Rury R Holman

Rury R Holman

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Rury R Holman

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Clinical Outcomes in Patients With Type 2 Diabetes Mellitus and Peripheral Artery Disease: Results From the EXSCEL Trial.

Circ Cardiovasc Interv 2019 Dec 22;12(12):e008018. Epub 2019 Nov 22.

Duke Clinical Research Institute (P.M., N.J.P., A.F.H., R.J.M., M.R.P. W.S.J.), Duke University School of Medicine, Durham, NC.

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008018DOI Listing
December 2019

Meta-analysis of the impact of alpha-glucosidase inhibitors on incident diabetes and cardiovascular outcomes.

Cardiovasc Diabetol 2019 Oct 17;18(1):135. Epub 2019 Oct 17.

Diabetes Trials Unit, OCDEM, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK.

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http://dx.doi.org/10.1186/s12933-019-0933-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798440PMC
October 2019

Long-term risk of cardiovascular disease in individuals with latent autoimmune diabetes in adults (UKPDS 85).

Diabetes Obes Metab 2019 Sep 19;21(9):2115-2122. Epub 2019 Jun 19.

Diabetes Trials Unit, OCDEM, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/dom.13788DOI Listing
September 2019

Antithrombotic treatment gap among patients with atrial fibrillation and type 2 diabetes.

Int J Cardiol 2019 08 30;289:58-62. Epub 2019 Apr 30.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2019.04.085DOI Listing
August 2019

The importance of randomised vs non-randomised trials - Authors' reply.

Lancet 2019 08;394(10199):635

Diabetes Trials Unit, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S0140-6736(19)31111-0DOI Listing
August 2019

Comment on Kim et al. The Effect of a Smartphone-Based, Patient-Centered Diabetes Care System in Patients With Type 2 Diabetes: A Randomized, Controlled Trial for 24 Weeks. Diabetes Care 2019;42:3-9.

Diabetes Care 2019 Jul;42(7):e125

Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/dc19-0535DOI Listing
July 2019

Comment on Davis et al. Effects of Severe Hypoglycemia on Cardiovascular Outcomes and Death in the Veterans Affairs Diabetes Trial. Diabetes Care 2019;42:157-163.

Diabetes Care 2019 Jun;42(6):e95

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC.

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http://dx.doi.org/10.2337/dc18-2597DOI Listing
June 2019

An outcome model approach to transporting a randomized controlled trial results to a target population.

J Am Med Inform Assoc 2019 May;26(5):429-437

Department of Biostatistics John Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1093/jamia/ocy188DOI Listing
May 2019

Testing for qualitative heterogeneity: An application to composite endpoints in survival analysis.

Stat Methods Med Res 2019 01 3;28(1):151-169. Epub 2017 Jul 3.

3 Diabetes Trial Unit (DTU), University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1177/0962280217717761DOI Listing
January 2019

Simulating the impact of targeting lower systolic blood pressure and LDL-cholesterol levels on type 2 diabetes complication rates.

J Diabetes Complications 2019 01 10;33(1):69-74. Epub 2018 Oct 10.

Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183069
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http://dx.doi.org/10.1016/j.jdiacomp.2018.09.017DOI Listing
January 2019

Real-world studies no substitute for RCTs in establishing efficacy.

Lancet 2019 01;393(10168):210-211

Diabetes Trials Unit, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S0140-6736(18)32840-XDOI Listing
January 2019

Progression of glucose-lowering diabetes therapy in TECOS.

Endocrinol Diabetes Metab 2019 Jan 22;2(1):e00053. Epub 2018 Dec 22.

Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism University of Oxford Oxford UK.

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http://dx.doi.org/10.1002/edm2.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354756PMC
January 2019

Sex differences in management and outcomes of patients with type 2 diabetes and cardiovascular disease: A report from TECOS.

Diabetes Obes Metab 2018 10 19;20(10):2379-2388. Epub 2018 Jun 19.

Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/dom.13377DOI Listing
October 2018

What does the Acarbose Cardiovascular Evaluation (ACE) trial tell us?

Authors:
Rury R Holman

J Diabetes 2018 Aug 17;10(8):683-685. Epub 2018 May 17.

Diabetes Trials Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/1753-0407.12770DOI Listing
August 2018

Management of T2DM in 2017: Clinically relevant results from cardiovascular outcome trials.

Authors:
Rury R Holman

Nat Rev Endocrinol 2018 02 5;14(2):67-68. Epub 2018 Jan 5.

University of Oxford, Radcliffe Department of Medicine, Diabetes Trials Unit, OCDEM, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK.

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http://dx.doi.org/10.1038/nrendo.2017.179DOI Listing
February 2018

Health selection into neighborhoods among patients enrolled in a clinical trial.

Prev Med Rep 2017 Dec 24;8:51-54. Epub 2017 Jul 24.

Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, England, United Kingdom.

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http://dx.doi.org/10.1016/j.pmedr.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593304PMC
December 2017

Once-Weekly Exenatide and Cardiovascular Outcomes in Type 2 Diabetes.

N Engl J Med 2017 12;377(25):2502

Duke University, Durham, NC

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http://dx.doi.org/10.1056/NEJMc1714163DOI Listing
December 2017

Safety of sitagliptin in patients with type 2 diabetes and chronic kidney disease: outcomes from TECOS.

Diabetes Obes Metab 2017 11 7;19(11):1587-1593. Epub 2017 Jul 7.

Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/dom.12983DOI Listing
November 2017

Hypertension Control in Adults With Diabetes Mellitus and Recurrent Cardiovascular Events: Global Results From the Trial Evaluating Cardiovascular Outcomes With Sitagliptin.

Hypertension 2017 11 28;70(5):907-914. Epub 2017 Aug 28.

From the Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.M.N., D.S.G., Y.L., J.B.G., E.D.P.); Division of Cardiology, University of Texas Southwestern Medical Center, Dallas (D.K.M.); Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada (P.W.A.); Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill (J.B.B.); Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ (S.S.E.); The George Washington University Biostatistics Center, Rockville, MD (J.M.L.); Munich Diabetes Research Institute, Helmholtz Center, Germany (E.S.); Department of Cardiovascular Sciences, University of Leuven, Belgium (F.V.d.W.); and Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, United Kingdom (R.R.H.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638706PMC
November 2017

Secondary Prevention of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus: International Insights From the TECOS Trial (Trial Evaluating Cardiovascular Outcomes With Sitagliptin).

Circulation 2017 Sep 16;136(13):1193-1203. Epub 2017 Jun 16.

From Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (N.J.P., A.M.N., K.S.P., J.B.G., Y.L., E.D.P.); Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, United Kingdom (M.A.B., R.R.H.); Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada (P.W.A.); St. Michael's Hospital, University of Toronto, Ontario, Canada (R.G.J.); Division of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas (D.K.M.); Noordwest Ziekenhuisgroep, Department of Cardiology, Alkmaar, the Netherlands (J.C.H.); Department of Cardiology, Oslo University Hospital, and University of Oslo, Norway (S.H.); University of Helsinki and Helsinki University Hospital, Finland (T.E.S.); University of Oulu, Center for Life Course Health Research, Finland (T.E.S.); and Department of Endocrinology and Metabolism, School of Medicine (Kastamonu), Hacettepe University, Ankara, Turkey (T.D.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.027252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614823PMC
September 2017

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.

N Engl J Med 2017 09 14;377(13):1228-1239. Epub 2017 Sep 14.

From the Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford (R.R.H., M.A.B.), and the International Centre for Circulatory Health, Imperial College London, London (N.P.) - both in the United Kingdom; Duke Clinical Research Institute, Duke University School of Medicine, Durham (R.J.M., V.P.T., Y.L., N.J.P., A.F.H.), and the Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill (J.B.B.) - both in North Carolina; the Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong (J.C.C.); AstraZeneca Research and Development, Gaithersburg, MD (J.C., S.M.G., N.I., P.Ö.); Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) Research Center, Florence, Italy (A.P.M.); the Department of Cardiology, University of Texas Southwestern Medical Center, Dallas (S.P.M.); the India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India (A.R.); and the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and University of Toronto, Toronto (B.Z.).

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http://dx.doi.org/10.1056/NEJMoa1612917DOI Listing
September 2017

Microvascular outcomes in type 2 diabetes - Authors' reply.

Lancet Diabetes Endocrinol 2017 08;5(8):580

The George Institute for Global Health, University of Sydney, Sydney, NSW 2050, Australia.

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http://dx.doi.org/10.1016/S2213-8587(17)30185-7DOI Listing
August 2017

Effect of valsartan on kidney outcomes in people with impaired glucose tolerance.

Diabetes Obes Metab 2017 06 17;19(6):791-799. Epub 2017 Mar 17.

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1111/dom.12877DOI Listing
June 2017

Corrections needed to 2016 ESC and AHA guidelines on heart failure.

Lancet Diabetes Endocrinol 2017 05 5;5(5):325-326. Epub 2017 Apr 5.

Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S2213-8587(17)30102-XDOI Listing
May 2017

Assessing the Safety of Sitagliptin in Older Participants in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS).

Diabetes Care 2017 Apr 5;40(4):494-501. Epub 2017 Jan 5.

Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/dc16-1135DOI Listing
April 2017

Pancreatic Safety of Sitagliptin in the TECOS Study.

Diabetes Care 2017 Feb 14;40(2):164-170. Epub 2016 Sep 14.

Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/dc15-2780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864139PMC
February 2017

Preface - Diabetes prevention and management.

Authors:
Rury R Holman

Best Pract Res Clin Endocrinol Metab 2016 06;30(3):329

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http://dx.doi.org/10.1016/j.beem.2016.07.001DOI Listing
June 2016

Sitagliptin and Cardiovascular Outcomes in Type 2 Diabetes.

N Engl J Med 2015 12;373(25):2479

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http://dx.doi.org/10.1056/NEJMc1510995DOI Listing
December 2015

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes.

N Engl J Med 2015 Jul 8;373(3):232-42. Epub 2015 Jun 8.

From the Duke Clinical Research Institute, Duke University School of Medicine, Durham (J.B.G., J.G., M.J.P., E.D.P.) and University of North Carolina School of Medicine, Chapel Hill (J.B.B.) - both in North Carolina; Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (M.A.B., R.R.H.); Canadian VIGOUR Centre, University of Alberta, Edmonton, AB (P.W.A.) and St. Michael's Hospital, University of Toronto, Toronto (R.J.) - both in Canada; Merck, Kenilworth, NJ (S.S.E., K.D.K., J.K., S.K., P.P.S., S.S.); George Washington University Biostatistics Center, Rockville, MD (J.M.L.); University of Texas Southwestern Medical Center, Dallas (D.K.M.); Munich Diabetes Research Group, Helmholtz Center, Neuherberg, Germany (E.S.); and University of Leuven, Leuven, Belgium (F.V.W.).

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http://dx.doi.org/10.1056/NEJMoa1501352DOI Listing
July 2015

Within-class differences of the sulfonylureas should be accounted for. Reply to Schrijnders D, Kleefstra N and Landman GWD [letter].

Diabetologia 2015 Jun 26;58(6):1376-7. Epub 2015 Mar 26.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK,

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http://dx.doi.org/10.1007/s00125-015-3574-zDOI Listing
June 2015

Normal weight individuals who develop type 2 diabetes: the personal fat threshold.

Clin Sci (Lond) 2015 Apr;128(7):405-10

†Diabetes Trials Unit, University of Oxford, U.K.

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http://clinsci.org/lookup/doi/10.1042/CS20140553
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http://dx.doi.org/10.1042/CS20140553DOI Listing
April 2015

The effect of glibenclamide on insulin secretion at normal glucose concentrations.

Diabetologia 2015 Jan 9;58(1):43-9. Epub 2014 Oct 9.

GMP Husby, Husby, Germany.

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http://dx.doi.org/10.1007/s00125-014-3399-1DOI Listing
January 2015

Heart failure: a cardiovascular outcome in diabetes that can no longer be ignored.

Lancet Diabetes Endocrinol 2014 Oct 13;2(10):843-51. Epub 2014 Mar 13.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/S2213-8587(14)70031-2DOI Listing
October 2014

Cardiovascular outcome trials of glucose-lowering strategies in type 2 diabetes--Authors' reply.

Lancet 2014 Sep;384(9948):1097-8

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1016/S0140-6736(14)61674-3DOI Listing
September 2014

Cardiovascular endocrinology: First-time heart failure increases risk of diabetes mellitus.

Authors:
Rury R Holman

Nat Rev Endocrinol 2014 Aug 1;10(8):453-4. Epub 2014 Jul 1.

University of Oxford, Diabetes Trials Unit, Radcliffe Department of Medicine, Churchill Hospital, Headington, Oxford OX3 7LJ, UK.

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http://dx.doi.org/10.1038/nrendo.2014.105DOI Listing
August 2014

Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes.

Lancet 2014 Jun;383(9933):2008-17

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1016/S0140-6736(14)60794-7DOI Listing
June 2014

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial.

Lancet Diabetes Endocrinol 2014 Feb 7;2(2):116-24. Epub 2013 Nov 7.

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1016/S2213-8587(13)70152-9DOI Listing
February 2014

Temporal validation of the UKPDS outcomes model using 10-year posttrial monitoring data.

Diabetes Care 2013 Jun 28;36(6):1541-6. Epub 2012 Dec 28.

Health Economics Research Centre, Department of Public Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.2337/dc12-1120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661828PMC
June 2013

Evaluation of a self-administered oral glucose tolerance test.

Diabetes Care 2013 Jun 15;36(6):1483-8. Epub 2013 Jan 15.

Diabetes Trials Unit Translational Research Group, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom.

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http://care.diabetesjournals.org/content/36/6/1483.full.pdf
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http://care.diabetesjournals.org/cgi/doi/10.2337/dc12-0643
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http://dx.doi.org/10.2337/dc12-0643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661807PMC
June 2013

Prognostic significance of silent myocardial infarction in newly diagnosed type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS) 79.

Circulation 2013 Mar 29;127(9):980-7. Epub 2013 Jan 29.

School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.000908DOI Listing
March 2013

Type 2 diabetes mellitus in 2012: Optimal management of T2DM remains elusive.

Authors:
Rury R Holman

Nat Rev Endocrinol 2013 Feb 8;9(2):67-8. Epub 2013 Jan 8.

Diabetes Trials Unit, The Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, UK.

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http://dx.doi.org/10.1038/nrendo.2012.243DOI Listing
February 2013

Prediabetes and the risk of diabetes.

Lancet 2012 Oct;380(9849):1225-6; author reply 1226

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http://dx.doi.org/10.1016/S0140-6736(12)61706-1DOI Listing
October 2012