Publications by authors named "Russell Broaddus"

100Publications

Evaluating Mismatch Repair/Microsatellite Instability Status Using Cytology Effusion Specimens to Determine Eligibility for Immunotherapy.

Arch Pathol Lab Med 2021 Jan;145(1):46-54

The Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston.

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January 2021

Endometrial Cancer.

N Engl J Med 2020 11;383(21):2053-2064

From the Department of Gynecologic Oncology and Reproductive Medicine, the University of Texas M.D. Anderson Cancer Center, Houston (K.H.L.); and the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill (R.R.B.).

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November 2020

Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma.

Oncogene 2020 10 25;39(40):6286-6299. Epub 2020 Aug 25.

Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA.

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October 2020

Endometrial biomarkers in premenopausal obese women: an at-risk cohort.

Am J Obstet Gynecol 2020 Aug 21. Epub 2020 Aug 21.

Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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August 2020

An immune competent orthotopic model of endometrial cancer with metastasis.

Heliyon 2020 May 27;6(5):e04075. Epub 2020 May 27.

Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids MI, USA.

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May 2020

Evaluating Mismatch Repair/Microsatellite Instability Status Using Cytology Effusion Specimens to Determine Eligibility for Immunotherapy.

Arch Pathol Lab Med 2020 Mar 30. Epub 2020 Mar 30.

From the Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston. Dr Jacobi is currently in the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas. Dr Broaddus is currently in the Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.

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March 2020

Long-term overall survival and prognostic score predicting survival: the IMPACT study in precision medicine.

J Hematol Oncol 2019 12 30;12(1):145. Epub 2019 Dec 30.

Department of Investigational Cancer Therapeutics, Phase I Clinical Trials Program, Unit 455, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.

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December 2019

Variable Expression of MSH6 in Endometrial Carcinomas With Intact Mismatch Repair and With MLH1 Loss Due to MLH1 Methylation.

Int J Gynecol Pathol 2020 Nov;39(6):507-513

Departments of Pathology (N.T., C.H., M.T.T.) Translational and Molecular Pathology (C.H., M.T.T.) Biostatistics (B.F.), The University of Texas M.D. Anderson Cancer Center, Houston, Texas Department of Pathology & Laboratory Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC (R.R.B).

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November 2020

Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland.

Virchows Arch 2020 Feb 19;476(2):295-305. Epub 2019 Aug 19.

Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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February 2020

G-protein coupled receptor 64 (GPR64) acts as a tumor suppressor in endometrial cancer.

BMC Cancer 2019 Aug 14;19(1):810. Epub 2019 Aug 14.

Department of Obstetrics and Gynecology & Reproductive Biology, College of Human Medicine, Michigan State University, 400 Monroe Avenue NW, Grand Rapids, MI, 49503, USA.

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August 2019

Genetic profiling as a clinical tool in advanced parathyroid carcinoma.

J Cancer Res Clin Oncol 2019 Aug 15;145(8):1977-1986. Epub 2019 Jul 15.

Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street Unit 1461, Houston, TX, 77030, USA.

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August 2019

Fasting Reduces Intestinal Radiotoxicity, Enabling Dose-Escalated Radiation Therapy for Pancreatic Cancer.

Int J Radiat Oncol Biol Phys 2019 11 2;105(3):537-547. Epub 2019 Jul 2.

Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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November 2019

Adjuvant combined-modality therapy for stage IIIC endometrioid and non-endometrioid endometrial cancer.

Gynecol Oncol 2019 07 17;154(1):22-28. Epub 2019 May 17.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

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July 2019

Identification of a subset of microsatellite-stable endometrial carcinoma with high PD-L1 and CD8+ lymphocytes.

Mod Pathol 2019 03 5;32(3):396-404. Epub 2018 Oct 5.

Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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March 2019

The ERM family member Merlin is required for endometrial gland morphogenesis.

Dev Biol 2018 10 15;442(2):301-314. Epub 2018 Aug 15.

Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Program of Genetics and Epigenetics, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address:

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October 2018

Challenges in next generation sequencing analysis of somatic mutations in transplant patients.

Cancer Genet 2018 10 10;226-227:17-22. Epub 2018 May 10.

Division of Pathology and Laboratory Medicine, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Pathology, University of Alabama at Birmingham, NP 3538, 619 19th Street S, Birmingham, AL 35249-7331, United States . Electronic address:

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October 2018

MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT.

BMC Cancer 2018 May 29;18(1):605. Epub 2018 May 29.

Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.

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May 2018

Nuclear β-catenin localization and mutation of the CTNNB1 gene: a context-dependent association.

Mod Pathol 2018 10 24;31(10):1553-1559. Epub 2018 May 24.

Department of Pathology, Unit 85, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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October 2018

Predicting high-risk endometrioid carcinomas using proteins.

Oncotarget 2018 Apr 13;9(28):19704-19715. Epub 2018 Apr 13.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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April 2018

Salvaging the supernatant: next generation cytopathology for solid tumor mutation profiling.

Mod Pathol 2018 07 20;31(7):1036-1045. Epub 2018 Feb 20.

Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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July 2018

Exon 3 mutations of drive tumorigenesis: a review.

Oncotarget 2018 Jan 24;9(4):5492-5508. Epub 2017 Nov 24.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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January 2018

Treatment of Low-Risk Endometrial Cancer and Complex Atypical Hyperplasia With the Levonorgestrel-Releasing Intrauterine Device.

Obstet Gynecol 2018 01;131(1):109-116

Department of Gynecologic Oncology and Reproductive Medicine and the Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas.

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January 2018

Molecular Modifiers of Hormone Receptor Action: Decreased Androgen Receptor Expression in Mismatch Repair Deficient Endometrial Endometrioid Adenocarcinoma.

Int J Gynecol Pathol 2019 Jan;38(1):44-51

Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

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January 2019

Loss of polarity alters proliferation and differentiation in low-grade endometrial cancers by disrupting Notch signaling.

PLoS One 2017 5;12(12):e0189081. Epub 2017 Dec 5.

Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX, United States of America.

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December 2017

Erratum to: MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis.

J Hematol Oncol 2017 10 6;10(1):163. Epub 2017 Oct 6.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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October 2017

Validation of Immunohistochemical Assays for Integral Biomarkers in the NCI-MATCH EAY131 Clinical Trial.

Clin Cancer Res 2018 02 24;24(3):521-531. Epub 2017 Aug 24.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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February 2018

Importance of PCR-based Tumor Testing in the Evaluation of Lynch Syndrome-associated Endometrial Cancer.

Adv Anat Pathol 2017 Nov;24(6):372-378

*Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR †Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX.

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November 2017

Universal Point of Care Testing for Lynch Syndrome in Patients with Upper Tract Urothelial Carcinoma.

J Urol 2018 01 7;199(1):60-65. Epub 2017 Aug 7.

Department of Urology, University of Texas M. D. Anderson Cancer Center, Houston, Texas. Electronic address:

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January 2018

Factors prognostic of survival in advanced-stage uterine serous carcinoma.

Gynecol Oncol 2017 07 30;146(1):27-33. Epub 2017 Apr 30.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

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July 2017

Template for Reporting Results of Biomarker Testing of Specimens From Patients With Carcinoma of the Endometrium.

Arch Pathol Lab Med 2017 11 16;141(11):1508-1512. Epub 2017 Mar 16.

From the Department of Pathology, Stanford Medicine, Stanford, California (Dr Longacre); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Broaddus); the Department of Obstetrics, Gynecology and Reproductive Science, Hess Center for Science and Medicine, Sinai Medical Center, New York, New York (Dr Chuang); the Department of Pathology, Huntsman Cancer Hospital, Salt Lake City, Utah (Dr Cohen); the Department of Pathology, University of Utah, Salt Lake City (Dr Jarboe); the Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (Dr Mutter); the Department of Pathology, Baystate Medical Center, Springfield, Massachusetts (Dr Otis); and the Department of Pathology, Penn State Hershey Medical Center, Hershey, Pennsylvania (Dr Zaino).

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November 2017

CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence.

Mod Pathol 2017 07 10;30(7):1032-1041. Epub 2017 Mar 10.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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July 2017

Immune Microenvironment in Microsatellite-Instable Endometrial Cancers: Hereditary or Sporadic Origin Matters.

Clin Cancer Res 2017 Aug 6;23(15):4473-4481. Epub 2017 Mar 6.

Department of Gynecologic Oncology, and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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August 2017

CD73s protection of epithelial integrity: Thinking beyond the barrier.

Tissue Barriers 2016 19;4(4):e1224963. Epub 2016 Aug 19.

Department of Pathology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.

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October 2017

Metastasis regulation by PPARD expression in cancer cells.

JCI Insight 2017 01 12;2(1):e91419. Epub 2017 Jan 12.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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January 2017

Clinical Use of Precision Oncology Decision Support.

JCO Precis Oncol 2017 13;2017. Epub 2017 Sep 13.

Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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September 2017

Clinical Challenges Associated with Universal Screening for Lynch Syndrome-Associated Endometrial Cancer.

Cancer Prev Res (Phila) 2017 Feb 13;10(2):108-115. Epub 2016 Dec 13.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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February 2017

Germline multi-gene hereditary cancer panel testing in an unselected endometrial cancer cohort.

Mod Pathol 2016 11 22;29(11):1381-1389. Epub 2016 Jul 22.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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November 2016

MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis.

J Hematol Oncol 2016 10 19;9(1):112. Epub 2016 Oct 19.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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October 2016

Prospective evaluation of the molecular effects of metformin on the endometrium in women with newly diagnosed endometrial cancer: A window of opportunity study.

Gynecol Oncol 2016 Dec 13;143(3):466-471. Epub 2016 Oct 13.

Department of Gynecologic Oncology and Reproductive Medicine, University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.

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December 2016

Clinicopathologic Significance of Mismatch Repair Defects in Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study.

J Clin Oncol 2016 09 20;34(25):3062-8. Epub 2016 Jun 20.

D. Scott McMeekin and Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; David L. Tritchler, Heather A. Lankes, and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; David E. Cohn, Floor J. Backes, and Paul J. Goodfellow, The Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; David G. Mutch, Matthew A. Powell, and Feng Gao, Washington University School of Medicine, St. Louis, MO; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Richard Zaino, Penn State Milton S. Hersey Medical Center, Hershey, PA; Russell D. Broaddus, The University of Texas MD Anderson Cancer Center, Houston, TX; Kathleen M. Darcy, Women's Health Integrated Research Collective, Annandale, VA; and Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI.

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September 2016

Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma.

Surg Pathol Clin 2016 Jun 11;9(2):289-99. Epub 2016 Apr 11.

Department of Pathology, Unit 85, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

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June 2016

MUC1 stimulates EGFR expression and function in endometrial cancer.

Oncotarget 2016 May;7(22):32796-809

Department of BioSciences, Rice University, Houston, TX 77005, USA.

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May 2016

Deletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice.

Biol Reprod 2016 Apr 9;94(4):93. Epub 2016 Mar 9.

Indiana University, Department of Obstetrics and Gynecology, Indianapolis, Indiana

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April 2016

Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study.

J Clin Oncol 2015 Dec 9;33(36):4301-8. Epub 2015 Nov 9.

Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.

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December 2015

Assessment of BRAF V600E Status in Colorectal Carcinoma: Tissue-Specific Discordances between Immunohistochemistry and Sequencing.

Mol Cancer Ther 2015 Dec 5;14(12):2887-95. Epub 2015 Oct 5.

Division of Pathology and Laboratory Medicine, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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December 2015

Factors affecting the success of next-generation sequencing in cytology specimens.

Cancer Cytopathol 2015 Nov 31;123(11):659-68. Epub 2015 Jul 31.

Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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November 2015

Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma.

JAMA Oncol 2015 Jul;1(4):486-94

Department of Pathology, University of Texas MD Anderson Cancer Center, Houston2Institute for Systems Biology/MD Anderson Cancer Center Genome Data Analysis Center, The Cancer Genome Atlas, Bethesda, Maryland.

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July 2015

The Genomic Heterogeneity of FIGO Grade 3 Endometrioid Carcinoma Impacts Diagnostic Accuracy and Reproducibility.

Int J Gynecol Pathol 2016 Jan;35(1):16-24

Department of Pathology (Y.R.H., B.W., R.A.S.) Gynecology Service, Department of Surgery (D.A.L.), Memorial Sloan Kettering Cancer Center, New York, New York Department of Pathology (R.B.), MD Anderson Cancer Center, Houston, Texas.

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January 2016

Intact PTEN Expression by Immunohistochemistry is Associated With Decreased Survival in Advanced Stage Ovarian/Primary Peritoneal High-grade Serous Carcinoma.

Int J Gynecol Pathol 2015 Nov;34(6):497-506

Departments of Pathology (R.B., S.-S.X., K.V., R.R.B.) Biostatistics (D.L.U.), University of Texas MD Anderson Cancer Center, Houston, Texas Eastern Ontario Regional Laboratory (B.D.), Department of Pathology and Laboratory Medicine, University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada.

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November 2015

Retrospective Review of MET Gene Mutations.

Oncoscience 2015 14;2(5):533-41. Epub 2015 May 14.

Department of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.

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June 2015