Publications by authors named "S Gail Eckhardt"

471 Publications

A grant-based experiment to train clinical investigators: the AACR/ASCO methods in clinical cancer research workshop.

Clin Cancer Res 2021 Jul 26. Epub 2021 Jul 26.

Unit of Development and Research in Medical Education (UDREM), University of Geneva Faculty of Medicine.

To address the need for clinical investigators in oncology, AACR and ASCO established the Methods in Clinical Cancer Research Workshop (MCCRW). The workshop's objectives were to: (1) provide training in the methods, design, and conduct of clinical trials; (2) ensure that clinical trials met federal and international ethical guidelines; (3) evaluate the effectiveness of the workshop; and (4) create networking opportunities for young investigators with mentoring senior faculty. Educational methods included: (1) didactic lectures; (2) Small Group Discussion Sessions; (3) Protocol Development Groups; (4) one-on-one mentoring. Learning focused on the development of an IRB-ready protocol, which was submitted on the last day of the workshop. Evaluation methods included: (1) pre- and post-workshop tests; (2) students' workshop evaluations; (3) faculty's ratings of protocol development; (4) students' productivity in clinical research after the workshop; (5) an independent assessment of the workshop. From 1996-2014, 1932 students from diverse backgrounds attended the workshop. There was a significant improvement in the students' level of knowledge from the pre- to the post-workshop exams (p < 0.001). Across the classes, student evaluations were very favorable. At the end of the workshop, faculty rated 92-100% of the students' protocols as ready for IRB submission. Intermediate and long-term follow-ups indicated that more than 92% of students were actively involved in patientrelated research, and 66% had implemented five or more protocols. This NCI-sponsored MCCRW has had a major impact on the training of clinicians in their ability to design and implement clinical trials in cancer research.
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http://dx.doi.org/10.1158/1078-0432.CCR-21-1799DOI Listing
July 2021

Introducing a nested multimedia fate and transport model for organic contaminants (NEM).

Environ Sci Process Impacts 2021 Aug 12;23(8):1146-1157. Epub 2021 Jul 12.

Norwegian Institute for Air Research, P.O. Box 100, NO-2027, Kjeller, Norway.

Some organic contaminants, including the persistent organic pollutants (POPs), have achieved global distribution through long range atmospheric transport (LRAT). Regulatory efforts, monitoring programs and modelling studies address the LRAT of POPs on national, continental (e.g. Europe) and/or global scales. Whereas national and continental-scale models require estimates of the input of globally dispersed chemicals from outside of the model domain, existing global-scale models either have relatively coarse spatial resolution or are so computationally demanding that it limits their usefulness. Here we introduce the Nested Exposure Model (NEM), which is a multimedia fate and transport model that is global in scale yet can achieve high spatial resolution of a user-defined target region without huge computational demands. Evaluating NEM by comparing model predictions for PCB-153 in air with measurements at nine long-term monitoring sites of the European Monitoring and Evaluation Programme (EMEP) reveals that nested simulations at a resolution of 1°× 1° yield results within a factor of 1.5 of observations at sites in northern Europe. At this resolution, the model attributes more than 90% of the atmospheric burden within any of the grid cells containing an EMEP site to advective atmospheric transport from elsewhere. Deteriorating model performance with decreasing resolution (15°× 15°, 5°× 5° and 1°× 1°), manifested by overestimation of concentrations across most of northern Europe by more than a factor of 3, illustrates the effect of numerical diffusion. Finally, we apply the model to demonstrate how the choice of spatial resolution affect predictions of atmospheric deposition to the Baltic Sea. While we envisage that NEM may be used for a wide range of applications in the future, further evaluation will be required to delineate the boundaries of applicability towards chemicals with divergent fate properties as well as in environmental media other than air.
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http://dx.doi.org/10.1039/d1em00084eDOI Listing
August 2021

Black Carbon Emission Reduction Due to COVID-19 Lockdown in China.

Geophys Res Lett 2021 Apr 21;48(8):e2021GL093243. Epub 2021 Apr 21.

Department of Meteorology and Geophysics University of Vienna UZA II Vienna Austria.

During the Lunar New Year Holiday of 2020, China implemented an unprecedented lockdown to fight the COVID-19 outbreak, which strongly affected the anthropogenic emissions. We utilized elemental carbon observations (equivalent to black carbon, BC) from 42 sites and performed inverse modeling to determine the impact of the lockdown on the weekly BC emissions and quantify the effect of the stagnant conditions on BC observations in densely populated eastern and northern China. BC emissions declined 70% (eastern China) and 48% (northern China) compared to the first half of January. In northern China, under the stagnant conditions of the first week of the lockdown, the observed BC concentrations rose unexpectedly (29%) even though the BC emissions fell. The emissions declined substantially thereafter until a week after the lockdown ended. On the contrary, in eastern China, BC emissions dropped sharply in the first week and recovered synchronously with the end of the lockdown.
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http://dx.doi.org/10.1029/2021GL093243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250075PMC
April 2021

Uterosacral Ligament Hysteropexy for Uterine Didelphys: A Case Report.

J Minim Invasive Gynecol 2021 Jul 4;28(7):1425-1428. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, UCLA Medical Center, Los Angeles (Drs. Bermudez and Rosenman) California.

Surgical approach to pelvic organ prolapse has traditionally included hysterectomy; however, in the past decade, uterine sparing prolapse surgery (hysteropexy) has become increasingly popular within female pelvic medicine and reconstructive surgery. The current literature demonstrates comparable outcomes for hysteropexy and traditional approach. As these procedures become more common, it is important to consider how to approach patients with unique anatomy such as uterine anomalies who desire uterine sparing surgery. In our case, we describe a woman aged 77 years with uterine didelphys who underwent a successful vaginal uterosacral ligament hysteropexy for stage 2 pelvic organ prolapse and was followed for 12 months postoperatively. Our case demonstrates that vaginal uterosacral ligament hysteropexy is feasible in a patient with uterine didelphys.
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http://dx.doi.org/10.1016/j.jmig.2021.04.018DOI Listing
July 2021

Patient reported outcomes affecting quality of life in socioeconomically disadvantaged cancer patients.

J Psychosoc Oncol 2021 May 3:1-16. Epub 2021 May 3.

Dell Medical School.

Purpose: The aim of this study was to identify correlates of quality of life (QOL) for socioeconomically disadvantaged cancer patients receiving care in the "safety net" health system.

Design: This cross-sectional study used linear regressions to determine the effect of patient reported outcome measures (PRO) on QOL.Sample/Methods: Cancer patients ( = 115) receiving drug therapy completed a series of PROs including: Functional Assessment of Cancer Therapy (FACT-G), PROMIS (Anxiety, Depression, Fatigue, Pain Interference, and Physical Function), and the Comprehensive Score for Financial Toxicity.

Findings: More than 60% of patients reported an annual income below $24,999. Forty-five percent of patients were either uninsured or county-funded. Depression, pain, and financial toxicity were found to be consistently significant correlates of QOL.Implications: Cancer patients with existing financial strain have unique psychosocial stressors. This study provides insight into the relationship between these stressors, and the need for targeted screening and intervention that address such aspects of care.
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http://dx.doi.org/10.1080/07347332.2021.1915441DOI Listing
May 2021
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