Russell P Tracy

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Russell P Tracy

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Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Authors:
Jason Flannick Josep M Mercader Christian Fuchsberger Miriam S Udler Anubha Mahajan Jennifer Wessel Tanya M Teslovich Lizz Caulkins Ryan Koesterer Francisco Barajas-Olmos Thomas W Blackwell Eric Boerwinkle Jennifer A Brody Federico Centeno-Cruz Ling Chen Siying Chen Cecilia Contreras-Cubas Emilio Córdova Adolfo Correa Maria Cortes Ralph A DeFronzo Lawrence Dolan Kimberly L Drews Amanda Elliott James S Floyd Stacey Gabriel Maria Eugenia Garay-Sevilla Humberto García-Ortiz Myron Gross Sohee Han Nancy L Heard-Costa Anne U Jackson Marit E Jørgensen Hyun Min Kang Megan Kelsey Bong-Jo Kim Heikki A Koistinen Johanna Kuusisto Joseph B Leader Allan Linneberg Ching-Ti Liu Jianjun Liu Valeriya Lyssenko Alisa K Manning Anthony Marcketta Juan Manuel Malacara-Hernandez Angélica Martínez-Hernández Karen Matsuo Elizabeth Mayer-Davis Elvia Mendoza-Caamal Karen L Mohlke Alanna C Morrison Anne Ndungu Maggie C Y Ng Colm O'Dushlaine Anthony J Payne Catherine Pihoker Wendy S Post Michael Preuss Bruce M Psaty Ramachandran S Vasan N William Rayner Alexander P Reiner Cristina Revilla-Monsalve Neil R Robertson Nicola Santoro Claudia Schurmann Wing Yee So Xavier Soberón Heather M Stringham Tim M Strom Claudia H T Tam Farook Thameem Brian Tomlinson Jason M Torres Russell P Tracy Rob M van Dam Marijana Vujkovic Shuai Wang Ryan P Welch Daniel R Witte Tien-Yin Wong Gil Atzmon Nir Barzilai John Blangero Lori L Bonnycastle Donald W Bowden John C Chambers Edmund Chan Ching-Yu Cheng Yoon Shin Cho Francis S Collins Paul S de Vries Ravindranath Duggirala Benjamin Glaser Clicerio Gonzalez Ma Elena Gonzalez Leif Groop Jaspal Singh Kooner Soo Heon Kwak Markku Laakso Donna M Lehman Peter Nilsson Timothy D Spector E Shyong Tai Tiinamaija Tuomi Jaakko Tuomilehto James G Wilson Carlos A Aguilar-Salinas Erwin Bottinger Brian Burke David J Carey Juliana C N Chan Josée Dupuis Philippe Frossard Susan R Heckbert Mi Yeong Hwang Young Jin Kim H Lester Kirchner Jong-Young Lee Juyoung Lee Ruth J F Loos Ronald C W Ma Andrew D Morris Christopher J O'Donnell Colin N A Palmer James Pankow Kyong Soo Park Asif Rasheed Danish Saleheen Xueling Sim Kerrin S Small Yik Ying Teo Christopher Haiman Craig L Hanis Brian E Henderson Lorena Orozco Teresa Tusié-Luna Frederick E Dewey Aris Baras Christian Gieger Thomas Meitinger Konstantin Strauch Leslie Lange Niels Grarup Torben Hansen Oluf Pedersen Philip Zeitler Dana Dabelea Goncalo Abecasis Graeme I Bell Nancy J Cox Mark Seielstad Rob Sladek James B Meigs Steve S Rich Jerome I Rotter David Altshuler Noël P Burtt Laura J Scott Andrew P Morris Jose C Florez Mark I McCarthy Michael Boehnke

Nature 2019 06 22;570(7759):71-76. Epub 2019 May 22.

Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.

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http://www.nature.com/articles/s41586-019-1231-2
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http://dx.doi.org/10.1038/s41586-019-1231-2DOI Listing
June 2019

Blood amyloid levels and risk of dementia in the Ginkgo Evaluation of Memory Study (GEMS): A longitudinal analysis.

Alzheimers Dement 2019 Jun 26. Epub 2019 Jun 26.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2019.04.008DOI Listing
June 2019

Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study.

Diab Vasc Dis Res 2019 May 8:1479164119847481. Epub 2019 May 8.

12 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1177/1479164119847481DOI Listing
May 2019

Collagen biomarkers predict new onset of hypertension in normotensive participants: the Multi-Ethnic Study of Atherosclerosis.

J Hypertens 2018 11;36(11):2245-2250

School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1097/HJH.0000000000001793DOI Listing
November 2018

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

Authors:
Symen Ligthart Ahmad Vaez Urmo Võsa Maria G Stathopoulou Paul S de Vries Bram P Prins Peter J Van der Most Toshiko Tanaka Elnaz Naderi Lynda M Rose Ying Wu Robert Karlsson Maja Barbalic Honghuang Lin René Pool Gu Zhu Aurélien Macé Carlo Sidore Stella Trompet Massimo Mangino Maria Sabater-Lleal John P Kemp Ali Abbasi Tim Kacprowski Niek Verweij Albert V Smith Tao Huang Carola Marzi Mary F Feitosa Kurt K Lohman Marcus E Kleber Yuri Milaneschi Christian Mueller Mahmudul Huq Efthymia Vlachopoulou Leo-Pekka Lyytikäinen Christopher Oldmeadow Joris Deelen Markus Perola Jing Hua Zhao Bjarke Feenstra Marzyeh Amini Jari Lahti Katharina E Schraut Myriam Fornage Bhoom Suktitipat Wei-Min Chen Xiaohui Li Teresa Nutile Giovanni Malerba Jian'an Luan Tom Bak Nicholas Schork Fabiola Del Greco M Elisabeth Thiering Anubha Mahajan Riccardo E Marioni Evelin Mihailov Joel Eriksson Ayse Bilge Ozel Weihua Zhang Maria Nethander Yu-Ching Cheng Stella Aslibekyan Wei Ang Ilaria Gandin Loïc Yengo Laura Portas Charles Kooperberg Edith Hofer Kumar B Rajan Claudia Schurmann Wouter den Hollander Tarunveer S Ahluwalia Jing Zhao Harmen H M Draisma Ian Ford Nicholas Timpson Alexander Teumer Hongyan Huang Simone Wahl YongMei Liu Jie Huang Hae-Won Uh Frank Geller Peter K Joshi Lisa R Yanek Elisabetta Trabetti Benjamin Lehne Diego Vozzi Marie Verbanck Ginevra Biino Yasaman Saba Ingrid Meulenbelt Jeff R O'Connell Markku Laakso Franco Giulianini Patrik K E Magnusson Christie M Ballantyne Jouke Jan Hottenga Grant W Montgomery Fernando Rivadineira Rico Rueedi Maristella Steri Karl-Heinz Herzig David J Stott Cristina Menni Mattias Frånberg Beate St Pourcain Stephan B Felix Tune H Pers Stephan J L Bakker Peter Kraft Annette Peters Dhananjay Vaidya Graciela Delgado Johannes H Smit Vera Großmann Juha Sinisalo Ilkka Seppälä Stephen R Williams Elizabeth G Holliday Matthijs Moed Claudia Langenberg Katri Räikkönen Jingzhong Ding Harry Campbell Michele M Sale Yii-Der I Chen Alan L James Daniela Ruggiero Nicole Soranzo Catharina A Hartman Erin N Smith Gerald S Berenson Christian Fuchsberger Dena Hernandez Carla M T Tiesler Vilmantas Giedraitis David Liewald Krista Fischer Dan Mellström Anders Larsson Yunmei Wang William R Scott Matthias Lorentzon John Beilby Kathleen A Ryan Craig E Pennell Dragana Vuckovic Beverly Balkau Maria Pina Concas Reinhold Schmidt Carlos F Mendes de Leon Erwin P Bottinger Margreet Kloppenburg Lavinia Paternoster Michael Boehnke A W Musk Gonneke Willemsen David M Evans Pamela A F Madden Mika Kähönen Zoltán Kutalik Magdalena Zoledziewska Ville Karhunen Stephen B Kritchevsky Naveed Sattar Genevieve Lachance Robert Clarke Tamara B Harris Olli T Raitakari John R Attia Diana van Heemst Eero Kajantie Rossella Sorice Giovanni Gambaro Robert A Scott Andrew A Hicks Luigi Ferrucci Marie Standl Cecilia M Lindgren John M Starr Magnus Karlsson Lars Lind Jun Z Li John C Chambers Trevor A Mori Eco J C N de Geus Andrew C Heath Nicholas G Martin Juha Auvinen Brendan M Buckley Anton J M de Craen Melanie Waldenberger Konstantin Strauch Thomas Meitinger Rodney J Scott Mark McEvoy Marian Beekman Cristina Bombieri Paul M Ridker Karen L Mohlke Nancy L Pedersen Alanna C Morrison Dorret I Boomsma John B Whitfield David P Strachan Albert Hofman Peter Vollenweider Francesco Cucca Marjo-Riitta Jarvelin J Wouter Jukema Tim D Spector Anders Hamsten Tanja Zeller André G Uitterlinden Matthias Nauck Vilmundur Gudnason Lu Qi Harald Grallert Ingrid B Borecki Jerome I Rotter Winfried März Philipp S Wild Marja-Liisa Lokki Michael Boyle Veikko Salomaa Mads Melbye Johan G Eriksson James F Wilson Brenda W J H Penninx Diane M Becker Bradford B Worrall Greg Gibson Ronald M Krauss Marina Ciullo Gianluigi Zaza Nicholas J Wareham Albertine J Oldehinkel Lyle J Palmer Sarah S Murray Peter P Pramstaller Stefania Bandinelli Joachim Heinrich Erik Ingelsson Ian J Deary Reedik Mägi Liesbeth Vandenput Pim van der Harst Karl C Desch Jaspal S Kooner Claes Ohlsson Caroline Hayward Terho Lehtimäki Alan R Shuldiner Donna K Arnett Lawrence J Beilin Antonietta Robino Philippe Froguel Mario Pirastu Tine Jess Wolfgang Koenig Ruth J F Loos Denis A Evans Helena Schmidt George Davey Smith P Eline Slagboom Gudny Eiriksdottir Andrew P Morris Bruce M Psaty Russell P Tracy Ilja M Nolte Eric Boerwinkle Sophie Visvikis-Siest Alex P Reiner Myron Gross Joshua C Bis Lude Franke Oscar H Franco Emelia J Benjamin Daniel I Chasman Josée Dupuis Harold Snieder Abbas Dehghan Behrooz Z Alizadeh

Am J Hum Genet 2018 11;103(5):691-706

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183032
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http://dx.doi.org/10.1016/j.ajhg.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218410PMC
November 2018

A Longitudinal Cohort Study of Aspirin Use and Progression of Emphysema-like Lung Characteristics on CT Imaging: The MESA Lung Study.

Chest 2018 Jul 12;154(1):41-50. Epub 2017 Dec 12.

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.

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http://dx.doi.org/10.1016/j.chest.2017.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045779PMC
July 2018

Association of Liver Fibrosis With Cardiovascular Diseases in the General Population: The Multi-Ethnic Study of Atherosclerosis (MESA).

Circ Cardiovasc Imaging 2018 03;11(3):e007241

From the Depatrment of Cardiology (M.R.O., T.F., H.B., E.G., J.A.C.L.) and the Department of Radiology (B.A.V.), Johns Hopkins University, Baltimore, MD; Department of Medicine, Harvard University, Boston, MA (R.S.); Department of Medicine, University of Michigan, Ann Arbor (V.L.M.); Department of Pathology and Laboratory Medicine, University of Vermont, Colchester (R.P.T.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (C.O.W.); and Department of Radiology, University of Wisconsin, Madison (D.A.B.).

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http://dx.doi.org/10.1161/CIRCIMAGING.117.007241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846116PMC
March 2018

A comparison of human serum and plasma metabolites using untargeted H NMR spectroscopy and UPLC-MS.

Metabolomics 2018 02 13;14(3):32. Epub 2018 Feb 13.

Department of Pathology and Laboratory Medicine, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT, 05446, USA.

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http://dx.doi.org/10.1007/s11306-018-1332-1DOI Listing
February 2018

Can Biomarkers Advance HIV Research and Care in the Antiretroviral Therapy Era?

J Infect Dis 2018 01;217(4):521-528

Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Colchester.

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http://dx.doi.org/10.1093/infdis/jix586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853399PMC
January 2018

HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer.

J Acquir Immune Defic Syndr 2017 08;75(5):500-508

*Medical Service/Infectious Diseases, South Texas Veterans Health Care System, San Antonio, TX; Department of Medicine, UT Health San Antonio, San Antonio, TX;†Department of Medicine, Boston University School of Medicine, Boston, MA;‡Section of General Internal Medicine, VA Connecticut Healthcare System, West Haven, CT; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT;§Medical Service, VA Medical Center, Atlanta, GA; Medical Service, Emory University School of Medicine, Atlanta, GA;‖Departments of Medicine and Biostatistics, Vanderbilt University School of Medicine, Nashville, TN;¶Department of Medicine, Infectious Diseases Section, VA North Texas Health Care System; UT Southwestern Medical Center, Dallas, TX;#Center for Health Equity Research and Promotion, VA Pittsburg Healthcare System, Pittsburgh, PA; Hamad Healthcare Quality Institute, Hamad Medical Corporation, Doha, Qatar; Department of Medicine, Weill Cornell Medical College, Doha, Qatar and New York, NY;**Medical Service/Infectious Diseases, VA Medical Center, Washington, DC; Department of Medicine, George Washington University Medical Center, Washington, DC;††Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA; David Geffen School of Medicine at UCLA, Los Angeles, CA;‡‡Infectious Diseases Section, Michael E. DeBakey VA Medical Center, Houston, TX; Infectious Diseases Section, Baylor College of Medicine, Houston, TX;§§VA Connecticut Healthcare System, West Haven, CT;‖‖Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii- Manoa, Honolulu, HI;¶¶Philadelphia VA Medical Center, Philadelphia, PA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, VA;##Division of Infectious Diseases, Columbia University Medical Center, New York, NY;***Infectious Diseases Section, VA Greater Los Angeles Healthcare System, Los Angeles, CA; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA;†††Departments of Pathology and Laboratory Medicine and Biochemistry, College of Medicine, University of Vermont, Burlington, VT; and‡‡‡Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Geriatric Research, Education, and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, TN.

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http://dx.doi.org/10.1097/QAI.0000000000001444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513170PMC
August 2017

Collagen Turnover Markers in Relation to Future Cardiovascular and Noncardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.

Clin Chem 2017 Jul 17;63(7):1237-1247. Epub 2017 May 17.

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1373/clinchem.2016.270520DOI Listing
July 2017

Physical activity predicts reduced plasma amyloid in the Cardiovascular Health Study.

Ann Clin Transl Neurol 2017 05 14;4(5):284-291. Epub 2017 Apr 14.

Department of Psychology University of Pittsburgh Pittsburgh Pennsylvania.

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http://dx.doi.org/10.1002/acn3.397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420805PMC
May 2017

D-Dimer Levels and Traditional Risk Factors Are Associated With Incident Hypertension Among HIV-Infected Individuals Initiating Antiretroviral Therapy in Uganda.

J Acquir Immune Defic Syndr 2016 Dec;73(4):396-402

*Department of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda; †Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA; ‡Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; §Epicentre Mbarara Research Centre, Mbarara, Uganda; ‖Center for Global Health, Massachusetts General Hospital, Boston, MA; ¶Harvard Medical School, Massachusetts General Hospital, Boston, MA; #Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California, San Francisco, CA; **Department of Biology, Boston College, Chestnut Hill, MA; ††Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT; ‡‡Department of Global Health and Populations, Harvard T.H Chan School of Public Health, Boston, MA; and §§Department of Medicine, University of California, San Francisco, CA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085880PMC
http://dx.doi.org/10.1097/QAI.0000000000001074DOI Listing
December 2016

Lipoprotein (a) level, apolipoprotein (a) size, and risk of unexplained ischemic stroke in young and middle-aged adults.

Atherosclerosis 2016 10 20;253:47-53. Epub 2016 Aug 20.

Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181117PMC
October 2016

Guidelines for Large-Scale Sequence-Based Complex Trait Association Studies: Lessons Learned from the NHLBI Exome Sequencing Project.

Am J Hum Genet 2016 Oct 22;99(4):791-801. Epub 2016 Sep 22.

Center for Statistical Genetics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065683PMC
October 2016

Biomarkers of Key Biological Pathways in CVD.

Glob Heart 2016 09;11(3):327-336.e3

Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA; Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT, USA.

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http://dx.doi.org/10.1016/j.gheart.2016.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108521PMC
September 2016

Associations of Circulating Lymphocyte Subpopulations with Type 2 Diabetes: Cross-Sectional Results from the Multi-Ethnic Study of Atherosclerosis (MESA).

PLoS One 2015 12;10(10):e0139962. Epub 2015 Oct 12.

Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, Vermont, United States of America; Department of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139962PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601795PMC
July 2016

Effect of Continuous Positive Airway Pressure on Cardiovascular Biomarkers: The Sleep Apnea Stress Randomized Controlled Trial.

Chest 2016 Jul 18;150(1):80-90. Epub 2016 Mar 18.

Sleep Disorders Center, Neurological Institute, Cleveland Clinic, Cleveland, OH; Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2016.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980547PMC
July 2016

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.

Authors:
Nathalie Chami Ming-Huei Chen Andrew J Slater John D Eicher Evangelos Evangelou Salman M Tajuddin Latisha Love-Gregory Tim Kacprowski Ursula M Schick Akihiro Nomura Ayush Giri Samuel Lessard Jennifer A Brody Claudia Schurmann Nathan Pankratz Lisa R Yanek Ani Manichaikul Raha Pazoki Evelin Mihailov W David Hill Laura M Raffield Amber Burt Traci M Bartz Diane M Becker Lewis C Becker Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Michelle L O'Donoghue David R Crosslin Simon de Denus Marie-Pierre Dubé Paul Elliott Gunnar Engström Michele K Evans James S Floyd Myriam Fornage He Gao Andreas Greinacher Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Jussi Hernesniemi Heather M Highland Joel N Hirschhorn Albert Hofman Marguerite R Irvin Mika Kähönen Ethan Lange Lenore J Launer Terho Lehtimäki Jin Li David C M Liewald Allan Linneberg Yongmei Liu Yingchang Lu Leo-Pekka Lyytikäinen Reedik Mägi Rasika A Mathias Olle Melander Andres Metspalu Nina Mononen Mike A Nalls Deborah A Nickerson Kjell Nikus Chris J O'Donnell Marju Orho-Melander Oluf Pedersen Astrid Petersmann Linda Polfus Bruce M Psaty Olli T Raitakari Emma Raitoharju Melissa Richard Kenneth M Rice Fernando Rivadeneira Jerome I Rotter Frank Schmidt Albert Vernon Smith John M Starr Kent D Taylor Alexander Teumer Betina H Thuesen Eric S Torstenson Russell P Tracy Ioanna Tzoulaki Neil A Zakai Caterina Vacchi-Suzzi Cornelia M van Duijn Frank J A van Rooij Mary Cushman Ian J Deary Digna R Velez Edwards Anne-Claire Vergnaud Lars Wallentin Dawn M Waterworth Harvey D White James G Wilson Alan B Zonderman Sekar Kathiresan Niels Grarup Tõnu Esko Ruth J F Loos Leslie A Lange Nauder Faraday Nada A Abumrad Todd L Edwards Santhi K Ganesh Paul L Auer Andrew D Johnson Alexander P Reiner Guillaume Lettre

Am J Hum Genet 2016 Jul 23;99(1):8-21. Epub 2016 Jun 23.

Department of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Montreal Heart Institute, Montréal, QC H1T 1C8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005438PMC
July 2016

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.

Authors:
John D Eicher Nathalie Chami Tim Kacprowski Akihiro Nomura Ming-Huei Chen Lisa R Yanek Salman M Tajuddin Ursula M Schick Andrew J Slater Nathan Pankratz Linda Polfus Claudia Schurmann Ayush Giri Jennifer A Brody Leslie A Lange Ani Manichaikul W David Hill Raha Pazoki Paul Elliot Evangelos Evangelou Ioanna Tzoulaki He Gao Anne-Claire Vergnaud Rasika A Mathias Diane M Becker Lewis C Becker Amber Burt David R Crosslin Leo-Pekka Lyytikäinen Kjell Nikus Jussi Hernesniemi Mika Kähönen Emma Raitoharju Nina Mononen Olli T Raitakari Terho Lehtimäki Mary Cushman Neil A Zakai Deborah A Nickerson Laura M Raffield Rakale Quarells Cristen J Willer Gina M Peloso Goncalo R Abecasis Dajiang J Liu Panos Deloukas Nilesh J Samani Heribert Schunkert Jeanette Erdmann Myriam Fornage Melissa Richard Jean-Claude Tardif John D Rioux Marie-Pierre Dube Simon de Denus Yingchang Lu Erwin P Bottinger Ruth J F Loos Albert Vernon Smith Tamara B Harris Lenore J Launer Vilmundur Gudnason Digna R Velez Edwards Eric S Torstenson Yongmei Liu Russell P Tracy Jerome I Rotter Stephen S Rich Heather M Highland Eric Boerwinkle Jin Li Ethan Lange James G Wilson Evelin Mihailov Reedik Mägi Joel Hirschhorn Andres Metspalu Tõnu Esko Caterina Vacchi-Suzzi Mike A Nalls Alan B Zonderman Michele K Evans Gunnar Engström Marju Orho-Melander Olle Melander Michelle L O'Donoghue Dawn M Waterworth Lars Wallentin Harvey D White James S Floyd Traci M Bartz Kenneth M Rice Bruce M Psaty J M Starr David C M Liewald Caroline Hayward Ian J Deary Andreas Greinacher Uwe Völker Thomas Thiele Henry Völzke Frank J A van Rooij André G Uitterlinden Oscar H Franco Abbas Dehghan Todd L Edwards Santhi K Ganesh Sekar Kathiresan Nauder Faraday Paul L Auer Alex P Reiner Guillaume Lettre Andrew D Johnson

Am J Hum Genet 2016 Jul 23;99(1):40-55. Epub 2016 Jun 23.

Population Sciences Branch, National Heart Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005441PMC
July 2016

Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People?

J Acquir Immune Defic Syndr 2016 06;72(2):206-213

*Department of Medicine, Boston University School of Medicine, Boston, MA; †Section of General Internal Medicine, VA Connecticut Healthcare System, West Haven, CT; ‡Department of Internal Medicine, Yale University School of Medicine, New Haven, CT; §Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA; ‖Hamad Healthcare Quality Institute, Hamad Medical Corporation, Doha, Qatar; ¶Department of Medicine, Weill Cornell Medical College, Doha, Qatar and New York, NY; #Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii-Manoa, Honolulu, HI; **Medical Service/Infectious Diseases, VA Medical Center, Washington, DC; ††Department of Medicine, George Washington University Medical Center, Washington, DC; ‡‡Infectious Diseases Section, VA Greater Los Angeles Healthcare System, Los Angeles, CA; §§Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; ‖‖Medical Service, VA Medical Center, Atlanta, GA; ¶¶Medical Service, Emory University School of Medicine, Atlanta, GA; ##Infectious Diseases Section, Michael E. DeBakey VA Medical Center, Houston, TX; ***Infectious Diseases Section, Baylor College of Medicine, Houston, TX; †††Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, CA; ‡‡‡Section of General Internal Medicine, Boston University School of Medicine, Boston, MA; §§§Department of Community Health Sciences, Boston University School of Public Health, Boston, MA; ‖‖‖Department of General Internal Medicine, Boston Medical Center, Boston, MA; ¶¶¶Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; ###Department of Medicine, Positive Health Program, San Francisco General Hospital, San Francisco, CA; ****Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Washington, Seattle, WA; ††††Departments of Pathology and Laboratory Medicine and Biochemistry, College of Medicine, University of Vermont, Burlington, VT; ‡‡‡‡Department of Medicine, University of Washington School of Medicine, Seattle, WA; §§§§Department of Medicine, Baltimore VA Medical Center, Baltimore, MD; ‖‖‖‖Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD; ¶¶¶¶Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; and ####Geriatric Research, Education, and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, TN.

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http://dx.doi.org/10.1097/QAI.0000000000000954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867134PMC
June 2016

Vitamin K-Dependent Protein Activity and Incident Ischemic Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.

Arterioscler Thromb Vasc Biol 2016 05 31;36(5):1037-42. Epub 2016 Mar 31.

From the Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.D., K.J.M.); Department of Biostatistics, University of Washington, Seattle (R.L.Y.); Human Nutrition Research Center on Aging, Tufts University, Boston, MA (K.M.S.); College of Medicine (R.P.T.) and Department of Pathology (N.S.J.), University of Vermont, Burlington; and Nephrology Section, Veterans Affairs San Diego Healthcare System, CA (J.H.I.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844474PMC
May 2016

In-depth analysis of clotting dynamics in burn patients.

J Surg Res 2016 05 12;202(2):341-51. Epub 2016 Jan 12.

Department of Surgery, The Burn Center, MedStar Washington Hospital Center, Washington, DC; Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2016.01.006DOI Listing
May 2016

Reply.

Arthritis Rheumatol 2016 Feb;68(2):555-6

University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1002/art.39471DOI Listing
February 2016

APOL1 Genotype, Kidney and Cardiovascular Disease, and Death in Older Adults.

Arterioscler Thromb Vasc Biol 2016 Feb 3;36(2):398-403. Epub 2015 Dec 3.

From the Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (K.J.M., J.T., D.J.F., M.R.P.); Veterans Affairs San Diego Healthcare System and Division of Nephrology-Hypertension, University of California San Diego School of Medicine (J.H.I.); Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA (L.H.K.); and Department of Pathology and Laboratory Medicine, University of Vermont, Burlington (R.P.T.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732891PMC
February 2016

Fetuin-A and risk of coronary heart disease: A Mendelian randomization analysis and a pooled analysis of AHSG genetic variants in 7 prospective studies.

Atherosclerosis 2015 Nov 5;243(1):44-52. Epub 2015 Sep 5.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.08.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609621PMC
November 2015

Metabolic syndrome and incident peripheral artery disease - the Multi-Ethnic Study of Atherosclerosis.

Atherosclerosis 2015 Nov 3;243(1):198-203. Epub 2015 Sep 3.

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 North Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA; Department of Medicine, Northwestern University Feinberg School of Medicine, 750 N Lake Shore Drive, 10th Floor, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.08.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656388PMC
November 2015

Plasma Levels of Soluble Interleukin-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan.

Arterioscler Thromb Vasc Biol 2015 Oct 20;35(10):2246-53. Epub 2015 Aug 20.

From the Departments of Pathology (P.D., N.S.J., M.C., R.P.T.), Medicine (M.C.), and Biochemistry (R.P.T.), University of Vermont College of Medicine, Burlington; Departments of Genetics (J.S., E.M.L., J.L., W.V., L.A.L.), Biostatistics (E.M.L., W.V.), Lineberger Comprehensive Cancer Center, School of Medicine (J.S., E.M.L., W.V.), University of North Carolina, Chapel Hill; Laboratory of Neurogenetics, Porter Neuroscience Research Center, National Institute on Aging, National Institute of Health, Bethesda, MD (M.A.N.); Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville (J.C.M.); Johns Hopkins Medical Institutions, Department of Medicine Geriatrics, Johns Hopkins University, John R. Burton Pavilion, Baltimore, MD (J.D.W.); Geriatric Epidemiology Section, National Institute on Aging, National Institute of Health, Bethesda, MD (T.B.H.); Cardiovascular Health Research Unit (B.M.P.), Departments of Medicine (B.M.P.) and Epidemiology (B.M.P., A.P.R.), University of Washington, Seattle; Group Health Research Institute, Division of Cardiology, Group Health Cooperative, Seattle, WA (B.M.P.); and Wake Forest University School of Medicine, Center for Genomics and Personalized Medicine Research, Winston-Salem, NC (Y.L.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395092PMC
October 2015

The transcriptional landscape of age in human peripheral blood.

Authors:
Marjolein J Peters Roby Joehanes Luke C Pilling Claudia Schurmann Karen N Conneely Joseph Powell Eva Reinmaa George L Sutphin Alexandra Zhernakova Katharina Schramm Yana A Wilson Sayuko Kobes Taru Tukiainen Yolande F Ramos Harald H H Göring Myriam Fornage Yongmei Liu Sina A Gharib Barbara E Stranger Philip L De Jager Abraham Aviv Daniel Levy Joanne M Murabito Peter J Munson Tianxiao Huan Albert Hofman André G Uitterlinden Fernando Rivadeneira Jeroen van Rooij Lisette Stolk Linda Broer Michael M P J Verbiest Mila Jhamai Pascal Arp Andres Metspalu Liina Tserel Lili Milani Nilesh J Samani Pärt Peterson Silva Kasela Veryan Codd Annette Peters Cavin K Ward-Caviness Christian Herder Melanie Waldenberger Michael Roden Paula Singmann Sonja Zeilinger Thomas Illig Georg Homuth Hans-Jörgen Grabe Henry Völzke Leif Steil Thomas Kocher Anna Murray David Melzer Hanieh Yaghootkar Stefania Bandinelli Eric K Moses Jack W Kent Joanne E Curran Matthew P Johnson Sarah Williams-Blangero Harm-Jan Westra Allan F McRae Jennifer A Smith Sharon L R Kardia Iiris Hovatta Markus Perola Samuli Ripatti Veikko Salomaa Anjali K Henders Nicholas G Martin Alicia K Smith Divya Mehta Elisabeth B Binder K Maria Nylocks Elizabeth M Kennedy Torsten Klengel Jingzhong Ding Astrid M Suchy-Dicey Daniel A Enquobahrie Jennifer Brody Jerome I Rotter Yii-Der I Chen Jeanine Houwing-Duistermaat Margreet Kloppenburg P Eline Slagboom Quinta Helmer Wouter den Hollander Shannon Bean Towfique Raj Noman Bakhshi Qiao Ping Wang Lisa J Oyston Bruce M Psaty Russell P Tracy Grant W Montgomery Stephen T Turner John Blangero Ingrid Meulenbelt Kerry J Ressler Jian Yang Lude Franke Johannes Kettunen Peter M Visscher G Gregory Neely Ron Korstanje Robert L Hanson Holger Prokisch Luigi Ferrucci Tonu Esko Alexander Teumer Joyce B J van Meurs Andrew D Johnson

Nat Commun 2015 Oct 22;6:8570. Epub 2015 Oct 22.

The National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.

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http://dx.doi.org/10.1038/ncomms9570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639797PMC
October 2015

Association Between Endogenous Sex Hormones and Liver Fat in a Multiethnic Study of Atherosclerosis.

Clin Gastroenterol Hepatol 2015 Sep 13;13(9):1686-93.e2. Epub 2015 Jan 13.

Department of Medicine, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.cgh.2014.12.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500744PMC
September 2015

Improving Adiponectin Levels in Individuals With Diabetes and Obesity: Insights From Look AHEAD.

Diabetes Care 2015 Aug 13;38(8):1544-50. Epub 2015 May 13.

Department of Medicine, Baylor College of Medicine, Houston, TX Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart & Vascular Center, Houston, TX.

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http://dx.doi.org/10.2337/dc14-2775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512135PMC
August 2015

GlycA: A Composite Nuclear Magnetic Resonance Biomarker of Systemic Inflammation.

Clin Chem 2015 May 16;61(5):714-23. Epub 2015 Mar 16.

Department of Pathology, University of Vermont College of Medicine, Colchester, VT.

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http://dx.doi.org/10.1373/clinchem.2014.232918DOI Listing
May 2015

Intercellular adhesion molecule 1 and progression of percent emphysema: the MESA Lung Study.

Respir Med 2015 Feb 22;109(2):255-64. Epub 2014 Oct 22.

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2014.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331236PMC
February 2015

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.

Nature 2015 Feb 10;518(7537):102-6. Epub 2014 Dec 10.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [2] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [3] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA. [4] Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://kooperberg.fhcrc.org/papers/2015do.pdf
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http://www.nature.com/doifinder/10.1038/nature13917
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http://dx.doi.org/10.1038/nature13917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319990PMC
February 2015

Association of markers of hemostasis with death in HIV-infected women.

J Acquir Immune Defic Syndr 2014 Nov;67(3):287-94

*John A. Burns School of Medicine, University of Hawaii, Honolulu, HI; †Institute for Health, Health Care Policy and Aging Research, Rutgers University, Piscataway, NJ; ‡New York Medical College, Valhalla, NY; §Albert Einstein College of Medicine, Bronx, NY; ‖State University at Downstate Medical Center, Brooklyn, NY; ¶Stroger Hospital and Rush University, Chicago, IL; #John Hopkins Bloomberg School of Public Health, Baltimore, MD; **Georgetown University, Washington, DC; ††Los Angeles County and University of Southern California Medical Center, Los Angeles, CA; ‡‡University of California, San Francisco, San Francisco, CA; §§University of Vermont, Burlington, VT; and ‖‖Montefiore Medical Center, Bronx, NY.

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http://dx.doi.org/10.1097/QAI.0000000000000306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197808PMC
November 2014

Age-related variations in the methylome associated with gene expression in human monocytes and T cells.

Nat Commun 2014 Nov 18;5:5366. Epub 2014 Nov 18.

Departments of Epidemiology & Prevention, and Biostatistics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1038/ncomms6366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280798PMC
November 2014

Plasma-free fatty acids, fatty acid-binding protein 4, and mortality in older adults (from the Cardiovascular Health Study).

Am J Cardiol 2014 Sep 1;114(6):843-8. Epub 2014 Jul 1.

Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Boston Veterans Affairs Healthcare System, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.amjcard.2014.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162821PMC
September 2014

Fibrosis-related biomarkers and incident cardiovascular disease in older adults: the cardiovascular health study.

Circ Arrhythm Electrophysiol 2014 Aug 24;7(4):583-9. Epub 2014 Jun 24.

From the Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA (I.A., E.B.R.); Department of Medicine, Boston University, MA (N.L.G.); Department of Research and Education, St. Francis Hospital/SUNY at Stony Brook, NY (E.B.); Department of Biostatistics (M.L.B.), Department of Epidemiology (A.L.F.), and Cardiovascular Health Research Unit, Department of Medicine (D.S.S.), University of Washington, Seattle; Department of Medicine (L.D.) and Channing Division of Network Medicine (E.B.R.), Brigham and Women's Hospital, Boston, MA; Department of Medicine, University of Maryland Medical School, Baltimore (J.S.G.); Department of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System (J.H.I.); Departments of Medicine, Epidemiology, and Population Health, Albert Einstein College of Medicine, Bronx, NY (J.R.K.); Department of Biochemistry, University of Vermont, Burlington (R.P.T.); and Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (K.J.M.).

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http://dx.doi.org/10.1161/CIRCEP.114.001610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140969PMC
August 2014

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.

N Engl J Med 2014 Jul 18;371(1):22-31. Epub 2014 Jun 18.

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http://dx.doi.org/10.1056/NEJMoa1307095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180269PMC
July 2014

CPAP versus oxygen in obstructive sleep apnea.

N Engl J Med 2014 Jun;370(24):2276-85

From the Veterans Affairs Boston Healthcare System (D.J.G., D.L.B.), Brigham and Women's Hospital (D.J.G., S.R.P., S.F.Q., M.R., E.F.L., D.L.B., S.R.), Harvard Medical School (D.J.G., S.R.P., S.F.Q., E.F.L., D.L.B., S.R.), Boston University School of Medicine (D.J.G.), and Beth Israel Deaconess Medical Center (S.R.P., S.R.) - all in Boston; Johns Hopkins University, Baltimore (N.M.P., R.S.B.); Cleveland Clinic (R.M.) and Case Western Reserve University (R.M., D.C.B.) - both in Cleveland; and the University of Vermont, Colchester (R.P.T.).

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http://dx.doi.org/10.1056/NEJMoa1306766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172401PMC
June 2014

Pentraxin-3 and the right ventricle: the Multi-Ethnic Study of Atherosclerosis-Right Ventricle Study.

Pulm Circ 2014 Jun;4(2):250-9

Department of Medicine, Center for Clinical Epidemiology and Biostatistics, and the Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1086/675988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070771PMC
June 2014