Ruth H Palmer

Ruth H Palmer

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Ruth H Palmer

Ruth H Palmer

Publications by authors named "Ruth H Palmer"

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Alectinib, an Anaplastic Lymphoma Kinase Inhibitor, Abolishes ALK Activity and Growth in ALK-Positive Neuroblastoma Cells.

Front Oncol 2019 5;9:579. Epub 2019 Jul 5.

Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.3389/fonc.2019.00579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625372PMC
July 2019

Analysis of ALK, MYCN, and the ALK ligand ALKAL2 (FAM150B/AUGα) in neuroblastoma patient samples with chromosome arm 2p rearrangements.

Genes Chromosomes Cancer 2019 Jul 24. Epub 2019 Jul 24.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1002/gcc.22790DOI Listing
July 2019

Targeting anaplastic lymphoma kinase in neuroblastoma.

APMIS 2019 May 3;127(5):288-302. Epub 2019 Apr 3.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1111/apm.12940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850425PMC
May 2019

Characterization of / reveals roles in basement membrane stability, barrier function and nervous system patterning.

Development 2019 01 16;146(2). Epub 2019 Jan 16.

Justus-Liebig-Universitaet Giessen, Institut für Allgemeine und Spezielle Zoologie, Allgemeine Zoologie und Entwicklungsbiologie, Stephanstraße 24, 35390 Gießen, Germany

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http://dev.biologists.org/lookup/doi/10.1242/dev.168948
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http://dx.doi.org/10.1242/dev.168948DOI Listing
January 2019

Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways.

Sci Signal 2018 11 20;11(557). Epub 2018 Nov 20.

Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, SE-405 30 Göteborg, Sweden.

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http://dx.doi.org/10.1126/scisignal.aar5680DOI Listing
November 2018

model of myosin myopathy rescued by overexpression of a TRIM-protein family member.

Proc Natl Acad Sci U S A 2018 07 26;115(28):E6566-E6575. Epub 2018 Jun 26.

Translational Medicine, School of Health and Education, University of Skövde, SE-541 28, Skövde, Sweden

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http://dx.doi.org/10.1073/pnas.1800727115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048496PMC
July 2018

ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.

Proc Natl Acad Sci U S A 2018 01 9;115(4):E630-E638. Epub 2018 Jan 9.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1719137115
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http://dx.doi.org/10.1073/pnas.1719137115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789956PMC
January 2018

MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas.

Sci Signal 2017 Nov 28;10(507). Epub 2017 Nov 28.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-405 30 Göteborg, Sweden.

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http://dx.doi.org/10.1126/scisignal.aam7550DOI Listing
November 2017

The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in .

Sci Signal 2017 Oct 24;10(502). Epub 2017 Oct 24.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 9A, SE-40530 Gothenburg, Sweden.

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http://dx.doi.org/10.1126/scisignal.aan0804DOI Listing
October 2017

Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation.

Cancers (Basel) 2017 Oct 30;9(11). Epub 2017 Oct 30.

Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, SE-40530 Göteborg, Sweden.

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http://dx.doi.org/10.3390/cancers9110149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704167PMC
October 2017

The Zic family homologue Odd-paired regulates Alk expression in Drosophila.

PLoS Genet 2017 04 3;13(4):e1006617. Epub 2017 Apr 3.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1371/journal.pgen.1006617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393633PMC
April 2017

Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent.

Oncotarget 2017 Feb;8(7):11566-11578

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden.

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http://dx.doi.org/10.18632/oncotarget.14141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355286PMC
February 2017

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice.

Oncotarget 2016 May;7(20):29011-22

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.18632/oncotarget.8508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045374PMC
May 2016

Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism.

PLoS One 2015 8;10(5):e0123542. Epub 2015 May 8.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Molecular Biology, Umeå University, Umeå, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123542PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425494PMC
April 2016

Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs.

Nat Cell Biol 2016 Apr 14;18(4):451-7. Epub 2016 Mar 14.

The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1038/ncb3325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817240PMC
April 2016

The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation.

PLoS One 2014 7;9(11):e112250. Epub 2014 Nov 7.

Department of Molecular Biology, Umeå University, Umeå, Sweden; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Göteborg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112250PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224452PMC
December 2015

FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.

Elife 2015 Sep 29;4:e09811. Epub 2015 Sep 29.

Department of Medical Biochemistry and Cell Biology, Instititute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.7554/eLife.09811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658194PMC
September 2015

Intragenic anaplastic lymphoma kinase (ALK) rearrangements: translocations as a novel mechanism of ALK activation in neuroblastoma tumors.

Genes Chromosomes Cancer 2015 Feb 23;54(2):99-109. Epub 2014 Sep 23.

Department of Medical and Clinical Genetics, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1002/gcc.22223DOI Listing
February 2015

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma.

Sci Signal 2014 Oct 28;7(349):ra102. Epub 2014 Oct 28.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-405 30 Göteborg, Sweden.

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http://dx.doi.org/10.1126/scisignal.2005470DOI Listing
October 2014

Microbiology of folliculitis: a histological study of 39 cases.

APMIS 2014 Jan 8;122(1):25-32. Epub 2013 May 8.

Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1111/apm.12103DOI Listing
January 2014

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology.

Nat Rev Cancer 2013 Oct;13(10):685-700

Department of Molecular Biology, Building 6L, Umeå University, Umeå S-90187, Sweden.

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http://dx.doi.org/10.1038/nrc3580DOI Listing
October 2013

Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm.

Development 2013 Aug 3;140(15):3156-66. Epub 2013 Jul 3.

Department of Molecular Biology, Building 6L, Umeå University, Umeå S-90187, Sweden.

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http://dx.doi.org/10.1242/dev.094466DOI Listing
August 2013

Spatial distribution of bacterial-fungal communities in facial skin.

J Dermatol Sci 2013 Apr 7;70(1):71-3. Epub 2012 Dec 7.

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http://dx.doi.org/10.1016/j.jdermsci.2012.11.592DOI Listing
April 2013

Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation.

EMBO J 2013 Feb 25;32(4):524-37. Epub 2013 Jan 25.

Department of Molecular Biology, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1038/emboj.2013.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579141PMC
February 2013

Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684.

Biochem J 2011 Dec;440(3):405-13

Department of Molecular Biology, Building 6L, Umeå University, Umeå 901 87, Sweden.

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http://dx.doi.org/10.1042/BJ20101796DOI Listing
December 2011

ALK and NSCLC: Targeted therapy with ALK inhibitors.

F1000 Med Rep 2011 1;3:21. Epub 2011 Nov 1.

Department of Molecular Biology, Umeå University, Umeå S-901 87 Sweden.

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http://dx.doi.org/10.3410/M3-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206708PMC
November 2011

The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.

PLoS Genet 2011 Sep 15;7(9):e1002281. Epub 2011 Sep 15.

Institute of Cellular and Developmental Biology, Biomedical Sciences Research Centre "Alexander Fleming," Vari, Greece.

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https://dx.plos.org/10.1371/journal.pgen.1002281
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http://dx.doi.org/10.1371/journal.pgen.1002281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174217PMC
September 2011

Crizotinib--latest champion in the cancer wars?

N Engl J Med 2010 Oct;363(18):1760-2

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http://dx.doi.org/10.1056/NEJMe1010404DOI Listing
October 2010

Characterisation of the role of Vrp1 in cell fusion during the development of visceral muscle of Drosophila melanogaster.

BMC Dev Biol 2010 Aug 11;10:86. Epub 2010 Aug 11.

Department of Molecular Biology, Building 6L, Umeå University, Umeå S-90187, Sweden.

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http://dx.doi.org/10.1186/1471-213X-10-86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931478PMC
August 2010

Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm.

Mech Dev 2009 Aug-Sep;126(8-9):721-36. Epub 2009 May 20.

Institut für Allgemeine und Spezielle Zoologie, Allgemeine Zoologie und Entwicklungsbiologie, Justus-Liebig-Universität Giessen, Stephanstrasse 24, D-35390 Giessen, Germany.

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http://dx.doi.org/10.1016/j.mod.2009.05.001DOI Listing
December 2009

Anaplastic lymphoma kinase: signalling in development and disease.

Biochem J 2009 May 27;420(3):345-61. Epub 2009 May 27.

Department of Molecular Biology, Umeå University, Umeå, Sweden.

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http://biochemj.org/lookup/doi/10.1042/BJ20090387
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http://dx.doi.org/10.1042/BJ20090387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708929PMC
May 2009

WASP and SCAR have distinct roles in activating the Arp2/3 complex during myoblast fusion.

J Cell Sci 2008 Apr;121(Pt 8):1303-13

Fachbereich Biologie, Entwicklungsbiologie, Philipps-Universität Marburg, Karl-von-Frisch Str. 8, D-35043 Marburg, Germany.

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http://dx.doi.org/10.1242/jcs.022269DOI Listing
April 2008

Drosophila Anaplastic Lymphoma Kinase regulates Dpp signalling in the developing embryonic gut.

Differentiation 2007 Jun 5;75(5):418-26. Epub 2007 Feb 5.

Umeå Center for Molecular Pathogenesis Umeå University Building 6L, Umeå S-901 87 Sweden.

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http://dx.doi.org/10.1111/j.1432-0436.2006.00148.xDOI Listing
June 2007

The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK.

J Exp Zool B Mol Dev Evol 2007 May;308(3):269-82

Department of Medical Biosciences, Umeå University, Umeå S-901 87, Sweden.

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http://dx.doi.org/10.1002/jez.b.21146DOI Listing
May 2007

Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation.

Br J Haematol 2007 Jan 30;136(2):260-8. Epub 2006 Nov 30.

Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1111/j.1365-2141.2006.06434.xDOI Listing
January 2007

The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut.

Biochem Biophys Res Commun 2006 Dec 30;351(4):839-46. Epub 2006 Oct 30.

Umeå Center for Molecular Pathogenesis, Building 6L, Umeå University, Umeå S-901 87, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2006.10.117DOI Listing
December 2006

Characterization of the expression of the ALK receptor tyrosine kinase in mice.

Gene Expr Patterns 2006 Jun 2;6(5):448-61. Epub 2006 Feb 2.

Department of Medical Biosciences/Pathology, Building 6M, 2nd Floor, Umeå University, S-901 87 Umeå, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S1567133X0500150
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http://dx.doi.org/10.1016/j.modgep.2005.11.006DOI Listing
June 2006

Delineation of exoenzyme S residues that mediate the interaction with 14-3-3 and its biological activity.

FEBS J 2006 Feb;273(3):638-46

Department of Medical Biosciences/Pathology, Umeå University, Sweden.

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http://dx.doi.org/10.1111/j.1742-4658.2005.05100.xDOI Listing
February 2006

Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster.

Dev Genes Evol 2006 Jan 12;216(1):10-8. Epub 2005 Oct 12.

Umeå Center for Molecular Pathogenesis, Umeå University, Umeå, 901 87, Sweden,

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http://dx.doi.org/10.1007/s00427-005-0025-8DOI Listing
January 2006

Focal adhesion kinase is not required for integrin function or viability in Drosophila.

Development 2004 Dec 3;131(23):5795-805. Epub 2004 Nov 3.

Umeå Center for Molecular Pathogenesis, Building 6L, Umeå University, Umeå, 901 87, Sweden.

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http://dx.doi.org/10.1242/dev.01462DOI Listing
December 2004

Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines.

Blood 2004 Jul 2;104(1):51-7. Epub 2004 Mar 2.

Umeå Center for Molecualr Medicine, and Department of Medical Biosciences/Pathology, Umeå University, S-901 87 Umea, Sweden.

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http://dx.doi.org/10.1182/blood-2003-07-2554DOI Listing
July 2004

Myoblast determination in the somatic and visceral mesoderm depends on Notch signalling as well as on milliways(mili(Alk)) as receptor for Jeb signalling.

Development 2004 Feb;131(4):743-54

Philipps-Universität Marburg, Fachbereich Biologie, Zoologie/Entwicklungsbiologie, Karl-von-Frisch-Strasse, 35039 Marburg, Germany.

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http://dx.doi.org/10.1242/dev.00972DOI Listing
February 2004

Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.

Nature 2003 Oct;425(6957):512-6

Umeå Center for Molecular Pathogenesis, Umeå University, Umeå, S-901 87, Sweden.

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http://dx.doi.org/10.1038/nature01950DOI Listing
October 2003