Publications by authors named "Ruizhen Chen"

57Publications

Cardiomyocyte-restricted high-mobility group box 1 (HMGB1) deletion leads to small heart and glycolipid metabolic disorder through GR/PGC-1α signalling.

Cell Death Discov 2020 20;6:106. Epub 2020 Oct 20.

Shanghai Institute of Cardiovascular Diseases, Shanghai Clinical Bioinformatics Research Institute, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.

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October 2020

Inhibition of calpain alleviates coxsackievirus B3-induced myocarditis through suppressing the canonical NLRP3 inflammasome/caspase-1-mediated and noncanonical caspase-11-mediated pyroptosis pathways.

Am J Transl Res 2020 15;12(5):1954-1964. Epub 2020 May 15.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College of Fudan University Shanghai 200032, China.

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May 2020

NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases.

Clin Transl Med 2020 Jan 9;10(1):91-106. Epub 2020 Apr 9.

Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Shanghai Medical College of Fudan University, Shanghai, China.

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January 2020

Left bundle branch area pacing is superior to right ventricular septum pacing concerning depolarization-repolarization reserve.

J Cardiovasc Electrophysiol 2020 01 10;31(1):313-322. Epub 2019 Dec 10.

Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.

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January 2020

microRNA-34a aggravates coxsackievirus B3-induced apoptosis of cardiomyocytes through the SIRT1-p53 pathway.

J Med Virol 2019 09 21;91(9):1643-1651. Epub 2019 May 21.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.

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September 2019

Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.

Basic Res Cardiol 2019 03 15;114(3):17. Epub 2019 Mar 15.

Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, China.

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March 2019

FTY720 alleviates coxsackievirus B3-induced myocarditis and inhibits viral replication through regulating sphingosine 1-phosphate receptors and AKT/caspase-3 pathways.

J Cell Physiol 2019 08 6;234(10):18029-18040. Epub 2019 Mar 6.

Department of Cardiology, Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Ministry of Public Health, Shanghai, China.

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August 2019

LAP Treg is a better biomarker than total Treg in viral myocarditis.

J Med Virol 2019 05 2;91(5):886-889. Epub 2019 Jan 2.

Department of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

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May 2019

Mitochondrial calcium uniporter inhibition provides cardioprotection in pressure overload-induced heart failure through autophagy enhancement.

Int J Cardiol 2018 Nov 20;271:161-168. Epub 2018 May 20.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China. Electronic address:

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November 2018

Comparison of single-coil lead versus dual-coil lead of implantable cardioverter defibrillator on lead-related venous complications in a canine model.

J Interv Card Electrophysiol 2018 Jul 23;52(2):195-201. Epub 2018 Mar 23.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.

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July 2018

Neural cell adhesion molecule-1 may be a new biomarker of coronary artery disease.

Int J Cardiol 2018 04;257:238-242

Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Clinical Bioinformatics, Zhongshan Hospital, Shanghai Medical College of Fudan University, China. Electronic address:

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April 2018

Electrocardiographic parameters effectively predict ventricular tachycardia/fibrillation in acute phase and abnormal cardiac function in chronic phase of ST-segment elevation myocardial infarction.

J Cardiovasc Electrophysiol 2018 05 28;29(5):756-766. Epub 2018 Feb 28.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, PR China.

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May 2018

Endothelial‑to‑mesenchymal transition in human idiopathic dilated cardiomyopathy.

Mol Med Rep 2018 Jan 8;17(1):961-969. Epub 2017 Nov 8.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.

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January 2018

Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells.

Exp Mol Pathol 2017 10 3;103(2):210-217. Epub 2017 Oct 3.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:

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October 2017

Integrative and quantitive evaluation of the efficacy of his bundle related pacing in comparison with conventional right ventricular pacing: a meta-analysis.

BMC Cardiovasc Disord 2017 08 11;17(1):221. Epub 2017 Aug 11.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.

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August 2017

Histamine promotes the differentiation of macrophages from CD11b myeloid cells and formation of foam cells through a Stat6-dependent pathway.

Atherosclerosis 2017 Aug 23;263:42-52. Epub 2017 May 23.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. Electronic address:

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August 2017

Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis.

Int J Cardiol 2016 Oct 9;221:1123-31. Epub 2016 Jul 9.

Department of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:

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October 2016

MicroRNA-19b Downregulates Gap Junction Protein Alpha1 and Synergizes with MicroRNA-1 in Viral Myocarditis.

Int J Mol Sci 2016 May 18;17(5). Epub 2016 May 18.

Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

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May 2016

Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway.

Springerplus 2016 29;5:215. Epub 2016 Feb 29.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai, 200032 China.

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March 2016

Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis.

J Infect Dis 2016 May 23;213(10):1661-70. Epub 2015 Dec 23.

Jiangsu Key Laboratory of Infection and Immunity, Institutes for Biology and Medical Sciences, Soochow University, Suzhou Lawson Health Research Institute Department of Medicine Department of Pathology, University of Western Ontario, London, Canada.

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May 2016

Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.

Circ Heart Fail 2015 Sep 5;8(5):988-96. Epub 2015 Aug 5.

From the Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu, China (R.N., D.Z., T.P.); Lawson Health Research Institute, Departments of Medicine (R.N., D.Z., T.S., T.P.), Pathology (R.N., D.Z., T.P.) and Biology (R.B.G.), University of Western Ontario, London, Ontario, Canada; Department of Dermatology (Q.W.) and Institute of Cardiovascular Diseases (Y.Y., R.C.), Zhongshan Hospital, Fudan University, Shanghai, China; Mitochondria and Metabolism Center, Departments of Anesthesiology and Pain Medicine, University of Washington, Seattle (W.W.); Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH (G.-C.F.); and Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute, Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada (P.A.G.).

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September 2015

Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice.

Diabetologia 2015 Aug 21;58(8):1949-58. Epub 2015 May 21.

Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu Province, China, 215123.

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August 2015

Remission of CVB3-induced myocarditis with Astragaloside IV treatment requires A20 (TNFAIP3) up-regulation.

J Cell Mol Med 2015 Apr 1;19(4):850-64. Epub 2015 Mar 1.

Institute for Immunobiology, Shanghai Medical College, Fudan University, Shanghai, China.

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April 2015

A pilot study of angiogenin in heart failure with preserved ejection fraction: a novel potential biomarker for diagnosis and prognosis?

J Cell Mol Med 2014 Nov 15;18(11):2189-97. Epub 2014 Aug 15.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.

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November 2014

Influence of cardioversion on asymptomatic cerebral lesions following atrial fibrillation ablation.

J Interv Card Electrophysiol 2014 Aug 14;40(2):129-36. Epub 2014 Jun 14.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

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August 2014

Association between ablation technology and asymptomatic cerebral injury following atrial fibrillation ablation.

Pacing Clin Electrophysiol 2014 Oct 1;37(10):1378-91. Epub 2014 Jun 1.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

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October 2014

The frequency of invariant natural killer T cells correlates with the severity of myocarditis.

Viral Immunol 2014 Apr 4;27(3):88-95. Epub 2014 Apr 4.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , Shanghai, China .

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April 2014

Cleavage of IκBα by calpain induces myocardial NF-κB activation, TNF-α expression, and cardiac dysfunction in septic mice.

Am J Physiol Heart Circ Physiol 2014 Mar 17;306(6):H833-43. Epub 2014 Jan 17.

Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China;

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March 2014

Coxsackievirus B3-induced calpain activation facilitates the progeny virus replication via a likely mechanism related with both autophagy enhancement and apoptosis inhibition in the early phase of infection: an in vitro study in H9c2 cells.

Virus Res 2014 Jan 28;179:177-86. Epub 2013 Oct 28.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China. Electronic address:

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January 2014

A problem in an article called "Immunoregulatory effects of α-GalCer in a murine model of autoimmune myocarditis" published in Experimental and Molecular Pathology 91 (2011) 636-642.

Exp Mol Pathol 2013 Dec 18;95(3):393. Epub 2013 Oct 18.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

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December 2013

Regulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis.

PLoS One 2013 3;8(10):e76529. Epub 2013 Oct 3.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China ; Department of Cardiology, Qingdao Municipal Hospital, Qingdao, China.

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April 2014

In vivo delivery of adenoviral vector containing interleukin-17 receptor a reduces cardiac remodeling and improves myocardial function in viral myocarditis leading to dilated cardiomyopathy.

PLoS One 2013 20;8(8):e72158. Epub 2013 Aug 20.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China ; Department of Cardiology, Xinhua Hospital affiliated to Shanghai Jiaotong University, Shanghai, China.

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April 2014

Preexposure to PM2.5 exacerbates acute viral myocarditis associated with Th17 cell.

Int J Cardiol 2013 Oct 11;168(4):3837-45. Epub 2013 Jul 11.

Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200092 China.

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October 2013

Over-expression of calpastatin aggravates cardiotoxicity induced by doxorubicin.

Cardiovasc Res 2013 Jun 1;98(3):381-90. Epub 2013 Mar 1.

Department of Cardiology, Shanghai 6th People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200233, China.

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June 2013

Clinical features and prognosis in Chinese patients with acute fulminant myocarditis.

Acta Cardiol 2012 Oct;67(5):571-6

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

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October 2012

A20 (TNFAIP3) alleviates CVB3-induced myocarditis via inhibiting NF-κB signaling.

PLoS One 2012 28;7(9):e46515. Epub 2012 Sep 28.

Institute for Immunobiology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.

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February 2013

Impaired cardiac microvascular endothelial cells function induced by Coxsackievirus B3 infection and its potential role in cardiac fibrosis.

Virus Res 2012 Oct 4;169(1):188-94. Epub 2012 Aug 4.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

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October 2012

Initial weight and virus dose: two factors affecting the onset of acute coxsackievirus B3 myocarditis in C57BL/6 mouse--a histopathology-based study.

Cardiovasc Pathol 2013 Jan-Feb;22(1):96-101. Epub 2012 Jul 10.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

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May 2013

Human leukocyte antigen-DQ beta 1 chain (DQB1) gene polymorphisms are associated with dilated cardiomyopathy: a systematic review and meta-analysis.

Heart Lung 2012 Jul-Aug;41(4):360-7. Epub 2012 Mar 3.

Department of Clinical Electrophysiology, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.

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November 2012

Blockade of interleukin-17A protects against coxsackievirus B3-induced myocarditis by increasing COX-2/PGE2 production in the heart.

FEMS Immunol Med Microbiol 2012 Apr 22;64(3):343-51. Epub 2011 Dec 22.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

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April 2012

Imbalance of Th1 and Th2 cells in cardiac injury induced by ambient fine particles.

Toxicol Lett 2012 Feb 23;208(3):225-31. Epub 2011 Nov 23.

Department of Environment Health, School of Public Health, Fudan University, the Key Laboratory of Public Health Safety, Ministry of Education, Shanghai 200032, China.

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February 2012

The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis.

Virology 2011 Dec 11;421(1):78-84. Epub 2011 Oct 11.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

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December 2011

MicroRNAs involved in the mitogen-activated protein kinase cascades pathway during glucose-induced cardiomyocyte hypertrophy.

Am J Pathol 2011 Aug 23;179(2):639-50. Epub 2011 Jun 23.

Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai, China.

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August 2011

Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy.

Eur J Pharmacol 2011 May 1;658(2-3):168-74. Epub 2011 Mar 1.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

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May 2011

Functional assembly of minicellulosomes on the Saccharomyces cerevisiae cell surface for cellulose hydrolysis and ethanol production.

Appl Environ Microbiol 2009 Oct 14;75(19):6087-93. Epub 2009 Aug 14.

Department of Chemical and Environmental Engineering, University of California at Riverside, California 92521, USA.

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October 2009

Coxsackievirus B3 infection promotes generation of myeloid dendritic cells from bone marrow and accumulation in the myocardium.

Int Immunopharmacol 2009 Oct 4;9(11):1304-12. Epub 2009 Aug 4.

Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

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October 2009

Calpain-1 induces apoptosis in pulmonary microvascular endothelial cells under septic conditions.

Microvasc Res 2009 Jun 18;78(1):33-9. Epub 2009 Apr 18.

Critical Illness Research, Lawson Health Research Institute, VRL A6-140, 800 Commissioners Road, London, Ontario, Canada.

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June 2009

Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia.

Cardiovasc Res 2009 Jul 24;83(1):72-9. Epub 2009 Mar 24.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

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July 2009

Phospholipase Cgamma1 signalling regulates lipopolysaccharide-induced cyclooxygenase-2 expression in cardiomyocytes.

J Mol Cell Cardiol 2007 Sep 22;43(3):308-18. Epub 2007 Jun 22.

Center for Critical Illness Research, Lawson Health Research Institute, London Health Sciences Center, University of Western Ontario, London, Ontario, Canada N6A 4G5.

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September 2007

Metabolic engineering of Agrobacterium sp. for UDP-galactose regeneration and oligosaccharide synthesis.

Metab Eng 2006 Sep 7;8(5):465-73. Epub 2006 Jun 7.

School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332-0100, USA.

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September 2006

Enhanced myocardial cathepsin B expression in patients with dilated cardiomyopathy.

Eur J Heart Fail 2006 May 15;8(3):284-9. Epub 2006 Feb 15.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Fenglin Road 180, Shanghai 200032, PR China.

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May 2006

Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats.

Life Sci 2006 Mar 23;78(17):1998-2005. Epub 2005 Nov 23.

Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, No. 555 Zuchongzhi Road, Zhangjiang Pudong, Shanghai, China.

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March 2006

The relationship between human cytomegalovirus infection and atherosclerosis development.

Mol Cell Biochem 2003 Jul;249(1-2):91-6

Key Laboratory of Viral Heart Diseases of Ministry of Public Health, Shanghai, PR of China.

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July 2003