Ruth Luthi-Carter

Ruth Luthi-Carter

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Ruth Luthi-Carter

Ruth Luthi-Carter

Publications by authors named "Ruth Luthi-Carter"

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60Publications

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Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis.

Front Neurosci 2014 9;8:441. Epub 2015 Jan 9.

The Bioinformatics Core and The Synaptic Neurobiology Laboratory, The Florey Institute of Neuroscience and Mental Health Parkville, VIC, Australia.

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http://dx.doi.org/10.3389/fnins.2014.00441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288238PMC
January 2015

Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington's disease.

J Huntingtons Dis 2013 ;2(3):263-77

Department of Neurology, Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.3233/JHD-130066DOI Listing
September 2014

Involvement of autophagy in hypoxic-excitotoxic neuronal death.

Autophagy 2014 May 11;10(5):846-60. Epub 2014 Mar 11.

Department of Fundamental Neurosciences; Faculty of Biology and Medicine; University of Lausanne; Lausanne, Switzerland; Clinic of Neonatology; Department of Pediatrics and Pediatric Surgery; Lausanne University Hospital and University of Lausanne; Lausanne, Switzerland.

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http://dx.doi.org/10.4161/auto.28264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119065PMC
May 2014

Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.

PLoS One 2012 27;7(7):e41423. Epub 2012 Jul 27.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041423PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407195PMC
March 2013

Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.

J Neurosci 2013 Mar;33(12):5127-37

Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.1523/JNEUROSCI.0600-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705001PMC
March 2013

What have we learned from gene expression profiles in Huntington's disease?

Neurobiol Dis 2012 Jan 12;45(1):83-98. Epub 2011 Jul 12.

Laboratory of Functional Neurogenomics, Ecole Polytechnique Federale de Lausanne, Station 15, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.nbd.2011.07.001DOI Listing
January 2012

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain.

Nat Methods 2011 Oct 9;8(11):945-7. Epub 2011 Oct 9.

Laboratory of Functional Neurogenomics, Ecole Polytechnique Fédérale de Lausanne, Switzerland.

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https://www.bioconductor.org/packages/3.3/bioc/vignettes/PSE
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http://www.nature.com/doifinder/10.1038/nmeth.1710
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http://dx.doi.org/10.1038/nmeth.1710DOI Listing
October 2011

Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons.

Mol Cell Neurosci 2010 Aug 12;44(4):374-85. Epub 2010 May 12.

Laboratory of Synaptic Mechanisms, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S10447431100010
Publisher Site
http://dx.doi.org/10.1016/j.mcn.2010.05.002DOI Listing
August 2010

Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.

FASEB J 2010 Jul 17;24(7):2464-74. Epub 2010 Mar 17.

Laboratory of Molecular and Cellular Biology of Alzheimer's Disease, Brain Mind Institute and School of Life Sciences, Swiss Federal Institute of Technology, Lausanne, Switzerland.

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http://dx.doi.org/10.1096/fj.09-148031DOI Listing
July 2010

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis.

Hum Mol Genet 2010 Apr 20;19(8):1438-52. Epub 2010 Jan 20.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1093/hmg/ddq018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846159PMC
April 2010

Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease.

Brain 2010 Apr;133(Pt 4):1094-110

Department of Anatomy with Radiology, University of Auckland, and Department of Forensic Pathology, Auckland City Hospital, Private Bag 92019, Auckland, New Zealand.

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http://dx.doi.org/10.1093/brain/awq047DOI Listing
April 2010

Expression analysis of novel striatal-enriched genes in Huntington disease.

Hum Mol Genet 2010 Feb 23;19(4):609-22. Epub 2009 Nov 23.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada

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http://dx.doi.org/10.1093/hmg/ddp527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807369PMC
February 2010

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons.

J Neurochem 2009 Oct 17;111(2):460-72. Epub 2009 Aug 17.

Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06344.xDOI Listing
October 2009

Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation.

PLoS One 2009 23;4(4):e5292. Epub 2009 Apr 23.

Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005292PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669182PMC
July 2009

Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration.

J Biol Chem 2009 May 24;284(18):12447-58. Epub 2009 Feb 24.

Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Station 15, Lausanne CH1015, Switzerland.

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http://dx.doi.org/10.1074/jbc.M804740200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673311PMC
May 2009

Sustained effects of nonallele-specific Huntingtin silencing.

Ann Neurol 2009 Mar;65(3):276-85

Commissariat à l'Energie Atomique, Institute of Biomedical Imaging (I2BM) and Molecular Imaging Research Center, France.

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http://dx.doi.org/10.1002/ana.21569DOI Listing
March 2009

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.

J Biol Chem 2008 Oct 11;283(42):28176-89. Epub 2008 Aug 11.

Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1074/jbc.M803159200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661389PMC
October 2008

Comprehensive spatiotemporal transcriptomic analyses of the ganglionic eminences demonstrate the uniqueness of its caudal subdivision.

Mol Cell Neurosci 2008 Apr 26;37(4):845-56. Epub 2008 Jan 26.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.mcn.2008.01.009DOI Listing
April 2008

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo.

Neurobiol Dis 2008 Jan 19;29(1):22-9. Epub 2007 Aug 19.

Signalisation Neuronale et Régulations Géniques, Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, UMR 7102, 9 quai Saint Bernard, 75005 Paris, France.

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http://dx.doi.org/10.1016/j.nbd.2007.07.028DOI Listing
January 2008

Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'.

BMC Bioinformatics 2008 Jan 17;9:26. Epub 2008 Jan 17.

Swiss Institute of Bioinformatics (SIB), CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1186/1471-2105-9-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267709PMC
January 2008

Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood.

Proc Natl Acad Sci U S A 2007 Sep 27;104(36):14424-9. Epub 2007 Aug 27.

Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1073/pnas.0703652104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964868PMC
September 2007

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease.

Mol Ther 2007 May 20;15(5):903-11. Epub 2007 Mar 20.

Ecole Polytechnique Fédérale de Lausanne (EPFL), Brain Mind Institute, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/mt.sj.6300141DOI Listing
May 2007

Modulation of nucleosome dynamics in Huntington's disease.

Hum Mol Genet 2007 May 2;16(10):1164-75. Epub 2007 Apr 2.

Geriatric Research Education and Clinical Center, Bedford VA Medical Center, Bedford, MA 01730, USA.

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http://dx.doi.org/10.1093/hmg/ddm064DOI Listing
May 2007

Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1.

Hum Mol Genet 2005 Jan 17;14(2):179-89. Epub 2004 Nov 17.

Department of Neurology, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA.

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http://dx.doi.org/10.1093/hmg/ddi014DOI Listing
January 2005

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease.

Neurobiol Dis 2004 Dec;17(3):455-61

Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA.

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http://dx.doi.org/10.1016/j.nbd.2004.07.006DOI Listing
December 2004

Progress towards a vaccine for Huntington's disease.

Mol Ther 2003 May;7(5 Pt 1):569-70

Massachusetts General Hospital, Charlestown 02129, USA.

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http://dx.doi.org/10.1016/s1525-0016(03)00107-2DOI Listing
May 2003

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.

Hum Mol Genet 2002 Aug;11(17):1939-51

Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, Children's and Women's Hospital, University of British Columbia, Vancouver, British Columbia, Canada, V5H 4H4.

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http://dx.doi.org/10.1093/hmg/11.17.1939DOI Listing
August 2002

Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease.

Brain Res Mol Brain Res 2002 Jun;102(1-2):118-28

Department of Neurology and Center for Aging, Genetics, and Neurodegeneration, Neurology/B114-2001, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1016/s0169-328x(02)00216-4DOI Listing
June 2002