Ryan Temel

Ryan Temel

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Ryan Temel

Ryan Temel

Publications by authors named "Ryan Temel"

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Simultaneous Determination of Biliary and Intestinal Cholesterol Secretion Reveals That CETP (Cholesteryl Ester Transfer Protein) Alters Elimination Route in Mice.

Arterioscler Thromb Vasc Biol 2019 Oct 29;39(10):1986-1995. Epub 2019 Aug 29.

From the Graduate Center for Nutritional Sciences (J.L., R.E.T., D.R.v.d.W., G.A.G.), University of Kentucky, Lexington.

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http://dx.doi.org/10.1161/ATVBAHA.119.312952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761010PMC
October 2019

microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO.

Physiol Genomics 2019 Feb 11;51(2):59-71. Epub 2019 Jan 11.

US Department of Agriculture, Agricultural Research Service Western Human Nutrition Research Center, Obesity and Metabolism Unit, Davis, California.

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http://dx.doi.org/10.1152/physiolgenomics.00079.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397334PMC
February 2019

ABCG5 and ABCG8: more than a defense against xenosterols.

J Lipid Res 2018 07 4;59(7):1103-1113. Epub 2018 May 4.

Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536

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http://dx.doi.org/10.1194/jlr.R084244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027916PMC
July 2018

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.

Elife 2017 10 25;6. Epub 2017 Oct 25.

Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, United States.

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http://dx.doi.org/10.7554/eLife.28766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656429PMC
October 2017

Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a.

Circ Res 2017 Aug 21;121(4):354-367. Epub 2017 Jun 21.

From the Toronto General Hospital Research Institute, University Health Network, Ontario, Canada (H.S.C, R.B., A.L., Z.C., E.A.S., N.K., S.A.M., M.H., M.I.C., C.S.R., J.E.F.); Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada (H.S.C, R.B., A.L., Z.C., E.A.S., N.K., S.A.M., M.H., M.I.C., C.S.R., J.E.F.); Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Ontario, Canada (H.S.C, R.B., A.L., Z.C., E.A.S., N.K., M.H., M.I.C., C.S.R., J.E.F.); Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Germany (M.N.-J., A.S.); INSERM, Unit 970, Paris Cardiovascular Research Center-PARCC, France (A.H., C.M.B.); University of Ottawa Heart Institute, Ontario, Canada (M.-A.N., M.G., K.J.R.); and Pharmacology and Nutritional Sciences, University of Kentucky, Lexington (L.C., T.L., R.E.T.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.310529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542783PMC
August 2017

Para-bile-osis Establishes a Role for Nonbiliary Macrophage to Feces Reverse Cholesterol Transport.

Arterioscler Thromb Vasc Biol 2017 05;37(5):738-739

From the Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, OH (J.M.B.); Saha Cardiovascular Research Center, University of Kentucky, Lexington (R.E.T.); and Department of Pharmaceutical Sciences, University of Kentucky, Lexington (G.A.G.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546086PMC
May 2017

miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux.

Arterioscler Thromb Vasc Biol 2016 05 3;36(5):942-951. Epub 2016 Mar 3.

Marc and Ruti Bell Vascular Biology and Disease Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY 10016.

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http://dx.doi.org/10.1161/ATVBAHA.116.307282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850101PMC
May 2016

Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion.

PLoS One 2014 5;9(6):e98953. Epub 2014 Jun 5.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America; Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098953PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047063PMC
July 2015

A new model of reverse cholesterol transport: enTICEing strategies to stimulate intestinal cholesterol excretion.

Trends Pharmacol Sci 2015 Jul 27;36(7):440-51. Epub 2015 Apr 27.

Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2015.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485953PMC
July 2015

Hepatic or intestinal ABCG5 and ABCG8 are sufficient to block the development of sitosterolemia.

Authors:
Ryan Temel

J Lipid Res 2015 Feb 19;56(2):201-2. Epub 2014 Dec 19.

Saha Cardiovascular Research Center & Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536-0509

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http://dx.doi.org/10.1194/jlr.C056945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306675PMC
February 2015

BMP7 drives human adipogenic stem cells into metabolically active beige adipocytes.

Lipids 2015 Feb 23;50(2):111-20. Epub 2014 Dec 23.

Department of Nutrition and Health Sciences, University of Nebraska, 316G Ruth Leverton Hall, Lincoln, NE, 68583, USA.

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http://dx.doi.org/10.1007/s11745-014-3981-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306630PMC
February 2015

The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice.

Cell Metab 2014 Nov 4;20(5):910-918. Epub 2014 Nov 4.

Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261644PMC
November 2014

Reduction of VLDL secretion decreases cholesterol excretion in niemann-pick C1-like 1 hepatic transgenic mice.

PLoS One 2014 3;9(1):e84418. Epub 2014 Jan 3.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America ; Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084418PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880293PMC
September 2014

Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys.

Arterioscler Thromb Vasc Biol 2014 Sep 26;34(9):1880-7. Epub 2014 Jun 26.

From the Department of Pathology, Sections on Lipid Sciences (S.C., H.C., S.M.M., A.L.M., R.E.T., J.S.P.) and Comparative Medicine (K.K.), and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Nutrition and Health Sciences, University of Nebraska, Lincoln (S.C.); Department of Food Science and Human Nutrition, University of Florida, Gainesville (S.C., J.-H.H.); and Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles (C.H., P.T.).

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http://dx.doi.org/10.1161/ATVBAHA.114.303896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140949PMC
September 2014

Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.

Arterioscler Thromb Vasc Biol 2014 Sep 17;34(9):1917-23. Epub 2014 Jul 17.

From the Children's Hospital Oakland Research Institute, CA (M.W.M., F.B., D.N., E.T., K.S., R.M.K.); Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany (J.S., H.R.); Sage Bionetworks, Seattle, WA (L.M.M.); Section on Lipid Sciences, Department of Pathology, Wake Forest University Health Sciences, Winston-Salem, NC (L.L.R., R.E.T.); and Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany (C.S., H.R.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141484PMC
September 2014

Cholesterol and lipoprotein metabolism: Early Career Committee contribution.

Arterioscler Thromb Vasc Biol 2014 Sep;34(9):1791-4

From the Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (H.Z.); Department of Pharmacology and Nutritional Sciences, Saha Cardiovascular Research Center, University of Kentucky, Lexington (R.E.T.); and Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (C.M.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142559PMC
September 2014

Hypercholesterolemia increases supraspinatus tendon stiffness and elastic modulus across multiple species.

J Shoulder Elbow Surg 2013 May 13;22(5):681-6. Epub 2012 Sep 13.

McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.jse.2012.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525802PMC
May 2013

Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice.

Am J Pathol 2013 Apr 1;182(4):1131-8. Epub 2013 Feb 1.

Section on Lipid Sciences, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029440130002
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http://dx.doi.org/10.1016/j.ajpath.2012.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620394PMC
April 2013

Biliary and nonbiliary contributions to reverse cholesterol transport.

Curr Opin Lipidol 2012 Apr;23(2):85-90

Department of Pathology-Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1040, USA.

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http://dx.doi.org/10.1097/MOL.0b013e3283508c21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711548PMC
April 2012

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.

Nature 2011 Oct 19;478(7369):404-7. Epub 2011 Oct 19.

Marc and Ruti Bell Vascular Biology and Disease Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/nature10486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235584PMC
October 2011

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis.

J Clin Invest 2011 Jul 6;121(7):2921-31. Epub 2011 Jun 6.

Marc and Ruti Bell Vascular Biology and Disease Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1172/JCI57275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223840PMC
July 2011

Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake.

PLoS One 2011 Apr 29;6(4):e19420. Epub 2011 Apr 29.

Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019420PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084847PMC
April 2011

Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent.

J Lipid Res 2009 May 13;50(5):915-23. Epub 2009 Jan 13.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1194/jlr.M800631-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666178PMC
May 2009

Diet effects on atherosclerosis in mice.

Curr Drug Targets 2007 Nov;8(11):1150-60

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.2174/138945007782403847DOI Listing
November 2007

ACAT2 stimulates cholesteryl ester secretion in apoB-containing lipoproteins.

J Lipid Res 2007 Jul 16;48(7):1618-27. Epub 2007 Apr 16.

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M700109-JLR200
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http://dx.doi.org/10.1194/jlr.M700109-JLR200DOI Listing
July 2007

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe.

J Clin Invest 2007 Jul;117(7):1968-78

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.

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http://dx.doi.org/10.1172/JCI30060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888567PMC
July 2007

Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2.

J Lipid Res 2005 Nov 8;46(11):2423-31. Epub 2005 Sep 8.

Department of Pathology, Section on Lipid Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1194/jlr.M500232-JLR200DOI Listing
November 2005

Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol.

J Biol Chem 2003 Nov 15;278(48):47594-601. Epub 2003 Sep 15.

Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1074/jbc.M308235200DOI Listing
November 2003

Enhancement of scavenger receptor class B type I-mediated selective cholesteryl ester uptake from apoA-I(-/-) high density lipoprotein (HDL) by apolipoprotein A-I requires HDL reorganization by lecithin cholesterol acyltransferase.

J Biol Chem 2003 Feb 6;278(7):4792-9. Epub 2002 Dec 6.

Department of Pharmacological Sciences, University Medical Center, State University of New York, Stony Brook, New York 11794, USA.

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http://dx.doi.org/10.1074/jbc.M208160200DOI Listing
February 2003

Apolipoprotein A-I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI-mediated cholesteryl ester-selective uptake.

J Biol Chem 2002 Jul 8;277(29):26565-72. Epub 2002 May 8.

Department of Pharmacological Sciences, University Medical Center, State University of New York, Stony Brook, New York 11794, USA.

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http://dx.doi.org/10.1074/jbc.M203014200DOI Listing
July 2002