Publications by authors named "Ruth Tal-Singer"

100Publications

Negative Food Effect of Danirixin: Use of PBPK Modelling to Explore the Effect of Formulation and Meal Type on Clinical PK.

Pharm Res 2020 Oct 29;37(12):233. Epub 2020 Oct 29.

Clinical Pharmacology and Modelling Simulation, GlaxoSmithKline R&D, 980 Great West Road, TW8 9GS, Brentford, UK.

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http://dx.doi.org/10.1007/s11095-020-02948-zDOI Listing
October 2020

COPDCompEx: A novel composite endpoint for COPD exacerbations to enable faster clinical development.

Respir Med 2020 Sep 28;173:106175. Epub 2020 Sep 28.

AstraZeneca, Early Respiratory & Immunology (R&I) Clinical Development, BioPharmaceuticals R&D, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2020.106175DOI Listing
September 2020

Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD.

Respir Res 2020 Jul 1;21(1):166. Epub 2020 Jul 1.

Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1186/s12931-020-01436-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329438PMC
July 2020

Managing Your Chronic Lung Disease during the COVID-19 Pandemic.

Am J Respir Crit Care Med 2020 07;202(2):P5-P6

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http://dx.doi.org/10.1164/rccm.2020C8DOI Listing
July 2020

Clinical endotypes of exacerbation are associated with differences in microbial composition and diversity in COPD.

Eur Respir J 2020 Oct 29;56(4). Epub 2020 Oct 29.

Scottish Centre for Respiratory Research, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1183/13993003.00391-2020DOI Listing
October 2020

The COPD Foundation Coronavirus Disease 2019 International Medical Experts Survey: Results.

Chronic Obstr Pulm Dis 2020 Jul;7(3):139-146

COPD Foundation, Research Department, Washington, DC.

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http://dx.doi.org/10.15326/jcopdf.7.3.2020.0164DOI Listing
July 2020

The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease.

J Allergy Clin Immunol 2020 Apr 28. Epub 2020 Apr 28.

the Scottish Centre for Respiratory Research, University of Dundee, Dundee, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.02.040DOI Listing
April 2020

Machine Learning and Prediction of All-Cause Mortality in COPD.

Chest 2020 Sep 27;158(3):952-964. Epub 2020 Apr 27.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2020.02.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478228PMC
September 2020

COPD at the Time of COVID-19: A COPD Foundation Perspective.

Chronic Obstr Pulm Dis 2020 Apr;7(2):73-75

Editor in Chief, Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, COPD Foundation, Washington, DC.

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http://dx.doi.org/10.15326/jcopdf.7.2.2020.0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454024PMC
April 2020

Short Physical Performance Battery: What Does Each Sub-Test Measure in Patients with Chronic Obstructive Pulmonary Disease?

Chronic Obstr Pulm Dis 2020 Jan;7(1):13-25

National Institute for Health Research, Respiratory Biomedical Research Unit, Royal Brompton and Harefield National Health Service Foundation Trust and Imperial College, London, United Kingdom.

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http://dx.doi.org/10.15326/jcopdf.7.1.2019.0144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182385PMC
January 2020

COPDGene 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.

Authors:
Katherine E Lowe Elizabeth A Regan Antonio Anzueto Erin Austin John H M Austin Terri H Beaty Panayiotis V Benos Christopher J Benway Surya P Bhatt Eugene R Bleecker Sandeep Bodduluri Jessica Bon Aladin M Boriek Adel Re Boueiz Russell P Bowler Matthew Budoff Richard Casaburi Peter J Castaldi Jean-Paul Charbonnier Michael H Cho Alejandro Comellas Douglas Conrad Corinne Costa Davis Gerard J Criner Douglas Curran-Everett Jeffrey L Curtis Dawn L DeMeo Alejandro A Diaz Mark T Dransfield Jennifer G Dy Ashraf Fawzy Margaret Fleming Eric L Flenaugh Marilyn G Foreman Spyridon Fortis Hirut Gebrekristos Sarah Grant Philippe A Grenier Tian Gu Abhya Gupta MeiLan K Han Nicola A Hanania Nadia N Hansel Lystra P Hayden Craig P Hersh Brian D Hobbs Eric A Hoffman James C Hogg John E Hokanson Karin F Hoth Albert Hsiao Stephen Humphries Kathleen Jacobs Francine L Jacobson Ella A Kazerooni Victor Kim Woo Jin Kim Gregory L Kinney Harald Koegler Sharon M Lutz David A Lynch Neil R MacIntye Barry J Make Nathaniel Marchetti Fernando J Martinez Diego J Maselli Anne M Mathews Meredith C McCormack Merry-Lynn N McDonald Charlene E McEvoy Matthew Moll Sarah S Molye Susan Murray Hrudaya Nath John D Newell Mariaelena Occhipinti Matteo Paoletti Trisha Parekh Massimo Pistolesi Katherine A Pratte Nirupama Putcha Margaret Ragland Joseph M Reinhardt Stephen I Rennard Richard A Rosiello James C Ross Harry B Rossiter Ingo Ruczinski Raul San Jose Estepar Frank C Sciurba Jessica C Sieren Harjinder Singh Xavier Soler Robert M Steiner Matthew J Strand William W Stringer Ruth Tal-Singer Byron Thomashow Gonzalo Vegas Sánchez-Ferrero John W Walsh Emily S Wan George R Washko J Michael Wells Chris H Wendt Gloria Westney Ava Wilson Robert A Wise Andrew Yen Kendra Young Jeong Yun Edwin K Silverman James D Crapo

Chronic Obstr Pulm Dis 2019 Nov;6(5):384-399

National Jewish Health, Denver, Colorado.

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http://dx.doi.org/10.15326/jcopdf.6.5.2019.0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020846PMC
November 2019

DSP variants may be associated with longitudinal change in quantitative emphysema.

Respir Res 2019 Jul 19;20(1):160. Epub 2019 Jul 19.

Department of Epidemiology, Johns Hopkins School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1186/s12931-019-1097-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642569PMC
July 2019

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort.

Sci Rep 2019 03 11;9(1):4064. Epub 2019 Mar 11.

Division of Infection Immunity and Respiratory Medicine, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, England.

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http://dx.doi.org/10.1038/s41598-019-40785-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412140PMC
March 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

Distribution, temporal stability and association with all-cause mortality of the 2017 GOLD groups in the ECLIPSE cohort.

Respir Med 2018 08 19;141:14-19. Epub 2018 Jun 19.

CIBER Enfermedades Respiratorias, Spain; Institut de Recerca Biomedica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Respiratory Institute, Hospital Clinic, University of Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2018.06.015DOI Listing
August 2018

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease.

J Allergy Clin Immunol 2018 06 28;141(6):2037-2047.e10. Epub 2018 Apr 28.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183062
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http://dx.doi.org/10.1016/j.jaci.2018.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994197PMC
June 2018

Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease: A Large Case-Controlled Study.

Hypertension 2018 03 22;71(3):499-506. Epub 2018 Jan 22.

From the Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom (M.F., C.M.M., K.M.-P., J.W.-S., J.C., I.B.W.); School of Healthcare Sciences (N.G.) and Department of Cardiology, Wales Heart Research Institute (M.M., J.R.C.), Cardiff University, United Kingdom; Cambridge Clinical Trials Unit (J.R.F., J.C., I.B.W.) and Division of Respiratory Medicine (J.F.), Cambridge University Hospitals NHS Foundation Trust, United Kingdom; GSK R&D, King of Prussia, PA (D.M., R.T.S.); and NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College, London, United Kingdom (D.M., M.I.P.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805278PMC
March 2018

Frailty: A global measure of the multisystem impact of COPD.

Chron Respir Dis 2018 11 16;15(4):347-355. Epub 2018 Jan 16.

1 School of Healthcare Sciences, Cardiff University, University Hospital of Wales, Cardiff, UK.

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http://dx.doi.org/10.1177/1479972317752763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234567PMC
November 2018

The St. George's Respiratory Questionnaire Appendix to the Food and Drug Administration Draft Guidance on COPD: Why a Small Step Forward Is So Important.

Chest 2017 11;152(5):914-916

Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1016/j.chest.2017.07.040DOI Listing
November 2017

Longitudinal follow-up of quadriceps strength and function in a COPD cohort after 3 years.

Eur Respir J 2017 08 10;50(2). Epub 2017 Aug 10.

NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1183/13993003.00707-2017DOI Listing
August 2017

Multiple biomarkers predict disease severity, progression and mortality in COPD.

Respir Res 2017 06 13;18(1):117. Epub 2017 Jun 13.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, 1400 Jackson St., Denver, CO, 80206, USA.

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http://dx.doi.org/10.1186/s12931-017-0597-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470282PMC
June 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers.

Chest 2017 Mar 21;151(3):555-563. Epub 2016 Nov 21.

Experimental Medicine and Immunotherapeutics (EMIT), University of Cambridge, Addenbrooke's Hospital, Cambridge, England; Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England.

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http://dx.doi.org/10.1016/j.chest.2016.10.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332206PMC
March 2017

High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD - results from the ECLIPSE study.

Respir Res 2016 10 4;17(1):125. Epub 2016 Oct 4.

Centre for Respiratory Medicine and Allergy, Manchester Academic Science Centre, The University of Manchester and University Hospital South Manchester NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1186/s12931-016-0440-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050854PMC
October 2016

Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study.

Respir Med 2016 10 25;119:87-95. Epub 2016 Aug 25.

Department of Research and Education, CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands; REVAL - Rehabilitation Research Center, BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2016.08.023DOI Listing
October 2016

Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease.

Eur Respir J 2016 10 1;48(4):1215-1218. Epub 2016 Sep 1.

MRC/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.

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http://dx.doi.org/10.1183/13993003.01125-2016DOI Listing
October 2016

A comparison of COPD patients with and without ACOS in the ECLIPSE study.

Eur Respir J 2016 05 17;47(5):1559-62. Epub 2016 Mar 17.

Centre for Respiratory Medicine and Allergy, University of Manchester Academic Health Science Centre, The University of Manchester and University Hospital South Manchester NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1183/13993003.02045-2015DOI Listing
May 2016

Lung microbiome dynamics in COPD exacerbations.

Eur Respir J 2016 Apr 25;47(4):1082-92. Epub 2016 Feb 25.

Computational Biology, Target Sciences, GSK R&D, Collegeville, PA, USA Both authors contributed equally.

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http://dx.doi.org/10.1183/13993003.01406-2015DOI Listing
April 2016

Long-term Course of Depression Trajectories in Patients With COPD: A 3-Year Follow-up Analysis of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Cohort.

Chest 2016 Apr 5;149(4):916-26. Epub 2016 Jan 5.

Respiratory Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands; Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.

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http://dx.doi.org/10.1016/j.chest.2015.10.081DOI Listing
April 2016

COPD subtypes identified by network-based clustering of blood gene expression.

Genomics 2016 Mar 8;107(2-3):51-58. Epub 2016 Jan 8.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, USA; Division of General Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygeno.2016.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761317PMC
March 2016

Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.

Br J Clin Pharmacol 2016 May 17;81(5):971-9. Epub 2016 Jan 17.

Experimental Medicine & Immunotherapeutics, Department of Medicine, University of Cambridge, and Cambridge Clinical Trials Unit, Cambridge.

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http://dx.doi.org/10.1111/bcp.12855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834590PMC
May 2016

Functional capacity, health status, and inflammatory biomarker profile in a cohort of patients with chronic obstructive pulmonary disease.

J Cardiopulm Rehabil Prev 2015 Sep-Oct;35(5):348-55

Division of Pulmonary and Critical Care Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts (Drs Kohli, Pinto-Plata, Divo, and Celli); Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (Drs Kohli and Harris); Division of Pulmonary and Critical Care Medicine, Division of Sleep Medicine, University of California San Diego School of Medicine, San Diego, California (Dr Malhotra); COPD Clinical Discovery, GalaxoSmithKline, King of Prussia, Pennsylvania (Drs Lazaar, Flynn, and Tal-Singer); and Division of Pulmonary, Allergy and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania (Dr Panettieri).

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/HCR.0000000000000123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551136PMC
June 2016

Low plasma CC16 levels in smokers are associated with a higher risk for chronic bronchitis.

Eur Respir J 2015 Nov 9;46(5):1501-3. Epub 2015 Jul 9.

Lovelace Respiratory Research Institute, Albuquerque, NM, USA

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http://dx.doi.org/10.1183/13993003.00682-2015DOI Listing
November 2015

Prognostic value of variables derived from the six-minute walk test in patients with COPD: Results from the ECLIPSE study.

Respir Med 2015 Sep 25;109(9):1138-46. Epub 2015 Jun 25.

Department of Research and Education; CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands; REVAL - Rehabilitation Research Center, BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.

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http://dx.doi.org/10.1016/j.rmed.2015.06.013DOI Listing
September 2015

Clinical and prognostic heterogeneity of C and D GOLD groups.

Eur Respir J 2015 Jul;46(1):250-4

Dept of Respiratory Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1183/09031936.00012215DOI Listing
July 2015

The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects.

BMC Pharmacol Toxicol 2015 Jun 20;16:18. Epub 2015 Jun 20.

Discovery Medicine, Respiratory Therapy Area Unit, GlaxoSmithKline R&D, 709 Swedeland Road, King of Prussia, PA, 19406, USA.

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http://dx.doi.org/10.1186/s40360-015-0017-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475328PMC
June 2015

Correlation Between Emphysema and Lung Function in Healthy Smokers and Smokers With COPD.

Chronic Obstr Pulm Dis 2015 May 19;2(3):204-213. Epub 2015 May 19.

Department of Respiratory Medicine, Gentofte Hospital, University of Copenhagen, Denmark.

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http://dx.doi.org/10.15326/jcopdf.2.3.2014.0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556883PMC
May 2015

One-year change in health status and subsequent outcomes in COPD.

Thorax 2015 May 17;70(5):420-5. Epub 2015 Mar 17.

Department of Research & Education, CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands Faculty of Medicine and Life Sciences, REVAL-Rehabilitation Research Center, BIOMED-Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.

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http://thorax.bmj.com/content/early/2015/03/17/thoraxjnl-201
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http://dx.doi.org/10.1136/thoraxjnl-2014-205697DOI Listing
May 2015

Gene expression changes caused by the p38 MAPK inhibitor dilmapimod in COPD patients: analysis of blood and sputum samples from a randomized, placebo-controlled clinical trial.

Pharmacol Res Perspect 2015 Feb 9;3(1):e00094. Epub 2014 Dec 9.

University of Manchester, Medicines Evaluation Unit, University Hospital of South Manchester Foundations Trust Manchester, United Kingdom.

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http://dx.doi.org/10.1002/prp2.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317226PMC
February 2015

Eosinophilic inflammation in COPD: prevalence and clinical characteristics.

Eur Respir J 2014 Dec 16;44(6):1697-700. Epub 2014 Oct 16.

GlaxoSmithKline, Research and Development, King of Prussia, PA, USA.

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http://dx.doi.org/10.1183/09031936.00162414DOI Listing
December 2014