Publications by authors named "Rui Liu"

3,188 Publications

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The relationship between physical fitness and competitive performance of Taekwondo athletes.

Authors:
Rui Liu Lumin He

PLoS One 2022 24;17(6):e0267711. Epub 2022 Jun 24.

Affiliated Athletics School of Beijing Sport University, Beijing, China.

The competition and physical fitness test results of the 2020 National Taekwondo Championship Series were analyzed using curve fitting, linear regression, and other statistical methods. As far as we know, it is the first Taekwondo competition that uses physical fitness test (PFT) scores as the 8-in-4 selection criteria. The results show that the probability of the final total score of the series of championships entering the top 8 or top 3 is exponentially related to PFT results. It finds that athletes with better PFT scores are more likely to enter the quarterfinals. Among athletes entering the semifinals, the athlete with the best physical fitness has the greatest probability of winning the championship. The difference in physical fitness between athletes is mainly reflected in the 30-meter sprint. Overall, the competitive performance of professional Taekwondo athletes is significantly positively correlated with their physical fitness, especially for female Taekwondo athletes. Through the results obtained, it is concluded that Taekwondo athletes need to strengthen physical training, specifically enhancing the explosive power.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267711PLOS
June 2022

Valorization of Wheat Bran by Three Fungi Solid-State Fermentation: Physicochemical Properties, Antioxidant Activity and Flavor Characteristics.

Foods 2022 Jun 13;11(12). Epub 2022 Jun 13.

China-Russia Agricultural Processing Joint Laboratory, Tianjin Agricultural University, Tianjin 300384, China.

Three medicinal fungi were used to carry out solid-state fermentation (SSF) of wheat bran. The results showed that the use of these fungi for SSF significantly improved wheat bran's nutritional properties including the extraction yield of soluble dietary fiber (SDF), total phenolic content (TPC), total flavonoid content (TFC), physical properties containing swelling capacity (SC) and oil absorption capacity (OAC), as well as antioxidant activities. Electronic nose and GC-MS analyses showed that fermented wheat bran had different volatiles profiles compared to unfermented wheat bran. The results suggest that SSF by medicinal fungi is a promising way for the high-value utilization of wheat bran.
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http://dx.doi.org/10.3390/foods11121722DOI Listing
June 2022

Intelligent Classification of Japonica Rice Growth Duration (GD) Based on CapsNets.

Plants (Basel) 2022 Jun 15;11(12). Epub 2022 Jun 15.

Qiqihar Branch of Heilongjiang Academy of Agricultural Sciences, Qiqihar 161006, China.

Rice cultivation in cold regions of China is mainly distributed in Heilongjiang Province, where the growing season of rice is susceptible to low temperature and cold damage. Choosing and planting rice varieties with suitable GD according to the accumulated temperate zone is an important measure to prevent low temperature and cold damage. However, the traditional identification method of rice GD requires lots of field investigations, which are time consuming and susceptible to environmental interference. Therefore, an efficient, accurate, and intelligent identification method is urgently needed. In response to this problem, we took seven rice varieties suitable for three accumulated temperature zones in Heilongjiang Province as the research objects, and we carried out research on the identification of japonica rice GD based on Raman spectroscopy and capsule neural networks (CapsNets). The data preprocessing stage used a variety of methods (signal.filtfilt, difference, segmentation, and superposition) to process Raman spectral data to complete the fusion of local features and global features and data dimension transformation. A CapsNets containing three neuron layers (one convolutional layer and two capsule layers) and a dynamic routing protocol was constructed and implemented in Python. After training 160 epochs on the CapsNets, the model achieved 89% and 93% accuracy on the training and test datasets, respectively. The results showed that Raman spectroscopy combined with CapsNets can provide an efficient and accurate intelligent identification method for the classification and identification of rice GD in Heilongjiang Province.
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http://dx.doi.org/10.3390/plants11121573DOI Listing
June 2022

Standard-free single magnetic bead evaluation: a stable nanoplatform for prostate disease differentiation.

Chem Sci 2022 Jun 29;13(21):6270-6275. Epub 2022 Apr 29.

Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University Chengdu 610064 PR China

Explicit interpretation of heterogeneity between prostate-specific antigen (PSA) subtypes is essential for prostate cancer differentiation during different disease courses, whereas a universal protocol with uniform criteria is still lacking across the globe. In this work, a standard-free single magnetic bead (SMB) nanoplatform utilizing metal nanoparticles with optimal diameters was proposed for prostate disease differentiation in a 134-donor model. The inaccuracy of detection in absolute quantification was diminished evaluations of metal intensities on the single magnetic bead. The intrinsic proportion of fPSA in tPSA was successfully evaluated by direct use of the Pt to Au intensity ratio (Pt/Au ratio), exhibiting better differentiation between healthy and unhealthy, benign prostatic hyperplasia (BPH) and cancer individuals compared with solo fPSA or tPSA. We generated thresholds respectively for prostate disease differentiation, envisioning that this standard-free SMB nanoplatform would establish a standardized methodology with uniform criteria worldwide in cancer diagnosis, staging, and postoperative assessments.
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http://dx.doi.org/10.1039/d2sc00928eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159090PMC
June 2022

AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway.

Oxid Med Cell Longev 2022 13;2022:8091464. Epub 2022 Jun 13.

School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Radiotherapy has been used for decades in the treatment of liver cancer. We previously found that adiponectin receptor (AdipoR1) is a prognostic biomarker for hepatoma carcinoma (HCC) after stereotactic body radiation therapy (SBRT) and blocking AdipoR1 enhances radiation sensitivity in hepatoma carcinoma cells. In the current study, we aimed to elucidate the roles of AdipoR1 in ionizing radiation- (IR-) induced radiosensitivity by activating ferroptosis pathway in HCC cells. We found that IR upregulated the expression of AdipoR1 and furthermore promoted the protein stability of transcription factor Nrf2, Nrf2 binded to the xCT promoter and increased xCT transcription and expression, and this directly contributed to the protective function in the early stage of radiation in HCC cells. AdipoR1 knockdown significantly inhibited expression of Nrf2 and xCT and, furthermore, increased both IR- and erastin-induced ferroptosis, which could be abolished by the rescue of Nrf2 and xCT. For the first time, we found that radiation-induced ferroptosis was mediated by AdipoR1-Nrf2-xCT pathway in HCC cells. These results provide new insights to the development and application of novel therapeutic strategies for hepatoma carcinoma.
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http://dx.doi.org/10.1155/2022/8091464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208988PMC
June 2022

The "Hand as Foot" teaching method in explaining O-type Congenital Vascular Ring.

Asian J Surg 2022 Jun 15. Epub 2022 Jun 15.

Department of Orthopedics, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Inner Mongolia, 010050, China.

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http://dx.doi.org/10.1016/j.asjsur.2022.05.098DOI Listing
June 2022

Hippo pathway monomerizes STAT3 to regulate prostate cancer growth.

Cancer Sci 2022 Jun 20. Epub 2022 Jun 20.

Department of Urology, Xindu district People's hospital of Chengdu, Chengdu, 610500, China.

Prostate cancer ranks among the most commonly diagnosed malignancies for men, and has become a non-negligible threat for public health. Interplay between inflammatory factors and cancer cells renders inflammatory tissue environment as a predisposing condition for cancer development. The Hippo pathway is a conserved signaling pathway across multiple species during evolution that regulates tissue homeostasis and organ development. Nevertheless, whether Hippo pathway regulates cancer-related inflammatory factors remain elusive. Here we show that high cell density-mediated activation of Hippo pathway blunts STAT3 activity in prostate cancer cells. Hippo pathway component MST2 kinase phosphorylates STAT3 at T622, which is located in the SH2 domain of STAT3. This phosphorylation blocks SH2 domain in one STAT3 molecule to bind with the phosphorylated Y705 site in another STAT3 molecule, which further counteracts IL6-induced STAT3 dimerization and activation. Expression of a non-phosphoryable STAT3 T622A mutant enhances STAT3 activity and IL6 expression at high cell density, and promotes tumor growth in mice xenograft model. Our findings demonstrate that STAT3 is a novel phosphorylation substrate for MST2, and thereby highlight a regulatory cascade underlying the crosstalk between inflammation and Hippo pathway in prostate cancer cells.
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http://dx.doi.org/10.1111/cas.15463DOI Listing
June 2022

Interference with connective tissue growth factor attenuated fibroblast-to-myofibroblast transition and pulmonary fibrosis.

Ann Transl Med 2022 May;10(10):566

Department of Emergency Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Background: The aberrant activation and phenotype shift of resident fibroblasts in lung tissues via fibroblast-to-myofibroblast transition (FMT) is considered a pivotal step in pulmonary fibrogenesis, resulting in excessive extracellular matrix (ECM) production and deposition. However, the molecular mechanisms regulating FMT and lung fibrosis are still unclear. Connective tissue growth factor (CTGF) has been reported to be both an ECM protein and a versatile signaling molecule that is involved in multiple pathophysiological contexts, especially fibrosis. The relationship between CTGF, FMT, and lung fibrosis has not yet been well defined.

Methods: In this study, a pulmonary fibrosis (PF) rat model and FMT cell model induced by paraquat (PQ) were established to explore the relevant regulatory mechanisms and .

Results: The results showed that the CTGF was highly activated and was a mediator of canonical Wnt signaling during FMT and PF. The inhibition of the CTGF by small-interfering ribonucleic acid decreased the expression of FMT markers, including α-smooth muscle actin, vimentin, and collagen I, inhibited the activated Wnt signaling pathway, and ameliorated lung fibrosis.

Conclusions: Our findings showed that CTGF was the key effector of the FMT and fibrotic changes, and emphasized the therapeutic potential of the inhibitor or monoclonal antibody against CTGF for PF.
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http://dx.doi.org/10.21037/atm-22-1397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201195PMC
May 2022

Medical Image Registration Algorithm Based on Bounded Generalized Gaussian Mixture Model.

Front Neurosci 2022 2;16:911957. Epub 2022 Jun 2.

Department of Orthopaedics, Daping Hospital, Army Medical University, Chongqing, China.

In this paper, a method for medical image registration based on the bounded generalized Gaussian mixture model is proposed. The bounded generalized Gaussian mixture model is used to approach the joint intensity of source medical images. The mixture model is formulated based on a maximum likelihood framework, and is solved by an expectation-maximization algorithm. The registration performance of the proposed approach on different medical images is verified through extensive computer simulations. Empirical findings confirm that the proposed approach is significantly better than other conventional ones.
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http://dx.doi.org/10.3389/fnins.2022.911957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201218PMC
June 2022

Development of Intron Polymorphism Markers and Their Association With Fatty Acid Component Variation in Oil Palm.

Front Plant Sci 2022 2;13:885418. Epub 2022 Jun 2.

Hainan Key Laboratory of Tropical Oil Crops Biology/Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wenchang, China.

Oil palm ( Jacq.) is a tropical woody oil crop of the palm family and is known as "the oil king of the world," but its palm oil contains about 50% palmitic acid, which is considered unhealthy for humans. Intron polymorphisms (IP) are highly efficient and easily examined molecular markers located adjacent to exon regions of functional genes, thus may be associated with targeted trait variation. In order to speed up the breeding of oil palm fatty acid composition, the current study identified a total of 310 introns located within 52 candidate genes involved in fatty acid biosynthesis in the oil palm genome. Based on the intron sequences, 205 primer pairs were designed, 64 of which showed polymorphism among 70 oil palm individuals. Phenotypic variation of fatty acid content in the 70 oil palm individuals was also investigated. Association analysis revealed that 13 IP markers were significantly associated with fatty acid content variation, and these IP markers were located on chromosomes 2, 5, 6, 8, 9, and 10 of oil palm. The development of such IP markers may be useful for the genetic improvement of fatty acid composition in oil palm.
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http://dx.doi.org/10.3389/fpls.2022.885418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201816PMC
June 2022

Iguratimod Restrains Circulating Follicular Helper T Cell Function by Inhibiting Glucose Metabolism Hif1α-HK2 Axis in Rheumatoid Arthritis.

Front Immunol 2022 1;13:757616. Epub 2022 Jun 1.

Department of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian, China.

Iguratimod (IGU) is a novel disease modified anti-rheumatic drug, which has been found to act directly on B cells for inhibiting the production of antibodies in rheumatoid arthritis (RA) patients. Follicular helper T (Tfh) cells, a key T cell subsets in supporting B cell differentiation and antibody production, have been shown to play critical roles in RA. However, whether IGU can inhibit RA Tfh cells which further restrains B cell function remains unclear. Here, we aimed to explore the roles of IGU in regulating RA circulating Tfh (cTfh) cell function and investigate the potential mechanism associated with cell glucose metabolism. In our study, we found that IGU could act on RA-CD4 T cells to reduce T cell-dependent antibody production. IGU decreased the percentage of RA cTfh cells and the expression of Tfh cell-related molecules and cytokines which were involved in B cell functions. Importantly, our data showed that IGU significantly restrained the cTfh cell function by inhibiting glucose metabolism, which relied on Hif1α-HK2 axis. In summary, we clarified a new target and mechanism of IGU by restraining RA cTfh cell function inhibiting Hif1α-HK2-glucose metabolism axis. Our study demonstrates the potential application of IGU in the treatment of diseases related to abnormal metabolism and function of Tfh cells.
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http://dx.doi.org/10.3389/fimmu.2022.757616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199372PMC
June 2022

The "Hand as Foot" teaching method in the ultrasound characteristics of connective tissue diseases associated interstitial lung disease (CTD-ILD).

Asian J Surg 2022 Jun 15. Epub 2022 Jun 15.

Inner Mongolia Medical University, Department of Orthopedics, Affiliated Hospital of Inner Mongolia Medical University, Huhhot North Street, Inner Mongolia, 010050, China.

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http://dx.doi.org/10.1016/j.asjsur.2022.05.106DOI Listing
June 2022

Possible changes in trade-off strategy in female lizards (Eremias argus) during hibernation following exposure to chlorantraniliprole: Impact on the HPG axis and the energy mobilization.

Pestic Biochem Physiol 2022 Jun 24;184:105059. Epub 2022 Feb 24.

Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, PR China. Electronic address:

Hibernation is a short-term survival strategy for ectotherms to cope with cold weather and food shortages. The energy sources stored before hibernation are used not only in the winter, but also in preparation for reproduction. Reproductive physiology and behavior are primarily regulated by the hypothalamus-pituitary-gonad (HPG) axis. In this study, we examined endocrine hormone changes in the HPG axis of female lizards (Eremias argus) after chlorantraniliprole insecticide (CAP) exposure during hibernation. The levels of gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone and progesterone were significantly decreased and the level of testosterone (T) was significantly increased after 135d experiment. This study verified the possible endocrine disrupting effects of CAP. More energy material consumption was observed in CAP treated group. Female E. argus preferred to invest energy to present survival when exposed to CAP, rather than to reserve material for following reproductive activity.
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http://dx.doi.org/10.1016/j.pestbp.2022.105059DOI Listing
June 2022

Hyaluronic Acid Hydrogels Hybridized With Au-Triptolide Nanoparticles for Intraarticular Targeted Multi-Therapy of Rheumatoid Arthritis.

Front Pharmacol 2022 27;13:849101. Epub 2022 May 27.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by synovial inflammation in multiple joints. Triptolide (TP) is a disease-modifying anti-rheumatic drug (DMARD) highly effective in patients with RA and has anti-inflammatory properties. However, its clinical application has been limited owing to practical disadvantages. In the present study, hyaluronic acid (HA) hydrogel-loaded RGD-attached gold nanoparticles (AuNPs) containing TP were synthesized to alleviate the toxicity and increase therapeutic specificity. The hydrogels can be applied for targeted photothermal-chemo treatment and imaging of RA. Hydrogel systems with tyramine-modified HA (TA-HA) conjugates have been applied to artificial tissue models as surrogates of cartilage to investigate drug transport and release properties. After degradation of HA chains, heat was locally generated at the inflammation region site due to near-infrared resonance (NIR) irradiation of AuNPs, and TP was released from nanoparticles, delivering heat and drug to the inflamed joints simultaneously. RA can be penetrated with NIR light. Intraarticular administration of the hydrogels containing low dosage of TP with NIR irradiation improved the inflamed conditions in mice with collagen-induced arthritis (CIA). Additionally, experiments were applied to deeply verify the antirheumatic mechanisms of [email protected]/HA hydrogels. [email protected]/HA hydrogel treatment significantly reduced the migratory and invasive capacities of RA fibroblast-like synoviocytes (RA-FLS) , through the decrease of phosphorylation of mTOR and its substrates, p70S6K1, thus inhibiting the mTOR pathway.
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http://dx.doi.org/10.3389/fphar.2022.849101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197263PMC
May 2022

Association Between Serum Uric Acid and Carotid Intima-Media Thickness in Different Fasting Blood Glucose Patterns: A Case-Control Study.

Front Endocrinol (Lausanne) 2022 27;13:899241. Epub 2022 May 27.

Department of VIP Unit, China-Japan Union Hospital of Jilin University, Changchun, China.

Our objective was to analyze the correlation between serum uric acid (SUA) levels and carotid intima-media thickness (CIMT) and explore the relationship between SUA and carotid atherosclerosis in different glucose metabolism patterns. A total of 614 patients were enrolled in this case-control study, including 406 in the normouricemia group and 208 in the hyperuricemia group. The two groups were each divided into three groups according to fasting blood glucose (FBG) level: normal, impaired fasting glucose (IFG), and diabetes mellitus (DM). CIMT and the CIMT thickening rate in the hyperuricemia group were significantly higher than those in the normouricemia group: 0.17 (0.11-0.24) cm vs. 0.12 (0.08-0.15) cm and 73.56% vs. 51.97% ( < 0.001). Pearson's correlation analysis showed that age, systolic blood pressure (SBP), diastolic blood pressure, FBG, triglyceride, SUA, creatinine, and blood urea nitrogen were positively correlated with CIMT, whereas high-density lipoprotein cholesterol and total cholesterol were negatively correlated with CIMT. Multiple linear regression analysis showed that age, SUA, FBG, and SBP were independent factors that affected CIMT. Furthermore, age and SBP were independent factors in the normouricemia group, and FBG was an independent factor that affected CIMT in the hyperuricemia group ( < 0.05). In the hyperuricemia group, CIMT in the DM group was significantly higher than that in the normal group [0.20 (0.14-0.25)cm vs. 0.15 (0.1-0.25); < 0.05], and the CIMT thickening rate in the DM group was significantly higher than those in the IFG and normal groups (90.38% vs. 78.38%, 90.38% vs. 65.81%; < 0.05). The ROC curve analysis showed that uric acid combined with age, SBP, and FBG had the highest area under the curve (AUC) for predicting CIMT thickening [0.855 (95% confidence interval (CI): 0.804-0.906)], followed by uric acid combined with FBG [AUC: 0.767 (95% CI: 0.726-0.808)]. In conclusion, SUA was closely associated with an increase in CIMT in patients with specific FBG metabolic patterns and may be an independent risk factor for carotid atherosclerosis. SUA, especially in combination with other factors (such as age, SBP, FBG), may serve as a specific model to help predict the incidence of CIMT thickening. http://www.chictr.org.cn, identifier ChiCTR2000039124.
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http://dx.doi.org/10.3389/fendo.2022.899241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197240PMC
June 2022

Encoding with a fluorescence-activating and absorption-shifting tag generates living bacterial probes for mammalian microbiota imaging.

Mater Today Bio 2022 Jun 6;15:100311. Epub 2022 Jun 6.

Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

The mammalian microbiota plays essential roles in health. A primary determinant to understand the interaction with the host is the distribution and viability of its key microorganisms. Here, a strategy of encoding with a fluorescence-activating and absorption-shifting tag (FAST) is reported to prepare living bacterial probes for real-time dynamic, dual-modal, and molecular oxygen-independent imaging of the host microbiota. Carrying FAST endows bacteria with rapid on-demand turn on-off fluorescence by adding or removal of corresponding fluorogens. Encoded bacteria are able to reversibly switch emission bands for dual-color fluorescence imaging via fluorogen exchange. Due to molecular oxygen-independent emission of FAST, encoded bacteria can emit fluorescence under anaerobic environments including the gut and tumor. These living probes demonstrate the applicability to quantify the vitality of bacteria transplanted to the gut microbiota. This work proposes a unique fluorescence probe for investigating the dynamics of the host microbiota.
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http://dx.doi.org/10.1016/j.mtbio.2022.100311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194656PMC
June 2022

The "Hand as Foot" teaching method in the carpal tunnel and the ankle tunnel.

Asian J Surg 2022 Jun 12. Epub 2022 Jun 12.

Inner Mongolia Medical University, Department of Orthopedics, Affiliated Hospital of Inner Mongolia Medical University, Huhehot North Street, Inner Mongolia 010050, China.

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http://dx.doi.org/10.1016/j.asjsur.2022.05.093DOI Listing
June 2022

A rice protein modulates endoplasmic reticulum homeostasis and coordinates with a transcription factor to initiate blast disease resistance.

Cell Rep 2022 Jun;39(11):110941

MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China. Electronic address:

Endoplasmic reticulum (ER) homeostasis is essential for plants to manage responses under environmental stress. Plant immune activation requires the ER, but how ER homeostasis is associated with plant immune activation is largely unexplored. Here we find that transcription of an HVA22 family gene, OsHLP1 (HVA22-like protein 1), is induced by Magnaporthe oryzae infection. Overexpression of OsHLP1 significantly enhances blast disease resistance but impairs ER morphology in rice (Oryza sativa), resulting in enhanced sensitivity to ER stress. OsHLP1 interacts with the NAC (NAM, ATAF, and CUC) transcription factor OsNTL6 at the ER. OsNTL6 localizes to the ER and is relocated to the nucleus after cleavage of the transmembrane domain. OsHLP1 suppresses OsNTL6 protein accumulation, whereas OsNTL6 counteracts OsHLP1 by alleviating sensitivity to ER stress and decreasing disease resistance in OsHLP1 overexpression plants. These findings unravel a mechanism whereby OsHLP1 promotes disease resistance by compromising ER homeostasis when plants are infected by pathogens.
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http://dx.doi.org/10.1016/j.celrep.2022.110941DOI Listing
June 2022

Preliminary Evaluation of a Smartphone App for Refractive Error Measurement.

Transl Vis Sci Technol 2022 Feb;11(2):40

Eye and ENT Hospital, NHC Key Laboratory of Myopia, Fudan University, Shanghai, China.

Purpose: The purpose of this study was to evaluate the potential feasibility of using a smartphone app in myopia screening.

Methods: The app estimates myopic refractive error by measuring the far point distance for reading three 20/20 Tumbling E letters. In total, 113 myopic subjects with astigmatism no greater than -1.75 diopters (D) were enrolled from 5 sites. The mean age was 22 ± 8.5 years. The app measurement was compared with noncycloplegic subjective refraction measurement or autorefractor if subjective refraction was not available. In addition, 22 subjects were tested with the app for repeatability.

Results: For 201 eyes included, the range of spherical equivalent refraction error was 0 to -10.2 D. The app measurement and clinical measurement was highly correlated (Pearson R = 0.91, P < 0.001). There was a small bias (0.17 D) in the app measurement overall, and it was significantly different across the 5 sites due to different age of subjects enrolled at those sites (P = 0.001) - young adults in their 20s were underestimated the most by 0.49 D, whereas children were overestimated by 0.29 D. The mean absolute deviation of the app measurement was 0.65 D. The repeatability of multiple testing in terms of 95% limit of agreement was ±0.61 D.

Conclusions: Overall, the app measurement is consistent with clinical measurement performed by vision care professionals. The repeatability is comparable with that of some autorefractors. Age-associated human factors may influence the app measurement.

Translational Relevance: The app could be potentially used as a mass screening tool for myopia.
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http://dx.doi.org/10.1167/tvst.11.2.40DOI Listing
February 2022

Quality evaluation of oil by cold-pressed peanut from different growing regions in China.

Food Sci Nutr 2022 Jun 14;10(6):1975-1987. Epub 2022 Mar 14.

Institute of Food and Nutrition Development Ministry of Agriculture and Rural Affairs Beijing China.

In this study, twenty-six peanut varieties and their cold-pressed oils from eleven provinces in China were investigated for their oil content, acid value, peroxide value, fatty acid profiles, bioactive constituents, and induction period (IP) of lipid oxidation. Meanwhile, the effect of the geographical origin of peanut on the quality of cold-pressed peanut oils (CPOs) was studied. The average acid value of CPOs in southern China was higher than that in northern China (0.49 mg KOH/g versus 0.22 mg KOH/g,  .05). In addition, the average of oleic acid content, ratio of oleic acid to linoleic acid (O/L), and IP were also higher in southern China than that in northern China ( .05). However, the average content of campesterol, -sitosterol, total phytosterol, linoleic acid, and ratio of unsaturated fatty acid to saturated fatty acid (UFA/SFA) exhibited reverse results ( < .05). At last, the comprehensive evaluation of CPOs based on principal component analysis (PCA) was performed. In all samples, Silihong from Liaoning province, northern China was No.1, and Zhonghua 21 from Xiaogan City, Hubei Province was No.4 which was the first one from southern China. Moreover, heat map clustering analysis further revealed the differences and similarities among different samples, and those results were in accordance with the comprehensive evaluation results.
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http://dx.doi.org/10.1002/fsn3.2813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179141PMC
June 2022

The "Hand as Foot" teaching method for the interventional experiment of diuretics in nuclear medicine.

Asian J Surg 2022 Jun 10. Epub 2022 Jun 10.

Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Key Laboratory of Molecular Imaging, Huhhot North Street, Inner Mongolia, 010050, China. Electronic address:

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http://dx.doi.org/10.1016/j.asjsur.2022.05.121DOI Listing
June 2022

The "Hand as Foot" teaching method in the cerebral arterial circle and basilar artery.

Asian J Surg 2022 Jun 10. Epub 2022 Jun 10.

Inner Mongolia Medical University, Department of Neurosurgery, Affiliated Hospital of Inner Mongolia Medical University, Huhehot North Street, Inner Mongolia, 010050, China.

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http://dx.doi.org/10.1016/j.asjsur.2022.05.105DOI Listing
June 2022

The extract from the roots of var. (Coll. et Hemsl.) Rehd. et Wils attenuates DSS-induced ulcerative colitis by regulating the Nrf2/NF-κB signaling pathways.

RSC Adv 2020 Mar 4;10(16):9450-9461. Epub 2020 Mar 4.

Tianjin University of Traditional Chinese Medicine Tianjin 300193 China.

Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease. Many natural medicines or ethnic drugs have been proven to be effective and beneficial in the treatment of UC. Among these, the root of var. (Coll. et Hemsl.) Rehd. et Wils. (ROS), a kind of Yi nationality medicine called "GU-GONG-GUO," has been shown to be useful as a therapeutic agent for sputum and diarrhea. However, the effects and mechanisms of ROS extract (ROE) on UC remain relatively unknown. The aim of this study was to explore the protective effects and the underlying mechanisms of ROE on UC. First, we established a dextran sulfate sodium (DSS)-induced experimental colitis mouse model and then evaluated the anti-inflammatory effects of ROE . Then, RAW264.7 cells were stimulated with lipopolysaccharide (LPS) in the presence or absence of ROE to explore its mechanisms . It was found that ROE attenuated DSS-induced colon length shortening, body weight loss, and colonic pathological damage. Furthermore, ROE inhibited the activity of nitric oxide synthase (NOS), myeloperoxidase (MPO), and malondialdehyde (MDA). Also, ROE decreased several LPS-induced inflammatory cytokines including TNF-α, IL-6, and IL-1β in RAW264.7. In addition, ROE inhibited the expression of p-NF-κB, p-IKKα/β, and Keap1 proteins and increased the expression of Nrf2 and HO-1 proteins. Our study suggested that ROE prevented DSS-induced colitis though the Nrf2/NF-κB pathway. Overall, it can be concluded that ROE may be a promising and effective agent for UC.
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http://dx.doi.org/10.1039/c9ra10747aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122567PMC
March 2020

CD20-specific chimeric antigen receptor-expressing T cells as salvage therapy in rituximab-refractory/relapsed B-cell non-Hodgkin lymphoma.

Cytotherapy 2022 Jun 9. Epub 2022 Jun 9.

Department of Hematology, Third Xiangya Hospital of Central South University, Changsha, China. Electronic address:

Background Aims: The infusion of chimeric antigen receptor (CAR) T cells that target specific tumor-associated antigens is a promising strategy that has exhibited encouraging results in clinical trials. However, few studies have focused on the effectiveness and safety of CD20 CAR T cells in rituximab-refractory/relapsed (R/R) B-cell non-Hodgkin lymphoma (B-NHL) patients, particularly those treated with rituximab for a short time. This prospective study aimed to assess the effectiveness and toxicity of CD20 CAR T cells in R/R B-NHL patients previously treated with rituximab.

Methods: The authors conducted a prospective, single-center phase I study on the effectiveness and toxicity of CD20 CAR T cells in rituximab-treated R/R B-NHL patients (no. ChiCTR2000036350). A total of 15 patients with R/R B-NHL were enrolled between November 21, 2017, and December 1, 2021.

Results: An overall response rate of 100% was shown in enrolled patients, with 12 (80%) achieving complete remission and three (20%) achieving partial remission for the best response. The median follow-up time was 12.4 months. Progression-free survival and overall survival were not yet reached by the data cutoff day. No patient developed grade 4 cytokine release syndrome, and only one patient had immune effector cell-associated neurotoxicity syndrome.

Conclusions: All enrolled B-NHL patients who were previously R/R to rituximab achieved different degrees of clinical response with tolerable toxicities. Notably, patients who had received rituximab within 3 months had a poorer prognosis.
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http://dx.doi.org/10.1016/j.jcyt.2022.05.001DOI Listing
June 2022

UPLC-Q-TOF-MS and NMR identification of structurally different A-type procyanidins from peanut skin and their inhibitory effect on acrylamide.

J Sci Food Agric 2022 Jun 11. Epub 2022 Jun 11.

College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.

Background: Flavan-3-ol polyphenols have been shown to have great advantages in inhibiting acrylamide formation. However, flavan-3-ol polyphenols have highly various structures, and existing research has been mainly focused on the effects of B-type procyanidins and structural units of procyanidins. This study aims to separate structurally different A-type procyanidins from peanut skin and compare their inhibitory effects on acrylamide in an asparagine-glucose simulation system.

Results: As a result, a total of five compounds were separated and identified from peanut skin, including epicatechin-(2β→O→7, 4β→8)-ent-epicatechin, epicatechin-(2β→O→7, 4β→8)-epicatechin, epicatechin-(2β→O→7, 4β→8)-epicatechin-(4β→6)-catechin, epicatechin-(2β→O→7, 4β→8)-epicatechin-(4β→8)-catechin, and epicatechin-(4β→6)-epicatechin-(4β→8, 2β→O→7)-catechin. All the procyanidins could decrease the content of acrylamide at a certain range of concentrations. The highest inhibition rates followed the order of compound 5 (A-type trimer) > compound 1 (A-type dimer) > compound 2 (A-type dimer) > compound 3 (A-type trimer) > compound 4 (A-type trimer). Comparison analysis showed that structurally different A-type procyanidins have various inhibitory effects on acrylamide production, which may be related to their spatial configuration and bond connection mode.

Conclusion: Overall, our findings help a better understanding of the relationship between the structure of procyanidins and their inhibitory effects on acrylamide, particularly the inhibitory effect of A-type. There is potential practical significance that people use A-type procyanidins as an acrylamide inhibitor in hot processed foods in the future. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/jsfa.12067DOI Listing
June 2022

Letter to the Editor: An ultra-sensitive assay using cell-free DNA fragmentomics for multi-cancer early detection.

Mol Cancer 2022 Jun 11;21(1):129. Epub 2022 Jun 11.

Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Early detection can benefit cancer patients with more effective treatments and better prognosis, but existing early screening tests are limited, especially for multi-cancer detection. This study investigated the most prevalent and lethal cancer types, including primary liver cancer (PLC), colorectal adenocarcinoma (CRC), and lung adenocarcinoma (LUAD). Leveraging the emerging cell-free DNA (cfDNA) fragmentomics, we developed a robust machine learning model for multi-cancer early detection. 1,214 participants, including 381 PLC, 298 CRC, 292 LUAD patients, and 243 healthy volunteers, were enrolled. The majority of patients (N = 971) were at early stages (stage 0, N = 34; stage I, N = 799). The participants were randomly divided into a training cohort and a test cohort in a 1:1 ratio while maintaining the ratio for the major histology subtypes. An ensemble stacked machine learning approach was developed using multiple plasma cfDNA fragmentomic features. The model was trained solely in the training cohort and then evaluated in the test cohort. Our model showed an Area Under the Curve (AUC) of 0.983 for differentiating cancer patients from healthy individuals. At 95.0% specificity, the sensitivity of detecting all cancer reached 95.5%, while 100%, 94.6%, and 90.4% for PLC, CRC, and LUAD, individually. The cancer origin model demonstrated an overall 93.1% accuracy for predicting cancer origin in the test cohort (97.4%, 94.3%, and 85.6% for PLC, CRC, and LUAD, respectively). Our model sensitivity is consistently high for early-stage and small-size tumors. Furthermore, its detection and origin classification power remained superior when reducing sequencing depth to 1× (cancer detection: ≥ 91.5% sensitivity at 95.0% specificity; cancer origin: ≥ 91.6% accuracy). In conclusion, we have incorporated plasma cfDNA fragmentomics into the ensemble stacked model and established an ultrasensitive assay for multi-cancer early detection, shedding light on developing cancer early screening in clinical practice.
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http://dx.doi.org/10.1186/s12943-022-01594-wDOI Listing
June 2022

What is the short-term outlook for the EU's natural gas demand? Individual differences and general trends based on monthly forecasts.

Environ Sci Pollut Res Int 2022 Jun 11. Epub 2022 Jun 11.

School of Economics and Management, China University of Petroleum, Beijing, 102249, China.

As a fossil energy with low carbon, natural gas has been regarded as an important energy for the energy green transition in the past few decades. It has long shouldered the mission of improving air quality and slowing climate warming. However, in recent years, with the acceleration of the energy transition, natural gas has become a major source of carbon emissions in Europe, but before the full coverage of renewable energy, natural gas remains the Europe's main energy in the short term. In such a complicated background, what is the short-term outlook for the European Union's (EU) natural gas demand? This paper will answer this question by forecasting the EU's natural gas consumption. A review of the literature that studies on gas consumption forecasting for the Europe has always been for one country or one region; there is no study for all EU countries, and the forecast periods are mostly for hourly, daily and annual data and no studies for monthly data. In order to fill these two research gaps, this paper forecasts the monthly natural gas consumption from 2021 to 2025 of the top seven gas-consuming countries in the EU and obtains the EU's total consumption on this basis. In addition, due to the nonlinear seasonal fluctuations in the monthly consumption data of the countries studied, a novel seasonal forecasting model is proposed to better fit this trend, named nonlinear grey Bernoulli model based on Hodrick-Prescott (HP) filter (HP-NGBM(1,1)). To demonstrate that HP-NGBM(1,1) model has better predictive ability, this paper uses other seasonal models to make comparative forecasts, and the results show that the HP-NGBM(1,1) model has the smallest error. The forecasting results can provide the reference for the EU's natural gas consumption market regulation and the formulation of short-term environmental protection strategies and climate change response plannings.
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http://dx.doi.org/10.1007/s11356-022-21285-9DOI Listing
June 2022

DAF-16 is involved in colonic metabolites of Ferulic acid promoted the longevity and stress resistance of C.elegans.

J Sci Food Agric 2022 Jun 11. Epub 2022 Jun 11.

Department of Food Science, Cornell University, Ithaca, New York, 14853, US.

Background: Ferulic acid (FA) is a dietary polyphenol widely found in plant tissues. It has long been considered to have health-promoting qualities. However, the biological properties of dietary polyphenols depend largely on their absorption during digestion, and the effects of their intestinal metabolites on human health have attracted the interest of researchers. This study evaluated the effects of three main colonic metabolites 3-(3,4-dihydroxyphenyl) propionic acid (3,4diOHPPA), 3-(3-hydroxyphenyl) propionic acid (3OHPPA) and 3-phenylpropionic acid (3PPA) of FA on longevity and stress resistance in C.elegans.

Results: Our results showed that 3,4diOHPPA, 3OHPPA and 3PPA extended the lifespan in normal conditions of C.elegans while FA did not. The high-doses of 3,4diOHPPA (0.5 mM), 3OHPPA (2.5 mM) and 3PPA (2.5 mM) prolonged the mean lifespan by 11.2%, 13.0% and 10.6%, respectively. Moreover, 3,4diOHPPA, 3OHPPA and 3PPA treatments promoted stress tolerance against heat, UV irradiation and paraquat. Furthermore, three metabolites ameliorated the physical functions including ROS and MDA levels, motility and pharyngeal pumping rate. The anti-aging activities mediated by 3,4diOHPPA, 3OHPPA and 3PPA depend on the HSF-1 and JNK-1 linked insulin/IGF-1 signaling pathway, which converge onto DAF-16.

Conclusion: The current findings suggest the colonic metabolites of FA have the potential to be used as anti-aging bioactivate compounds. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/jsfa.12063DOI Listing
June 2022

Effects of Ganoderic Acid A on Gastrointestinal Motility and Brain-Gut Peptide in Rats with Functional Dyspepsia.

Evid Based Complement Alternat Med 2022 31;2022:2298665. Epub 2022 May 31.

Department of Gastroenterology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province 441021, China.

Objective: The therapeutic effect of drugs for functional dyspepsia (FD) is still limited. Ganoderic acid A (GAA) has anti-inflammatory and cellular protective activities. The aim of this study is to explore the therapeutic effect of GAA on FD.

Methods: The FD rat model was established via tail damping and forced exercise fatigue. The gastric emptying rate and intestinal propulsion rate of the rats in each group were then detected, and the pathological damage of gastric antrum and duodenum tissues was observed by hematoxylin-eosin (HE) staining. An enzyme-linked immunosorbent assay (ELISA) was conducted to determine the levels of motilin (MTL), vasoactive intestinal peptide (VIP), leptin, gastrin (GAS), calcitonin gene-related peptide (CGRP), and somatostatin (SS) in plasma, and Western blot was used to detect the protein expression levels of occludin, zonula occluden-1 (ZO-1), and junctional adhesion molecule-1 (JAM-1) in the duodenal tissue.

Results: Treatment with GAA significantly raised the gastric emptying rate and intestinal propulsion rate of FD rats and histologically alleviated the gastric and duodenal damage. Meanwhile, GAA positively regulated the secretion of brain-gut proteins, such as upregulation of MTL, GAS, and SS and downregulation of VIP, leptin, and CGRP. In addition, GAA treatment increased the protein expression levels of occludin, ZO-1, and JAM-1 in the duodenal tissue of the FD rats.

Conclusion: GAA may exhibit protective effects on FD by regulating the secretion of brain-gut peptide, protecting the intestinal barrier and improving gastrointestinal motility.
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http://dx.doi.org/10.1155/2022/2298665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173975PMC
May 2022

Evaluating the Nutritional Properties of Food: A Scoping Review.

Nutrients 2022 Jun 5;14(11). Epub 2022 Jun 5.

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

There are many methods or indicators used for evaluating the nutritional value of foods; however, it is difficult to accurately reflect the comprehensive nutritional value of a food with a single indicator, and a systematic evaluation system is lacking. In this article, we systematically summarize the common evaluation methods and indicators of the nutritional value of foods. The purpose of this review was to establish an evaluation procedure for nutritional properties of foodstuffs and to help scientists choose more direct and economical evaluation methods according to food types or relevant indicators. The procedure involves the selection of a three-level evaluation method that covers the whole spectrum of a food's nutritional characteristics. It is applicable to scientific research in the fields of agricultural science, food science, nutrition, and so on.
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http://dx.doi.org/10.3390/nu14112352DOI Listing
June 2022
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