Publications by authors named "S Atilla"

34 Publications

Concordance between a Mohs surgeon and a dermatopathologist in evaluating Mohs cryosections.

J Eur Acad Dermatol Venereol 2021 Jul 31. Epub 2021 Jul 31.

Department of Dermatology and Venereology, School of Medicine, Hacettepe University, Ankara, Turkey.

Background: Mohs micrographic surgery is the gold standard treatment for high-risk non-melanoma skin cancers. The success of Mohs relies on accurate histopathologic evaluation. Due to law restrictions in some European countries, Mohs surgeons are not permitted to report on histopathology; therefore, a pathologist evaluates the frozen sections.

Objective: To retrospectively assess the concordance between the certified Mohs surgeon and the pathologist in evaluating the Mohs slides that were intraoperatively evaluated by the pathologist.

Materials And Methods: Frozen section slides of a total of 237 Mohs cases between 2013 and 2020 were examined by the blinded Mohs surgeon, and the tumours were marked on copy maps. The copy maps and the original maps were compared, and the non-concordant cases were re-evaluated together by the Mohs surgeon and the dermatopathologist. The concordance rate was calculated, and the inter-rater agreement was statistically analysed using Cohen's Kappa coefficient.

Results: We report a high concordance rate (97.9%) and inter-rater agreement (0.96) between Mohs surgeon and dermatopathologist in evaluating Mohs slides.

Conclusion: As a newly settled centre, our results are in alignment with experienced centres where the Mohs surgeon evaluates the slides herself and performs the surgery.
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http://dx.doi.org/10.1111/jdv.17574DOI Listing
July 2021

A retrospective evaluation of laboratory parameters and hyperuricemia in patients with acne vulgaris under systemic isotretinoin treatment.

J Dermatolog Treat 2020 Aug 9:1-4. Epub 2020 Aug 9.

School of Medicine, Hacettepe University, Ankara, Turkey.

Background: Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit. Systemic isotretinoin (SI) is an effective, synthetic vitamin A derivative in the treatment of resistant acne or nodulocystic acne. This study aimed to investigate uric acid levels and laboratory parameters in patients receiving isotretinoin treatment.

Materials And Methods: This study included 114 patients who were under SI treatment of 0.2-0.5 mg/kg/day aged between 17 and 44 years old. We retrospectively evaluated total cholesterol, triglyceride, aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, creatinine kinase, uric acid, thrombocyte (Plt), and leucocyte (WBC) levels prior and on the fourth month of the treatment from the patients' records and compared these data statistically.

Results: The AST, creatinine kinase, cholesterol, triglyceride, and thrombocyte levels were significantly different (<.001, <.001, <.001, <.001, and =.02, respectively), and no statistically significant differences were noted among the uric acid, creatinine, ALT, and WBC levels in the comparison of the baseline values and values at the fourth month of treatment (>.05).

Conclusions: SI treatment of 0.2-0.5 mg/kg/day did not make significant alterations on serum uric acid levels. Besides, all alterations occurred within normal ranges.
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http://dx.doi.org/10.1080/09546634.2020.1800575DOI Listing
August 2020

Complete Genome Sequence of the Model Oleaginous Alga CCMP1894.

Genome Announc 2018 Feb 15;6(7). Epub 2018 Feb 15.

Synthetic Genomics, La Jolla, California, USA

The model oleaginous alga was completely sequenced using a combination of optical mapping and next-generation sequencing technologies to generate one of the most complete eukaryotic genomes published to date. The assembled genome is 30.7 Mb long.
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http://dx.doi.org/10.1128/genomeA.01448-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814478PMC
February 2018

Can We Predict the Perioperative Pulmonary Complications Before Laparoscopic Sleeve Gastrectomy: Original Research.

Obes Surg 2017 06;27(6):1524-1528

Department of Chest Diseases, Kahramanmaras Necip Fazıl State Hospital, Kahramanmaras, Turkey.

Background: The increasing prevalence of obesity in worldwide is one of the most serious chronic public health problems and is considered to be a global epidemic. Bariatric surgical procedures have also been applied more often with increased prevalence of obesity. As a result, the incidence of surgical complications has increased. Preoperative evaluation is quite important for these patients.

Aims: The aim of our study is to determine the predictors of perioperative pulmonary complications of laparoscopic sleeve gastrectomy.

Study Design: The study is a cross-sectional study.

Methods: One hundred eighty-three consecutive patients who received laparoscopic bariatric surgery were followed up during 3 months. Patients were divided into two groups A and B. Group A being the patients who had perioperative pulmonary complications (n = 28) and group B being patients who had not (n = 155). Pulmonary function test (PFT), body mass index (BMI), preoperative oxygen saturation, age, gender, comorbid diseases, and smoking history were compared between these groups.

Results: Mean age, size, weight, BMI, PFT parameters of groups A and B were close to each other. The strongest predictors of perioperative pulmonary complications were duration of smoking in current smokers and low baseline oxygen saturation.

Conclusions: Preoperative oxygen saturation and smoking history may help to predict perioperative complications of laparoscopic sleeve gastrectomy.
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http://dx.doi.org/10.1007/s11695-016-2522-4DOI Listing
June 2017

Effects of different consolidation periods on bone formation and implant success in alveolar distraction osteogenesis: a clinical study.

J Craniomaxillofac Surg 2013 Apr 25;41(3):194-7. Epub 2012 Oct 25.

Marmara Üniversitesi Nişantaşı Kampusu, Büyük Çiftlik Sk. No: 6, Nişantaşı, Şişli, Istanbul 34365, Turkey.

Purpose: The aims of this study were to compare the consolidation periods in alveolar distraction osteogenesis and evaluate the effects of this condition on bone formation, bone relapse and implant success in reconstruction of resorbed edentulous mandibles.

Patients And Methods: Eighteen patients were underwent vertical alveolar distraction osteogenesis under the same distraction protocol, except for variations in consolidation time. After a consolidation period of 5 weeks for Group 1 and 14 weeks for Group 2, 36 implants were placed to support their dentures. Bone height and relapse were evaluated using digital orthopantomographic radiographs.

Results: The radiological findings showed that the mean distraction was 6.968 mm in Group 1 and 7.031 mm in Group 2. At the end of the consolidation period, the mean bone relapse was 0.832 ± 0.135 mm in Group 1 and 0.738 ± 0.135 mm in Group 2. At the end of 6 months, the mean bone relapse was 1.380 ± 0.144 mm in Group 1 and 1.112 ± 0.144 mm in Group 2. No significant difference existed between the two groups at any time.

Conclusion: Consolidation periods may be reduced in alveolar distraction osteogenesis to enable more patient comfort by providing dentures early.
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http://dx.doi.org/10.1016/j.jcms.2012.08.002DOI Listing
April 2013
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