Ryan B Corcoran

Ryan B Corcoran

UNVERIFIED PROFILE

Are you Ryan B Corcoran?   Register this Author

Register author
Ryan B Corcoran

Ryan B Corcoran

Publications by authors named "Ryan B Corcoran"

Are you Ryan B Corcoran?   Register this Author

54Publications

3696Reads

26Profile Views

Targeting Alterations in the RAF-MEK Pathway.

Cancer Discov 2019 03 15;9(3):329-341. Epub 2019 Feb 15.

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
Publisher Site
http://dx.doi.org/10.1158/2159-8290.CD-18-1321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397699PMC
March 2019

Cell-free DNA Analysis in Cancer.

N Engl J Med 2019 01;380(5):501-502

Massachusetts General Hospital Cancer Center, Boston, MA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1816154DOI Listing
January 2019

Integrating Biomarkers and Targeted Therapy Into Colorectal Cancer Management.

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:207-215. Epub 2019 May 17.

3 Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/EDBK_240839DOI Listing
January 2019

Therapeutic strategies to target RAS-mutant cancers.

Nat Rev Clin Oncol 2018 11;15(11):709-720

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41571-018-0105-0
Publisher Site
http://dx.doi.org/10.1038/s41571-018-0105-0DOI Listing
November 2018

Application of Cell-free DNA Analysis to Cancer Treatment.

N Engl J Med 2018 Nov;379(18):1754-1765

From the Massachusetts General Hospital Cancer Center and the Department of Medicine, Harvard Medical School, Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMra1706174DOI Listing
November 2018

Blood-Based Prediction of Tumor Relapse: The cfDNA Forecast.

Cancer Discov 2018 10;8(10):1213-1215

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
Publisher Site
http://dx.doi.org/10.1158/2159-8290.CD-18-0952DOI Listing
October 2018

Clinical Cancer Advances 2018: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology.

J Clin Oncol 2018 04 30;36(10):1020-1044. Epub 2018 Jan 30.

John Heymach, Maura L. Gillison, and Shannon Neville Westin, The University of Texas MD Anderson Cancer Center, Houston, TX; Lada Krilov and Richard L. Schilsky, American Society of Clinical Oncology, Alexandria; Robert Dreicer, University of Virginia School of Medicine, Charlottesville, VA; Anthony Alberg, Medical University of South Carolina, Charleston, SC; Nancy Baxter, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Susan Marina Chang and Andrew H. Ko, University of California, San Francisco; William Dale, City of Hope National Medical Center, Duarte, CA; Ryan Corcoran, Massachusetts General Hospital; Harold Burstein, Dana-Farber Cancer Institute, Boston, MA; Angela DeMichele and Joshua Jones, University of Pennsylvania, Philadelphia, PA; Catherine S. Magid Diefenbach, University of New York; Andrew S. Epstein, Memorial Sloan Kettering Cancer Center, New York; Robert G. Maki, Hofstra-Northwell School of Medicine, Hempstead, NY; David L. Graham, Carolinas Medical Center, Charlotte, NC; Ana Maria Lopez, University of Utah, Salt Lake City, UT; Carlos Rodriguez-Galindo, St Jude Children's Research Hospital, Memphis, TN; and Mario Sznol, Yale University, New Haven, CT.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2017.77.0446DOI Listing
April 2018

Fast-TRKing Drug Development for Rare Molecular Targets.

Cancer Discov 2017 09;7(9):934-936

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-17-0704DOI Listing
September 2017

Strategies for monitoring and combating resistance to combination kinase inhibitors for cancer therapy.

Genome Med 2017 04 21;9(1):37. Epub 2017 Apr 21.

Massachusetts General Hospital Cancer Center, Boston, MA, 02129, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13073-017-0431-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399860PMC
April 2017

Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations.

Mol Cell Oncol 2016 Jan 21;3(1):e1048405. Epub 2015 May 21.

Massachusetts General Hospital Cancer Center, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/23723556.2015.1048405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845183PMC
January 2016

Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.

J Clin Oncol 2015 Dec 21;33(34):4023-31. Epub 2015 Sep 21.

Ryan B. Corcoran, Eunice L. Kwak, and David P. Ryan, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA; Chloe E. Atreya, Adil Daud, and Alan P. Venook, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco; Omid Hamid, Angeles Clinic and Research Institute, Los Angeles, CA; Gerald S. Falchook, Sarah Cannon Research Institute at HealthONE, Denver; Wells A. Messersmith, University of Colorado Cancer Center and University of Colorado, Aurora, CO; Johanna C. Bendell, Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN; Razelle Kurzrock and Scott Kopetz, University of Texas, MD Anderson Cancer Center, Houston, TX; Mariaelena Pierobon, Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA; Peng Sun, Elizabeth Cunningham, Shonda Little, Keith Orford, Monica Motwani, and Yuchen Bai, GlaxoSmithKline, Philadelphia, PA; and Kiran Patel, Incyte, Wilmington, DE.

View Article

Download full-text PDF

Source
http://jco.ascopubs.org/content/33/34/4023.full.pdf
Web Search
http://jco.ascopubs.org/content/suppl/2015/09/21/JCO.2015.63
Web Search
http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.63.2471
Publisher Site
http://dx.doi.org/10.1200/JCO.2015.63.2471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669588PMC
December 2015

New therapeutic strategies for BRAF mutant colorectal cancers.

Authors:
Ryan B Corcoran

J Gastrointest Oncol 2015 Dec;6(6):650-9

1 Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA ; 2 Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3978/j.issn.2078-6891.2015.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671849PMC
December 2015

Expanded RAS: refining the patient population.

J Clin Oncol 2015 Mar 12;33(7):682-5. Epub 2015 Jan 12.

The University of Texas MD Anderson Cancer Center, Houston, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2014.58.9325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334773PMC
March 2015

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

Cancer Discov 2014 Apr 20;4(4):452-65. Epub 2014 Jan 20.

Departments of 1Medical Oncology and 2Cancer Biology, Dana-Farber Cancer Institute; 3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston; 4Broad Institute of Harvard and MIT, Cambridge; 5MGH Cancer Center, 6Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts; and 7Department of Surgery, Division of Biology and Biomedical Sciences, Washington University, St. Louis, Missouri.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-13-0646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980023PMC
April 2014

mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.

Cancer Discov 2014 Jan 25;4(1):42-52. Epub 2013 Oct 25.

1Massachusetts General Hospital Cancer Center; 2Department of Medicine, Harvard Medical School; 3Division of Gastroenterology, Department of Medicine, Tufts Medical Center; 4Department of Pathology, Massachusetts General Hospital, Boston; and 5Radiation Oncology, Steele Lab for Tumor Biology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-13-0315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973435PMC
January 2014

The PI3K pathway as drug target in human cancer.

J Clin Oncol 2010 Feb 19;28(6):1075-83. Epub 2010 Jan 19.

Massachusetts General Hospital Cancer Center, 149 13th St, Charlestown, 02129, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2009.25.3641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834432PMC
February 2010

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.

Proc Natl Acad Sci U S A 2009 Mar 13;106(9):3196-201. Epub 2009 Feb 13.

Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0813373106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642660PMC
March 2009

Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice.

Cancer Res 2008 Nov;68(21):8788-95

Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-08-2135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597356PMC
November 2008

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells.

Proc Natl Acad Sci U S A 2006 May 17;103(22):8408-13. Epub 2006 May 17.

Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0602852103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462959PMC
May 2006