Publications by authors named "Rui-Yu Lin"

9 Publications

  • Page 1 of 1

Features for Predicting Absorbable Pulmonary Solid Nodules as Depicted on Thin-Section Computed Tomography.

J Inflamm Res 2021 2;14:2933-2939. Epub 2021 Jul 2.

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Purpose: To investigate the clinical and computed tomography (CT) characteristics of absorbable pulmonary solid nodules (PSNs) and to clarify CT features for distinguishing absorbable PSNs from malignant ones.

Materials And Methods: From January 2015 to February 2021, a total of 316 patients with 348 PSNs (171 absorbable and 177 size-matched malignant) were retrospectively enrolled. Their clinical and CT data were analyzed and compared to determine CT features for predicting absorbable PSNs.

Results: Between absorbable and malignant PSNs, there were significant differences in patients' age, lesions' locations, shapes, homogeneity, borders, distance from the pleura, vacuoles, air bronchograms, lobulation, spiculation, halo sign, multiple concomitant nodules and pleural indentation (each < 0.05). Multivariate analysis revealed that the independent predictors of absorbable PSNs were the following: patient age ≤55 years (OR, 2.660; 95% CI, 1.432-4.942; = 0.002), homogeneous density (OR, 2.487; 95% CI, 1.107-5.590; = 0.027), ill-defined border (OR, 5.445; 95% CI, 1.661-17.846; = 0.005), halo sign (OR, 3.135; 95% CI, 1.154-8.513; = 0.025), multiple concomitant nodules (OR, 8.700; 95% CI, 4.401-17.197; <0.001), and abutting pleura (OR, 3.759; 95% CI, 1.407-10.044; = 0.008). The indicators for malignant PSNs were the following: lobulation (OR, 3.904; 95% CI, 1.956-7.791; <0.001), spiculation (OR, 4.980; 95% CI, 2.202-11.266, <0.001), and pleural indentation (OR, 4.514; 95% CI, 1.223-16.666; = 0.024).

Conclusion: In patients younger than 55 years, PSNs with homogeneous density, ill-defined border, halo sign, multiple concomitant nodules, and abutting pleura should be highly suspected as absorbable ones.
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http://dx.doi.org/10.2147/JIR.S318125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259943PMC
July 2021

Solitary Pulmonary Inflammatory Nodule: CT Features and Pathological Findings.

J Inflamm Res 2021 25;14:2741-2751. Epub 2021 Jun 25.

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Purpose: Solitary pulmonary inflammatory nodules (SPINs) are frequently misdiagnosed as malignancy. We aimed to investigate CT features and pathological findings of SPINs for improving diagnosis strategies.

Patients And Methods: In this retrospective study, 225 and 310 consecutive patients with confirmed SPINs and lung cancerous nodules were enrolled from January 2013 to December 2020. Nodules were classified into different types based on the key CT features: I, homogeneous and well-defined nodules with smooth (Ia), coarse (Ib), or spiculated margins (Ic); II, nodules with blurred boundaries, peripheral patches, or both; III, nodules exhibiting heterogeneous density; and IV, polygonal nodules. The pathological findings of SPINs were simultaneously studied and summarized.

Results: Among the 225 SPINs, type I (Ia, Ib, and Ic), II, III, and IV were 137 (60.9%) (47 [20.9%], 33 [14.7%], and 57 [25.3%]), 62 (27.6%), 12 (5.3%) and 14 (6.2%), respectively. Correspondingly, those in 310 cancerous nodules were 275 (88.7%) (119 [38.4%], 70 [22.6%], and 86 [27.7%]), 20 (6.5%), 15 (4.8%), and 0, respectively. Compared with lung cancers, type I nodules were less common but type II and IV nodules were more common in SPINs (each < 0.0001). Though the frequencies of subtype I ( = 0.095) and type III ( = 0.796) nodules were similar between two groups, their specific CT features were significantly different. The main pathological findings of each type of SPINs were most extensively identical (82.2 - 100%).

Conclusion: Between cancerous nodules and SPINs, differences in overall or specific CT features exist. The type II and IV nodules are highly indicative of SPINs, and each type of SPINs have almost similar pathological findings.
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http://dx.doi.org/10.2147/JIR.S304431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242128PMC
June 2021

Significance of intra-nodular vessel sign in differentiating benign and malignant pulmonary ground-glass nodules.

Insights Imaging 2021 May 26;12(1):65. Epub 2021 May 26.

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuanjiagang, Yuzhong District, Chongqing, 400016, China.

Background: The presence of pulmonary vessels inside ground-glass nodules (GGNs) of different nature is a very common occurrence. This study aimed to reveal the significance of pulmonary vessels displayed in GGNs in their diagnosis and differential diagnosis.

Results: A total of 149 malignant and 130 benign GGNs confirmed by postoperative pathological examination were retrospectively enrolled in this study. There were significant differences in size, shape, nodule-lung interface, pleural traction, lobulation, and spiculation (each p < 0.05) between benign and malignant GGNs. Compared with benign GGNs, intra-nodular vessels were more common in malignant GGNs (67.79% vs. 54.62%, p = 0.024), while the vascular categories were similar (p = 0.663). After adjusting the nodule size and the distance between the nodule center and adjacent pleura [radius-distance ratio, RDR], the occurrences of internal vessels between them were similar. The number of intra-nodular vessels was positively correlated with nodular diameter and RDR. Vascular changes were more common in malignant than benign GGNs (52.48% vs. 18.31%, p < 0.0001), which mainly manifested as distortion and/or dilation of pulmonary veins (61.19%). The occurrence rate, number, and changes of internal vessels had no significant differences among all the pre-invasive and invasive lesions (each p > 0.05).

Conclusions: The incidence of internal vessels in GGNs is mainly related to their size and the distance between nodule and pleura rather than the pathological nature. However, GGNs with dilated or distorted internal vessels, especially pulmonary veins, have a higher possibility of malignancy.
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http://dx.doi.org/10.1186/s13244-021-01012-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155149PMC
May 2021

[Effects of Pseudomonas aeruginosa on root activity and leaf physiological characteristics in rice (Oryza sativa L.) seedling under cadmium stress].

Ying Yong Sheng Tai Xue Bao 2019 Aug;30(8):2767-2774

College of Life Sciences, Fujian Agriculture and Forestry University, Fujian Provincial Key Laboratory of Agroecological Processing and Safety Monitoring, Fuzhou 350002, China.

To reveal the physiological effects of rice alleviated by cadmium-tolerant Pseudomonas aeruginosa under cadmium stress condition, the influences of bacterial strian on the root vigor and leaf physiological characteristics were analyzed under a set of hydroponic experiments involving adding bacteria suspension, empty carrier, microbial inoculum with 20 μmol·L Cd. Cadmium-free treatment as control. The results showed that the root vigor was significantly inhibited, leaf photosynthetic rate decreased, and the contents of soluble protein, flavonoid and total phenols in rice leaves were reduced, while the contents of malondialdehyde (MDA) and superoxide anion(O) increased significantly under cadmium stress condition. Compared with cadmium treatment, root vigors of rice were increased by 36.1%-42.5% and 49.4%-53.0% respectively in bacteria suspension and microbial inoculum additions, net photosynthetic rates in leaves were increased by 118.5%-147.1% and 137.6%-156.9%, and the contents of soluble protein were increased by 37.0%-49.3% and 37.7%-72.6%, respectively. For the bacteria suspension treatment, the activities of SOD, POD and CAT in leaves were increased by 25.8%-36.6%, 40.9%-55.9%, 24.0%-29.2%, and the activities of SOD, POD and CAT in leaves under microbial inoculum treatment were increased by 36.9%-42.6%, 82.7%-92.6% and 43.3%-52.2%, respectively, with the stimulative effects on antioxidation enzymes in rice leaves being higher than those of bacteria suspension. Compared with cadmium treatment, the contents of MDA and O in rice leaves were reduced by 44.8%-54.7%, 29.4%-41.9% and 9.9%-10.2%, 3.0%-7.1% in microbial inoculum and bacteria suspension treatments, respectively. In contrast, the contents of flavonoids and total phenols were increased by 125.4%-135.7%, 100.8%-119.4% and 139.4%-146.7%, 115.0%-134.7%, respectively. In summary, P. aeruginosa and the microbial inoculum could promote rice seedling growth by improving root vigor and photosynthetic rate, as well as the contents of flavonoids and total phenols, which led to the fact that P. aeruginosa could significantly alleviate the stress of cadmium on rice.
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http://dx.doi.org/10.13287/j.1001-9332.201908.037DOI Listing
August 2019

[Responses of fungal community structure and functional group to fertilization in yellow clayey soil.]

Ying Yong Sheng Tai Xue Bao 2018 Aug;29(8):2721-2729

College of Resources and Environment, Fujian Agriculture and Forestry University,Fuzhou 350002, China.

We investigated the responses and underlying mechanisms of community composition, and function group of fungi in yellow clayey paddy soil to different long-term fertilization, which may provide scientific basis for rational fertilization and sustainable development in agriculture ecosystems. There were four treatments, including control (CK), inorganic fertilizer (NPK), inorganic fertilizer combined with manure (NPKM), and inorganic fertilizer combined with straw (NPKS). Illumina high-throughput sequencing and FUNGuild were performed to investigate the fungal community structure and functional group, respectively. Ascomycota, Basidiomycota, and Zygomycota were identified as the three dominant ones. The proportion of Ascomycota in NPKM and NPKS were significantly lower (49% and 47%, respectively) compared with CK (71%) and NPK (74%) treatments, with the main reduced orders of Hypocreales, Pleosporales and Eurotiales. While there was higher relative abundance of Basidiomycota in NPKM and NPKS (18% and 28%) compared to CK (14%) and NPK (10%), the orders with enhancement were Tremellales, Trechisporales, and Agaricales. The ratio of Basidiomycota was decreased with sole inorganic fertilizer. Moreover, the relative abundance of Zygomycota was increased after 33 years of fertilization, which was dominated by Mortierellales and Basidiobolales at order level. Diversity indices including Shannon, Simpson, Chao1 and ACE were all significantly declined in NPK compared with CK, NPKM and NPKS treatments, whereas Chao1 index and ACE index in NPKM and NPKS were higher than that in CK and NPK. Saprotroph was the main fungal functional group across all the four treatments (48%-57%). Higher proportion of symbiotroph fungi was identified in soils with NPKS and NPKM (17%) in comparison to CK and NPK. The main guilds with the increasing proportion were arbuscular mycorrhizal fungi and ectomycorrhizal fungi. However, significantly higher proportion of animal pathogen fungi were detected in NPK (10%) than other treatments. Redundancy analysis (RDA) showed that moisture, salinity and porosity in soil were more strongly related with fungal community composition and fungal functional composition than soil organic matter and total nitrogen. Our results suggest that sole application of inorganic fertilizer results in great changes in fungal community compositions and the hazard of over production of pathogen fungi, whereas combined organic-inorganic fertilization would be beneficial to maintain the healthy environment through increasing fungal diversity and the ratio of symbiotrophic fungi in yellow clayey paddy soil.
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http://dx.doi.org/10.13287/j.1001-9332.201808.003DOI Listing
August 2018

[Differential expression of proteins in Oryza sativa leaves in response to cadmium stress].

Ying Yong Sheng Tai Xue Bao 2011 Apr;22(4):1013-9

Institute of Agroecology, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

In order to explore the cadmium (Cd)-tolerance mechanism of rice (Oryza sativa), a hydroponic experiment with Cd-tolerant rice cultivar PI312777 and Cd-sensitive rice cultivar IR24 was conducted. The cultivars were treated with 0 (control), 50, and 100 micromol L(-1) of Cd(2+) for 7 days, and the differential expression of proteins in their leaves were analyzed by two-dimensional electrophoresis and MALDI-TOF/MS approach. Under Cd stress, 31 protein spots in PI312777 leaves and 19 protein spots in IR24 leaves had significantly different expression, compared with the control. In PI312777 leaves, the 24 of 31 proteins had 4 proteins related to photosynthesis, 11 proteins related to cell metabolism and defense, 3 proteins related to other metabolism pathway, and 2 proteins were unknown proteins; in IR24 leaves, the 15 of 19 proteins were identified. Under Cd-stress, the heat shock protein, glutathione-diulfide reductase, poteasome subunit alpha type-6, 1,6-bisphosphate aldolase, thioredoxin, and DNA repair-recombination protein in PI312777 leaves were up-regulated expressed, while these proteins in IR24 were not significantly changed except the down-regulation of 1,6-bisphosphate aldolase and thioredoxin. The higher Cd-tolerance of PI312777 could have close relations with the differentially expressed proteins.
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April 2011

[Effects of continuous cropping on bacterial community diversity in rhizosphere soil of Rehmannia glutinosa].

Ying Yong Sheng Tai Xue Bao 2010 Nov;21(11):2843-8

Department of Chinese Medicinal Materials, Henan Agricultural University, Zhengzhou, China.

In this paper, T-RFLP (terminal restriction fragment length polymorphism) technique was adopted to study the dynamic changes of bacterial community in the rhizosphere soil of continuously cropped Rehmannia glutinosa L. The results showed that the Shannon diversity index, Margalef index, and similarity index of bacterial community in the rhizosphere soil all decreased in the order of control > one-year cropping > two-year continuous cropping. Under continuous cropping, the proportion of dominant bacterial species declined obviously. In one-year cropping soil, the class Bacilli of phylum Firmicute dominated the bacteria community; while in two-year continuous cropping soil, the class Epsilonproteobacteria of phylum Proteobacteria became dominant. Continuous cropping of R. glutinosa decreased the bacteria species, and simplified the bacterial community structure. The changes of bacterial community diversity under continuous cropping of R. glutinosa led to the disorder of the functions of bacterial community, and thereby, the destruction of the ecological balance in rhizosphere soil, which might be one of reasons causing the obstacles of continuous cropping of R. glutinosa.
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November 2010

Characterization of metaproteomics in crop rhizospheric soil.

J Proteome Res 2011 Mar 18;10(3):932-40. Epub 2011 Jan 18.

School of Life Sciences, §Institute of Agricultural Ecology, Fujian Agricultural and Forestry University, Fuzhou 35002, P. R. China.

Soil rhizospheric metaproteomics is a powerful scientific tool to uncover the interactions between plants and microorganisms in the soil ecosystem. The present study established an extraction method suitable for different soils that could increase the extracted protein content. Close to 1000 separate spots with high reproducibility could be identified in the stained 2-DE gels. Among the spots, 189 spots representing 122 proteins on a 2-DE gel of rice soil samples were successfully identified by MALDI-TOF/TOF-MS. These proteins mainly originated from rice and microorganisms. They were involved in protein, energy, nucleotide, and secondary metabolisms, as well as signal transduction and resistance. Three characteristics of the crop rhizospheric metaproteomics seemed apparent: (1) approximately one-third of the protein spots could not be identified by MALDI-TOF/TOF/MS, (2) the conservative proteins from plants formed a feature distribution of crop rhizospheric metaproteome, and (3) there were very complex interactions between plants and microorganisms existing in a crop rhizospheric soil. Further functional analysis on the identified proteins unveiled various metabolic pathways and signal transductions involved in the soil biotic community. This study provides a paradigm for metaproteomic research on soil biology.
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http://dx.doi.org/10.1021/pr100981rDOI Listing
March 2011

[Effects of fertilizer application on contents of 2-undecanone and soluble carbonhydrate in Houttuynia cordata with different fertilizers].

Zhongguo Zhong Yao Za Zhi 2007 Nov;32(22):2352-6

School of Life Sciences, Fujian Agriculture & Forestry University, Fuzhou 350002, China.

Objective: To investigate the effect of five kinds of fertilizers at three application levels on the content of 2-undecanone and carbohydrate in Houttuynia cordata.

Method: A single factor randomized block design was used to investigate the content of 2-undecanone and carbohydrate in the plant.

Result: The results showed that the content of 2-undecanone was the highest both in aerial and underground parts of H. cordata, which was fertilized with complex fertilizers served in conventional way, having the content 18.6 microg g(-1) and 26.0 microg g(-1) respectively. In addition, 2-undecanone contents in aerial parts of H. cordata (14.9 microg g(-1)) fertilized with manure of human were also higher than that with chemical fertilizer, pig and duck manures, but no significant difference were found among the other treatments in aerial or underground parts of the plants, respectively. The results also demonstrated that fertilized with organic fertilizer might be beneficial to enhance the quality of sugar in H. cordata, mainly including the contents of total sugar, solutable sugar, fructose and reduced sugar in the plants, especially with manure of human and pig.

Conclusion: As the result of this study and the related previous research on yield of H. cordata were considered, the fertilizing ways for increasing quality of H. cordata should take the manure of human as a main fertilizer and mix with the other organic fertilizers, complex fertilizers and chemical ones may be needed to balance the plant nutrient. In the field practice, the amount of organic fertilizer including 108,000 kg hm(-2) human mature, together with some high-efficient complex fertilizer and a small amount of quick-acting chemical fertilizer is recommended.
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November 2007