Ruzong Fan

Ruzong Fan

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Ruzong Fan

Publications by authors named "Ruzong Fan"

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Gene-based association analysis of survival traits via functional regression-based mixed effect cox models for related samples.

Genet Epidemiol 2019 Sep 10. Epub 2019 Sep 10.

Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University Medical Center, Washington, District of Columbia.

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http://dx.doi.org/10.1002/gepi.22254DOI Listing
September 2019

Rare copy number variants identified in prune belly syndrome.

Eur J Med Genet 2018 Mar 23;61(3):145-151. Epub 2017 Nov 23.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.1016/j.ejmg.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803418PMC
March 2018

Genome-wide analysis of disease progression in age-related macular degeneration.

Hum Mol Genet 2018 03;27(5):929-940

Division of Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC University of Pittsburgh, Pittsburgh, PA 15224, USA.

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http://dx.doi.org/10.1093/hmg/ddy002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059197PMC
March 2018

Copy-number variants and candidate gene mutations in isolated split hand/foot malformation.

J Hum Genet 2017 Oct 25;62(10):877-884. Epub 2017 May 25.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/jhg.2017.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612852PMC
October 2017

A quadratically regularized functional canonical correlation analysis for identifying the global structure of pleiotropy with NGS data.

PLoS Comput Biol 2017 Oct 17;13(10):e1005788. Epub 2017 Oct 17.

Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659802PMC
October 2017

Genetic Variants in Isolated Ebstein Anomaly Implicated in Myocardial Development Pathways.

PLoS One 2016 27;11(10):e0165174. Epub 2016 Oct 27.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165174PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082909PMC
June 2017

Copy number variants in a population-based investigation of Klippel-Trenaunay syndrome.

Am J Med Genet A 2017 Feb 30;173(2):352-359. Epub 2016 Nov 30.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/ajmg.a.37868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205266PMC
February 2017

Meta-analysis of quantitative pleiotropic traits for next-generation sequencing with multivariate functional linear models.

Eur J Hum Genet 2017 02 21;25(3):350-359. Epub 2016 Dec 21.

Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD USA.

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http://dx.doi.org/10.1038/ejhg.2016.170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315507PMC
February 2017

A comparison study of multivariate fixed models and Gene Association with Multiple Traits (GAMuT) for next-generation sequencing.

Genet Epidemiol 2017 Jan 5;41(1):18-34. Epub 2016 Dec 5.

Biostatistics and Bioinformatics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.1002/gepi.22014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154843PMC
January 2017

Rare copy number variants in a population-based investigation of hypoplastic right heart syndrome.

Birth Defects Res 2017 01;109(1):8-15

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/bdra.23586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388571PMC
January 2017

A Comparison Study of Fixed and Mixed Effect Models for Gene Level Association Studies of Complex Traits.

Genet Epidemiol 2016 Dec 4;40(8):702-721. Epub 2016 Jul 4.

Human Genetics Center, University of Texas-Houston, Houston, Texas, United States of America.

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http://dx.doi.org/10.1002/gepi.21984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567849PMC
December 2016

Copy-number variant analysis of classic heterotaxy highlights the importance of body patterning pathways.

Hum Genet 2016 12 15;135(12):1355-1364. Epub 2016 Sep 15.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Bethesda, MD, 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065782PMC
http://dx.doi.org/10.1007/s00439-016-1727-xDOI Listing
December 2016

Rare copy number variants implicated in posterior urethral valves.

Am J Med Genet A 2016 Mar 14;170(3):622-33. Epub 2015 Dec 14.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/ajmg.a.37493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205289PMC
March 2016

Gene-Based Association Analysis for Censored Traits Via Fixed Effect Functional Regressions.

Genet Epidemiol 2016 Feb 18;40(2):133-43. Epub 2016 Jan 18.

Division of Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh at The University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1002/gepi.21947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724326PMC
February 2016

B-vitamin status and bone mineral density and risk of lumbar osteoporosis in older females in the United States.

Am J Clin Nutr 2015 Sep 29;102(3):687-94. Epub 2015 Jul 29.

Eunice Kennedy Shriver National Institute of Child and Human Development, NIH, Bethesda, MD;

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http://dx.doi.org/10.3945/ajcn.115.108787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548174PMC
September 2015

Gene Level Meta-Analysis of Quantitative Traits by Functional Linear Models.

Genetics 2015 Aug 9;200(4):1089-104. Epub 2015 Jun 9.

Human Genetics Center, University of Texas, Houston, Texas 77225.

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http://dx.doi.org/10.1534/genetics.115.178343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574252PMC
August 2015

Novel copy-number variants in a population-based investigation of classic heterotaxy.

Genet Med 2015 May 18;17(5):348-57. Epub 2014 Sep 18.

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/gim.2014.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901701PMC
May 2015

Pleiotropy analysis of quantitative traits at gene level by multivariate functional linear models.

Genet Epidemiol 2015 May 23;39(4):259-75. Epub 2015 Mar 23.

Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1002/gepi.21895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443751PMC
May 2015

A Functional Data Analysis Approach for Circadian Patterns of Activity of Teenage Girls.

J Circadian Rhythms 2015 Apr 8;13. Epub 2015 Apr 8.

Health Behavior Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.5334/jcr.acDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831276PMC
April 2015

Stochastic dynamic models and Chebyshev splines.

Can J Stat 2014 Dec;42(4):610-634

Department of Statistics & Applied Probability, University of California-Santa Barbara, Santa Barbara, CA 93106, U.S.A.

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http://dx.doi.org/10.1002/cjs.11233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451187PMC
December 2014

Rationale, design, and method of the Diabetes & Women's Health study--a study of long-term health implications of glucose intolerance in pregnancy and their determinants.

Acta Obstet Gynecol Scand 2014 Nov 9;93(11):1123-30. Epub 2014 Jun 9.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA.

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http://dx.doi.org/10.1111/aogs.12425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205761PMC
November 2014

Generalized functional linear models for gene-based case-control association studies.

Genet Epidemiol 2014 Nov 9;38(7):622-637. Epub 2014 Sep 9.

Human Genetics Center, University of Texas - Houston P.O. Box 20334, Houston, Texas 77225.

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http://dx.doi.org/10.1002/gepi.21840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189986PMC
November 2014

Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.

Am J Clin Nutr 2014 Oct 13;100(4):1069-74. Epub 2014 Aug 13.

From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (JLM, RF, AL, and YW), and Genome Technology Branch, National Human Genome Research Institute (LCB), NIH, Bethesda, MD; the Department of Clinical Science, University of Bergen and Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); the Health Research Board of Ireland, Dublin, Ireland (PNK); the University of California, Berkeley, Berkeley, CA (BS); and the Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland (AMM).

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http://www.folk.uib.no/mfapu/Pages/papers%20pdf/2014/mills_2
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http://ajcn.nutrition.org/cgi/doi/10.3945/ajcn.113.079319
Publisher Site
http://dx.doi.org/10.3945/ajcn.113.079319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163794PMC
October 2014

Is low iron status a risk factor for neural tube defects?

Birth Defects Res A Clin Mol Teratol 2014 Feb 18;100(2):100-6. Epub 2014 Feb 18.

The Institute of Molecular Medicine, School of Medicine, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1002/bdra.23223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018583PMC
February 2014

Genotype-based association models of complex diseases to detect gene-gene and gene-environment interactions.

Stat Interface 2014;7(1):51-60

Ronald O. Perelman Department of Dermatology, School of Medicine, New York University, New York, NY 10016, USA.

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http://dx.doi.org/10.4310/SII.2014.v7.n1.a6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504431PMC
January 2014

Functional linear models for association analysis of quantitative traits.

Genet Epidemiol 2013 Nov;37(7):726-42

Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, United States of America.

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http://dx.doi.org/10.1002/gepi.21757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163942PMC
November 2013

Association analysis of complex diseases using triads, parent-child dyads and singleton monads.

BMC Genet 2013 Sep 4;14:78. Epub 2013 Sep 4.

Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd, MSC 7510, Rockville, MD 20852, USA.

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http://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156
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http://dx.doi.org/10.1186/1471-2156-14-78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844511PMC
September 2013

Longitudinal association analysis of quantitative traits.

Genet Epidemiol 2012 Dec 10;36(8):856-69. Epub 2012 Sep 10.

Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland.

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http://dx.doi.org/10.1002/gepi.21673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444073PMC
December 2012

A discussion of gene-gene and gene-environment interactions and longitudinal genetic analysis of complex traits.

Stat Med 2012 Sep;31(22):2565-8

Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics, and Prevention, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd, Room 7B05, MSC 7510, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1002/sim.5495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458189PMC
September 2012

Genotype-Based Bayesian Analysis of Gene-Environment Interactions with Multiple Genetic Markers and Misclassification in Environmental Factors.

J Probab Stat 2012;2012

Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1155/2012/151259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500528PMC
January 2012

A cross-population extended haplotype-based homozygosity score test to detect positive selection in genome-wide scans.

Stat Interface 2011;4(1):51-63

Department of Statistics, The Texas A&M University, 447 Blocker Building, College Station, Texas 77843-3143, USA.

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http://dx.doi.org/10.4310/SII.2011.v4.n1.a6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470573PMC
January 2011

Genotype-based association mapping of complex diseases: gene-environment interactions with multiple genetic markers and measurement error in environmental exposures.

Genet Epidemiol 2010 Dec;34(8):792-802

Division of Biostatistics, New York University, School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1002/gepi.20523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021130PMC
December 2010

A powerful score test to detect positive selection in genome-wide scans.

Eur J Hum Genet 2010 Oct 12;18(10):1148-59. Epub 2010 May 12.

Department of Statistics, The Texas A&M University, College Station, TX 77843-3143, USA.

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http://dx.doi.org/10.1038/ejhg.2010.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987455PMC
October 2010

Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice.

Physiol Genomics 2009 Dec 29;40(1):15-22. Epub 2009 Sep 29.

Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77845-4243, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00116.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807210PMC
December 2009

A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests.

BMC Proc 2009 Dec 15;3 Suppl 7:S6. Epub 2009 Dec 15.

Department of Statistics, Texas A&M University, 447 Blocker Building, College Station, TX 77843, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795960PMC
http://dx.doi.org/10.1186/1753-6561-3-s7-s6DOI Listing
December 2009

Bivariate combined linkage and association mapping of quantitative trait loci.

Genet Epidemiol 2008 Jul;32(5):396-412

Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, Indiana, USA.

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http://doi.wiley.com/10.1002/gepi.20313
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http://dx.doi.org/10.1002/gepi.20313DOI Listing
July 2008

Combined linkage and association mapping of quantitative trait Loci with missing completely at random genotype data.

Behav Genet 2008 May 27;38(3):316-36. Epub 2008 Feb 27.

Department of Statistics, Texas A&M University, 447 Blocker Building, 3143 TAMUS, College Station, TX 77843, USA.

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http://link.springer.com/10.1007/s10519-008-9194-3
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http://dx.doi.org/10.1007/s10519-008-9194-3DOI Listing
May 2008

Haplotypes of the surfactant protein genes A and D as susceptibility factors for the development of respiratory distress syndrome.

Acta Paediatr 2007 Jul 24;96(7):985-9. Epub 2007 May 24.

Department of Pediatrics, Penn State Children's Hospita, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1111/j.1651-2227.2007.00319.xDOI Listing
July 2007

High-resolution association mapping of quantitative trait loci: a population-based approach.

Genetics 2006 Jan 19;172(1):663-86. Epub 2005 Sep 19.

Department of Statistics, Texas A&M University, College Station, Texas 77843, USA.

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http://www.genetics.org/cgi/doi/10.1534/genetics.105.046417
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http://dx.doi.org/10.1534/genetics.105.046417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456191PMC
January 2006

Combined linkage and association mapping of quantitative trait loci by multiple markers.

Genetics 2005 Jun 31;170(2):881-98. Epub 2005 Mar 31.

Department of Human Genetics, University of Pittsburgh, Graduate School of Public Health, Pennsylvania 15261, USA.

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http://www.genetics.org/lookup/doi/10.1534/genetics.104.0351
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http://dx.doi.org/10.1534/genetics.104.035147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450431PMC
June 2005

Sibship T2 association tests of complex diseases for tightly linked markers.

Hum Genomics 2005 Jun;2(2):90-112

Department of Statistics, The Texas A&M University, College Station, Texas 77843-3143, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530186PMC
June 2005

High resolution T association tests of complex diseases based on family data.

Ann Hum Genet 2005 Mar;69(Pt 2):187-208

The Texas A&M University, 447 Blocker Building, College Station, TX 77843-3143, USA.

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http://dx.doi.org/10.1046/j.1529-8817.2004.00151.xDOI Listing
March 2005

Pedigree linkage disequilibrium mapping of quantitative trait loci.

Eur J Hum Genet 2005 Feb;13(2):216-31

Department of Statistics, Texas A&M University, 447 Blocker Building, 3143 TAMUS, College Station, TX 77843, USA.

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http://www.nature.com/articles/5201301
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http://dx.doi.org/10.1038/sj.ejhg.5201301DOI Listing
February 2005

High-resolution joint linkage disequilibrium and linkage mapping of quantitative trait loci based on sibship data.

Hum Hered 2003 ;56(4):166-87

Department of Statistics, Texas A&M University, College Station, TX 77843, USA.

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http://dx.doi.org/10.1159/000076392DOI Listing
November 2004

Association studies of QTL for multi-allele markers by mixed models.

Hum Hered 2002 ;54(3):132-50

Department of Statistics, Texas A&M University, College Station, TX 77843-3143, USA.

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https://www.karger.com/Article/FullText/68839
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http://dx.doi.org/10.1159/000068839DOI Listing
November 2003

Genome association studies of complex diseases by case-control designs.

Am J Hum Genet 2003 Apr 19;72(4):850-68. Epub 2003 Mar 19.

Department of Statistics, Texas A&M University, College Station, TX 77843, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000292970760608
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http://dx.doi.org/10.1086/373966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180349PMC
April 2003

Combined high resolution linkage and association mapping of quantitative trait loci.

Eur J Hum Genet 2003 Feb;11(2):125-37

Department of Statistics, The Texas A&M University, 447 Blocker Building, College Station, Texas 77843-3143, USA.

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http://dx.doi.org/10.1038/sj.ejhg.5200941DOI Listing
February 2003

Linkage and association studies of QTL for nuclear families by mixed models.

Biostatistics 2003 Jan;4(1):75-95

Department of Statistics, Texas A&M University, 447 Blocker Building, College Station, TX 77843-3143, USA.

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http://dx.doi.org/10.1093/biostatistics/4.1.75DOI Listing
January 2003

High resolution mapping of quantitative trait loci by linkage disequilibrium analysis.

Eur J Hum Genet 2002 Oct;10(10):607-15

Department of Statistics, The Texas A&M University, 447 Blocker Building, College Station, Texas, TX 77843-3143, USA.

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http://dx.doi.org/10.1038/sj.ejhg.5200843DOI Listing
October 2002