Publications by authors named "Rui Ma"

902 Publications

Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson's Disease.

Research (Wash D C) 2022 18;2022:9781323. Epub 2022 Jul 18.

Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.

Parkinson's disease (PD) is the second most common neurodegenerative disease globally, and there is currently no effective treatment for this condition. Excessive accumulation of reactive oxygen species (ROS) and neuroinflammation are major contributors to PD pathogenesis. Herein, ultrasmall nanoscale coordination polymers (NCPs) coordinated by ferric ions and natural product curcumin (Cur) were exploited, showing efficient neuroprotection by scavenging excessive radicals and suppressing neuroinflammation. In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse PD model, such ultrasmall Fe-Cur NCPs with prolonged blood circulation and BBB traversing capability could effectively alleviate oxidative stress, mitochondrial dysfunction, and inflammatory condition in the midbrain and striatum to reduce PD symptoms. Thus, this study puts forth a unique type of therapeutics-based NCPs that could be used for safe and efficient treatment of PD with potential in clinical translation.
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http://dx.doi.org/10.34133/2022/9781323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343083PMC
July 2022

Risk assessment and dose-effect of co-exposure to benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS) on pulmonary function: A cross-sectional study.

Environ Pollut 2022 Aug 3:119894. Epub 2022 Aug 3.

Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China; Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, Guangdong, China. Electronic address:

Inhalation is the most frequent route and the lung is the primary damaged organ for human exposure to benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS). However, there is limited information on the risk and dose-effect of the BTEXS mixture on pulmonary function, particularly the overall effect. We conducted a cross-sectional study in a petrochemical plant in southern China. Spirometry and cumulative exposure dose (CED) of BTEXS were used to measure lung function and exposure levels for 635 workers in 2020, respectively. Forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV) were tested and interpreted as percentages to predicted values [FVC or FEV% predicted], and FEV to FVC ratio [FEV/FVC (%)]. We found the reduction in FVC% predicted and the risk of lung ventilation dysfunction (LVD) and its two subtypes (mixed and restrictive ventilation dysfunction, MVD, and MVD) were significantly associated with BTEXS individuals. In addition, pulmonary function damage associated with BTEXS was modified by the smoking status and age. Generalized weighted quantile sum (gWQS) regressions were used to estimate the overall dose-effect on lung function damage induced by the BTEXS mixture. Our results show wqs, an index of weighted quartiles for BTEXS, was potentially associated with the reduction in FVC and FEV% predicted with the coefficients [95% confidence intervals (CI)] between -1.136 (-2.202, -0.070) and -1.230 (-2.265, -0.195). Odds ratios (ORs) and 95% CIs for the wqs index of LVD, MVD, and RVD were 1.362 (1.129, 1.594), 1.323 (1.084, 1.562), and 1.394 (1.096, 1.692), respectively. Furthermore, xylene, benzene, and toluene in the BTEXS mixture potentially contribute to the development of lung function impairment. Our novel findings demonstrated the dose-response relationships between pulmonary function impairment and the BTEXS mixture and disclosed the potential key pollutants in the BTEXS mixture.
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http://dx.doi.org/10.1016/j.envpol.2022.119894DOI Listing
August 2022

Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine (Sinopharm BBIBP-CorV) coadministered with quadrivalent split-virion inactivated influenza vaccine and 23-valent pneumococcal polysaccharide vaccine in China: A multicentre, non-inferiority, open-label, randomised, controlled, phase 4 trial.

Vaccine 2022 Jul 29. Epub 2022 Jul 29.

China National Biotec Group Company Limited, Beijing, China; National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Company Limited, Wuhan, China. Electronic address:

Background: The safety and immunogenicity of the coadministration of an inactivated SARS-CoV-2 vaccine (Sinopharm BBIBP-CorV), quadrivalent split-virion inactivated influenza vaccine (IIV4), and 23-valent pneumococcal polysaccharide vaccine (PPV23) in adults in China is unknown.

Methods: In this open-label, non-inferiority, randomised controlled trial, participants aged ≥ 18 years were recruited from the community. Individuals were eligible if they had no history of SARS-CoV-2 vaccine or any pneumonia vaccine and had not received an influenza vaccine during the 2020-21 influenza season. Eligible participants were randomly assigned (1:1:1), using block randomization stratified, to either: SARS-CoV-2 vaccine and IIV4 followed by SARS-CoV-2 vaccine and PPV23 (SARS-CoV-2 + IIV4/PPV23 group); two doses of SARS-CoV-2 vaccine (SARS-CoV-2 vaccine group); or IIV4 followed by PPV23 (IIV4/PPV23 group). Vaccines were administered 28 days apart, with blood samples taken on day 0 and day 28 before vaccination, and on day 56.

Results: Between March 10 and March 15, 2021, 1152 participants were recruited and randomly assigned to three groups (384 per group). 1132 participants were included in the per-protocol population (375 in the SARS-CoV-2 + IIV4/PPV23 group, 380 in the SARS-CoV-2 vaccine group, and 377 in the IIV4/PPV23 group). The seroconversion rate (100 % vs 100 %) and GMT (159.13 vs 173.20; GMT ratio of 0.92 [95 % CI 0.83 to 1.02]) of SARS-CoV-2 neutralising antibodies in the SARS-CoV-2 + IIV4/PPV23 group was not inferior to those in the SARS-CoV-2 vaccine group. The SARS-CoV-2 + IIV4/PPV23 group was not inferior to the IIV4/PPV23 group in terms of seroconversion rates and GMT of influenza virus antibodies for all strains except for the seroconversion rate for the B/Yamagata strain. The SARS-CoV-2 + IIV4/PPV23 group was not inferior to the IIV4/PPV23 group regarding seroconversion rates and GMC of Streptococcus pneumoniae IgG antibodies specific to all serotypes. All vaccines were well tolerated.

Conclusions: The coadministration of the inactivated SARS-CoV-2 vaccine and IIV4/PPV23 is safe with satisfactory immunogenicity. This study is registered with ClinicalTrials.gov, NCT04790851.
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http://dx.doi.org/10.1016/j.vaccine.2022.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334936PMC
July 2022

Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy.

Front Neurol 2022 19;13:948599. Epub 2022 Jul 19.

Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Cognitive impairment and neuropsychiatric disorders are very common in patients with temporal lobe epilepsy (TLE). These comorbidities complicate the treatment of epilepsy and seriously affect the quality of life. So far, there is still no effective intervention to prevent the development of epilepsy-associated comorbidities. Gut dysbiosis has been recognized to be involved in the pathology of epilepsy development. Modulating gut microbiota by probiotics has shown an antiseizure effect on humans and animals with epilepsy. Whether this treatment strategy has a positive effect on epilepsy-associated comorbidities remains unclear. Therefore, this study aimed to objectively assess the effect of probiotics on cognitive function and neuropsychiatric performance of patients with TLE. Participants enrolled in an epilepsy clinic were randomly assigned to the probiotic and placebo groups. These two groups were treated with probiotics or placebo for 12 weeks, and then the cognitive function and psychological performance of participants were assessed. We enrolled 76 participants in this study, and 70 subjects were finally included in the study (35 in the probiotics group and 35 in the placebo group). Our results showed significant seizure reduction in patients with TLE treated with probiotics. No significant differences were observed on cognitive function (including intelligence and memory) between groups. For neuropsychiatric performances, supplementation of probiotics significantly decreased the Hamilton Anxiety Rating and Depression Scale scores and increased the 89-item Quality of Life in Epilepsy Inventory score in patients with TLE. In conclusion, probiotics have a positive impact on seizures control, and improve anxiety, depression, and quality of life in patients with TLE.
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http://dx.doi.org/10.3389/fneur.2022.948599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343833PMC
July 2022

Virome of Giant Panda-Infesting Ticks Reveals Novel Bunyaviruses and Other Viruses That Are Genetically Close to Those from Giant Pandas.

Microbiol Spectr 2022 Aug 2:e0203422. Epub 2022 Aug 2.

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.

Tick infestations have been reported as one of the factors threatening the health of giant pandas, but studies of viral pathogens carried by ticks feeding on the blood of giant pandas are limited. To assess whether blood-sucking ticks of giant pandas can carry viral pathogens and if so, whether the viruses in ticks are associated with those previously detected in giant panda hosts, we determined the viromes of ticks detached from giant pandas in a field stocking area in Sichuan Province, southwest China. Using viral metagenomics we identified 32 viral species in ticks, half of which (including anellovirus [ = 9], circovirus [ = 3], and gemycircularvirus [ = 4]) showed homology to viruses carried by giant pandas and their associated host species (such as red pandas and mosquitoes) in the same living domain. Remarkably, several viruses in this study phylogenetically assigned as bunyavirus, hepe-like virus, and circovirus were detected with relatively high abundance, but whether these newly identified tick-associated viruses can replicate in ticks and then transmit to host animals during a blood meal will require further investigation. These findings further expand our understanding of the role of giant panda-infesting ticks in the local ecosystem, especially related to viral acquisition and transmission, and lay a foundation to assess the risk for giant panda exposure to tick-borne viruses. Ticks rank only second to mosquitoes as blood-feeding arthropods, capable of spreading pathogens (including viruses, bacteria, and parasites) to hosts during a blood meal. To better understand the relationship between viruses carried by ticks and viruses that have been reported in giant pandas, it is necessary to analyze the viromes of giant panda-parasitic blood-sucking ticks. This study collected 421 ticks on the body surface of giant pandas in Sichuan Province, China. We characterized the extensive genetic diversity of viruses harbored by these ticks and reported frequent communication of viruses between giant pandas and their ticks. While most of the virome discovered here are nonpathogenic viruses from giant pandas and potentially tick-specific viruses, we revealed some possible tick-borne viruses, represented by novel bunyaviruses. This research contributes to the literature because currently there are few studies on the virome of giant panda-infesting ticks.
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http://dx.doi.org/10.1128/spectrum.02034-22DOI Listing
August 2022

A straightforward plant prime editing system enabled highly efficient precise editing of rice Waxy gene.

Plant Sci 2022 Jul 26:111400. Epub 2022 Jul 26.

Beidahuang Kenfeng Seed, 380 Changjiang Road, Nangang District, Harbin, Heilongjiang, P. R. China.

CRISPR Cas9-mediated genome editing is highly efficient at targeted site-specific gene knock-out through NHEJ (Non-Homology End Joining), but ineffective for specific DNA integration through HDR (Homology Directed Repair) for precise gene editing. Base editors can make limited base substitutions but only within restricted small windows of the protospacer. Prime editing has been applied in plants with various degrees of success. However, several questions such as low and inconsistent editing efficiencies across different target sites need to be addressed. We compared two prime editing approaches PE3 and PE2 at two neighboring target sites within rice Waxy gene to partially address those questions. A straightforward PE2 plant prime editing system retrofitted from a regular CRISPR-Cas9 editing system can deliver highly efficient up to 66.7% precise gene editing. Various forms of precise editing including base substitutions, small deletions and insertions can be accurately achieved. The secondary structure variations of different pegRNAs may be the primary reason for inconsistent editing across different target sites and should be the optimization focus to further improve plant prime editing.
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http://dx.doi.org/10.1016/j.plantsci.2022.111400DOI Listing
July 2022

Diagnostic and prognostic value of microRNA-486 in patients with lung cancer: A systematic review and meta-analysis.

Int J Biol Markers 2022 Jul 28:3936155221115750. Epub 2022 Jul 28.

Medical Oncology Department of Thoracic Cancer (2), 74665Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, People's Republic of China.

Purpose: There are conflicting opinions on whether miR-486 could be used for cancer diagnosis and prognosis. Therefore, this present study investigated the potential effect of miR-486 on lung cancer diagnosis and prognosis.

Methods: We researched PubMed, Embase, Wanfang and Chinese National Knowledge Infrastructure databases to select relevant publications. Specificity and sensitivity were obtained for the pooled and subgroup diagnostic meta-analysis while the hazard ratio was for prognostic meta-analysis. Publication analyses and sensitivity analyses were conducted to investigate possible sources of heterogeneity.

Results: The overall sensitivity and specificity with 95% confidence intervals were 0.8 (0.8-0.9) and 0.9 (0.9-0.9). Results of subgroup analysis showed that high diagnostic efficacy might be obtained by miR-486 combined with other microRNAs (area under the curve (AUC): 0.9 (0.9-1.0)) to distinguish lung cancer patients from healthy controls (AUC: 1.0 (0.9-1.0)), especially for lung adenocarcinoma (AUC: 1.0 (1.0-1.0)) in the Asian population (AUC: 0.9 (0.9-1.0)). For prognosis prediction of miR-486 in overall non-small cell lung cancer, the overall hazard ratio with 95% confidence interval was 1.15 (0.85-1.54) for high versus low expression of miR-486, which indicated that a high miR-486 level was not related to the high risk of poor outcome. However, for the subgroup of progression-free survival and patients with chemotherapy, the hazard ratio was 0.41 (0.21-0.77), indicating that the higher miR-486 level would decrease the risk of poor progression-free survival for lung cancer patients with chemotherapy.

Conclusion: This study suggested circulating miR-486 combined with other microRNAs could be used as ideal biomarkers in early diagnosis and prognosis prediction for lung cancer, especially for lung adenocarcinoma in the Asian population.
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http://dx.doi.org/10.1177/03936155221115750DOI Listing
July 2022

Arene-Ruthenium(II)/Osmium(II) Complexes Potentiate the Anticancer Efficacy of Metformin via Glucose Metabolism Reprogramming.

Angew Chem Int Ed Engl 2022 Jul 28:e202208570. Epub 2022 Jul 28.

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yucai Road, Guilin, 541004, China.

Targeting metabolic reprogramming to treat cancer could increase overall survival and reduce side effects. Here, we put forward a strategy using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming. Complexes 1-6 with oxoglaucine derivatives as ligands were synthesized and their anti-tumor activities were tested under hypoglycemia. Results indicated that 2 and 5 potentiated the anticancer effects of Met. under hypoglycemia, exhibiting lower toxicity, slower blood glucose decline and inhibition of early tumor liver metastasis. Combination of 5 with Met. could be used as a new strategy to treat cancer under hypoglycemia through glucose metabolism reprogramming.
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http://dx.doi.org/10.1002/anie.202208570DOI Listing
July 2022

Direct Construction of Isomeric Benzobisoxazole-Vinylene-Linked Covalent Organic Frameworks with Distinct Photocatalytic Properties.

J Am Chem Soc 2022 Aug 25;144(30):13953-13960. Epub 2022 Jul 25.

Key Laboratory of Marine Materials and Related Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.

Vinylene/olefin-linked two-dimensional covalent organic frameworks (v-2D-COFs) have emerged as advanced semiconducting materials with excellent in-plane conjugation, high chemical stabilities, and precisely tunable electronic structures. Exploring new linkage chemistry for the reticular construction of v-2D-COFs remains in infancy and challenging. Herein, we present a solid-state benzobisoxazole-mediated aldol polycondensation reaction for the construction of two novel isomeric benzobisoxazole-bridged v-2D-COFs (v-2D-COF-NO1 and v-2D-COF-NO2) with and configurations of benzobisoxazole. Interestingly, the isomeric benzobisoxazole linkers endow the two v-2D-COFs with distinct optoelectronic and electrochemical properties, ranging from light absorption and emission to charge-transfer properties. When employed as the photocathode, v-2D-COF-NO1 exhibits a photocurrent of up to ∼18 μA/cm under AM 1.5G irradiation at -0.3 V vs reversible hydrogen electrode (RHE), which is twice the value of v-2D-COF-NO2 (∼9.1 μA/cm). With Pt as a cocatalyst, v-2D-COF-NO1 demonstrates a photocatalytic hydrogen evolution rate of ∼1.97 mmol h g, also in clear contrast to that of v-2D-COF-NO2 (∼0.86 mmol h g) under identical conditions. This work demonstrates the synthesis of v-2D-COFs via benzobisoxazole-mediated aldol polycondensation with isomeric structures and distinct photocatalytic properties.
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http://dx.doi.org/10.1021/jacs.2c06042DOI Listing
August 2022

Thermal Enhancement of Luminescence for Negative Thermal Expansion in Molecular Materials.

J Am Chem Soc 2022 Aug 25;144(30):13688-13695. Epub 2022 Jul 25.

Beijing Advanced Innovation Center for Materials Genome Engineering, Institute of Solid State Chemistry, University of Science and Technology Beijing, Beijing 100083, China.

Overcoming thermal quenching is an essential issue in the practical application of luminescent materials. Herein, we found that negative thermal expansion (NTE) can achieve the thermal enhancement of luminescence in molecular materials based on three metal-organic frameworks CuX-bpy (X = Cl, Br, I; bpy = 4,4'-bipyridine). All complexes exhibit NTE on the -axis, and the strongest NTE leads to a contraction of the Cu...Cu distance in CuCl-bpy, which further intensifies the luminescence emission. This phenomenon indicates the existence of thermally enhanced charge transfer. Moreover, the origin of the distinction in charge transfer attributed to the different valence states of the copper is investigated through the combined studies of X-ray photoelectron spectroscopy, X-ray absorption near-edge structure, and density functional theory calculations. This research provides a new approach to modulating the luminescence thermal enhancement by NTE.
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http://dx.doi.org/10.1021/jacs.2c04316DOI Listing
August 2022

Rational coordination regulation in carbon-based single-metal-atom catalysts for electrocatalytic oxygen reduction reaction.

Nano Converg 2022 Jul 22;9(1):34. Epub 2022 Jul 22.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 117585, Singapore, Singapore.

Single-metal-atom catalysts (SMACs) have garnered extensive attention for various electrocatalytic applications, owing to their maximum atom-utilization efficiency, tunable electronic structure, and remarkable catalytic performance. In particular, carbon-based SMACs exhibit optimal electrocatalytic activity for the oxygen reduction reaction (ORR) which is of paramount importance for several sustainable energy conversion and generation technologies, such as fuel cells and metal-air batteries. Despite continuous endeavors in developing various advanced carbon-based SMACs for electrocatalytic ORR, the rational regulation of coordination structure and thus the electronic structure of carbon-based SMACs remains challenging. In this review, we critically examine the role of coordination structure, including local coordination structure (i.e., metal atomic centers and the first coordination shell) and extended local coordination structure (i.e., the second and higher coordination shells), on the rational design of carbon-based SMACs for high-efficiency electrocatalytic ORR. Insights into the relevance between coordination structures and their intrinsic ORR activities are emphatically exemplified and discussed. Finally, we also propose the major challenges and future perspectives in the rational design of advanced carbon-based SMACs for electrocatalytic ORR. This review aims to emphasize the significance of coordination structure and deepen the insightful understanding of structure-performance relationships.
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http://dx.doi.org/10.1186/s40580-022-00324-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307705PMC
July 2022

Recent advancements in noninvasive glucose monitoring and closed-loop management systems for diabetes.

J Mater Chem B 2022 Jul 27;10(29):5537-5555. Epub 2022 Jul 27.

Institute of Biopharmaceutical and Healthcare Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.

Diabetes can cause many complications, and has become one of the most common diseases that may lead to death. Currently, the number of diabetics continues to increase year by year. Thus, it is very important and highly desirable to monitor, control and cure diabetes. However, such management usually require long-term blood glucose monitoring and regular medication to reduce the risk of many complications. In order to provide patients with more effective and more convenient treatments, a portable, miniaturized, intelligent, painless and automatic closed-loop system is highly required and many related research studies have recently been reported. It is the right time and important to provide a summary in this field. Here, this review covers important parts of a closed-loop management system for diabetes, including the principle of electrochemical sensing of glucose, recent progress of noninvasive glucose monitoring technology, and its applications in wearable glucose sensors. Moreover, the latest advancements in an insulin delivery system and a diabetic closed-loop management system are also presented in detail. Finally, challenges and perspectives for an artificial pancreas are also presented. We believe that with the innovative glucose monitoring technology and the optimization of the drug delivery system, the closed-loop management system for diabetes will make much progress in the near future.
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http://dx.doi.org/10.1039/d2tb00749eDOI Listing
July 2022

Chemical constituents of the stem of and their bioactivities.

Nat Prod Res 2022 Jul 12:1-8. Epub 2022 Jul 12.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.

Phytochemical investigation of (Annonaceae) led to the isolation of a new phenylpropanoid glycoside, lyciumphenylpropanoid B (), along with nine known compounds (-) from an aqueous methanolic extract of the stem. Most compounds are reported from this genus for the first time. The structures of the isolated compounds were elucidated using spectroscopic methods including NMR spectroscopy, high-resolution mass spectrometry, and quantum chemical electronic circular dichroism (ECD) calculations. Cytotoxic and antitubercular activities of several isolated compounds were evaluated. Dipyrithione () displayed anti-mycobacterial (MIC = 0.23 μM) and cytotoxic (IC = 0.8 μM in Hep G2 cells; 4.1 μM in HCT 116 cells) activities. Kelampayoside A () showed moderate cytotoxic activity against cancer cells.
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http://dx.doi.org/10.1080/14786419.2022.2097229DOI Listing
July 2022

Effects of Acute Hypoxic Stress on Physiological and Hepatic Metabolic Responses of Triploid Rainbow Trout ().

Front Physiol 2022 24;13:921709. Epub 2022 Jun 24.

State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, China.

This experiment simulated the hypoxic environment caused by actual production operations in fish farming (i.e., catching, gathering, transferring, and weighting) to study the effects of acute hypoxic conditions on the physiological and metabolic responses of triploid rainbow trout (). Two groups of fish weighting 590 g were sampled in the normoxia group (dissolved oxygen above 7 mg/L) and hypoxia group (dissolved oxygen ranged from 2 to 5 mg/L for 10 min). The results showed that 1) regarding stress response, hypoxia increased plasma levels of cortisol, heat shock protein 70 (HSP-70), lysozyme, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatine phosphokinase (CPK); induced the expression of hepatic genes encoding nuclear factor erythroid 2 related factor 2 (), interferon () and interleukin-1β (). 2) Regarding metabolism response, hypoxia increased plasma levels of globulin (GLOB), glucose (GLU), triglyceride (TG) and lactate dehydrogenase (LDH); upregulated the hepatic gene expression of phosphoenolpyruvate carboxykinase, (), pyruvate dehydrogenase kinase (), acetyl-CoA carboxylase () and acetyl-CoA oxidase (); downregulated the hepatic gene expression of carnitine palmitoyl transferase 1 (); and unchanged the expression of hepatic genes in glycolysis and autophagy. 3) In response to hypoxia-inducible factors (HIFs), the hepatic gene was activated in the hypoxia group, but gene expression remained unchanged. Thus, during acute hypoxic stress, triploid rainbow trout were in a defensive state, with an enhanced immune response and altered antioxidant status. Additionally, the hepatic mitochondrial oxidation of glucose- and lipid-derived carbon in trout was suppressed, and hepatic gluconeogenesis and lipid synthesis were activated, which might be regulated by the HIF-2α pathway.
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http://dx.doi.org/10.3389/fphys.2022.921709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263268PMC
June 2022

Different soil particle size changes the N retention in soil and N utilization by maize.

Sci Total Environ 2022 Jul 2;843:157133. Epub 2022 Jul 2.

College of Resource and Environmental Science, Jilin Agricultural University, Changchun, Jilin Province 130118, China.

Improving soil structure is key to improving soil quality and nitrogen utilization efficiency (NUE) in global cropping systems. Soil sieving is a direct means of dividing soil activity into components with different practical functional significance. In order to have a more intuitive understanding of nutrient turnover and NUE under different soil particle sizes, we identified the key soil particle sizes that affect N cycling in cropping systems. An in-situ field experiment was conducted in Mollisol for three years using the N isotope tracer technique to examine the effect of soil structure on maize growth, nutrient uptake, and NUE. We artificially destructed the soil structure by sieving it into four particle size classes: (i) unsieved soil (CK), (ii) <0.5 mm size (A), (iii) 0.5-2 mm size (B), and (iv) 2-5 mm size (C). Then each year, the physical properties of the soil, N loss and retention rate (NRR), the NUE, N absorption, and distribution, as well as maize growth and yield, were measured. The results showed that the 0.5-2 mm size (B) and 2-5 mm size (C) improved soil physical properties and increased the uptake of N by maize (especially in the leaves and grains), thereby increasing maize yield. The B and C particle sizes had lower soil NRR and higher alkaline hydrolysable N content than the other treatments in the depth. We concluded that the B sieving treatment is the key aggregate fraction to increasing maize NUE and yield and minimizing the negative effects on soil N retention capacity. Furthermore, the B treatment is key to affecting crop nutrient absorption and utilization.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157133DOI Listing
July 2022

Silver nanoparticles exposure induces developmental neurotoxicity in hiPSC-derived cerebral organoids.

Sci Total Environ 2022 Jun 30;845:157047. Epub 2022 Jun 30.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China; National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. Electronic address:

Silver nanoparticles (AgNPs) are used in various research fields. Although the neurotoxicity of AgNPs has been explored in animal models and 2D cell-culture models, including human stem cells, these models cannot accurately mimic the development of the human brain. Therefore, the potential mechanisms of AgNPs-induced developmental neurotoxicity in humans are still largely unclear. In this study, cerebral organoids derived from induced pluripotent stem cells were treated with 0.1 μg/mL or 0.5 μg/mL AgNPs for 7 days. At the low concentration (0.1 μg/mL), AgNPs increased the cell proliferation and inhibited the neural apoptosis in the organoids, but impaired the cilium assembly and elongation, which may perturb the cell cycle and induce abnormal cerebral-organoid growth. Conversely, at the high concentration (0.5 μg/mL), AgNPs significantly inhibited cell proliferation and induced apoptosis in cerebral organoids. High-concentration AgNPs reduced the expression and co-localization of the cytoskeleton proteins F-actin, myosin, and tubulin, thereby perturbing neurite growth. In conclusion, AgNPs exposure induces developmental neurotoxic effects in cerebral organoids and is thus a potential congenital risk factor.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157047DOI Listing
June 2022

Synergistic optimization of syngas quality and heavy metal immobilization during continuous microwave pyrolysis of sludge: Competitive relationships, reaction mechanisms, and energy efficiency assessment.

J Hazard Mater 2022 Jun 26;438:129451. Epub 2022 Jun 26.

College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China.

To realize the efficient resource utilization of sewage sludge, this work explored the competitive relationship and reaction mechanisms between syngas quality optimization and heavy metals (HMs) immobilization. The results showed that continuous microwave pyrolysis (CMP) technology with an instantaneous temperature increase could shorten the pyrolysis time, and the biogas yield and syngas concentration reached 51.68 wt% and 83.6 vol%, respectively. Although a higher pyrolysis (750 °C) temperature could optimize the syngas quality, the HMs immobilization efficiency was reduced due to the deep pyrolysis of the biochar. The moderate pyrolysis temperature (650 °C) facilitated the rapid formation of biochar with abundant surface functional groups and pore structure, thus enhancing HMs immobilization. Furthermore, the HMs could also form more stable crystalline compounds with inorganic components (SiO, AlO, inorganic sulfur). By optimizing the process parameters, the risk factor of HMs in the sludge decreased from 117.36 to 62.5 while obtaining high-quality syngas. The energy utilization efficiency of microwave pyrolysis also increased significantly from 11.20% to 82.01%. This work provided new insight into the efficient resource utilization and environmentally friendly treatment of sludge, and demonstrated that CMP technology has significant potential for future industrial applications as an alternative to traditional pyrolysis.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129451DOI Listing
June 2022

Catalytic oxidative dehydrogenation of N-heterocycles with nitrogen/phosphorus co-doped porous carbon materials.

Chem Sci 2022 Jun 17;13(23):6865-6872. Epub 2022 May 17.

Leibniz-Institute for Catalysis Albert-Einstein-Straße 29a Rostock 18059 Germany

A metal-free oxidative dehydrogenation of N-heterocycles utilizing a nitrogen/phosphorus co-doped porous carbon (NPCH) catalyst is reported. The optimal material is robust against traditional poisoning agents and shows high antioxidant resistance. It exhibits good catalytic performance for the synthesis of various quinoline, indole, isoquinoline, and quinoxaline 'on-water' under air atmosphere. The active sites in the NPCH catalyst are proposed to be phosphorus and nitrogen centers within the porous carbon network.
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http://dx.doi.org/10.1039/d2sc01838aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200114PMC
June 2022

Aptamer-based biosensing through the mapping of encoding upconversion nanoparticles for sensitive CEA detection.

Analyst 2022 Jul 12;147(14):3350-3359. Epub 2022 Jul 12.

Institute of Biopharmaceutical and Healthcare Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.

A sensitive detection system based on aptamer-based biosensors for the detection of carcinoembryonic antigen (CEA) by mapping encoding upconversion nanoparticles (UCNPs) was constructed. In this sensor, oligonucleotides with CEA aptamer fragments immobilized on magnetic beads (MBs) were hybridized to complementary DNA modified on UCNPs (cDNA-UCNPs); thus, sandwich-structured probes were formed. In the presence of CEA, due to the stronger interaction between the aptamer and CEA than that of the aptamer and complementary DNA on UCNPs, the cDNA-UCNPs were isolated from the MBs, and the number of isolated UCNPs was directly related to the concentration of CEA. Using an inverted fluorescence microscope, the number of target-dependent UCNPs on a glass slide was counted, enabling the accurate determination of CEA in the solution. The dynamic range for CEA detection in PBS buffer was 0.02-6.0 ng mL (0.1-30 pM) and a limit of detection (LOD) of 65 fM was achieved. We envisage that the system we developed can also have many promising applications in the sensitive detection of other biomarkers for early cancer diagnosis.
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http://dx.doi.org/10.1039/d2an00669cDOI Listing
July 2022

Investigation of Statin Medication Use in Elderly Patients with Cardiovascular Disease on Regular Physical Examination and the Relationship with Glucolipid Metabolism and Adverse Cardiovascular Prognosis.

Dis Markers 2022 16;2022:8714392. Epub 2022 Jun 16.

Department of Gastroenterology, The 305th Hospital of the PLA, Beijing, China.

Our purpose of this study was to investigate the use of statins in elderly patients with cardiovascular diseases during regular physical examination and to analyze the relationship between statins and glucose and lipid metabolism and adverse cardiovascular prognosis. From January 2019 to December 2021, 2121 elderly patients with cardiovascular disease underwent regular physical examination as the study subjects to investigate the use and intensity of statins. The patients were divided into the dosing group ( = 1848) and the nondosing group ( = 273) according to whether they were taking statins or not. The cardiac function, glucose and lipid metabolism indexes, and cardiovascular adverse events were compared between the two groups. Statin use in elderly patients with cardiovascular disease was 87.13% (1848/2121). The intensity of statin use decreased with age ( < 0.05); the left ventricular ejection fraction (LVEF) was greater in the medicated group than in the nonmedicated group, and the left ventricular end-diastolic internal diameter (LVDd) and left ventricular end-systolic internal diameter (LVDs) were smaller than in the nonmedicated group ( < 0.05). The total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose (FBG) levels were lower in the medicated group than in the nonmedicated group, the high-density lipoprotein cholesterol (HDL-C) levels were higher than in the nonmedicated group, and the glycated hemoglobin (HbA1c) values were lower than in the nonmedicated group ( < 0.05). The overall incidence of cardiovascular adverse events in the medicated group was lower than that in the nonmedicated group ( < 0.05). Statin use was higher in elderly patients with cardiovascular disease; the intensity of drug use decreased with age. The patients' cardiac function, glucose metabolism, and prognosis were significantly improved after statin treatment.
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http://dx.doi.org/10.1155/2022/8714392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225898PMC
June 2022

Effects of Total Flavonoids of Epimedium on Bone Marrow Adipose Tissue in Ovariectomized Rats.

Front Endocrinol (Lausanne) 2022 6;13:900816. Epub 2022 Jun 6.

Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Bone marrow adipose tissue has brown fat characteristics. Several studies have demonstrated that total flavonoids of Epimedium (TFE) could prevent bone loss and reduce the white adiposity in bone marrow induced by ovariectomy (OVX) in rats. However, the effects of TFE on marrow brown fat in OVX rats remain unclear. In this word, we addressed this question expected to provide a new target for preventing and treating osteoporosis. Thirty-six 3-month-old female Sprague-Dawley rats were equally divided into Sham controls, OVX controls, and OVX treated with TFE. Chemical shift coding magnetic resonance was performed to detect marrow fat fraction at the left femur at baseline, 6 and 12 weeks post-OVX. Bone mineral density at the lumbar spine and femur was measured by dual-energy x-ray absorptiometry. Serum bone biomarkers by ELISA, trabecular bone microarchitecture at the proximal tibia by micro-CT, quantitative parameters of marrow adipocyte by hematoxylin, and eosin staining were evaluated. The marrow adipocyte gene and protein expressions profile were determined by real-time quantitative PCR and immunostaining in whole tibiae. We found that TFE treatment could decrease bone turnover rate and improved bone mineral density and trabecular microarchitecture in OVX rats. OVX resulted in marrow adipogenesis as evidenced by increased marrow fat fraction, larger marrow adipocyte size, increased adipocyte number and percentage of adipocyte area, marrow white adipocyte gene, and protein expression, including PPARγ2 and FABP4. These pathological changes induced by estrogen deficiency were restored by TFE treatment. TFE also increased brown adipocyte expressions of the transcription factor Ucp1 and Prdm16 in whole tibiae. There was no detectible protein expression of brown adipocyte markers in the proximal tibia. Taken together, TFE regulation of bone marrow adiposity in OVX rats is mediated, at least in part, maintaining the reciprocity of white and brown adipose tissue.
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http://dx.doi.org/10.3389/fendo.2022.900816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207204PMC
June 2022

Genome-Wide Transcriptome Analysis in Type 2 Diabetes Patients Treated by Sitagliptin.

Diabetes Metab Syndr Obes 2022 9;15:1761-1770. Epub 2022 Jun 9.

Department of Endocrinology, People's Hospital of Shenzhen Baoan District, Shenzhen, Guangdong, 518101, People's Republic of China.

Objective: In this study, transcriptome sequencing was performed on patients with type 2 diabetes mellitus treated with different prognosis to explore the differential level genes of different hypoglycemic effects of sitagliptin.

Methods: Patients with newly diagnosed T2DM (within six months of diagnosis) were selected as the study subjects. Patients were given sitagliptin 100 mg once a day orally. After 12 weeks of regular drug therapy, the reduction in glycated hemoglobin was compared before and after drug administration. The patients were then divided into two groups: the significantly effective group (M) and the less effective group (N). High-throughput sequencing of the transcriptome was conducted to detect the differential expression levels of genes in peripheral blood mononuclear cells. Expanded sample size validation of the candidate differential genes was conducted using reverse transcription-polymerase chain reaction (RT-PCR).

Results: After 12 weeks of treatment with sitagliptin, high-throughput sequencing of the transcriptome found that expression of the following genes was different when comparing the significantly effective group (M) and the less effective group (N): ghrelin (), insulin-like growth factor-1 receptor (), mitogen-activated protein kinase-3 (), phosphatidylinositol-4,5-bisphosphonate 3-kinase, catalytic subunit delta (), and the suppressor of cytokine signaling-3 (). The validation results of RT-PCR showed that, in the significantly effective group (M), the expression of IGF1R was significantly increased ( = 0.034), the expression of was significantly reduced ( = 0.002), and the expression of was also significantly reduced ( < 0.001).

Conclusion: There was a significant difference in gene level between patients with significant hypoglycemic effect and patients with poor hypoglycemic effect, and the expression of IGF1R increased and the expression of MAPK3 and SOCS3 decreased.
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http://dx.doi.org/10.2147/DMSO.S334144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191836PMC
June 2022

Publisher Correction: ILC1s control leukemia stem cell fate and limit development of AML.

Nat Immunol 2022 Aug;23(8):1286

Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41590-022-01265-4DOI Listing
August 2022

-Related Epilepsy: Novel Mutations and Rare Phenotypes.

Front Mol Neurosci 2022 19;15:826183. Epub 2022 May 19.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objectives: To expand the genotypes and phenotypes of sodium voltage-gated channel alpha subunit 1 (SCN1A)-related epilepsy.

Methods: We retrospectively collected the clinical and genetic information of 22 epilepsy patients (10 males, 12 females; mean: 9.2 ± 3.9 years; 3.9-20.3 years) carrying 22 variants of SCN1A. SCN1A mutations were identified by next-generation sequencing.

Results: Twenty-two variants were identified, among which 12 have not yet been reported. The median age at seizure onset was 6 months. Sixteen patients were diagnosed with Dravet syndrome (DS), two with genetic epilepsy with febrile seizures plus [one evolved into benign epilepsy with centrotemporal spikes (BECTS)], one with focal epilepsy, one with atypical childhood epilepsy with centrotemporal spikes (ABECTS) and two with unclassified epilepsy. Fourteen patients showed a global developmental delay/intellectual disability (GDD/ID). Slow background activities were observed in one patient and epileptiform discharges were observed in 11 patients during the interictal phase.

Significance: This study enriches the genotypes and phenotypes of SCN1A-related epilepsy. The clinical characteristics of patients with 12 previously unreported variants were described.
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http://dx.doi.org/10.3389/fnmol.2022.826183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162153PMC
May 2022

Efficacy and Safety of Limertinib (ASK120067) in Patients With Locally Advanced or Metastatic EGFR Thr790Met-Mutated NSCLC: A Multicenter, Single-Arm, Phase 2b Study.

J Thorac Oncol 2022 Jun 2. Epub 2022 Jun 2.

Oncology Department, Yueyang Central hospital, Yueyang, People's Republic of China.

Introduction: Limertinib (ASK120067) is a newly developed third-generation EGFR tyrosine kinase inhibitor targeting both sensitizing EGFR and EGFR Thr790Met (T790M) mutations. This study aimed to evaluate the efficacy and safety of limertinib in patients with locally advanced or metastatic EGFR T790M-mutated NSCLC.

Methods: This is a single-arm, open-label, phase 2b study conducted at 62 hospitals across the People's Republic of China. Patients with locally advanced or metastatic NSCLC with centrally confirmed EGFR T790M mutations in tumor tissue or blood plasma who progressed after first- or second-generation EGFR tyrosine kinase inhibitors or with primary EGFR T790M mutations were enrolled. Patients received limertinib 160 mg orally twice daily until disease progression or unacceptable toxicity. The primary end point was objective response rate (ORR) assessed by independent review committee per the Response Evaluation Criteria in Solid Tumors version 1.1. Secondary end points included disease control rate, progression-free survival (PFS), duration of response (DoR), overall survival, and safety. Safety was assessed according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.03.

Results: From July 16, 2019, to March 10, 2021, a total of 301 patients were enrolled and started the treatment of limertinib. All patients entered the full analysis set and safety set. By the data cutoff date on September 9, 2021, 76 (25.2%) remained on treatment. The median follow-up time was 10.4 months (range: 0.3-26.3). On the basis of full analysis set, the independent review committee-assessed ORR was 68.8% (95% confidence interval [CI]: 63.2%-74.0%) and disease control rate was 92.4% (95% CI: 88.8%-95.1%). The median PFS was 11.0 months (95% CI: 9.7-12.4), median DoR was 11.1 months (95% CI: 9.6-13.8), and median OS was not reached (95% CI 19.7 months-not evaluable). Objective responses were achieved across all prespecified subgroups. For 99 patients (32.9%) with central nervous system (CNS) metastases, the ORR was 64.6% (95% CI: 54.4%-74.0%), median PFS was 9.7 months (95% CI: 5.9-11.6), and median DoR was 9.6 months (95% CI: 8.1-15.2). For 41 patients who had assessable CNS lesion, the confirmed CNS-ORR was 56.1% (95% CI: 39.7%-71.5%) and median CNS-PFS was 10.6 months (95% CI: 5.6-not evaluable). In safety set, 289 patients (96.0%) experienced at least one treatment-related adverse event (TRAE), with the most common being diarrhea (81.7%), anemia (32.6%), rash (29.9%), and anorexia (28.2%). Grade ≥3 TRAEs occurred in 104 patients (34.6%), with the most common including diarrhea (13.0%), hypokalemia (4.3%), anemia (4.0%), and rash (3.3%). TRAEs leading to dose interruption and dose discontinuation occurred in 24.6% and 2% of patients, respectively. No TRAE leading to death occurred.

Conclusions: Limertinib (ASK120067) was found to have promising efficacy and an acceptable safety profile for the treatment of patients with locally advanced or metastatic EGFR T790M-mutated NSCLC.

Clinical Trial Information: NCT03502850.
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http://dx.doi.org/10.1016/j.jtho.2022.05.011DOI Listing
June 2022

Biomarker-Driven Studies With Multi-targets and Multi-drugs by Next-Generation Sequencing for Patients With Non-Small-Cell Lung Cancer: An Open-Label, Multi-center, Phase II Adaptive Umbrella Trial and a Real-World Observational Study (CTONG1702&CTONG1705).

Clin Lung Cancer 2022 May 11. Epub 2022 May 11.

Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address:

Background: With rare genetic variations having been increasingly recognized at a preclinical stage, a variety of early-phase clinical trials have been launched. Due to the low incidence rate of these variations, although the sample size of trials are small, it still needs a large number of patients for screening. With the advent of next-generation sequencing (NGS), multiple genetic variations can be detected simultaneously. Multiple biomarkers and agents can be evaluated using umbrella clinical trials, which rapidly and effectively screen and enroll patients for parallel sub-studies using NGS.

Patients And Methods: We designed an open-label, multi-center, phase II clinical trial CTONG1702. This is an adaptive umbrella trial that will evaluate the efficacy and safety of several biomarker-driven agents, including tyrosine kinase inhibitors (TKIs) and a PD-1 inhibitor, in stage IIIB to IV patients (eighth AJCC) with non-small-cell lung cancer (NSCLC) patients. Patients will be enrolled in parallel sub-studies based on the results of NGS and PD-L1 IHC analysis. Patients who are not eligible for CTONG1702 will be enrolled in the observational real-world study CTONG1705. This study aims to develop a large-scale genomic database and explore the relationship between genetic variations in NSCLC patients and clinical outcomes.

Conclusions: The adaptive umbrella trial will evaluate multi-targets and multi-drugs in advanced NSCLC patients (CTONG1702). In addition, the simultaneously initiated real-world study will provide additional data for clinical practice (CTONG1705).
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http://dx.doi.org/10.1016/j.cllc.2022.05.009DOI Listing
May 2022

Two-Dimensional Negative Thermal Expansion in a Facile and Low-Cost Oxalate-Based Metal-Organic Framework.

Inorg Chem 2022 Jun 2;61(23):8634-8638. Epub 2022 Jun 2.

Beijing Advanced Innovation Center for Materials Genome Engineering, Institute of Solid State Chemistry, University of Science and Technology Beijing, Beijing 100083, China.

Two-dimensional negative thermal expansion (NTE) is achieved in a tetragonal oxalate-based metal-organic framework (MOF), CdZrSr(CO), within a temperature range from 123 to 398 K [space group 4̅2, α = -2.4(7) M K, α = 11.3(3) M K, and α = 6.4(1) M K]. By combining variable-temperature X-ray diffraction, a high-resolution synchrotron X-ray pair distribution function, and thermogravimetry-differential scanning calorimetry, we shows that NTE within the plane derives from the oriented rotation of an oxalate ligand in zigzag chains (-CdO-ox-ZrO-ox-). That is simplified to the Zr atom rotating with an unchanged Zr···Cd distance as the radius, which also gives rise to the deformation of a hingelike connection along the axis and results in its positive thermal expansion. By virtue of the facile and low-cost oxalate ligand, the present NTE MOF may show application prospects in the future.
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http://dx.doi.org/10.1021/acs.inorgchem.2c01320DOI Listing
June 2022

Application of CRISPR/CasΦ2 System for Genome Editing in Plants.

Int J Mol Sci 2022 May 20;23(10). Epub 2022 May 20.

Maize Resources Institute, Jilin Academy of Agricultural Sciences, Gongzhuling 136100, China.

CRISPR/Cas system has developed a new technology to modify target genes. In this study, CasΦ2 is a newly Cas protein that we used for genome modification in Arabidopsis and tobacco. and of marker genes were chosen for targeting. CasΦ2 has the function to cleave pre-crRNA. In the presence of 10 mM Mg irons concentration, sgRNA3 type guided CasΦ2 to edit target gene and generate mutation, and a mutant seedling of gene with an expected male sterile phenotype was obtained. In the process of tobacco transformation, the gene editing activity of CasΦ2 can be activated by 100 nM Mg irons concentration, and sgRNA1 type guided CasΦ2 to edit target gene. Mutant seedlings of gene with an expected albino were obtained. The results indicate that CasΦ2 can effectively edit target genes under the guidance of different sgRNA type in the presence of Mg ions. Together, our results verify that the CRISPR/CasΦ2 system is an effective and precise tool for genome editing in plants.
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http://dx.doi.org/10.3390/ijms23105755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147844PMC
May 2022

2D/1D BiOI/g-CN nanotubes heterostructure for photoelectrochemical overall water splitting.

Sci Total Environ 2022 Sep 23;838(Pt 2):156166. Epub 2022 May 23.

Centre for Technology in Water and Wastewater, School of Civil and Environmental Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia.

To boost the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) performances, the BiOI/graphitic carbon nitride nanotubes (g-CN nanotubes) heterojunction was synthesized herein through the hydrothermal method. BiOI in-situ grew on the surface of g-CN nanotubes derived from melamine. The rapid recombination between photoexcited electrons and holes of pristine semiconductors was prevented via building the stable heterojunction. The SEM results indicated that the BiOI was wrapped around the surface of g-CN nanotubes, resulting in an optimized electronic transmission pathway. Much lower charge transfer resistance at the p-n heterojunction was demonstrated compared with pristine BiOI according to the EIS results, thus leading to the faster surface reaction rates. Moreover, the composite exhibited both outstanding OER and HER activities under illuminated conditions. This study may shed light upon establishing a bifunctional photoelectrocatalysis for photoelectrochemical water splitting based on stable 2D metal and 1D metal-free nanocomposite.
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http://dx.doi.org/10.1016/j.scitotenv.2022.156166DOI Listing
September 2022

Fabrication of a nanocomposite film decorated with highly dispersive nanoparticles by following an interface-induced strategy.

Chem Commun (Camb) 2022 Jun 9;58(47):6753-6756. Epub 2022 Jun 9.

Department of Materials Science and Engineering, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, China.

A polymer nanocomposite film decorated with highly dispersive nanoparticles was prepared by a liquid-liquid interface induced self-assembly method based on a breath figure process. The distribution as well as the orientation preference of the Janus particles within the polymer matrix could be dynamically controlled by adjusting the environmental conditions. Antibacterial and photocatalytic functionality was obtained for the nanocomposite films decorated with silver and titanium dioxide nanoparticles, respectively.
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http://dx.doi.org/10.1039/d2cc01871cDOI Listing
June 2022
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