Publications by authors named "Ruth Ashery-Padan"

61Publications

Zeb2 regulates the balance between retinal interneurons and Müller glia by inhibition of BMP-Smad signaling.

Dev Biol 2020 Dec 17;468(1-2):80-92. Epub 2020 Sep 17.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2020.09.006DOI Listing
December 2020

Pax6 regulation of in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development.

Development 2018 08 9;145(15). Epub 2018 Aug 9.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel

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http://dev.biologists.org/lookup/doi/10.1242/dev.163691
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http://dx.doi.org/10.1242/dev.163691DOI Listing
August 2018

Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis.

Dev Biol 2017 12 7;432(1):140-150. Epub 2017 Oct 7.

Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2017.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882491PMC
December 2017

The retinal pigmented epithelium - from basic developmental biology research to translational approaches.

Int J Dev Biol 2017 ;61(3-4-5):225-234

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1387/ijdb.160393raDOI Listing
June 2018

The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis.

Development 2016 11 3;143(22):4182-4192. Epub 2016 Oct 3.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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http://dx.doi.org/10.1242/dev.129734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117211PMC
November 2016

Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers.

Epigenetics Chromatin 2016 9;9(1):37. Epub 2016 Sep 9.

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461 USA ; Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461 USA.

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http://dx.doi.org/10.1186/s13072-016-0087-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018195PMC
September 2016

Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals.

Development 2016 08 6;143(15):2829-41. Epub 2016 Jul 6.

Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv 69978, Israel

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http://dx.doi.org/10.1242/dev.136101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004910PMC
August 2016

Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.

Nucleic Acids Res 2015 Aug 2;43(14):6827-46. Epub 2015 Jul 2.

The Departments of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA

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http://dx.doi.org/10.1093/nar/gkv589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538810PMC
August 2015

MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors.

Development 2015 Jul 10;142(14):2487-98. Epub 2015 Jun 10.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel

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http://dx.doi.org/10.1242/dev.121533DOI Listing
July 2015

Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse.

Development 2015 Mar;142(5):972-82

Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA

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http://dx.doi.org/10.1242/dev.120022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352985PMC
March 2015

Lack of centrioles and primary cilia in STIL(-/-) mouse embryos.

Cell Cycle 2014 ;13(18):2859-68

a Sheba Cancer Research Center and the Edmond and Lily Safra Children's Hospital; Sheba Medical Center ; Tel-Hashomer, Ramat Gan , Israel.

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http://dx.doi.org/10.4161/15384101.2014.946830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615128PMC
August 2015

The cellular and molecular mechanisms of vertebrate lens development.

Development 2014 Dec 18;141(23):4432-47. Epub 2014 Nov 18.

Sackler School of Medicine and Sagol School of Neuroscience, Tel-Aviv University, 69978 Ramat Aviv, Tel Aviv, Israel

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http://dx.doi.org/10.1242/dev.107953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302924PMC
December 2014

Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression.

Oncotarget 2014 Oct;5(20):9594-608

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA. Department of Human Molecular Genetics and Biochemistry, Tel-Aviv University, Tel Aviv, Israel. Howard Hughes Medical Institute, Chevy Chase, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259422PMC
http://dx.doi.org/10.18632/oncotarget.2468DOI Listing
October 2014

Protein phosphatase magnesium dependent 1A governs the wound healing-inflammation-angiogenesis cross talk on injury.

Am J Pathol 2014 Nov 6;184(11):2936-50. Epub 2014 Sep 6.

Department of Cell Research and Immunology, The George S. Wise Faculty of Life Sciences, Tel Hashomer, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.07.022DOI Listing
November 2014

Pax6 is required for normal cell-cycle exit and the differentiation kinetics of retinal progenitor cells.

PLoS One 2013 20;8(9):e76489. Epub 2013 Sep 20.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076489PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779171PMC
May 2014

Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.

Nucleic Acids Res 2013 Dec 12;41(22):10199-214. Epub 2013 Sep 12.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, Department of Surgery, Creighton University, Omaha, NE 68178, USA, Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105, USA and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978.

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http://dx.doi.org/10.1093/nar/gkt824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905850PMC
December 2013

Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits.

Nat Neurosci 2013 Aug 7;16(8):1060-7. Epub 2013 Jul 7.

Molecular Neurobiology Laboratory, The Salk Institute For Biological Studies, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nn.3454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769112PMC
August 2013

Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model.

Hum Mol Genet 2013 Jul 20;22(14):2785-94. Epub 2013 Mar 20.

Department of Human Molecular Genetics and Biochemistry.

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http://dx.doi.org/10.1093/hmg/ddt126DOI Listing
July 2013

Pax6: a multi-level regulator of ocular development.

Prog Retin Eye Res 2012 Sep 3;31(5):351-76. Epub 2012 May 3.

Sackler Faculty of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1016/j.preteyeres.2012.04.002DOI Listing
September 2012

Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium.

Dev Biol 2011 Nov 17;359(1):26-36. Epub 2011 Aug 17.

Department of Developmental Biology and Cancer Research, The institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2011.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746519PMC
November 2011

The mechanism of lens placode formation: a case of matrix-mediated morphogenesis.

Dev Biol 2011 Jul 21;355(1):32-42. Epub 2011 Apr 21.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ydbio.2011.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104088PMC
July 2011

Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium.

Development 2011 Jan;138(1):127-38

Sackler Faculty of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dev.biologists.org/cgi/doi/10.1242/dev.053637
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http://dx.doi.org/10.1242/dev.053637DOI Listing
January 2011

Reduced expression of Pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucoma.

Hum Mol Genet 2010 Sep 10;19(17):3332-42. Epub 2010 Jun 10.

Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1093/hmg/ddq237DOI Listing
September 2010

Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis.

Development 2009 Sep;136(17):2977-85

Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1242/dev.037341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723069PMC
September 2009

Pax6 is essential for lens fiber cell differentiation.

Development 2009 Aug 1;136(15):2567-78. Epub 2009 Jul 1.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1242/dev.032888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709063PMC
August 2009

Pax6 dosage requirements in iris and ciliary body differentiation.

Dev Biol 2009 Sep 27;333(1):132-42. Epub 2009 Jun 27.

Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1016/j.ydbio.2009.06.023DOI Listing
September 2009

Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system.

Exp Neurol 2009 Jul 1;218(1):24-32. Epub 2009 Apr 1.

Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978 Israel.

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http://dx.doi.org/10.1016/j.expneurol.2009.03.026DOI Listing
July 2009

In vivo MRI of altered brain anatomy and fiber connectivity in adult pax6 deficient mice.

Cereb Cortex 2009 Dec 27;19(12):2838-47. Epub 2009 Mar 27.

Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, 37070 Göttingen, Germany.

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http://dx.doi.org/10.1093/cercor/bhp057DOI Listing
December 2009

Dual requirement for Pax6 in retinal progenitor cells.

Development 2008 Dec 12;135(24):4037-4047. Epub 2008 Nov 12.

Sackler Faculty of Medicine, Human Molecular Genetics and Biochemistry, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel.

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http://dx.doi.org/10.1242/dev.028308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231183PMC
December 2008

Altered molecular regionalization and normal thalamocortical connections in cortex-specific Pax6 knock-out mice.

J Neurosci 2008 Aug;28(35):8724-34

Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX13QX, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.2565-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844775PMC
August 2008

Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing.

RNA 2007 Nov 5;13(11):1988-99. Epub 2007 Sep 5.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1261/rna.492907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040095PMC
November 2007

Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina.

J Comp Neurol 2007 Nov;505(1):58-72

Department of Neuroanatomy, Max-Planck-Institute for Brain Research, Deutschordenst. 46, 60218 Frankfurt, Germany.

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http://dx.doi.org/10.1002/cne.21458DOI Listing
November 2007

CAMTAs: calmodulin-binding transcription activators from plants to human.

FEBS Lett 2007 Aug 1;581(21):3893-8. Epub 2007 Aug 1.

Department of Plant Sciences, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1016/j.febslet.2007.07.051DOI Listing
August 2007

Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas.

Development 2007 Aug 27;134(15):2719-25. Epub 2007 Jun 27.

Department of Genetic Medicine and Development, University of Geneva Faculty of Medicine, 1 Rue Michel-Servet, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1242/dev.02875DOI Listing
August 2007

Iris development in vertebrates; genetic and molecular considerations.

Brain Res 2008 Feb 20;1192:17-28. Epub 2007 Mar 20.

Sackler Faculty of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel.

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http://linkinghub.elsevier.com/retrieve/pii/S000689930700723
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http://dx.doi.org/10.1016/j.brainres.2007.03.043DOI Listing
February 2008

The proliferation and expansion of retinal stem cells require functional Pax6.

Dev Biol 2007 Apr 19;304(2):713-21. Epub 2007 Jan 19.

Department of Medical Genetics and Microbiology, University of Toronto, and Program in Developmental Biology and Genetics, Research Institute, Hospital for Sick Children, Canada.

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http://dx.doi.org/10.1016/j.ydbio.2007.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950846PMC
April 2007

Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells.

Mol Cell Biol 2007 Jan 23;27(1):182-94. Epub 2006 Oct 23.

Laboratory of Molecular and Developmental Biology, National Eye Institute/NIH, 7 Memorial Drive, Room 129, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1128/MCB.00846-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800665PMC
January 2007

Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina.

Development 2006 Apr 1;133(7):1367-78. Epub 2006 Mar 1.

Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1242/dev.02311DOI Listing
April 2006

Genetic dissection of Pax6 dosage requirements in the developing mouse eye.

Hum Mol Genet 2005 Aug 29;14(15):2265-76. Epub 2005 Jun 29.

Sackler Faculty of Medicine, Department of Human Genetics and Molecular Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1093/hmg/ddi231DOI Listing
August 2005

Neuronal fate determinants of adult olfactory bulb neurogenesis.

Nat Neurosci 2005 Jul;8(7):865-72

GSF-National Research Center for Environment and Health, Institute for Stem Cell Research, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/nn1479DOI Listing
July 2005

Contributions by members of the TGFbeta superfamily to lens development.

Int J Dev Biol 2004 ;48(8-9):845-56

Dept. Ophthalmology and Visual Sciences, Washington University, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1387/ijdb.041869dbDOI Listing
June 2005

An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice.

Mamm Genome 2004 Jun;15(6):424-32

Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.

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http://dx.doi.org/10.1007/s00335-004-2334-zDOI Listing
June 2004

Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes.

Dev Biol 2004 May;269(2):479-88

Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978 Israel.

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http://dx.doi.org/10.1016/j.ydbio.2004.01.040DOI Listing
May 2004

Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6.

Development 2003 Jul;130(13):2903-15

Department of Molecular Cell Biology, Max-Planck-Institute of Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany.

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http://dx.doi.org/10.1242/dev.00450DOI Listing
July 2003

Somatic gene targeting in the developing and adult mouse retina.

Methods 2002 Dec;28(4):457-64

Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Israel.

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http://dx.doi.org/10.1016/s1046-2023(02)00265-7DOI Listing
December 2002

Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle.

Development 2002 Oct;129(19):4535-45

Max-Planck-Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D-37077 Göttingen, Germany.

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October 2002