Ruili Huang

Ruili Huang

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Ruili Huang

Publications by authors named "Ruili Huang"

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The NCATS Pharmaceutical Collection: a 10-year update.

Drug Discov Today 2019 Oct 1. Epub 2019 Oct 1.

Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.drudis.2019.09.019DOI Listing
October 2019

Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library.

Environ Health Perspect 2019 Sep 30;127(9):97009. Epub 2019 Sep 30.

National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/EHP5314DOI Listing
September 2019

Identifying Compounds with Genotoxicity Potential Using Tox21 High-Throughput Screening Assays.

Chem Res Toxicol 2019 Jul 18;32(7):1384-1401. Epub 2019 Jun 18.

Division of the National Toxicology Program , National Institute of Environmental Health Sciences , Research Triangle Park , North Carolina 27709 , United States.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740247PMC
July 2019

Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides.

Toxicol In Vitro 2019 Apr 6;56:93-100. Epub 2019 Jan 6.

Division for Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08872333183054
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http://dx.doi.org/10.1016/j.tiv.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713233PMC
April 2019

Quantitative Chemotherapeutic Profiling of Gynecologic Cancer Cell Lines Using Approved Drugs and Bioactive Compounds.

Transl Oncol 2019 Mar 18;12(3):441-452. Epub 2018 Dec 18.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2018.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302136PMC
March 2019

Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements.

Appl In Vitro Toxicol 2019 Mar 9;5(1):10-25. Epub 2019 Mar 9.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1089/aivt.2018.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442399PMC
March 2019

Toxicogenomics: A 2020 Vision.

Trends Pharmacol Sci 2019 02 26;40(2):92-103. Epub 2018 Dec 26.

National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01656147183022
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http://dx.doi.org/10.1016/j.tips.2018.12.001DOI Listing
February 2019

Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays.

Molecules 2019 Feb 27;24(5). Epub 2019 Feb 27.

National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Bethesda, MD 20814, USA.

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http://dx.doi.org/10.3390/molecules24050841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429183PMC
February 2019

Drug-Induced Rhabdomyolysis Atlas (DIRA) for idiosyncratic adverse drug reaction management.

Drug Discov Today 2019 01 11;24(1):9-15. Epub 2018 Jun 11.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2018.06.006DOI Listing
January 2019

Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library.

Toxicol Sci 2019 01;167(1):282-292

Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1093/toxsci/kfy242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657574PMC
January 2019

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

ACS Cent Sci 2018 Dec 5;4(12):1727-1741. Epub 2018 Dec 5.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/acscentsci.8b00747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311695PMC
December 2018

Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention.

Sci Rep 2018 10 16;8(1):15280. Epub 2018 Oct 16.

Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, 20892-8132, USA.

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http://www.nature.com/articles/s41598-018-33599-1
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http://dx.doi.org/10.1038/s41598-018-33599-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191451PMC
October 2018

Identification of Angiogenesis Inhibitors Using a Co-culture Cell Model in a High-Content and High-Throughput Screening Platform.

SLAS Technol 2018 06 18;23(3):217-225. Epub 2017 Sep 18.

1 Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1177/2472630317729792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032403PMC
June 2018

Computational drug repositioning for rare diseases in the era of precision medicine.

Drug Discov Today 2018 Feb 18;23(2):382-394. Epub 2017 Oct 18.

National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2017.10.009DOI Listing
February 2018

The Toxmatrix: Chemo-Genomic Profiling Identifies Interactions That Reveal Mechanisms of Toxicity.

Chem Res Toxicol 2018 02 4;31(2):127-136. Epub 2017 Dec 4.

National Center for Advancing Translational Sciences (NCATS), National Institutes of Health , 9800 Medical Center Drive, Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00290DOI Listing
February 2018

Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease.

Antiviral Res 2018 02 27;150:217-225. Epub 2017 Dec 27.

Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA; Department of Biomedical Sciences, School of Public Health, University at Albany, PO Box 509, Empire State Plaza, Albany NY 12201, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01663542173045
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http://dx.doi.org/10.1016/j.antiviral.2017.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892443PMC
February 2018

Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles.

Sci Rep 2018 02 28;8(1):3783. Epub 2018 Feb 28.

Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, 20850, USA.

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http://dx.doi.org/10.1038/s41598-018-22046-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830476PMC
February 2018

A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling.

Authors:
Ruili Huang

Methods Mol Biol 2016 ;1473:111-22

National Center for Advancing Translational Sciences, National Institutes of Health, Building B, MSC: 3370, 9800 Medical Center Drive, Bethesda, MD, 20892, USA.

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http://link.springer.com/10.1007/978-1-4939-6346-1_12
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http://dx.doi.org/10.1007/978-1-4939-6346-1_12DOI Listing
January 2018

Correction of Microplate Data from High-Throughput Screening.

Methods Mol Biol 2016 ;1473:123-34

National Center for Advancing Translational Sciences, National Institutes of Health, Building B, MSC: 3370, 9800 Medical Center Drive, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/978-1-4939-6346-1_13DOI Listing
January 2018

Omics-Based Platform for Studying Chemical Toxicity Using Stem Cells.

J Proteome Res 2018 01 20;17(1):579-589. Epub 2017 Dec 20.

Newomics Inc. , Emeryville, California 94608, United States.

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http://dx.doi.org/10.1021/acs.jproteome.7b00693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756105PMC
January 2018

Why are most phospholipidosis inducers also hERG blockers?

Arch Toxicol 2017 Dec 27;91(12):3885-3895. Epub 2017 May 27.

Division of Systems Biology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA.

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http://link.springer.com/10.1007/s00204-017-1995-9
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http://dx.doi.org/10.1007/s00204-017-1995-9DOI Listing
December 2017

Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.

PLoS One 2017 22;12(5):e0177902. Epub 2017 May 22.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177902PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439695PMC
September 2017

Assessment of the DNA damaging potential of environmental chemicals using a quantitative high-throughput screening approach to measure p53 activation.

Environ Mol Mutagen 2017 08 17;58(7):494-507. Epub 2017 Jul 17.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1002/em.22112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555817PMC
August 2017

In Silico Prediction of hPXR Activators Using Structure-Based Pharmacophore Modeling.

J Pharm Sci 2017 07 16;106(7):1752-1759. Epub 2017 Mar 16.

Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549173016
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http://dx.doi.org/10.1016/j.xphs.2017.03.004DOI Listing
July 2017

Development of Novel Cell Lines for High-Throughput Screening to Detect Estrogen-Related Receptor Alpha Modulators.

SLAS Discov 2017 07 31;22(6):720-731. Epub 2017 Jan 31.

1 Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA.

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http://dx.doi.org/10.1177/2472555216689772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486949PMC
July 2017

Identification of acetylcholinesterase inhibitors using homogenous cell-based assays in quantitative high-throughput screening platforms.

Biotechnol J 2017 May 6;12(5). Epub 2017 Apr 6.

Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/biot.201600715DOI Listing
May 2017

Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing.

Mol Inform 2017 04 21;36(4). Epub 2016 Dec 21.

National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/minf.201600126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382096PMC
April 2017

Integrating Drug's Mode of Action into Quantitative Structure-Activity Relationships for Improved Prediction of Drug-Induced Liver Injury.

J Chem Inf Model 2017 04 10;57(4):1000-1006. Epub 2017 Apr 10.

National Center for Toxicological Research, U.S. Food and Drug Administration , 3900 NCTR RD, Jefferson, Arkansas 72079, United States.

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http://dx.doi.org/10.1021/acs.jcim.6b00719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233892PMC
April 2017

Development and Application of Human Renal Proximal Tubule Epithelial Cells for Assessment of Compound Toxicity.

Curr Chem Genom Transl Med 2017 14;11:19-30. Epub 2017 Feb 14.

9800 Medical Center Drive, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892-3375, USA.

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http://benthamopen.com/ABSTRACT/CCGTM-11-19
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http://dx.doi.org/10.2174/2213988501711010019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362976PMC
February 2017

One-Step Seeding of Neural Stem Cells with Vitronectin-Supplemented Medium for High-Throughput Screening Assays.

J Biomol Screen 2016 Dec 26;21(10):1112-1124. Epub 2016 Sep 26.

1 National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1177/1087057116670068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285267PMC
December 2016

Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.

Toxicol Appl Pharmacol 2016 12 20;313:138-148. Epub 2016 Oct 20.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2016.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124510PMC
December 2016

Application of dynamic topic models to toxicogenomics data.

BMC Bioinformatics 2016 Oct 6;17(Suppl 13):368. Epub 2016 Oct 6.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, AR, USA.

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http://dx.doi.org/10.1186/s12859-016-1225-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073961PMC
October 2016

Corrigendum to Performance of the BG1Luc ER TA method in a qHTS format.

ALTEX 2016 ;33(1):79

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.14573/altex.1512041DOI Listing
August 2016

A cell-based quantitative high-throughput image screening identified novel autophagy modulators.

Pharmacol Res 2016 08 7;110:35-49. Epub 2016 May 7.

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995889PMC
August 2016

Identification of HDAC Inhibitors Using a Cell-Based HDAC I/II Assay.

J Biomol Screen 2016 Jul 8;21(6):643-52. Epub 2016 Feb 8.

National Center for Advancing Translational Sciences, Bethesda, MD, USA

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http://dx.doi.org/10.1177/1087057116629381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917448PMC
July 2016

A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies.

Cancer Res 2016 07 4;76(14):4183-91. Epub 2016 Jun 4.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland. Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea. Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033673PMC
July 2016

Performance of the BG1Luc ER TA method in a qHTS format.

ALTEX 2015 28;32(4):287-96. Epub 2015 Jun 28.

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.14573/altex.1505121DOI Listing
June 2016

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers.

Sci Rep 2016 05 5;6:25379. Epub 2016 May 5.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/srep25379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857081PMC
May 2016

Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.

Toxicol In Vitro 2016 Apr 25;32:287-96. Epub 2016 Jan 25.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, United States.

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http://dx.doi.org/10.1016/j.tiv.2016.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779714PMC
April 2016

Discovery of Transcriptional Targets Regulated by Nuclear Receptors Using a Probabilistic Graphical Model.

Toxicol Sci 2016 Mar 7;150(1):64-73. Epub 2015 Dec 7.

FDA/National Center for Toxicological Research, Jefferson, Arkansas 72079

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http://dx.doi.org/10.1093/toxsci/kfv261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009613PMC
March 2016

Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling.

Oncotarget 2016 Feb;7(7):8172-83

Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.6995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884984PMC
February 2016

Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.

Mutagenesis 2016 Jan 4;31(1):69-81. Epub 2015 Aug 4.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, MSC: 3375 Bethesda, MD 20892, USA and

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http://dx.doi.org/10.1093/mutage/gev055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723671PMC
January 2016

Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.

Nat Commun 2016 Jan 26;7:10425. Epub 2016 Jan 26.

Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.

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http://dx.doi.org/10.1038/ncomms10425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777217PMC
January 2016

Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses.

Environ Sci Technol 2014 10;48(15):8706-16. Epub 2014 Jul 10.

Department of Environmental Sciences and Engineering, University of North Carolina , Chapel Hill, North Carolina 27514, United States.

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http://dx.doi.org/10.1021/es502676eDOI Listing
November 2015

A Data Analysis Pipeline Accounting for Artifacts in Tox21 Quantitative High-Throughput Screening Assays.

J Biomol Screen 2015 Aug 22;20(7):887-97. Epub 2015 Apr 22.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1177/1087057115581317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568956PMC
August 2015

Identification of known drugs targeting the endoplasmic reticulum stress response.

Anal Bioanal Chem 2015 Jul 30;407(18):5343-51. Epub 2015 Apr 30.

Life Science Solutions Group, Thermo Fisher Scientific, Rockford, IL, 61105, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs00216-015-86
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http://link.springer.com/10.1007/s00216-015-8694-2
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http://dx.doi.org/10.1007/s00216-015-8694-2DOI Listing
July 2015

Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response.

Cell Rep 2015 Jul 16;12(4):661-72. Epub 2015 Jul 16.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132, USA; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PRC. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520759PMC
July 2015

Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.

Sci Rep 2015 May 20;5:10405. Epub 2015 May 20.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, 21201 Maryland.

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http://dx.doi.org/10.1038/srep10405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438668PMC
May 2015

Identification of small molecule modulators of gene transcription with anticancer activity.

ACS Chem Biol 2014 Nov 16;9(11):2603-11. Epub 2014 Sep 16.

Hamon Center for Therapeutic Oncology Research and ∥Department of Pharmacology, University of Texas Southwestern Medical Center , Dallas, Texas 75390, United States.

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http://dx.doi.org/10.1021/cb500532xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245161PMC
November 2014

Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.

DNA Repair (Amst) 2014 Sep 29;21:177-82. Epub 2014 Apr 29.

Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125495PMC
September 2014

Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.

Sci Rep 2014 Sep 26;4:6437. Epub 2014 Sep 26.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1038/srep06437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894417PMC
September 2014

Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform.

Curr Chem Genom Transl Med 2014 7;8:36-46. Epub 2014 Mar 7.

Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands ; Subdepartment of Environmental Technology, Wageningen University, and Wageningen-IMARES, Axis Z (Building number 118), Room TT.1.100, Bornse Weilanden 96708, WG Wageningen, The Netherlands.

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http://benthamopen.com/ABSTRACT/CCGTM-8-36
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http://dx.doi.org/10.2174/2213988501408010036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999704PMC
April 2014

Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format.

J Biomol Screen 2014 Jan 3;19(1):66-76. Epub 2013 Sep 3.

1National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://journals.sagepub.com/doi/10.1177/1087057113502851
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http://dx.doi.org/10.1177/1087057113502851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550094PMC
January 2014

Chemical signatures and new drug targets for gametocytocidal drug development.

Sci Rep 2014 Jan 17;4:3743. Epub 2014 Jan 17.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, United States.

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http://www.nature.com/articles/srep03743
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http://dx.doi.org/10.1038/srep03743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894558PMC
January 2014

Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening.

Chem Res Toxicol 2013 Sep 15;26(9):1323-32. Epub 2013 Aug 15.

National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/tx4001754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154066PMC
September 2013

The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.

Drug Discov Today 2013 Aug 31;18(15-16):716-23. Epub 2013 May 31.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.drudis.2013.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771082PMC
August 2013

Are hERG channel blockers also phospholipidosis inducers?

Bioorg Med Chem Lett 2013 Aug 20;23(16):4587-90. Epub 2013 Jun 20.

National Center for Advancing Translational Sciences, National Institutes of Health (NIH), 9800 Medical Center Drive, Bethesda, Rockville, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736554PMC
August 2013

Identification of repurposed small molecule drugs for chordoma therapy.

Cancer Biol Ther 2013 Jul 10;14(7):638-47. Epub 2013 May 10.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/cbt.24596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742493PMC
July 2013

Bisphenol A affects androgen receptor function via multiple mechanisms.

Chem Biol Interact 2013 May 4;203(3):556-64. Epub 2013 Apr 4.

DNTP Biomolecular Screening Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, NC, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00092797130007
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http://dx.doi.org/10.1016/j.cbi.2013.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722857PMC
May 2013

Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals.

Environ Health Perspect 2013 Jan 28;121(1):7-14. Epub 2012 Sep 28.

Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1205065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546348PMC
January 2013

A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.

Antimicrob Agents Chemother 2013 Jan 5;57(1):425-35. Epub 2012 Nov 5.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.00920-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535893PMC
January 2013

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.

ACS Med Chem Lett 2013 Jan;4(1):79-84

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1021/ml300286hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770298PMC
January 2013

Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules.

Mol Inform 2012 Nov 11;31(11-12):783-792. Epub 2012 Oct 11.

National Center for Advancing Translational Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/minf.201200065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583379PMC
November 2012

Paradigm shift in toxicity testing and modeling.

AAPS J 2012 Sep 20;14(3):473-80. Epub 2012 Apr 20.

Department of Health and Human Services, NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892-3370, USA.

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http://dx.doi.org/10.1208/s12248-012-9358-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385826PMC
September 2012

Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach.

Environ Health Perspect 2012 Aug 2;120(8):1150-6. Epub 2012 May 2.

NIH Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA.

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http://dx.doi.org/10.1289/ehp.1104709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440086PMC
August 2012

Structure based model for the prediction of phospholipidosis induction potential of small molecules.

J Chem Inf Model 2012 Jul 5;52(7):1798-805. Epub 2012 Jul 5.

National Institutes of Health (NIH) Chemical Genomics Center, NIH, Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/ci3001875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484221PMC
July 2012

Application of a homogenous membrane potential assay to assess mitochondrial function.

Physiol Genomics 2012 May 20;44(9):495-503. Epub 2012 Mar 20.

NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892-3370, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00161.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426425PMC
May 2012

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.

Proc Natl Acad Sci U S A 2012 Apr 19;109(14):5423-8. Epub 2012 Mar 19.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1114278109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325711PMC
April 2012

Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data.

J Chem Inf Model 2011 Oct 26;51(10):2474-81. Epub 2011 Sep 26.

National Institutes of Health, Chemical Genomics Center, NIH, Bethesda, Maryland 20892, United States.

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http://pubs.acs.org/doi/abs/10.1021/ci200311w
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http://dx.doi.org/10.1021/ci200311wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200453PMC
October 2011

Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors.

Bioorg Med Chem Lett 2011 Sep 21;21(18):5239-43. Epub 2011 Jul 21.

NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Dr., Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.07.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681418PMC
September 2011