Publications by authors named "Ruihui Li"

8 Publications

  • Page 1 of 1

A Rotation-Invariant Framework for Deep Point Cloud Analysis.

IEEE Trans Vis Comput Graph 2021 Jun 25;PP. Epub 2021 Jun 25.

Recently, many deep neural networks were designed to process 3D point clouds, but a common drawback is that rotation invariance is not ensured, leading to poor generalization to arbitrary orientations. In this paper, we introduce a new low-level purely rotation-invariant representation to replace common 3D Cartesian coordinates as the network inputs. Also, we present a network architecture to embed these representations into features, encoding local relations between points and their neighbors, and the global shape structure. To alleviate inevitable global information loss caused by the rotation-invariant representations, we further introduce a region relation convolution to encode local and non-local information. We evaluate our method on multiple point cloud analysis tasks, including (i) shape classification, (ii) part segmentation, and (iii) shape retrieval. Extensive experimental results show that our method achieves consistent, and also the best performance, on inputs at arbitrary orientations, compared with all the state-of-the-art methods.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/TVCG.2021.3092570DOI Listing
June 2021

Effect of Osteoporosis on Adjacent Segmental Degeneration After Posterior Lumbar Interbody Fusion Under Whole Body Vibration.

World Neurosurg 2021 Aug 12;152:e700-e707. Epub 2021 Jun 12.

School of Chinese Medicine, Jinan University, Guangzhou, China. Electronic address:

Background: Adjacent segmental degeneration (ASD) is one of the common complications after posterior lumbar interbody fusion (PLIF). Both whole body vibration (WBV) and osteoporosis are important factors associated with the biomechanics of the lumbar spine. However, to the best of our knowledge, no studies have investigated the effects of osteoporosis on ASD after PLIF under WBV.

Methods: In the present study, using one normal model, one PLIF model and one PLIF with osteoporosis model of the L1-S1 segment were developed. A 5-Hz, 40-N sinusoidal vertical load was imposed on the superior surface of L1 of each model to simulate WBV, and the dynamic responses and maximal values of intradiscal pressure, shear stress on annulus fibrosus, total deformation, and disc bulge were evaluated in the L1-L2, L2-L3, L3-L4, and L5-S1 segments.

Results: At the L1-L2, L2-L3, and L3-L4 levels, the differences in the dynamic responses and maximal values in intradiscal pressure, shear stress, total deformation, and disc bulge between the PLIF and PLIF with osteoporosis models were slight. However, at the L5-S1 level, the dynamic response curves and maximal intradiscal pressure, shear stress, and disc bulge values in the PLIF with osteoporosis model were significantly lower than those in the PLIF model.

Conclusions: Osteoporosis can mitigate the development of ASD in the lower adjacent segment but has no obvious influence on the upper adjacent segments during WBV.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2021.06.031DOI Listing
August 2021

Involvement of non-coding RNAs during infection of rice by Acidovorax oryzae.

Environ Microbiol Rep 2021 Aug 13;13(4):540-554. Epub 2021 Jun 13.

State Key Laboratory of Rice Biology and Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, 310058, China.

The expression of non-coding RNAs (ncRNAs) has been observed in a variety of bacteria. However, the function of ncRNAs and their regulatory targets are largely unknown, and few ncRNAs are found to be associated with bacterial virulence. The bacterial brown stripe pathogen Acidovorax oryzae (Ao) RS-1 shows a high level of condition-dependent differential expression of ncRNA, which we identified in a genome wide screen. We experimentally validated 66 differentially expressed ncRNAs using an integrative analysis of conservative genome sequences and transcriptomic data during in vivo interaction of the bacterial pathogen with the rice plant. To test the relevance of the differentially expressed ncRNAs, we chose four with different positions within the genome, and with different secondary structures and promoter activities. The results show that the overexpression of the four ncRNAs caused a significant change in virulence-related phenotypes, resistance to various environmental stresses, expression of secretion systems and effector proteins, while changing the expression of ncRNA putative target genes. We conclude that these ncRNAs are examples for the inherent regulatory roles for many of the observed ncRNAs in response to changing conditions such as host interaction or environmental adaption.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1758-2229.12982DOI Listing
August 2021

DNF-Net: A Deep Normal Filtering Network for Mesh Denoising.

IEEE Trans Vis Comput Graph 2021 Oct 1;27(10):4060-4072. Epub 2021 Sep 1.

This article presents a deep normal filtering network, called DNF-Net, for mesh denoising. To better capture local geometry, our network processes the mesh in terms of local patches extracted from the mesh. Overall, DNF-Net is an end-to-end network that takes patches of facet normals as inputs and directly outputs the corresponding denoised facet normals of the patches. In this way, we can reconstruct the geometry from the denoised normals with feature preservation. Besides the overall network architecture, our contributions include a novel multi-scale feature embedding unit, a residual learning strategy to remove noise, and a deeply-supervised joint loss function. Compared with the recent data-driven works on mesh denoising, DNF-Net does not require manual input to extract features and better utilizes the training data to enhance its denoising performance. Finally, we present comprehensive experiments to evaluate our method and demonstrate its superiority over the state of the art on both synthetic and real-scanned meshes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/TVCG.2020.3001681DOI Listing
October 2021

CB receptor-dependent desensitisation of TRPV1 channels contributes to the analgesic effect of dipyrone in sensitised primary sensory neurons.

Br J Pharmacol 2020 10 6;177(20):4615-4626. Epub 2020 Sep 6.

Pain Studies Lab - Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, Brazil.

Background And Purpose: While dipyrone is a widely used analgesic, its mechanism of action is not completely understood. Recently, we have reported that the dipyrone metabolite 4-aminoantipyrine (4-AA) reduces PGE -induced pain-related behaviour through cannabinoid CB receptors. Here, we ascertained, in naive and PGE -induced "inflamed" conditions, both in vivo and in vitro, the molecular mechanisms involved in the 4-AA-induced analgesic effects.

Experimental Approach: The effect of local administration of 4-AA (160 μg per paw) on capsaicin (0.12 μg per paw) injection-induced pain-related behaviour and 4-AA's effect on 500-nM capsaicin-induced changes in intracellular calcium concentration ([Ca ] ) in cultured primary sensory neurons were assessed in vivo and in vitro, respectively.

Key Results: 4-AA reduced capsaicin-induced nociceptive behaviour in naive and inflamed conditions through CB receptors. 4-AA (100 μM) reduced capsaicin-induced increase in [Ca ] in a CB receptor-dependent manner, when PGE was not present. Following PGE application, 4-AA (1-50 μM) increased the [Ca ] . Although 4-AA activated both TRPV1 and TRPA1 channels, increased [Ca ] was mediated through TRPV1 channels. Activation of TRPV1 channels resulted in their desensitisation. Blocking CB receptors reduced both the excitatory and desensitising effects of 4-AA.

Conclusion And Implications: CB receptor-mediated inhibition of TRPV1 channels and TRPV1-mediated Ca -influx- and CB receptor-dependent desensitisation of TRPV1 channels contribute to the anti-nociceptive effect of 4-AA in naive and inflamed conditions respectively. Agonists active at both CB receptors and TRPV1 channels might be useful as analgesics, particularly in inflammatory conditions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.15170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520441PMC
October 2020

Effects of the tumor suppressor PTEN on the pathogenesis of idiopathic pulmonary fibrosis in Chinese patients.

Mol Med Rep 2016 Mar 3;13(3):2715-23. Epub 2016 Feb 3.

Department of Respiratory Medicine, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive interstitial fibrosis, and is associated with a fatal outcome. The critical pathological mechanisms underlying IPF are largely unknown; however, accumulating evidence has indicated similarities between IPF and cancer. Therefore, the present study examined the expression levels of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in Chinese patients with IPF, using an enzyme‑linked immunosorbent assay. To determine the effects of PTEN on the development of pulmonary fibrosis, PTEN was overexpressed in transforming growth factor (TGF)‑β1‑treated human embryonic lung fibroblasts (HFL‑I cells). The serum levels of PTEN were significantly lower in 42 patients with IPF, as compared with in the healthy controls. In addition, PTEN overexpression enhanced apoptosis, and suppressed basal levels of proliferation and migration in fibroblasts. Notably, PTEN was able to specifically inhibit TGF‑β1‑induced proliferation and migration of the cells. Overexpression of PTEN also suppressed phosphorylation of Akt and Smad3, and decreased the expression levels of numerous proteins with critical roles in TGF‑β1‑induced fibrosis, including α‑smooth muscle actin, matrix metalloproteinase (MMP)‑2 and MMP‑9. These results indicated that PTEN may inhibit TGF‑β1‑mediated myofibroblast differentiation of fibroblasts by attenuating signaling via the phosphatidylinositol 3‑kinase/Akt and TGF‑β/Smad3 pathways.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2016.4852DOI Listing
March 2016

[Motion signal extraction method based on sEMG energy Gauss distribution characteristics].

Zhongguo Yi Liao Qi Xie Za Zhi 2014 May;38(3):177-80

Motion segment and extraction from continuous signals is the premise of surface electromyography (sEMG) analysis. For the problem that sEMG energy threshold required repeated manual testing to set, this the paper established a this mathematical model of continuous actions based on Gaussian sEMG energy curve, in which the energy threshold was set according to the distribution of Gaussian signal section, and differentiated the action signals from no-action signals combined with energy comparison method. The experiment results showed the method can achieve continuous repetitive action segmentation, and compared with manual segmentation of the same signal, has a higher degree of coincidence.
View Article and Find Full Text PDF

Download full-text PDF

Source
May 2014

Clinical implications for BRCA gene mutation in breast cancer.

Mol Biol Rep 2012 Mar 21;39(3):3097-102. Epub 2011 Jun 21.

Department of Hepatic-Biliary-Pancreas Surgery, Affiliated ShengJing Hospital, China Medical University, No 36 Sanhao Street, Shenyang 110004, China.

To investigate the mutations of BRCA1 and BRCA2 and determine whether clinic-pathological factors related to BRCA gene mutation. Mastectomy specimens from 360 breast cancers were enrolled and examined in the study. The relationship between BRCA gene mutation and clinic-pathological factors was evaluated. Overall, 280 patients were BRCA negative and 80 got BRCA gene mutation. Triple-negative breast cancers--i.e., breast cancers that do not express estrogen receptors (ER), progesterone receptors (PR) or human epidermal growth factor receptor 2 (HER2/neu)--was observed in 53.85% of the BRCA1 mutation patients, in 28.57% of the BRCA2 mutation cases, while 14.29% of BRCA negative patients. BRCA1 mutation patients got a heavy lymph node metastasis and higher nuclear grade tumors than the others (P = 0.004, 0.007). Furthermore, BRCA mutation was also found to be significantly related to ER, PR and HER2/neu status (P < 0.05). BRCA1 expression was not associated with breast cancer-specific survival in the triple-negative breast cancers (P = 0.742). After Cox regression, BRCA1 mutation was not shown to be an independent prognostic factor for breast cancer. These findings substantiated the possibility of tumors associated with BRCA1 mutations divided into two distinct groups, triple-negative and non-triple-negative groups requires further investigation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11033-011-1073-yDOI Listing
March 2012
-->