Ruud Delwel

Ruud Delwel

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Ruud Delwel

Ruud Delwel

Publications by authors named "Ruud Delwel"

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Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Cancer Cell 2019 Aug;36(2):194-209.e9

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore; Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacological Sciences and Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.07.003DOI Listing
August 2019

Puzzling pieces of chromosome 7 loss or deletion.

Blood 2018 06;131(26):2871-2872

Erasmus MC Cancer Institute.

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http://dx.doi.org/10.1182/blood-2018-04-844746DOI Listing
June 2018

Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation.

Blood 2017 04 8;129(15):2083-2091. Epub 2017 Feb 8.

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2016-09-687822DOI Listing
April 2017

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.

Cancer Discov 2016 05 25;6(5):501-15. Epub 2016 Mar 25.

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861898PMC
May 2016

A somatic mutation of GFI1B identified in leukemia alters cell fate via a SPI1 (PU.1) centered genetic regulatory network.

Dev Biol 2016 Mar 3;411(2):277-286. Epub 2016 Feb 3.

UCL Cancer Institute, Paul O'Gorman Building 72 Huntley St., London WC1E6BT, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2016.02.002DOI Listing
March 2016

Congenital thrombocytopenia in a neonate with an interstitial microdeletion of 3q26.2q26.31.

Am J Med Genet A 2016 Feb 10;170A(2):504-509. Epub 2015 Nov 10.

Department of Paediatrics, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.a.37451DOI Listing
February 2016

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia.

Blood 2016 Jan 10;127(1):42-52. Epub 2015 Dec 10.

Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2015-07-604512DOI Listing
January 2016

Myeloid disorders arise in Dnmt3a-null marrow.

Authors:
Ruud Delwel

Blood 2015 Jan;125(4):585-6

ERASMUS UNIVERSITY MEDICAL CENTER.

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http://dx.doi.org/10.1182/blood-2014-12-614164DOI Listing
January 2015

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.

Blood 2014 Oct 3;124(15):2391-9. Epub 2014 Sep 3.

Harvard Stem Cell Institute, Harvard Medical School, Boston, MA; Cancer Science Institute, National University of Singapore, Singapore; and.

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http://dx.doi.org/10.1182/blood-2014-01-550855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192750PMC
October 2014

HAT: a novel statistical approach to discover functional regions in the genome.

Methods Mol Biol 2013 ;1067:125-41

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/978-1-62703-607-8_9DOI Listing
March 2014

Hypergeometric analysis of tiling-array and sequence data: detection and interpretation of peaks.

Adv Appl Bioinform Chem 2013 25;6:55-62. Epub 2013 Oct 25.

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands ; Delft Bioinformatics Lab (DBL), Delft University of Technology, Delft, The Netherlands.

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http://dx.doi.org/10.2147/AABC.S51271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810201PMC
November 2013

Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα.

J Clin Invest 2012 Aug 17;122(8):2955-66. Epub 2012 Jul 17.

Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1172/JCI43354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408728PMC
August 2012

The expression of the peripheral cannabinoid receptor CB2 has no effect on clinical outcome in diffuse large B-cell lymphomas.

Eur J Haematol 2011 Jun 1;86(6):466-76. Epub 2011 Apr 1.

Departments of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1600-0609.2011.01596.xDOI Listing
June 2011

Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells.

Cell Stem Cell 2011 Jun;8(6):649-62

Leukaemia and Stem Cell Biology Lab, Department of Haematological Medicine, King's College London, London SE5 9NU, UK.

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http://dx.doi.org/10.1016/j.stem.2011.05.004DOI Listing
June 2011

HAT: hypergeometric analysis of tiling-arrays with application to promoter-GeneChip data.

BMC Bioinformatics 2010 May 21;11:275. Epub 2010 May 21.

Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, the Netherlands.

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http://dx.doi.org/10.1186/1471-2105-11-275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892465PMC
May 2010

Age-specific differences in oncogenic pathway dysregulation and anthracycline sensitivity in patients with acute myeloid leukemia.

J Clin Oncol 2009 Nov 26;27(33):5580-6. Epub 2009 Oct 26.

Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC 27708, USA.

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http://dx.doi.org/10.1200/JCO.2009.22.2547DOI Listing
November 2009

AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4A mRNA with prognostic significance.

Blood 2009 Oct 10;114(14):2869-77. Epub 2009 Aug 10.

Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-03-21
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http://dx.doi.org/10.1182/blood-2009-03-212688DOI Listing
October 2009

A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects.

Blood 2009 Jan 14;113(2):291-8. Epub 2008 Aug 14.

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2008-04-153239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615646PMC
January 2009

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling.

Haematologica 2009 Jan 6;94(1):131-4. Epub 2008 Oct 6.

Erasmus University Medical Center Rotterdam, Department of Hematology, Rotterdam, The Netherlands.

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http://dx.doi.org/10.3324/haematol.13299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2625407PMC
January 2009

A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.

Blood 2009 Jan 23;113(5):1075-85. Epub 2008 Oct 23.

Masonic Cancer Center and Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-03-14
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http://dx.doi.org/10.1182/blood-2008-03-144436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635073PMC
January 2009

High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome.

Haematologica 2008 Dec;93(12):1894-8

Department of Hematology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.3324/haematol.13113DOI Listing
December 2008

Gene expression profiling for improved dissection of acute leukemia: a recently identified immature myeloid/T-lymphoid subgroup as an example.

Blood Cells Mol Dis 2008 May-Jun;40(3):395-400. Epub 2007 Dec 21.

Department of Hematology, Erasmus University Medical Center, Room Ee1342, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bcmd.2007.10.006DOI Listing
August 2008

A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a.

FEBS Lett 2008 Aug 11;582(18):2761-7. Epub 2008 Jul 11.

Department of Hematology, Erasmus University Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2008.06.056DOI Listing
August 2008

Myeloid transforming protein Evi1 interacts with methyl-CpG binding domain protein 3 and inhibits in vitro histone deacetylation by Mbd3/Mi-2/NuRD.

Biochemistry 2008 Jun 24;47(24):6418-26. Epub 2008 May 24.

Department of Hematology, Erasmus University Medical Center, Rotterdam 3015 GE, The Netherlands.

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http://dx.doi.org/10.1021/bi800267fDOI Listing
June 2008

Viral insertion in Evi12 causes expression of aberrant Grp94 mRNAs containing the viral gag myristylation motif.

Virology 2007 Sep 1;366(2):227-33. Epub 2007 Jun 1.

Department of Hematology, Erasmus University Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S004268220700316
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http://dx.doi.org/10.1016/j.virol.2007.04.026DOI Listing
September 2007

The expression of the peripheral cannabinoid receptor on cells of the immune system and non-Hodgkin's lymphomas.

Leuk Lymphoma 2007 Jul;48(7):1389-99

Department of Hematology, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1080/10428190701377030DOI Listing
July 2007

Text-derived concept profiles support assessment of DNA microarray data for acute myeloid leukemia and for androgen receptor stimulation.

BMC Bioinformatics 2007 Jan 18;8:14. Epub 2007 Jan 18.

Department of Medical Informatics, Erasmus MC--University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/1471-2105-8-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784107PMC
January 2007

Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.

Cancer Cell 2006 Nov;10(5):401-11

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839500PMC
November 2006

Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia.

Cancer Res 2006 Jan;66(2):622-6

Department of Hematology, Erasmus University Medical Center, 3000 DR Rotterdam, the Netherlands.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-2908DOI Listing
January 2006

Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia.

Oncogene 2005 Jun;24(25):4129-37

Department of Hematology, ErasmusMC, Dr Molewaterplein 50, Rotterdam 3015GE, The Netherlands.

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http://dx.doi.org/10.1038/sj.onc.1208588DOI Listing
June 2005

Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11.

Blood 2005 Apr 7;105(7):2900-7. Epub 2004 Dec 7.

Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation St, LRB/622, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1182/blood-2004-09-3630DOI Listing
April 2005

AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.

Proc Natl Acad Sci U S A 2005 Mar 24;102(11):4016-21. Epub 2005 Feb 24.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1073/pnas.0404701102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC554792PMC
March 2005

Gene expression profiling in acute myeloid leukemia.

Curr Opin Hematol 2005 Jan;12(1):76-81

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/01.moh.0000149610.14438.9aDOI Listing
January 2005