Publications by authors named "Ryna Karina Then"

3 Publications

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Would you use novel oral anticoagulants (NOACs) for thromboprophylaxis in patients with an underlying hypercoagulable state? A literature review through a case report.

BMJ Case Rep 2020 Oct 30;13(10). Epub 2020 Oct 30.

Neurology, Cooper Hospital University Medical Center, Camden, New Jersey, USA.

Antiphospholipid syndrome (APLS) is an autoimmune condition that predisposes to venous and arterial thrombosis. Warfarin is the agent of choice for anticoagulation. However, a need for routine international normalised ratio (INR) checks and multiple drug interactions are some of the difficulties with warfarin. Currently, there is mixed evidence for and against the use of novel oral anticoagulants (NOACs) for thromboprophylaxis. We present a case report of a patient with APLS on a NOAC for secondary thromboprophylaxis who developed a stroke and discuss current evidence regarding the use of NOACs in patients with APLS. The patient was switched to warfarin for secondary thromboprophylaxis with an INR goal of 2-3. Literature review revealed mixed case reports for and against NOACs for secondary prevention of thrombotic events in patients with APLS. There needs to be further randomised controlled trials to evaluate the efficacy of NOACs for thromboprophylaxis in patients with APLS.
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http://dx.doi.org/10.1136/bcr-2020-237238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604795PMC
October 2020

Interhemispheric subdural and subarachnoid haemorrhage in a patient with amphetamine-induced vasculitis.

BMJ Case Rep 2017 Dec 7;2017. Epub 2017 Dec 7.

Department of Neurosurgery, Cooper University Hospital, Camden, New Jersey, USA.

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http://dx.doi.org/10.1136/bcr-2017-222918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728227PMC
December 2017

Multiple recurrent ischaemic strokes in a patient with cancer: is there a role for the initiation of anticoagulation therapy for secondary stroke prevention?

BMJ Case Rep 2017 Jun 3;2017. Epub 2017 Jun 3.

Department of Neurology, Cooper University Hospital, Camden, New Jersey, USA.

A 52-year-old woman with a medical history of cervical and thyroid cancer, hypertension, dyslipidaemia, uncontrolled diabetes and heavy smoking was diagnosed with a new metastatic cholangiocarcinoma. While undergoing palliative chemotherapy, she developed dysarthria and left-sided weakness. Imaging studies showed multiple bilateral ischaemic strokes. On hospital days 2 and 5, she developed worsening neurological symptoms and imaging studies revealed new areas of ischaemia on respective days. Subsequent workup did not revealed a clear aetiology for the multiple ischaemic events and hypercoagulability studies were only significant for a mildly elevated serum D-dimer level. Although guidelines are unclear, full-dose anticoagulation with low molecular weight heparin was initiated given her high risk of stroke recurrence. She was discharged to acute rehabilitation but, within a month, she experienced complications of her malignant disease progression and a new pulmonary thromboembolism. The patient died soon after being discharged home with hospice care.
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http://dx.doi.org/10.1136/bcr-2016-218105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534754PMC
June 2017