Rune Frants

Rune Frants

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Rune Frants

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Genetics of headaches.

Handb Clin Neurol 2010 ;97:85-97

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/S0072-9752(10)97006-1DOI Listing
April 2016

RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice.

Cephalalgia 2014 Mar 28;34(3):174-82. Epub 2013 Aug 28.

Department of Human Genetics, Leiden University Medical Centre, The Netherlands.

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http://dx.doi.org/10.1177/0333102413502736DOI Listing
March 2014

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

Authors:
Verneri Anttila Bendik S Winsvold Padhraig Gormley Tobias Kurth Francesco Bettella George McMahon Mikko Kallela Rainer Malik Boukje de Vries Gisela Terwindt Sarah E Medland Unda Todt Wendy L McArdle Lydia Quaye Markku Koiranen M Arfan Ikram Terho Lehtimäki Anine H Stam Lannie Ligthart Juho Wedenoja Ian Dunham Benjamin M Neale Priit Palta Eija Hamalainen Markus Schürks Lynda M Rose Julie E Buring Paul M Ridker Stacy Steinberg Hreinn Stefansson Finnbogi Jakobsson Debbie A Lawlor David M Evans Susan M Ring Markus Färkkilä Ville Artto Mari A Kaunisto Tobias Freilinger Jean Schoenen Rune R Frants Nadine Pelzer Claudia M Weller Ronald Zielman Andrew C Heath Pamela A F Madden Grant W Montgomery Nicholas G Martin Guntram Borck Hartmut Göbel Axel Heinze Katja Heinze-Kuhn Frances M K Williams Anna-Liisa Hartikainen Anneli Pouta Joyce van den Ende Andre G Uitterlinden Albert Hofman Najaf Amin Jouke-Jan Hottenga Jacqueline M Vink Kauko Heikkilä Michael Alexander Bertram Muller-Myhsok Stefan Schreiber Thomas Meitinger Heinz Erich Wichmann Arpo Aromaa Johan G Eriksson Bryan Traynor Daniah Trabzuni Elizabeth Rossin Kasper Lage Suzanne B R Jacobs J Raphael Gibbs Ewan Birney Jaakko Kaprio Brenda W Penninx Dorret I Boomsma Cornelia van Duijn Olli Raitakari Marjo-Riitta Jarvelin John-Anker Zwart Lynn Cherkas David P Strachan Christian Kubisch Michel D Ferrari Arn M J M van den Maagdenberg Martin Dichgans Maija Wessman George Davey Smith Kari Stefansson Mark J Daly Dale R Nyholt Daniel Chasman Aarno Palotie

Nat Genet 2013 Aug 23;45(8):912-917. Epub 2013 Jun 23.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.2676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041123PMC
August 2013

Dysferlin regulates cell adhesion in human monocytes.

J Biol Chem 2013 May 4;288(20):14147-57. Epub 2013 Apr 4.

Departments of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M112.448589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656271PMC
May 2013

Migraine is not associated with enhanced atherosclerosis.

Cephalalgia 2013 Mar 12;33(4):228-35. Epub 2012 Nov 12.

Department of Neurology, Leiden University Medical Centre, The Netherlands.

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http://dx.doi.org/10.1177/0333102412466966DOI Listing
March 2013

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Authors:
Zari Dastani Marie-France Hivert Nicholas Timpson John R B Perry Xin Yuan Robert A Scott Peter Henneman Iris M Heid Jorge R Kizer Leo-Pekka Lyytikäinen Christian Fuchsberger Toshiko Tanaka Andrew P Morris Kerrin Small Aaron Isaacs Marian Beekman Stefan Coassin Kurt Lohman Lu Qi Stavroula Kanoni James S Pankow Hae-Won Uh Ying Wu Aurelian Bidulescu Laura J Rasmussen-Torvik Celia M T Greenwood Martin Ladouceur Jonna Grimsby Alisa K Manning Ching-Ti Liu Jaspal Kooner Vincent E Mooser Peter Vollenweider Karen A Kapur John Chambers Nicholas J Wareham Claudia Langenberg Rune Frants Ko Willems-Vandijk Ben A Oostra Sara M Willems Claudia Lamina Thomas W Winkler Bruce M Psaty Russell P Tracy Jennifer Brody Ida Chen Jorma Viikari Mika Kähönen Peter P Pramstaller David M Evans Beate St Pourcain Naveed Sattar Andrew R Wood Stefania Bandinelli Olga D Carlson Josephine M Egan Stefan Böhringer Diana van Heemst Lyudmyla Kedenko Kati Kristiansson Marja-Liisa Nuotio Britt-Marie Loo Tamara Harris Melissa Garcia Alka Kanaya Margot Haun Norman Klopp H-Erich Wichmann Panos Deloukas Efi Katsareli David J Couper Bruce B Duncan Margreet Kloppenburg Linda S Adair Judith B Borja James G Wilson Solomon Musani Xiuqing Guo Toby Johnson Robert Semple Tanya M Teslovich Matthew A Allison Susan Redline Sarah G Buxbaum Karen L Mohlke Ingrid Meulenbelt Christie M Ballantyne George V Dedoussis Frank B Hu Yongmei Liu Bernhard Paulweber Timothy D Spector P Eline Slagboom Luigi Ferrucci Antti Jula Markus Perola Olli Raitakari Jose C Florez Veikko Salomaa Johan G Eriksson Timothy M Frayling Andrew A Hicks Terho Lehtimäki George Davey Smith David S Siscovick Florian Kronenberg Cornelia van Duijn Ruth J F Loos Dawn M Waterworth James B Meigs Josee Dupuis J Brent Richards Benjamin F Voight Laura J Scott Valgerdur Steinthorsdottir Christian Dina Ryan P Welch Eleftheria Zeggini Cornelia Huth Yurii S Aulchenko Gudmar Thorleifsson Laura J McCulloch Teresa Ferreira Harald Grallert Najaf Amin Guanming Wu Cristen J Willer Soumya Raychaudhuri Steve A McCarroll Oliver M Hofmann Ayellet V Segrè Mandy van Hoek Pau Navarro Kristin Ardlie Beverley Balkau Rafn Benediktsson Amanda J Bennett Roza Blagieva Eric Boerwinkle Lori L Bonnycastle Kristina Bengtsson Boström Bert Bravenboer Suzannah Bumpstead Noël P Burtt Guillaume Charpentier Peter S Chines Marilyn Cornelis Gabe Crawford Alex S F Doney Katherine S Elliott Amanda L Elliott Michael R Erdos Caroline S Fox Christopher S Franklin Martha Ganser Christian Gieger Niels Grarup Todd Green Simon Griffin Christopher J Groves Candace Guiducci Samy Hadjadj Neelam Hassanali Christian Herder Bo Isomaa Anne U Jackson Paul R V Johnson Torben Jørgensen Wen H L Kao Augustine Kong Peter Kraft Johanna Kuusisto Torsten Lauritzen Man Li Aloysius Lieverse Cecilia M Lindgren Valeriya Lyssenko Michel Marre Thomas Meitinger Kristian Midthjell Mario A Morken Narisu Narisu Peter Nilsson Katharine R Owen Felicity Payne Ann-Kristin Petersen Carl Platou Christine Proença Inga Prokopenko Wolfgang Rathmann N William Rayner Neil R Robertson Ghislain Rocheleau Michael Roden Michael J Sampson Richa Saxena Beverley M Shields Peter Shrader Gunnar Sigurdsson Thomas Sparsø Klaus Strassburger Heather M Stringham Qi Sun Amy J Swift Barbara Thorand Jean Tichet Tiinamaija Tuomi Rob M van Dam Timon W van Haeften Thijs van Herpt Jana V van Vliet-Ostaptchouk G Bragi Walters Michael N Weedon Cisca Wijmenga Jacqueline Witteman Richard N Bergman Stephane Cauchi Francis S Collins Anna L Gloyn Ulf Gyllensten Torben Hansen Winston A Hide Graham A Hitman Albert Hofman David J Hunter Kristian Hveem Markku Laakso Andrew D Morris Colin N A Palmer Igor Rudan Eric Sijbrands Lincoln D Stein Jaakko Tuomilehto Andre Uitterlinden Mark Walker Richard M Watanabe Goncalo R Abecasis Bernhard O Boehm Harry Campbell Mark J Daly Andrew T Hattersley Oluf Pedersen Inês Barroso Leif Groop Rob Sladek Unnur Thorsteinsdottir James F Wilson Thomas Illig Philippe Froguel Cornelia M van Duijn Kari Stefansson David Altshuler Michael Boehnke Mark I McCarthy Nicole Soranzo Eleanor Wheeler Nicole L Glazer Nabila Bouatia-Naji Reedik Mägi Joshua Randall Paul Elliott Denis Rybin Abbas Dehghan Jouke Jan Hottenga Kijoung Song Anuj Goel Taina Lajunen Alex Doney Christine Cavalcanti-Proença Meena Kumari Nicholas J Timpson Carina Zabena Erik Ingelsson Ping An Jeffrey O'Connell Jian'an Luan Amanda Elliott Steven A McCarroll Rosa Maria Roccasecca François Pattou Praveen Sethupathy Yavuz Ariyurek Philip Barter John P Beilby Yoav Ben-Shlomo Sven Bergmann Murielle Bochud Amélie Bonnefond Knut Borch-Johnsen Yvonne Böttcher Eric Brunner Suzannah J Bumpstead Yii-Der Ida Chen Peter Chines Robert Clarke Lachlan J M Coin Matthew N Cooper Laura Crisponi Ian N M Day Eco J C de Geus Jerome Delplanque Annette C Fedson Antje Fischer-Rosinsky Nita G Forouhi Maria Grazia Franzosi Pilar Galan Mark O Goodarzi Jürgen Graessler Scott Grundy Rhian Gwilliam Göran Hallmans Naomi Hammond Xijing Han Anna-Liisa Hartikainen Caroline Hayward Simon C Heath Serge Hercberg David R Hillman Aroon D Hingorani Jennie Hui Joe Hung Marika Kaakinen Jaakko Kaprio Y Antero Kesaniemi Mika Kivimaki Beatrice Knight Seppo Koskinen Peter Kovacs Kirsten Ohm Kyvik G Mark Lathrop Debbie A Lawlor Olivier Le Bacquer Cécile Lecoeur Yun Li Robert Mahley Massimo Mangino María Teresa Martínez-Larrad Jarred B McAteer Ruth McPherson Christa Meisinger David Melzer David Meyre Braxton D Mitchell Sutapa Mukherjee Silvia Naitza Matthew J Neville Marco Orrù Ruth Pakyz Giuseppe Paolisso Cristian Pattaro Daniel Pearson John F Peden Nancy L Pedersen Andreas F H Pfeiffer Irene Pichler Ozren Polasek Danielle Posthuma Simon C Potter Anneli Pouta Michael A Province Nigel W Rayner Kenneth Rice Samuli Ripatti Fernando Rivadeneira Olov Rolandsson Annelli Sandbaek Manjinder Sandhu Serena Sanna Avan Aihie Sayer Paul Scheet Udo Seedorf Stephen J Sharp Beverley Shields Gunnar Sigurðsson Eric J G Sijbrands Angela Silveira Laila Simpson Andrew Singleton Nicholas L Smith Ulla Sovio Amy Swift Holly Syddall Ann-Christine Syvänen Anke Tönjes André G Uitterlinden Ko Willems van Dijk Dhiraj Varma Sophie Visvikis-Siest Veronique Vitart Nicole Vogelzangs Gérard Waeber Peter J Wagner Andrew Walley Kim L Ward Hugh Watkins Sarah H Wild Gonneke Willemsen Jaqueline C M Witteman John W G Yarnell Diana Zelenika Björn Zethelius Guangju Zhai Jing Hua Zhao M Carola Zillikens Ingrid B Borecki Pierre Meneton Patrik K E Magnusson David M Nathan Gordon H Williams Kaisa Silander Stefan R Bornstein Peter Schwarz Joachim Spranger Fredrik Karpe Alan R Shuldiner Cyrus Cooper Manuel Serrano-Ríos Lars Lind Lyle J Palmer Frank B Hu Paul W Franks Shah Ebrahim Michael Marmot W H Linda Kao Peter Paul Pramstaller Alan F Wright Michael Stumvoll Anders Hamsten Thomas A Buchanan Timo T Valle Jerome I Rotter Brenda W J H Penninx Dorret I Boomsma Antonio Cao Angelo Scuteri David Schlessinger Manuela Uda Aimo Ruokonen Marjo-Riitta Jarvelin Leena Peltonen Vincent Mooser Robert Sladek Kiran Musunuru Albert V Smith Andrew C Edmondson Ioannis M Stylianou Masahiro Koseki James P Pirruccello Daniel I Chasman Christopher T Johansen Sigrid W Fouchier Gina M Peloso Maja Barbalic Sally L Ricketts Joshua C Bis Mary F Feitosa Marju Orho-Melander Olle Melander Xiaohui Li Mingyao Li Yoon Shin Cho Min Jin Go Young Jin Kim Jong-Young Lee Taesung Park Kyunga Kim Xueling Sim Rick Twee-Hee Ong Damien C Croteau-Chonka Leslie A Lange Joshua D Smith Andreas Ziegler Weihua Zhang Robert Y L Zee John B Whitfield John R Thompson Ida Surakka Tim D Spector Johannes H Smit Juha Sinisalo James Scott Juha Saharinen Chiara Sabatti Lynda M Rose Robert Roberts Mark Rieder Alex N Parker Guillaume Pare Christopher J O'Donnell Markku S Nieminen Deborah A Nickerson Grant W Montgomery Wendy McArdle David Masson Nicholas G Martin Fabio Marroni Gavin Lucas Robert Luben Marja-Liisa Lokki Guillaume Lettre Lenore J Launer Edward G Lakatta Reijo Laaksonen Kirsten O Kyvik Inke R König Kay-Tee Khaw Lee M Kaplan Åsa Johansson A Cecile J W Janssens Wilmar Igl G Kees Hovingh Christian Hengstenberg Aki S Havulinna Nicholas D Hastie Tamara B Harris Talin Haritunians Alistair S Hall Leif C Groop Elena Gonzalez Nelson B Freimer Jeanette Erdmann Kenechi G Ejebe Angela Döring Anna F Dominiczak Serkalem Demissie Panagiotis Deloukas Ulf de Faire Gabriel Crawford Yii-der I Chen Mark J Caulfield S Matthijs Boekholdt Themistocles L Assimes Thomas Quertermous Mark Seielstad Tien Y Wong E-Shyong Tai Alan B Feranil Christopher W Kuzawa Herman A Taylor Stacey B Gabriel Hilma Holm Vilmundur Gudnason Ronald M Krauss Jose M Ordovas Patricia B Munroe Jaspal S Kooner Alan R Tall Robert A Hegele John J P Kastelein Eric E Schadt David P Strachan Muredach P Reilly Nilesh J Samani Heribert Schunkert L Adrienne Cupples Manjinder S Sandhu Paul M Ridker Daniel J Rader Sekar Kathiresan

PLoS Genet 2012 29;8(3):e1002607. Epub 2012 Mar 29.

Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1002607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315470PMC
September 2012

A genome-wide association search for type 2 diabetes genes in African Americans.

Authors:
Nicholette D Palmer Caitrin W McDonough Pamela J Hicks Bong H Roh Maria R Wing S Sandy An Jessica M Hester Jessica N Cooke Meredith A Bostrom Megan E Rudock Matthew E Talbert Joshua P Lewis Assiamira Ferrara Lingyi Lu Julie T Ziegler Michele M Sale Jasmin Divers Daniel Shriner Adebowale Adeyemo Charles N Rotimi Maggie C Y Ng Carl D Langefeld Barry I Freedman Donald W Bowden Benjamin F Voight Laura J Scott Valgerdur Steinthorsdottir Andrew P Morris Christian Dina Ryan P Welch Eleftheria Zeggini Cornelia Huth Yurii S Aulchenko Gudmar Thorleifsson Laura J McCulloch Teresa Ferreira Harald Grallert Najaf Amin Guanming Wu Cristen J Willer Soumya Raychaudhuri Steve A McCarroll Claudia Langenberg Oliver M Hofmann Josée Dupuis Lu Qi Ayellet V Segrè Mandy van Hoek Pau Navarro Kristin Ardlie Beverley Balkau Rafn Benediktsson Amanda J Bennett Roza Blagieva Eric Boerwinkle Lori L Bonnycastle Kristina Bengtsson Boström Bert Bravenboer Suzannah Bumpstead Noël P Burtt Guillaume Charpentier Peter S Chines Marilyn Cornelis David J Couper Gabe Crawford Alex S F Doney Katherine S Elliott Amanda L Elliott Michael R Erdos Caroline S Fox Christopher S Franklin Martha Ganser Christian Gieger Niels Grarup Todd Green Simon Griffin Christopher J Groves Candace Guiducci Samy Hadjadj Neelam Hassanali Christian Herder Bo Isomaa Anne U Jackson Paul R V Johnson Torben Jørgensen Wen H L Kao Norman Klopp Augustine Kong Peter Kraft Johanna Kuusisto Torsten Lauritzen Man Li Aloysius Lieverse Cecilia M Lindgren Valeriya Lyssenko Michel Marre Thomas Meitinger Kristian Midthjell Mario A Morken Narisu Narisu Peter Nilsson Katharine R Owen Felicity Payne John R B Perry Ann-Kristin Petersen Carl Platou Christine Proença Inga Prokopenko Wolfgang Rathmann N William Rayner Neil R Robertson Ghislain Rocheleau Michael Roden Michael J Sampson Richa Saxena Beverley M Shields Peter Shrader Gunnar Sigurdsson Thomas Sparsø Klaus Strassburger Heather M Stringham Qi Sun Amy J Swift Barbara Thorand Jean Tichet Tiinamaija Tuomi Rob M van Dam Timon W van Haeften Thijs van Herpt Jana V van Vliet-Ostaptchouk G Bragi Walters Michael N Weedon Cisca Wijmenga Jacqueline Witteman Richard N Bergman Stephane Cauchi Francis S Collins Anna L Gloyn Ulf Gyllensten Torben Hansen Winston A Hide Graham A Hitman Albert Hofman David J Hunter Kristian Hveem Markku Laakso Karen L Mohlke Andrew D Morris Colin N A Palmer Peter P Pramstaller Igor Rudan Eric Sijbrands Lincoln D Stein Jaakko Tuomilehto Andre Uitterlinden Mark Walker Nicholas J Wareham Richard M Watanabe Goncalo R Abecasis Bernhard O Boehm Harry Campbell Mark J Daly Andrew T Hattersley Frank B Hu James B Meigs James S Pankow Oluf Pedersen H-Erich Wichmann Inês Barroso Jose C Florez Timothy M Frayling Leif Groop Rob Sladek Unnur Thorsteinsdottir James F Wilson Thomas Illig Philippe Froguel Cornelia M van Duijn Kari Stefansson David Altshuler Michael Boehnke Mark I McCarthy Nicole Soranzo Eleanor Wheeler Nicole L Glazer Nabila Bouatia-Naji Reedik Mägi Joshua Randall Toby Johnson Paul Elliott Denis Rybin Peter Henneman Abbas Dehghan Jouke Jan Hottenga Kijoung Song Anuj Goel Josephine M Egan Taina Lajunen Alex Doney Stavroula Kanoni Christine Cavalcanti-Proença Meena Kumari Nicholas J Timpson Carina Zabena Erik Ingelsson Ping An Jeffrey O'Connell Jian'an Luan Amanda Elliott Steven A McCarroll Rosa Maria Roccasecca François Pattou Praveen Sethupathy Yavuz Ariyurek Philip Barter John P Beilby Yoav Ben-Shlomo Sven Bergmann Murielle Bochud Amélie Bonnefond Knut Borch-Johnsen Yvonne Böttcher Eric Brunner Suzannah J Bumpstead Yii-Der Ida Chen Peter Chines Robert Clarke Lachlan J M Coin Matthew N Cooper Laura Crisponi Ian N M Day Eco J C de Geus Jerome Delplanque Annette C Fedson Antje Fischer-Rosinsky Nita G Forouhi Rune Frants Maria Grazia Franzosi Pilar Galan Mark O Goodarzi Jürgen Graessler Scott Grundy Rhian Gwilliam Göran Hallmans Naomi Hammond Xijing Han Anna-Liisa Hartikainen Caroline Hayward Simon C Heath Serge Hercberg Andrew A Hicks David R Hillman Aroon D Hingorani Jennie Hui Joe Hung Antti Jula Marika Kaakinen Jaakko Kaprio Y Antero Kesaniemi Mika Kivimaki Beatrice Knight Seppo Koskinen Peter Kovacs Kirsten Ohm Kyvik G Mark Lathrop Debbie A Lawlor Olivier Le Bacquer Cécile Lecoeur Yun Li Robert Mahley Massimo Mangino Alisa K Manning María Teresa Martínez-Larrad Jarred B McAteer Ruth McPherson Christa Meisinger David Melzer David Meyre Braxton D Mitchell Sutapa Mukherjee Silvia Naitza Matthew J Neville Ben A Oostra Marco Orrù Ruth Pakyz Giuseppe Paolisso Cristian Pattaro Daniel Pearson John F Peden Nancy L Pedersen Markus Perola Andreas F H Pfeiffer Irene Pichler Ozren Polasek Danielle Posthuma Simon C Potter Anneli Pouta Michael A Province Bruce M Psaty Nigel W Rayner Kenneth Rice Samuli Ripatti Fernando Rivadeneira Olov Rolandsson Annelli Sandbaek Manjinder Sandhu Serena Sanna Avan Aihie Sayer Paul Scheet Udo Seedorf Stephen J Sharp Beverley Shields Eric J G Sijbrands Angela Silveira Laila Simpson Andrew Singleton Nicholas L Smith Ulla Sovio Amy Swift Holly Syddall Ann-Christine Syvänen Toshiko Tanaka Anke Tönjes André G Uitterlinden Ko Willems van Dijk Dhiraj Varma Sophie Visvikis-Siest Veronique Vitart Nicole Vogelzangs Gérard Waeber Peter J Wagner Andrew Walley Kim L Ward Hugh Watkins Sarah H Wild Gonneke Willemsen Jaqueline C M Witteman John W G Yarnell Diana Zelenika Björn Zethelius Guangju Zhai Jing Hua Zhao M Carola Zillikens Ingrid B Borecki Ruth J F Loos Pierre Meneton Patrik K E Magnusson David M Nathan Gordon H Williams Kaisa Silander Veikko Salomaa George Davey Smith Stefan R Bornstein Peter Schwarz Joachim Spranger Fredrik Karpe Alan R Shuldiner Cyrus Cooper George V Dedoussis Manuel Serrano-Ríos Lars Lind Lyle J Palmer Paul W Franks Shah Ebrahim Michael Marmot W H Linda Kao Peter Paul Pramstaller Alan F Wright Michael Stumvoll Anders Hamsten Thomas A Buchanan Timo T Valle Jerome I Rotter David S Siscovick Brenda W J H Penninx Dorret I Boomsma Panos Deloukas Timothy D Spector Luigi Ferrucci Antonio Cao Angelo Scuteri David Schlessinger Manuela Uda Aimo Ruokonen Marjo-Riitta Jarvelin Dawn M Waterworth Peter Vollenweider Leena Peltonen Vincent Mooser Robert Sladek

PLoS One 2012 4;7(1):e29202. Epub 2012 Jan 4.

Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America.

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https://spiral.imperial.ac.uk/bitstream/10044/1/28917/2/A%20
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http://dx.plos.org/10.1371/journal.pone.0029202
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029202PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251563PMC
May 2012

Self-regulated alternative splicing at the AHNAK locus.

FASEB J 2012 Jan 22;26(1):93-103. Epub 2011 Sep 22.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.fasebj.org/doi/10.1096/fj.11-187971
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http://dx.doi.org/10.1096/fj.11-187971DOI Listing
January 2012

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.

Nat Genet 2010 Oct 29;42(10):869-73. Epub 2010 Aug 29.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

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https://openaccess.leidenuniv.nl/bitstream/handle/1887/16353
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ftp://ftp.sanger.ac.uk/pub/resources/theses/sc14/chapter3.pd
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http://www.nature.com/doifinder/10.1038/ng.652
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http://dx.doi.org/10.1038/ng.652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948563PMC
October 2010

Severe and progressive neurotransmitter release aberrations in familial hemiplegic migraine type 1 Cacna1a S218L knock-in mice.

J Neurophysiol 2010 Sep 14;104(3):1445-55. Epub 2010 Jul 14.

Department of Neurology, Leiden Univ. Medical Ctr., Leiden, The Netherlands.

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http://dx.doi.org/10.1152/jn.00012.2010DOI Listing
September 2010

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

Authors:
Josée Dupuis Claudia Langenberg Inga Prokopenko Richa Saxena Nicole Soranzo Anne U Jackson Eleanor Wheeler Nicole L Glazer Nabila Bouatia-Naji Anna L Gloyn Cecilia M Lindgren Reedik Mägi Andrew P Morris Joshua Randall Toby Johnson Paul Elliott Denis Rybin Gudmar Thorleifsson Valgerdur Steinthorsdottir Peter Henneman Harald Grallert Abbas Dehghan Jouke Jan Hottenga Christopher S Franklin Pau Navarro Kijoung Song Anuj Goel John R B Perry Josephine M Egan Taina Lajunen Niels Grarup Thomas Sparsø Alex Doney Benjamin F Voight Heather M Stringham Man Li Stavroula Kanoni Peter Shrader Christine Cavalcanti-Proença Meena Kumari Lu Qi Nicholas J Timpson Christian Gieger Carina Zabena Ghislain Rocheleau Erik Ingelsson Ping An Jeffrey O'Connell Jian'an Luan Amanda Elliott Steven A McCarroll Felicity Payne Rosa Maria Roccasecca François Pattou Praveen Sethupathy Kristin Ardlie Yavuz Ariyurek Beverley Balkau Philip Barter John P Beilby Yoav Ben-Shlomo Rafn Benediktsson Amanda J Bennett Sven Bergmann Murielle Bochud Eric Boerwinkle Amélie Bonnefond Lori L Bonnycastle Knut Borch-Johnsen Yvonne Böttcher Eric Brunner Suzannah J Bumpstead Guillaume Charpentier Yii-Der Ida Chen Peter Chines Robert Clarke Lachlan J M Coin Matthew N Cooper Marilyn Cornelis Gabe Crawford Laura Crisponi Ian N M Day Eco J C de Geus Jerome Delplanque Christian Dina Michael R Erdos Annette C Fedson Antje Fischer-Rosinsky Nita G Forouhi Caroline S Fox Rune Frants Maria Grazia Franzosi Pilar Galan Mark O Goodarzi Jürgen Graessler Christopher J Groves Scott Grundy Rhian Gwilliam Ulf Gyllensten Samy Hadjadj Göran Hallmans Naomi Hammond Xijing Han Anna-Liisa Hartikainen Neelam Hassanali Caroline Hayward Simon C Heath Serge Hercberg Christian Herder Andrew A Hicks David R Hillman Aroon D Hingorani Albert Hofman Jennie Hui Joe Hung Bo Isomaa Paul R V Johnson Torben Jørgensen Antti Jula Marika Kaakinen Jaakko Kaprio Y Antero Kesaniemi Mika Kivimaki Beatrice Knight Seppo Koskinen Peter Kovacs Kirsten Ohm Kyvik G Mark Lathrop Debbie A Lawlor Olivier Le Bacquer Cécile Lecoeur Yun Li Valeriya Lyssenko Robert Mahley Massimo Mangino Alisa K Manning María Teresa Martínez-Larrad Jarred B McAteer Laura J McCulloch Ruth McPherson Christa Meisinger David Melzer David Meyre Braxton D Mitchell Mario A Morken Sutapa Mukherjee Silvia Naitza Narisu Narisu Matthew J Neville Ben A Oostra Marco Orrù Ruth Pakyz Colin N A Palmer Giuseppe Paolisso Cristian Pattaro Daniel Pearson John F Peden Nancy L Pedersen Markus Perola Andreas F H Pfeiffer Irene Pichler Ozren Polasek Danielle Posthuma Simon C Potter Anneli Pouta Michael A Province Bruce M Psaty Wolfgang Rathmann Nigel W Rayner Kenneth Rice Samuli Ripatti Fernando Rivadeneira Michael Roden Olov Rolandsson Annelli Sandbaek Manjinder Sandhu Serena Sanna Avan Aihie Sayer Paul Scheet Laura J Scott Udo Seedorf Stephen J Sharp Beverley Shields Gunnar Sigurethsson Eric J G Sijbrands Angela Silveira Laila Simpson Andrew Singleton Nicholas L Smith Ulla Sovio Amy Swift Holly Syddall Ann-Christine Syvänen Toshiko Tanaka Barbara Thorand Jean Tichet Anke Tönjes Tiinamaija Tuomi André G Uitterlinden Ko Willems van Dijk Mandy van Hoek Dhiraj Varma Sophie Visvikis-Siest Veronique Vitart Nicole Vogelzangs Gérard Waeber Peter J Wagner Andrew Walley G Bragi Walters Kim L Ward Hugh Watkins Michael N Weedon Sarah H Wild Gonneke Willemsen Jaqueline C M Witteman John W G Yarnell Eleftheria Zeggini Diana Zelenika Björn Zethelius Guangju Zhai Jing Hua Zhao M Carola Zillikens Ingrid B Borecki Ruth J F Loos Pierre Meneton Patrik K E Magnusson David M Nathan Gordon H Williams Andrew T Hattersley Kaisa Silander Veikko Salomaa George Davey Smith Stefan R Bornstein Peter Schwarz Joachim Spranger Fredrik Karpe Alan R Shuldiner Cyrus Cooper George V Dedoussis Manuel Serrano-Ríos Andrew D Morris Lars Lind Lyle J Palmer Frank B Hu Paul W Franks Shah Ebrahim Michael Marmot W H Linda Kao James S Pankow Michael J Sampson Johanna Kuusisto Markku Laakso Torben Hansen Oluf Pedersen Peter Paul Pramstaller H Erich Wichmann Thomas Illig Igor Rudan Alan F Wright Michael Stumvoll Harry Campbell James F Wilson Richard N Bergman Thomas A Buchanan Francis S Collins Karen L Mohlke Jaakko Tuomilehto Timo T Valle David Altshuler Jerome I Rotter David S Siscovick Brenda W J H Penninx Dorret I Boomsma Panos Deloukas Timothy D Spector Timothy M Frayling Luigi Ferrucci Augustine Kong Unnur Thorsteinsdottir Kari Stefansson Cornelia M van Duijn Yurii S Aulchenko Antonio Cao Angelo Scuteri David Schlessinger Manuela Uda Aimo Ruokonen Marjo-Riitta Jarvelin Dawn M Waterworth Peter Vollenweider Leena Peltonen Vincent Mooser Goncalo R Abecasis Nicholas J Wareham Robert Sladek Philippe Froguel Richard M Watanabe James B Meigs Leif Groop Michael Boehnke Mark I McCarthy Jose C Florez Inês Barroso

Nat Genet 2010 Feb 17;42(2):105-16. Epub 2010 Jan 17.

Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA.

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http://www.nature.com/articles/ng.520
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http://dx.doi.org/10.1038/ng.520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018764PMC
February 2010

Comprehensive expression analysis of FSHD candidate genes at the mRNA and protein level.

Eur J Hum Genet 2009 Dec 7;17(12):1615-24. Epub 2009 Oct 7.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/ejhg.2009.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987013PMC
December 2009

Common epigenetic changes of D4Z4 in contraction-dependent and contraction-independent FSHD.

Hum Mutat 2009 Oct;30(10):1449-59

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/humu.21091DOI Listing
October 2009

Molecular genetics of migraine.

Hum Genet 2009 Jul 20;126(1):115-32. Epub 2009 May 20.

Department of Human Genetics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.

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July 2009

Familial hemiplegic migraine.

Adv Genet 2008 ;63:57-83

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/S0065-2660(08)01003-1DOI Listing
June 2009

Epigenetic mechanisms of facioscapulohumeral muscular dystrophy.

Mutat Res 2008 Dec 3;647(1-2):94-102. Epub 2008 Aug 3.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.mrfmmm.2008.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650037PMC
December 2008

Calpain 3 is a modulator of the dysferlin protein complex in skeletal muscle.

Hum Mol Genet 2008 Jun 11;17(12):1855-66. Epub 2008 Mar 11.

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddn081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900895PMC
June 2008

Alpha-1 antitrypsin Null mutations and severity of emphysema.

Respir Med 2008 Jun 18;102(6):876-84. Epub 2008 Mar 18.

Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.rmed.2008.01.009DOI Listing
June 2008

Reduced ACh release at neuromuscular synapses of heterozygous leaner Ca(v)2.1-mutant mice.

Synapse 2008 May;62(5):337-44

Department of Neurology, Leiden University Medical Center, NL-2300 RC, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/syn.20490
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May 2008

The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides.

J Lipid Res 2007 Oct 3;48(10):2182-92. Epub 2007 Jul 3.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1194/jlr.M700009-JLR200DOI Listing
October 2007

T(1) relaxation in in vivo mouse brain at ultra-high field.

Magn Reson Med 2007 Aug;58(2):390-5

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/mrm.21313
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August 2007

Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism.

Atherosclerosis 2007 Jul 13;193(1):129-34. Epub 2006 Jun 13.

Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2006.05.030DOI Listing
July 2007

Genetic models of migraine.

Arch Neurol 2007 May;64(5):643-6

Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/arc
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May 2007

Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a-mutant mouse rolling Nagoya.

Eur J Neurosci 2007 Apr;25(7):2009-20

Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/j.1460-9568.2007.05438.xDOI Listing
April 2007

Facioscapulohumeral muscular dystrophy.

Biochim Biophys Acta 2007 Feb 6;1772(2):186-94. Epub 2006 Jun 6.

Leiden University Medical Center (LUMC), Department of Human Genetics, Postal zone S-3-P, PO box 9600, 2300 RC Leiden, The Netherlands.

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February 2007

FRG1P-mediated aggregation of proteins involved in pre-mRNA processing.

Chromosoma 2007 Feb 14;116(1):53-64. Epub 2006 Nov 14.

Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.1007/s00412-006-0083-3DOI Listing
February 2007

Inhibition of neointima formation by local delivery of estrogen receptor alpha and beta specific agonists.

Cardiovasc Res 2007 Jan 10;73(1):217-26. Epub 2006 Nov 10.

Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.cardiores.2006.10.024DOI Listing
January 2007

Genetic biomarkers for migraine.

Headache 2006 Jul-Aug;46(7):1059-68

Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/j.1526-4610.2006.00499.xDOI Listing
December 2006

Conditional inactivation of the Cacna1a gene in transgenic mice.

Genesis 2006 Dec;44(12):589-94

Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/dvg.20255DOI Listing
December 2006

Mutation analysis of CACNA1A and ATP1A2 genes in Brazilian FHM families.

Arq Neuropsiquiatr 2006 Sep;64(3A):549-52

Instituto de Ensino e Pesquisa, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil, and Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1590/s0004-282x2006000400001DOI Listing
September 2006

Reliable and controllable antibody fragment selections from Camelid non-immune libraries for target validation.

Biochim Biophys Acta 2006 Aug 10;1764(8):1307-19. Epub 2006 Jun 10.

University of Utrecht, Department of Molecular and Cellular Biology, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.bbapap.2006.05.011DOI Listing
August 2006

Two de novo mutations in the Na,K-ATPase gene ATP1A2 associated with pure familial hemiplegic migraine.

Eur J Hum Genet 2006 May;14(5):555-60

Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands, and Department of Neurology, Dr Lütfi Kirdar State Hospital, Maltepe, Istanbul, Turkey.

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http://dx.doi.org/10.1038/sj.ejhg.5201607DOI Listing
May 2006

Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.

J Neurophysiol 2006 Apr 28;95(4):2698-704. Epub 2005 Dec 28.

Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://www.physiology.org/doi/10.1152/jn.01221.2005
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April 2006

Equal proportions of affected cells in muscle and blood of a mosaic carrier of facioscapulohumeral muscular dystrophy.

Hum Genet 2006 Mar 8;119(1-2):23-8. Epub 2005 Dec 8.

Departamento de Biologia, Human Genome Research Center, Universidade de São Paulo, Rua do Matão, 277 Cidade Universitária, CEP: 05508-090, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1007/s00439-005-0100-2DOI Listing
March 2006

Migraine and MTHFR C677T genotype in a population-based sample.

Ann Neurol 2006 Feb;59(2):372-5

Department of Preventive Medicine and Biometrics, Uniformed Services University, Bethesda, MD 20814-4799, USA.

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http://dx.doi.org/10.1002/ana.20755DOI Listing
February 2006

Variable hypomethylation of D4Z4 in facioscapulohumeral muscular dystrophy.

Ann Neurol 2005 Oct;58(4):569-76

Department of Human Genetics, Center for Human and Clinical Genetics, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ana.20625DOI Listing
October 2005

Migraine: new treatment options from molecular biology.

Expert Rev Neurother 2005 Sep;5(5):653-61

Department of Neurology, Leiden University Medical Centre, Leiden, 2300 RC Leiden, The Netherlands.

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http://www.tandfonline.com/doi/full/10.1586/14737175.5.5.653
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September 2005

Clinical and genetic aspects of idiopathic epilepsies in childhood.

Eur J Paediatr Neurol 2005 ;9(2):91-103

Department of Neurology, University Medical Centre Groningen, Hanzeplein 1/P.O. Box 30001, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.ejpn.2004.12.005DOI Listing
July 2005

Migraine genetics: an update.

Curr Pain Headache Rep 2005 Jun;9(3):213-20

Department of Neurology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands. E-mail:

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June 2005

Genetic confirmation of facioscapulohumeral muscular dystrophy in a case with complex D4Z4 rearrangments.

Hum Genet 2005 Mar 12;116(4):262-6. Epub 2005 Jan 12.

Department of Neurology, Sofia Medical University, Sofia, Bulgaria.

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http://dx.doi.org/10.1007/s00439-004-1237-0DOI Listing
March 2005

The D4Z4 repeat-mediated pathogenesis of facioscapulohumeral muscular dystrophy.

Am J Hum Genet 2005 Mar 24;76(3):375-86. Epub 2005 Jan 24.

Leiden University Medical Center, Center for Human and Clinical Genetics, Leiden, The Netherlands.

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http://dx.doi.org/10.1086/428361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196390PMC
March 2005

Contractions of D4Z4 on 4qB subtelomeres do not cause facioscapulohumeral muscular dystrophy.

Am J Hum Genet 2004 Dec 4;75(6):1124-30. Epub 2004 Oct 4.

Leiden University Medical Center, Center for Human and Clinical Genetics, Department of Human Genetics, Leiden, The Netherlands.

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http://dx.doi.org/10.1086/426035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182148PMC
December 2004

Toward a molecular genetic classification of familial hemiplegic migraine.

Curr Pain Headache Rep 2004 Jun;8(3):238-43

Department of Neurology (K5Q), Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.

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June 2004

Recent findings in headache genetics.

Curr Opin Neurol 2004 Jun;17(3):283-8

Department of Neurology and Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://pdfs.journals.lww.com/co-neurology/2004/06000/Recent_
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June 2004

Somatic mosaicism in FSHD often goes undetected.

Ann Neurol 2004 Jun;55(6):845-50

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ana.20106DOI Listing
June 2004

A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression.

Neuron 2004 Mar;41(5):701-10

Department of Biomedical Sciences, University of Padova, CNR Institute of Neuroscience, Viale G. Colombo 3, 35121 Padova, Italy.

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March 2004

Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy.

Nat Genet 2003 Dec 23;35(4):315-7. Epub 2003 Nov 23.

Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1038/ng1262DOI Listing
December 2003