Russell G A Jones

Russell G A Jones

London | United Kingdom

Russell G A Jones

Russell G A Jones

Introduction

Publications

21Publications

268Reads

1Profile Views

152PubMed Central Citations

Targeted localized use of therapeutic antibodies: a review of non-systemic, topical and oral applications.

Crit Rev Biotechnol 2016 20;36(3):506-20. Epub 2015 Jan 20.

a Department of Chemistry , University of Warwick , Coventry , UK.

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http://dx.doi.org/10.3109/07388551.2014.992388DOI Listing
December 2016
29 Reads
4 Citations
7.180 Impact Factor

Linear models of ovine IgG1 and IgG2 subclasses and predicted pepsin cleavage sites.

J Pharm Biomed Anal 2016 Jan 29;117:150-4. Epub 2015 Aug 29.

SGS UK Ltd., Wokingham, Berkshire, UK.

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http://dx.doi.org/10.1016/j.jpba.2015.08.035DOI Listing
January 2016
26 Reads
2.980 Impact Factor

Use of a new functional dual coating (FDC) assay to measure low toxin levels in serum and food samples following an outbreak of human botulism.

J Med Microbiol 2013 Jun 21;62(Pt 6):828-835. Epub 2013 Mar 21.

Department of Anesthesia, University of California, San Francisco, USA.

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http://dx.doi.org/10.1099/jmm.0.053124-0DOI Listing
June 2013
17 Reads
3 Citations
2.250 Impact Factor

A functional dual-coated (FDC) microtiter plate method to replace the botulinum toxin LD50 test.

Anal Biochem 2012 Jun 6;425(1):28-35. Epub 2012 Mar 6.

Division of Bacteriology, National Institute for Biological Standards and Control, Health Protection Agency, South Mimms, Hertfordshire, UK.

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http://dx.doi.org/10.1016/j.ab.2012.02.038DOI Listing
June 2012
5 Reads
10 Citations
2.220 Impact Factor

Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin.

BMC Biotechnol 2011 Nov 23;11:113. Epub 2011 Nov 23.

Unité de Biotechnologie des Anticorps, et des Toxines, Département de Microbiologie, Institut de Recherche Biomédicale des Armées (IRBA-CRSSA), 24 Avenue des Maquis du Grésivaudan, BP 87, 38702 La Tronche Cedex, France.

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http://bmcbiotechnol.biomedcentral.com/articles/10.1186/1472
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http://dx.doi.org/10.1186/1472-6750-11-113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252318PMC
November 2011
24 Reads
11 Citations
2.034 Impact Factor

Phrenic nerve-hemidiaphragm as a highly sensitive replacement assay for determination of functional botulinum toxin antibodies.

Toxicon 2011 Jun 13;57(7-8):1008-16. Epub 2011 Apr 13.

Division of Bacteriology and Biostatistics Section, National Institute for Biological Standards and Control (NIBSC), Health Protection Agency (HPA), South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.

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http://dx.doi.org/10.1016/j.toxicon.2011.04.003DOI Listing
June 2011
20 Reads
14 Citations
2.492 Impact Factor

Release of proteolytic activity following reduction in therapeutic human serum albumin containing products: detection with a new neoepitope endopeptidase immunoassay.

J Pharm Biomed Anal 2011 Jan 19;54(1):74-80. Epub 2010 Aug 19.

National Institute for Biological Standards and Control, Health Protection Agency, Division of Bacteriology, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S07317085100047
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http://dx.doi.org/10.1016/j.jpba.2010.08.013DOI Listing
January 2011
44 Reads
5 Citations
2.980 Impact Factor

Measurement of botulinum types A, B and E neurotoxicity using the phrenic nerve-hemidiaphragm: improved precision with in-bred mice.

Toxicon 2009 Apr;53(5):503-11

Division of Bacteriology, National Institute for Biological Standards and Control Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK.

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http://dx.doi.org/10.1016/j.toxicon.2009.01.019DOI Listing
April 2009
7 Reads
14 Citations
2.492 Impact Factor

New highly specific botulinum type C1 endopeptidase immunoassays utilising SNAP25 or Syntaxin substrates.

J Immunol Methods 2009 Mar 25;343(1):21-7. Epub 2009 Jan 25.

Division of Bacteriology, National Institute for Biological Standards and Control, Hertfordshire, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00221759090000
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http://dx.doi.org/10.1016/j.jim.2009.01.001DOI Listing
March 2009
4 Reads
7 Citations
2.005 Impact Factor

An improved method for development of toxoid vaccines and antitoxins.

J Immunol Methods 2008 Aug 9;337(1):42-8. Epub 2008 Jun 9.

Division of Bacteriology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK.

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http://dx.doi.org/10.1016/j.jim.2008.05.009DOI Listing
August 2008
3 Reads
12 Citations
2.005 Impact Factor

Development of improved SNAP25 endopeptidase immuno-assays for botulinum type A and E toxins.

J Immunol Methods 2008 Jan 23;329(1-2):92-101. Epub 2007 Oct 23.

Division of Bacteriology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK.

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http://dx.doi.org/10.1016/j.jim.2007.09.014DOI Listing
January 2008
1 Read
21 Citations
2.005 Impact Factor

A review of WHO International Standards for botulinum antitoxins.

Biologicals 2006 Sep 20;34(3):223-6. Epub 2006 Feb 20.

Division of Bacteriology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire EN6 3QG, UK.

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http://dx.doi.org/10.1016/j.biologicals.2005.11.009DOI Listing
September 2006
5 Reads
6 Citations
1.210 Impact Factor

Botulinum type A toxin neutralisation by specific IgG and its fragments: a comparison of mouse systemic toxicity and local flaccid paralysis assays.

Toxicon 2006 Sep 14;48(3):246-54. Epub 2006 Jun 14.

Division of Bacteriology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK.

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http://dx.doi.org/10.1016/j.toxicon.2006.05.007DOI Listing
September 2006
4 Reads
9 Citations
2.492 Impact Factor

Detection of antibodies against botulinum toxins.

Mov Disord 2004 Mar;19 Suppl 8:S85-91

Division of Bacteriology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom.

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http://dx.doi.org/10.1002/mds.20021DOI Listing
March 2004
3 Reads
13 Citations
5.680 Impact Factor

A protocol for 'enhanced pepsin digestion': a step by step method for obtaining pure antibody fragments in high yield from serum.

J Immunol Methods 2003 Apr;275(1-2):239-50

Division of Bacteriology, National Institute for Biological Standards and Control (NIBSC), Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.

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http://dx.doi.org/10.1016/s0022-1759(03)00005-xDOI Listing
April 2003
3 Reads
6 Citations
2.005 Impact Factor

Facile F(ab′)2 Manufacturing: Strategies for the Production of Snake Antivenoms

Food Bioprod Process. 2002 June; 80(2):88-97.

Food and Bioproducts Processing

A simple process for the manufacture of polyclonal F(ab′)2 fragments that might be adopted for the facile preparation of antivenoms is described. The production of polyclonal F(ab′)2 fragments from serum commonly involves the initial purification of IgG's prior to their proteolytic cleavage and further purification. To reduce the number of processing steps the authors have compared the digestion of whole serum by free and immobilized pepsin with that of pure IgG. It was observed that with equal units of pepsin activity, caprylic acid pre-purified IgG was digested more rapidly than whole serum but that the overall retention of antigen binding activity was significantly greater in the latter case. The efficiencies of whole serum digestion by the same total units of free and immobilized pepsin was also compared. IgG digestion was complete after 12 hours, as was serum digestion. About 80% of the antigen binding activity was retained in either case after 24 hours though the immobilized pepsin lost about 40% of its proteolytic activity after first use. The purification of F(ab′)2 on two ion exchange adsorbents (StreamlineTMSP and paramagnetic CM beads) on paramagnetic thiophilic beads and on a hydrophobic custom assembled guanidine agarose was studied. The binding capacity on CM beads was too low to be useful for F(ab′)2 preparation. Most of the F(ab′)2 bound to the Streamline SP at low pH (pH 4.0 and 3.0), as did significant amounts of low molecular weight digestion products. The F(ab′)2 fragments were eluted completely with 0.3M NaCl whilst the low molecular weight digestion products required 1M NaCl to elute them. F(ab′)2 also bound to the thiophilic beads, free from the low molecular weight digestion products, and could be eluted with low ionic strength solutions. The guanidine agarose beads showed a lower capacity than the thiophilic beads but their selectivity was comparable. Overall the thiophilic and hydrophobic matrices showed better selectivity than the cation exchange matrices.

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June 2002
4 Reads

Enhanced pepsin digestion: a novel process for purifying antibody F(ab')(2) fragments in high yield from serum.

J Immunol Methods 2002 May;263(1-2):57-74

Department of Clinical Biochemistry, Barts and The London, Queen Mary's School of Medicine and Dentistry, UK.

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http://dx.doi.org/10.1016/s0022-1759(02)00031-5DOI Listing
May 2002
49 Reads
7 Citations
2.005 Impact Factor

A novel Fab-based antivenom for the treatment of mass bee attacks.

Am J Trop Med Hyg 1999 Sep;61(3):361-6

Department of Chemical Pathology, St. Bartholomew's Hospital, London, United Kingdom.

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http://dx.doi.org/10.4269/ajtmh.1999.61.361DOI Listing
September 1999
5 Reads
5 Citations
2.700 Impact Factor

The effects of specific antibody fragments on the 'irreversible' neurotoxicity induced by Brown snake (Pseudonaja) venom.

Br J Pharmacol 1999 Feb;126(3):581-4

Department of Chemical Pathology, The Medical College of St. Bartholomew's Hospital, London.

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http://dx.doi.org/10.1038/sj.bjp.0702286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1565833PMC
February 1999
3 Reads
1 Citation
4.842 Impact Factor

Experimental evaluation of ovine antisera to Thai cobra (Naja kaouthia) venom and its alpha-neurotoxin.

Toxicon 1994 Dec;32(12):1657-65

Venom Research Unit, Liverpool School of Tropical Medicine, U.K.

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http://dx.doi.org/10.1016/0041-0101(94)90324-7DOI Listing
December 1994
10 Reads
1 Citation
2.492 Impact Factor

Top co-authors

Dorothea Sesardic
Dorothea Sesardic

National Institute for Biological Standards and Control

7
Yvonne Liu
Yvonne Liu

National Institute for Biological Standards and Control

4
Y Liu
Y Liu

Sun Yat-sen Memorial Hospital

3
James D Marks
James D Marks

University of California

2
Angela Martino
Angela Martino

National Institute of Nursing Research

2
Peter Rigsby
Peter Rigsby

National Institute for Biological Standards and Control

2
Tong Leung
Tong Leung

National Institute for Biological Standards and Control

1
Toni Alsop
Toni Alsop

National Institute for Biological Standards and Control

1
R Hull
R Hull

UQ Centre for Clinical Research

1