Russell W Jenkins

Russell W Jenkins

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Russell W Jenkins

Russell W Jenkins

Publications by authors named "Russell W Jenkins"

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39Publications

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Mechanisms of Resistance to Immune Checkpoint Blockade.

Am J Clin Dermatol 2019 Feb;20(1):41-54

Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 7E, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s40257-018-0389-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358473PMC
February 2019

Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Cancer Discov 2018 02 3;8(2):196-215. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809290PMC
February 2018

Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer.

Annu Rev Med 2018 01 3;69:333-347. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; email:

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http://dx.doi.org/10.1146/annurev-med-060116-022926DOI Listing
January 2018

Mechanisms of resistance to immune checkpoint inhibitors.

Br J Cancer 2018 01 2;118(1):9-16. Epub 2018 Jan 2.

Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/bjc.2017.434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765236PMC
January 2018

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase.

PLoS One 2017 14;12(6):e0177805. Epub 2017 Jun 14.

Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177805PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470663PMC
September 2017

Refining Targeted Therapy Opportunities for -Mutant Melanoma.

Cancer Discov 2017 08;7(8):799-801

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0607DOI Listing
August 2017

Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration.

PLoS One 2015 13;10(7):e0133032. Epub 2015 Jul 13.

Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133032PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500403PMC
April 2016

mutant melanoma: an overview for the clinician for melanoma management.

Melanoma Manag 2016 Mar 17;3(1):47-59. Epub 2016 Feb 17.

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.2217/mmt.15.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097550PMC
March 2016

Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation.

Clin Lung Cancer 2015 Sep 7;16(5):e101-4. Epub 2015 Feb 7.

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2015.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529392PMC
September 2015

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.

Prostaglandins Other Lipid Mediat 2012 Dec 31;99(3-4):124-30. Epub 2012 Aug 31.

Ralph H Johnson VA Medical Center, Medical University of South Carolina, Charleston, SC 29401, United States.

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http://dx.doi.org/10.1016/j.prostaglandins.2012.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661865PMC
December 2012

Numb chin syndrome in acute myeloid leukemia.

Am J Med Sci 2012 Sep;344(3):237-40

Medical Scientist Training Program and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29403, USA.

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http://dx.doi.org/10.1097/MAJ.0b013e318256041fDOI Listing
September 2012

Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase.

J Biol Chem 2011 Jun 2;286(24):21565-76. Epub 2011 May 2.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M110.193375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122215PMC
June 2011

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.

Br J Pharmacol 2011 Jun;163(4):694-712

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1111/j.1476-5381.2011.01279.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111673PMC
June 2011

Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events.

J Biol Chem 2011 May 9;286(18):15929-42. Epub 2011 Mar 9.

Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M111.230870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091202PMC
May 2011

Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.

J Biol Chem 2011 Apr 18;286(15):13292-303. Epub 2011 Feb 18.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M110.163378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075676PMC
April 2011

A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing.

J Biol Chem 2011 Feb 22;286(5):3777-88. Epub 2010 Nov 22.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M110.155234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030379PMC
February 2011

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism.

J Lipid Res 2011 Jan 11;52(1):68-77. Epub 2010 Oct 11.

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1194/jlr.M009142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999923PMC
January 2011

Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.

J Biol Chem 2010 Nov 31;285(46):35706-18. Epub 2010 Aug 31.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.125609
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http://dx.doi.org/10.1074/jbc.M110.125609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975195PMC
November 2010

Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.

J Biol Chem 2010 Oct 2;285(42):32476-85. Epub 2010 Aug 2.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M110.141028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952249PMC
October 2010

Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis.

Am J Respir Cell Mol Biol 2009 Sep 23;41(3):367-75. Epub 2009 Jan 23.

Department of Pediatrics, Medical University of South Carolina, 173 Ashley BSB 749, Charleston, SC 29403, USA.

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http://dx.doi.org/10.1165/rcmb.2008-0295OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742756PMC
September 2009

Roles and regulation of secretory and lysosomal acid sphingomyelinase.

Cell Signal 2009 Jun;21(6):836-46

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488588PMC
http://dx.doi.org/10.1016/j.cellsig.2009.01.026DOI Listing
June 2009

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.

J Biol Chem 2009 May 11;284(19):12979-88. Epub 2009 Mar 11.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1074/jbc.M809500200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676030PMC
May 2009

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation.

J Biol Chem 2009 May 11;284(19):12972-8. Epub 2009 Mar 11.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1074/jbc.M802790200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676029PMC
May 2009

Molecular targeting of acid ceramidase: implications to cancer therapy.

Curr Drug Targets 2008 Aug;9(8):653-61

Department of Biochemistry and Molecular Biology Medical University of South Carolina .175 Ashley Avenue, P.O. Box 250509. Charleston, South Carolina, 29425, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402562PMC
http://dx.doi.org/10.2174/138945008785132358DOI Listing
August 2008

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway.

J Cell Biol 2008 Apr;181(2):335-50

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1083/jcb.200705060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315679PMC
April 2008

A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

FASEB J 2008 Jan 13;22(1):183-93. Epub 2007 Aug 13.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://www.fasebj.org/doi/10.1096/fj.07-8967com
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http://dx.doi.org/10.1096/fj.07-8967comDOI Listing
January 2008

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

J Biol Chem 2006 Dec 9;281(48):36793-802. Epub 2006 Oct 9.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M608137200DOI Listing
December 2006