Publications by authors named "Rui D Prediger"

97Publications

Propolis: A useful agent on psychiatric and neurological disorders? A focus on CAPE and pinocembrin components.

Med Res Rev 2020 Nov 11. Epub 2020 Nov 11.

Laboratory of Pharmacology of Inflammation and Behavior, Faculty of Pharmacy, Institute of Health Science, Federal University of Pará, Belém, Pará, Brazil.

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November 2020

Guanosine Promotes Proliferation in Neural Stem Cells from Hippocampus and Neurogenesis in Adult Mice.

Mol Neurobiol 2020 Sep 26;57(9):3814-3826. Epub 2020 Jun 26.

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.

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September 2020

Combined effects of caloric restriction and fish oil attenuated anti-depressant and anxiolytic-like effects of fish oil: association with hippocampal BDNF concentrations.

Behav Brain Res 2020 Sep 16;393:112770. Epub 2020 Jun 16.

Post Graduate Program in Nutrition, Department of Nutrition, Health Sciences Centre, Universidade Federal de Santa Catarina (UFSC), Brazil. Electronic address:

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September 2020

Animal models of olfactory dysfunction in neurodegenerative diseases.

Handb Clin Neurol 2019 ;164:431-452

Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.

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March 2020

Treadmill Exercise Attenuates L-DOPA-Induced Dyskinesia and Increases Striatal Levels of Glial Cell-Derived Neurotrophic Factor (GDNF) in Hemiparkinsonian Mice.

Mol Neurobiol 2019 Apr 2;56(4):2944-2951. Epub 2018 Aug 2.

Graduate Program of Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.

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April 2019

Agmatine attenuates depressive-like behavior and hippocampal oxidative stress following amyloid β (Aβ1-40) administration in mice.

Behav Brain Res 2018 11 28;353:51-56. Epub 2018 Jun 28.

Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis, SC, 84049-900, Brazil. Electronic address:

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November 2018

Tetrahydrobiopterin improves hippocampal nitric oxide-linked long-term memory.

Mol Genet Metab 2018 09 11;125(1-2):104-111. Epub 2018 Jun 11.

Laboratório de Bioenergética e Estresse Oxidativo - LABOX, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil; Centre de Psychiatrie et Neurosciences, INSERM UMR 894, Paris, France.

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September 2018

Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats.

Behav Brain Res 2018 09 9;350:99-108. Epub 2018 May 9.

Laboratory of Pharmacology of Inflammation and Behavior, Faculty of Pharmacy, Institute of Health Science, Federal University of Pará, Belém, Pará, Brazil. Electronic address:

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September 2018

Intranasal administration of sodium dimethyldithiocarbamate induces motor deficits and dopaminergic dysfunction in mice.

Neurotoxicology 2018 05 29;66:107-120. Epub 2018 Mar 29.

Department of Pharmacology, Centre of Biological Sciences, Federal University of Santa Catarina (UFSC), Campus Universitário, Florianópolis, SC, Brazil. Electronic address:

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May 2018

Atorvastatin Prevents Early Oxidative Events and Modulates Inflammatory Mediators in the Striatum Following Intranasal 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Administration in Rats.

Neurotox Res 2018 04 21;33(3):549-559. Epub 2017 Nov 21.

Programa de Pós-Graduação em Bioquímica, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Trindade, Florianópolis, SC, 88040-900, Brazil.

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April 2018

Ursolic acid affords antidepressant-like effects in mice through the activation of PKA, PKC, CAMK-II and MEK1/2.

Pharmacol Rep 2017 Dec 24;69(6):1240-1246. Epub 2017 May 24.

Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil. Electronic address:

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December 2017

Angiotensin II type 1/adenosine A receptor oligomers: a novel target for tardive dyskinesia.

Sci Rep 2017 05 12;7(1):1857. Epub 2017 May 12.

Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL-Universitat de Barcelona, L'Hospitalet de Llobregat, Spain.

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May 2017

The effects of physical exercise on nonmotor symptoms and on neuroimmune RAGE network in experimental parkinsonism.

J Appl Physiol (1985) 2017 Jul 6;123(1):161-171. Epub 2017 Apr 6.

Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal;

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July 2017

Neuroprotection in Neurodegenerative Disease: From Basic Science to Clinical Applications.

Oxid Med Cell Longev 2017;2017:2949102. Epub 2017 Feb 28.

Faculty of Pharmacy, Center of Health Sciences, Universidade Federal do Pará (UFPA), Belém, PA, Brazil.

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January 2019

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.

Ann Neurol 2017 Mar 17;81(3):407-418. Epub 2017 Feb 17.

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

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March 2017

The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats.

Epilepsy Res 2016 11 29;127:160-167. Epub 2016 Aug 29.

Programa de Pós- graduação em Neurociências, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil; Centro de Neurociências Aplicadas, Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil; Programa de Pós- graduação em Ciências Médicas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil; Serviço de Neurologia, Departamento de Clínica Médica, Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

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November 2016

Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.

CNS Neurosci Ther 2017 Feb 19;23(2):119-126. Epub 2016 Oct 19.

Laboratory of Pharmacology and Experimental Therapeutics/Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

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February 2017

Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats.

Behav Brain Res 2017 01 24;316:74-81. Epub 2016 Aug 24.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, SC, Brazil. Electronic address:

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January 2017

Agmatine attenuates reserpine-induced oral dyskinesia in mice: Role of oxidative stress, nitric oxide and glutamate NMDA receptors.

Behav Brain Res 2016 10 13;312:64-76. Epub 2016 Jun 13.

Programa de Pós-Graduação em Neurociências, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil; Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis 88049-900, Brazil. Electronic address:

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October 2016

Caffeine Mitigates the Locomotor Hyperactivity in Middle-aged Low-density Lipoprotein Receptor (LDLr)-Knockout Mice.

CNS Neurosci Ther 2016 May 25;22(5):420-2. Epub 2016 Mar 25.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.

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May 2016

Depression as a Glial-Based Synaptic Dysfunction.

Front Cell Neurosci 2015 22;9:521. Epub 2016 Jan 22.

CNC - Center for Neuroscience and Cell Biology, University of CoimbraCoimbra, Portugal; Faculty of Medicine, University of CoimbraCoimbra, Portugal.

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February 2016

Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats.

Behav Brain Res 2016 Mar 18;301:43-54. Epub 2015 Dec 18.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis 88049-900, SC, Brazil; Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. Electronic address:

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March 2016

CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration.

Neurotox Res 2016 Apr 24;29(3):364-80. Epub 2015 Sep 24.

Sorbonne Université UPMC UM75 INSERM U1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle Epinière, Thérapeutique Expérimentale de la neurodégénérescence, Hôpital de la Salpêtrière - Bâtiment ICM, 47 boulevard de l'Hôpital, 75651, Paris, France.

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April 2016

Developmental exposure to manganese induces lasting motor and cognitive impairment in rats.

Neurotoxicology 2015 Sep 26;50:28-37. Epub 2015 Jul 26.

Programa de Pós-graduação em Neurociências, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil; Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. Electronic address:

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September 2015

Temporal Dissociation of Striatum and Prefrontal Cortex Uncouples Anhedonia and Defense Behaviors Relevant to Depression in 6-OHDA-Lesioned Rats.

Mol Neurobiol 2016 08 12;53(6):3891-3899. Epub 2015 Jul 12.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, 88049-900, Brazil.

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August 2016

Adenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain.

Behav Brain Res 2015 Apr 31;282:103-10. Epub 2014 Dec 31.

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Campus Trindade, 88040-900 Florianópolis, SC, Brazil. Electronic address:

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April 2015

Nitric oxide, a new player in L-DOPA-induced dyskinesia?

Front Biosci (Elite Ed) 2015 Jan 1;7:168-92. Epub 2015 Jan 1.

Departamento MFP-Fisiologia, Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, USP, Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), Ribeirao Preto, SP, Brazil.

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January 2015

Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson's disease.

PLoS One 2014 8;9(12):e114216. Epub 2014 Dec 8.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, 88049-900, SC, Brazil.

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August 2015

Antidepressant- and anxiolytic-like activities of an oil extract of propolis in rats.

Phytomedicine 2014 Sep 7;21(11):1466-72. Epub 2014 Jul 7.

Pharmaceutical Science Post-graduation Program, Health Science Institute, Federal University of Pará, Brazil; Neuroscience and Celular Biology Post-graduation Program, Federal University of Pará, Brazil; Laboratory Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, 66075-900 Belém, Pará, Brazil. Electronic address:

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September 2014

Cellular prion protein (PrP(C)) modulates ethanol-induced behavioral adaptive changes in mice.

Behav Brain Res 2014 Sep 26;271:325-32. Epub 2014 Jun 26.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, SC, Brazil; Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário, Universidade Federal de Santa Catarina, UFSC, Florianópolis, SC, Brazil.

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September 2014

Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system.

Eur J Neurosci 2014 Aug 26;40(3):2479-86. Epub 2014 Apr 26.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, Brazil; Center for Neuroscience and Cell Biology, Faculty of Medicine, Rua Larga University of Coimbra, 3004-504 Coimbra, Portugal.

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August 2014

A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice.

Neurotox Res 2014 Apr 26;25(3):295-304. Epub 2013 Sep 26.

Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Faculty of Medicine, University of Coimbra, Subunit 1 - Polo 3, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal.

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April 2014

Mechanisms involved in abdominal nociception induced by either TRPV1 or TRPA1 stimulation of rat peritoneum.

Eur J Pharmacol 2013 Aug 1;714(1-3):332-44. Epub 2013 Aug 1.

Graduate Program in Biological Sciences, Toxicological Biochemistry, Department of Chemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil.

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August 2013

Six weeks of voluntary exercise don't protect C57BL/6 mice against neurotoxicity of MPTP and MPP(+).

Neurotox Res 2014 Feb 20;25(2):147-52. Epub 2013 Jul 20.

Departamento de Bioquímica, Centro de Ciências Biológicas (CCB), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, 88040-900, Brazil,

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February 2014

Spatial reference memory deficits precede motor dysfunction in an experimental autoimmune encephalomyelitis model: the role of kallikrein-kinin system.

Brain Behav Immun 2013 Oct 15;33:90-101. Epub 2013 Jun 15.

Laboratory of Autoimmunity and Immunopharmacology, Campus Araranguá, Universidade Federal de Santa Catarina, 88900-000 Araranguá, SC, Brazil; Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, 88049-900 Florianópolis, SC, Brazil. Electronic address:

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October 2013

Parkin-knockout mice did not display increased vulnerability to intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Neurotox Res 2013 Aug 16;24(2):280-7. Epub 2013 Apr 16.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, SC, Brazil.

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August 2013

Ghrelin as a neuroprotective and palliative agent in Alzheimer's and Parkinson's disease.

Curr Pharm Des 2013 ;19(38):6773-90

Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, 88049-900, Florianópolis, SC, Brazil.

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August 2014

Neuroprotective effects of agmatine in mice infused with a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Behav Brain Res 2012 Dec 17;235(2):263-72. Epub 2012 Aug 17.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, 88049-900 Florianópolis, SC, Brazil.

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December 2012

Lithium and valproate prevent olfactory discrimination and short-term memory impairments in the intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rat model of Parkinson's disease.

Behav Brain Res 2012 Apr 17;229(1):208-15. Epub 2012 Jan 17.

Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, 88049-900, Brazil.

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April 2012

Intranasal administration of neurotoxicants in animals: support for the olfactory vector hypothesis of Parkinson's disease.

Neurotox Res 2012 Jan 15;21(1):90-116. Epub 2011 Oct 15.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Campus Trindade, Florianópolis, SC, 88049-900, Brazil.

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January 2012

Anxiety in Parkinson's disease: a critical review of experimental and clinical studies.

Neuropharmacology 2012 Jan 31;62(1):115-24. Epub 2011 Aug 31.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), 88049-900 Florianópolis, SC, Brazil.

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January 2012

Mice with genetic deletion of the heparin-binding growth factor midkine exhibit early preclinical features of Parkinson's disease.

J Neural Transm (Vienna) 2011 Aug 8;118(8):1215-25. Epub 2011 Feb 8.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Campus Trindade, Florianópolis, SC, 88049-900, Brazil.

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August 2011

A new naphthoquinone isolated from the bulbs of Cipura paludosa and pharmacological activity of two main constituents.

Planta Med 2011 Jul 31;77(10):1035-43. Epub 2011 Jan 31.

Núcleo de Investigações Químico-Farmacêuticas (NIQFAR) and Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil.

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July 2011

Chronic caffeine treatment during prepubertal period confers long-term cognitive benefits in adult spontaneously hypertensive rats (SHR), an animal model of attention deficit hyperactivity disorder (ADHD).

Behav Brain Res 2010 Dec 25;215(1):39-44. Epub 2010 Jun 25.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário Trindade, 88049-900 Florianópolis, SC, Brazil.

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December 2010

Cipura paludosa attenuates long-term behavioral deficits in rats exposed to methylmercury during early development.

Ecotoxicol Environ Saf 2010 Sep 5;73(6):1150-8. Epub 2010 May 5.

Faculdade de Ciências da Saúde, Curso de Ciências Farmacêuticas, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro (Asa Norte), 70910-900 DF, Brazil.

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September 2010

Altered emotionality leads to increased pain tolerance in amyloid beta (Abeta1-40) peptide-treated mice.

Behav Brain Res 2010 Sep 2;212(1):96-102. Epub 2010 Apr 2.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, SC 88049-900, Brazil.

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September 2010

Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms.

Authors:
Rui D S Prediger

J Alzheimers Dis 2010 ;20 Suppl 1:S205-20

Departamento de Farmacologia, Centro de Ciências Biológicas, Hospital Universitário, Universidade Federal de Santa Catarina, UFSC, Florianópolis-SC, Brazil.

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September 2010

The role of TNF-alpha signaling pathway on COX-2 upregulation and cognitive decline induced by beta-amyloid peptide.

Behav Brain Res 2010 May 1;209(1):165-73. Epub 2010 Feb 1.

Departamento de Farmacologia, Universidade Federal de Santa Catarina, Santa Catarina, Brazil.

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May 2010

Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice.

Brain Behav Immun 2010 Mar 16;24(3):493-501. Epub 2009 Dec 16.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

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March 2010

Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease.

Ann N Y Acad Sci 2009 Jul;1170:629-36

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, SC, Brazil.

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July 2009

Physical exercise improves motor and short-term social memory deficits in reserpinized rats.

Brain Res Bull 2009 Aug 20;79(6):452-7. Epub 2009 May 20.

Laboratório Experimental de Doenças Neurodegenerativas, Departamento de Farmacologia, Universidade Federal de Santa Catarina (UFSC), 88049-900 Florianópolis, SC, Brazil.

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August 2009

Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder.

Behav Pharmacol 2009 Mar;20(2):134-45

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

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March 2009

Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory.

J Ethnopharmacol 2008 Dec 27;120(3):465-73. Epub 2008 Sep 27.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, Florianópolis-SC 88049-900, Brazil.

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December 2008

Mild cognitive deficits associated to neocortical microgyria in mice with genetic deletion of cellular prion protein.

Brain Res 2008 Nov 24;1241:148-56. Epub 2008 Sep 24.

Departamento de Neurologia, Psiquiatria e Psicologia Médica, FMRP-USP, Ribeirão Preto, São Paulo, Brazil.

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November 2008

The exercise redox paradigm in the Down's syndrome: improvements in motor function and increases in blood oxidative status in young adults.

J Neural Transm (Vienna) 2008 Dec 16;115(12):1643-50. Epub 2008 Sep 16.

Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, 88049-900, Brazil.

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December 2008

Downhill training upregulates mice hippocampal and striatal brain-derived neurotrophic factor levels.

J Neural Transm (Vienna) 2008 Sep 16;115(9):1251-5. Epub 2008 Jul 16.

Laboratório de Fisiologia e Bioquímica do Exercício, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciuma, SC 88806-000, Brazil.

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September 2008

Antioxidant responses and lipid peroxidation following intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats: increased susceptibility of olfactory bulb.

Life Sci 2007 Apr 24;80(20):1906-14. Epub 2007 Feb 24.

Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis-SC, Brazil.

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April 2007

Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2.

Eur J Pharmacol 2007 Jun 17;563(1-3):141-8. Epub 2007 Feb 17.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis-SC 88049-900, Brazil.

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June 2007

The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats.

Psychopharmacology (Berl) 2006 Nov 1;188(4):641-9. Epub 2006 Sep 1.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário Trindade, Florianópolis, Santa Catarina, 88049-900, Brazil.

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November 2006

The risk is in the air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson's disease.

Exp Neurol 2006 Dec 14;202(2):391-403. Epub 2006 Aug 14.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC Campus Trindade, Florianópolis-SC 88049-900, Brazil.

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December 2006

Pilocarpine improves olfactory discrimination and social recognition memory deficits in 24 month-old rats.

Eur J Pharmacol 2006 Feb 24;531(1-3):176-82. Epub 2006 Jan 24.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Campus Trindade, 88049-900, Florianópolis-SC, Brazil.

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February 2006

Activation of adenosine A1 receptors reduces anxiety-like behavior during acute ethanol withdrawal (hangover) in mice.

Neuropsychopharmacology 2006 Oct 11;31(10):2210-20. Epub 2006 Jan 11.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, Santa Catarina, Brazil.

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October 2006

Blockade of adenosine and dopamine receptors inhibits the development of rapid tolerance to ethanol in mice.

Psychopharmacology (Berl) 2005 Oct 29;181(4):714-21. Epub 2005 Sep 29.

Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, 88049-900, Florianópolis, SC, Brazil.

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October 2005

Caffeine improves spatial learning deficits in an animal model of attention deficit hyperactivity disorder (ADHD) -- the spontaneously hypertensive rat (SHR).

Int J Neuropsychopharmacol 2005 Dec 9;8(4):583-94. Epub 2005 May 9.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, SC, Brasil.

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December 2005

Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats.

Behav Brain Res 2005 Apr 8;159(2):197-205. Epub 2004 Dec 8.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Campus Trindade, 88049-900 Florianópolis, SC, Brazil.

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April 2005

Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors.

Neurosci Lett 2005 Mar 9;376(3):160-5. Epub 2004 Dec 9.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianópolis, SC 88049-900, Brazil.

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March 2005

Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors.

Neurobiol Aging 2005 Jun;26(6):957-64

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Campus Trindade, 88049-900 Florianópolis, SC, Brazil.

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June 2005

Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice.

Eur J Pharmacol 2004 Sep;499(1-2):147-54

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Rua Ferreira Lima 82, Florianópolis, SC 88015-420, Brazil.

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September 2004

Facilitation of short-term social memory by ethanol in rats is mediated by dopaminergic receptors.

Behav Brain Res 2004 Aug;153(1):149-57

Departamento de Farmacologia, Universidade Federal de Santa Catarina, Rua Ferreira Lima 82, 88015-420 Florianópolis, SC, Brazil.

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August 2004

Ethanol improves short-term social memory in rats. Involvement of opioid and muscarinic receptors.

Eur J Pharmacol 2003 Feb;462(1-3):115-23

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Rua Ferreira Lima 82, 88015-420 Florianópolis SC, Brazil.

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February 2003