology Laboratory, Division of Inflammation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.4049/jimmunol.1002923DOI Listing
May 2011

Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-κB pathway.

Immunol Cell Biol 2011 Feb 10;89(2):294-303. Epub 2010 Aug 10.

Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1038/icb.2010.93DOI Listing
February 2011

Roles of the NF-kappaB pathway in lymphocyte development and function.

Cold Spring Harb Perspect Biol 2010 May 23;2(5):a000182. Epub 2009 Dec 23.

The Burnet Institute, 85 Commercial Rd, Prahran, Victoria 3004, Australia.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a000182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857169PMC
May 2010

c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.

Eur J Immunol 2010 Mar;40(3):867-77

Campbell Family Institute, Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/eji.200939445DOI Listing
March 2010

Illumina WG-6 BeadChip strips should be normalized separately.

BMC Bioinformatics 2009 Nov 11;10:372. Epub 2009 Nov 11.

Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.1186/1471-2105-10-372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780421PMC
November 2009

Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-kappaB and NFAT.

J Immunol 2008 Oct;181(8):5405-13

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.4049/jimmunol.181.8.5405DOI Listing
October 2008

The nuclear factor-kappaB and p53 pathways function independently in primary cells and transformed fibroblasts responding to genotoxic damage.

Mol Cancer Res 2008 Jul 26;6(7):1193-203. Epub 2008 Jun 26.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-07
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http://dx.doi.org/10.1158/1541-7786.MCR-07-2125DOI Listing
July 2008

Coordinating TLR-activated signaling pathways in cells of the immune system.

Immunol Cell Biol 2007 Aug-Sep;85(6):420-4. Epub 2007 Jul 17.

Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://doi.wiley.com/10.1038/sj.icb.7100098
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http://dx.doi.org/10.1038/sj.icb.7100098DOI Listing
November 2007

Regulating B-cell activation and survival in response to TLR signals.

Immunol Cell Biol 2007 Aug-Sep;85(6):471-5. Epub 2007 Jul 17.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1038/sj.icb.7100097DOI Listing
November 2007

Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel.

J Immunol 2007 Jun;178(11):7097-109

Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia.

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http://dx.doi.org/10.4049/jimmunol.178.11.7097DOI Listing
June 2007

Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction.

FASEB J 2006 Sep 12;20(11):1918-20. Epub 2006 Jul 12.

Medizinische Klinik und Poliklinik I, Herzkreislauf-Zentrum, Universität Würzburg, Germany.

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http://dx.doi.org/10.1096/fj.05-5133fjeDOI Listing
September 2006

Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells.

Proc Natl Acad Sci U S A 2006 Feb 16;103(9):3274-9. Epub 2006 Feb 16.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1073/pnas.0511113103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413910PMC
February 2006

A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.

Genes Dev 2005 Sep;19(18):2138-51

Howard Hughes Medical Institute, Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095-1662, USA.

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http://dx.doi.org/10.1101/gad.1329805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221885PMC
September 2005

Histone dynamics on the interleukin-2 gene in response to T-cell activation.

Mol Cell Biol 2005 Apr;25(8):3209-19

Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1128/MCB.25.8.3209-3219.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069623PMC
April 2005

The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappaB-dependent c-myc expression.

Immunity 2004 Jul;21(1):19-30

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1016/j.immuni.2004.06.004DOI Listing
July 2004

The role of Rel/NF-kappaB transcription factors in B lymphocyte survival.

Semin Immunol 2003 Jun;15(3):159-66

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Vic., Melbourne, Australia.

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June 2003

c-Rel is required for chromatin remodeling across the IL-2 gene promoter.

J Immunol 2003 Apr;170(7):3724-31

Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia.

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http://kendallasmith.com/pdf/Rao_Shannon_2003.pdf
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http://dx.doi.org/10.4049/jimmunol.170.7.3724DOI Listing
April 2003

B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-kappaB regulated c-myc transcription.

Mol Cell 2002 Dec;10(6):1283-94

The Walter and Eliza Hall Institute of Medical Research, P.O. Box The Royal Melbourne Hospital, 3050, Victoria, Australia.

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December 2002

NF-kappaB is required for CD38-mediated induction of C(gamma)1 germline transcripts in murine B lymphocytes.

Int Immunol 2002 Sep;14(9):1055-64

Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan.

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http://dx.doi.org/10.1093/intimm/dxf072DOI Listing
September 2002

NF-kappaB1 can inhibit v-Abl-induced lymphoid transformation by functioning as a negative regulator of cyclin D1 expression.

Mol Cell Biol 2002 Aug;22(15):5563-74

The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Victoria 3050, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133951PMC
http://dx.doi.org/10.1128/mcb.22.15.5563-5574.2002DOI Listing
August 2002

The cross-priming APC requires a Rel-dependent signal to induce CTL.

J Immunol 2002 Apr;168(7):3283-7

Immunology Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.

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http://dx.doi.org/10.4049/jimmunol.168.7.3283DOI Listing
April 2002