Publications by authors named "Ryan C Gimple"

30Publications

FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.

Cell 2021 Jan 23;184(2):352-369.e23. Epub 2020 Dec 23.

Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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January 2021

Targeting Nuclear Receptors for Cancer Therapy: Premises, Promises, and Challenges.

Trends Cancer 2020 Dec 16. Epub 2020 Dec 16.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China. Electronic address:

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December 2020

Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin.

Proc Natl Acad Sci U S A 2020 Dec 14;117(52):33295-33304. Epub 2020 Dec 14.

The Brain Science Center, Beijing Institute of Basic Medical Sciences, 100850 Beijing, China;

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December 2020

Pharmacological Activation of Estrogen Receptor Beta Overcomes Tumor Resistance to Immune Checkpoint Blockade Therapy.

iScience 2020 Aug 12;23(9):101458. Epub 2020 Aug 12.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, P. R. China. Electronic address:

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August 2020

"Reprogram Enablement" as an Assay for Identifying Early Oncogenic Pathways by Their Ability to Allow Neoplastic Cells to Reacquire an Epiblast State.

Stem Cell Reports 2020 09 13;15(3):761-775. Epub 2020 Aug 13.

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA; Department of Pediatrics, University of California, La Jolla, CA, USA. Electronic address:

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September 2020

THE PRESENT AND FUTURE OF THE MASS SPECTROMETRY-BASED INVESTIGATION OF THE EXOSOME LANDSCAPE.

Mass Spectrom Rev 2020 Sep 29;39(5-6):745-762. Epub 2020 May 29.

Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, People's Republic of China.

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September 2020

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αβ Axis.

Cell Stem Cell 2020 02 16;26(2):187-204.e10. Epub 2020 Jan 16.

Department of Medicine, Division of Regenerative Medicine, University of California School of Medicine, San Diego, La Jolla, CA 92037, USA; Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA 92037, USA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92037, USA. Electronic address:

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February 2020

Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.

Cell 2019 11 21;179(6):1330-1341.e13. Epub 2019 Nov 21.

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, OH 44106, USA. Electronic address:

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November 2019

Immunoregulatory Functions of Nuclear Receptors: Mechanisms and Therapeutic Implications.

Trends Endocrinol Metab 2020 02 6;31(2):93-106. Epub 2019 Nov 6.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China. Electronic address:

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February 2020

RAS: Striking at the Core of the Oncogenic Circuitry.

Front Oncol 2019 24;9:965. Epub 2019 Sep 24.

Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing, China.

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September 2019

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock.

Cancer Discov 2019 11 27;9(11):1556-1573. Epub 2019 Aug 27.

Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Consortium for Regenerative Medicine, University of California, San Diego, California.

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November 2019

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer.

Genes Dev 2019 06;33(11-12):591-609

Division of Regenerative Medicine, Department of Medicine, University of California at San Diego, La Jolla, California 92037, USA.

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June 2019

LIM kinase 1 acts as a profibrotic mediator in permanent atrial fibrillation patients with valvular heart disease.

J Biosci 2019 Mar;44(1)

Department of Cardiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.

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March 2019