Publications by authors named "Russell W Jenkins"

42Publications

Targeting TANK-binding kinase 1 (TBK1) in cancer.

Expert Opin Ther Targets 2020 Nov 5;24(11):1065-1078. Epub 2020 Oct 5.

Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, MA, USA.

View Article and Find Full Text PDF
November 2020

Treatment of Advanced Melanoma in 2020 and Beyond.

J Invest Dermatol 2021 Jan 5;141(1):23-31. Epub 2020 Apr 5.

Cutaneous Biology Research Center, Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

View Article and Find Full Text PDF
January 2021

Mechanisms of Resistance to Immune Checkpoint Blockade.

Am J Clin Dermatol 2019 Feb;20(1):41-54

Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 7E, Boston, MA, 02114, USA.

View Article and Find Full Text PDF
February 2019

Mechanisms of resistance to immune checkpoint inhibitors.

Br J Cancer 2018 01 2;118(1):9-16. Epub 2018 Jan 2.

Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

View Article and Find Full Text PDF
January 2018

Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Cancer Discov 2018 02 3;8(2):196-215. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

View Article and Find Full Text PDF
February 2018

Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer.

Annu Rev Med 2018 01 3;69:333-347. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; email:

View Article and Find Full Text PDF
January 2018

Refining Targeted Therapy Opportunities for -Mutant Melanoma.

Cancer Discov 2017 08;7(8):799-801

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

View Article and Find Full Text PDF
August 2017

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase.

PLoS One 2017 14;12(6):e0177805. Epub 2017 Jun 14.

Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America.

View Article and Find Full Text PDF
September 2017

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.

Cancer Immunol Res 2016 06 11;4(6):520-30. Epub 2016 Apr 11.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts.

View Article and Find Full Text PDF
June 2016

mutant melanoma: an overview for the clinician for melanoma management.

Melanoma Manag 2016 Mar 17;3(1):47-59. Epub 2016 Feb 17.

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

View Article and Find Full Text PDF
March 2016

Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration.

PLoS One 2015 13;10(7):e0133032. Epub 2015 Jul 13.

Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, United States of America.

View Article and Find Full Text PDF
April 2016

Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation.

Clin Lung Cancer 2015 Sep 7;16(5):e101-4. Epub 2015 Feb 7.

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA. Electronic address:

View Article and Find Full Text PDF
September 2015

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.

Prostaglandins Other Lipid Mediat 2012 Dec 31;99(3-4):124-30. Epub 2012 Aug 31.

Ralph H Johnson VA Medical Center, Medical University of South Carolina, Charleston, SC 29401, United States.

View Article and Find Full Text PDF
December 2012

Numb chin syndrome in acute myeloid leukemia.

Am J Med Sci 2012 Sep;344(3):237-40

Medical Scientist Training Program and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29403, USA.

View Article and Find Full Text PDF
September 2012

Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.

PLoS One 2011 8;6(6):e20411. Epub 2011 Jun 8.

Department of Medicine Medical University of South Carolina, Charleston, South Carolina, United States of America.

View Article and Find Full Text PDF
October 2011

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.

Br J Pharmacol 2011 Jun;163(4):694-712

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.

View Article and Find Full Text PDF
June 2011

Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase.

J Biol Chem 2011 Jun 2;286(24):21565-76. Epub 2011 May 2.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article and Find Full Text PDF
June 2011

Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events.

J Biol Chem 2011 May 9;286(18):15929-42. Epub 2011 Mar 9.

Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article and Find Full Text PDF
May 2011

Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.

J Biol Chem 2011 Apr 18;286(15):13292-303. Epub 2011 Feb 18.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article and Find Full Text PDF
April 2011

A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing.

J Biol Chem 2011 Feb 22;286(5):3777-88. Epub 2010 Nov 22.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article and Find Full Text PDF
February 2011

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism.

J Lipid Res 2011 Jan 11;52(1):68-77. Epub 2010 Oct 11.

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

View Article and Find Full Text PDF
January 2011

Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.

J Biol Chem 2010 Nov 31;285(46):35706-18. Epub 2010 Aug 31.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article and Find Full Text PDF
November 2010

Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.

J Biol Chem 2010 Oct 2;285(42):32476-85. Epub 2010 Aug 2.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article and Find Full Text PDF
October 2010

Roles and regulation of secretory and lysosomal acid sphingomyelinase.

Cell Signal 2009 Jun;21(6):836-46

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.

View Article and Find Full Text PDF
June 2009

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation.

J Biol Chem 2009 May 11;284(19):12972-8. Epub 2009 Mar 11.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

View Article and Find Full Text PDF
May 2009

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.

J Biol Chem 2009 May 11;284(19):12979-88. Epub 2009 Mar 11.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

View Article and Find Full Text PDF
May 2009

Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis.

Am J Respir Cell Mol Biol 2009 Sep 23;41(3):367-75. Epub 2009 Jan 23.

Department of Pediatrics, Medical University of South Carolina, 173 Ashley BSB 749, Charleston, SC 29403, USA.

View Article and Find Full Text PDF
September 2009

Molecular targeting of acid ceramidase: implications to cancer therapy.

Curr Drug Targets 2008 Aug;9(8):653-61

Department of Biochemistry and Molecular Biology Medical University of South Carolina .175 Ashley Avenue, P.O. Box 250509. Charleston, South Carolina, 29425, USA.

View Article and Find Full Text PDF
August 2008

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway.

J Cell Biol 2008 Apr;181(2):335-50

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

View Article and Find Full Text PDF
April 2008

A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

FASEB J 2008 Jan 13;22(1):183-93. Epub 2007 Aug 13.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

View Article and Find Full Text PDF
January 2008

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

J Biol Chem 2006 Dec 9;281(48):36793-802. Epub 2006 Oct 9.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article and Find Full Text PDF
December 2006