Publications by authors named "Rudolf S N Fehrmann"

51Publications

Data-driven prioritization and preclinical evaluation of therapeutic targets in glioblastoma.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa151. Epub 2020 Nov 5.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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November 2020

Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors.

Oncogenesis 2020 Oct 7;9(10):88. Epub 2020 Oct 7.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713GZ, Groningen, The Netherlands.

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October 2020

Genome-wide association study of cardiovascular disease in testicular cancer patients treated with platinum-based chemotherapy.

Pharmacogenomics J 2020 Oct 3. Epub 2020 Oct 3.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

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October 2020

Transcriptional Activity and Stability of CD39+CD103+CD8+ T Cells in Human High-Grade Endometrial Cancer.

Int J Mol Sci 2020 May 27;21(11). Epub 2020 May 27.

Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

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May 2020

Reconsider radiation exposure from imaging during immune checkpoint inhibitor trials to reduce risk of secondary cancers in long-term survivors?

Cancer Treat Rev 2020 Jul 4;87:102027. Epub 2020 May 4.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

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July 2020

Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy.

Cancer Metastasis Rev 2020 09;39(3):999-1013

Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.

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September 2020

Transcriptional effects of copy number alterations in a large set of human cancers.

Nat Commun 2020 02 5;11(1):715. Epub 2020 Feb 5.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

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February 2020

Serotonin and Dopamine Receptor Expression in Solid Tumours Including Rare Cancers.

Pathol Oncol Res 2020 Jul 2;26(3):1539-1547. Epub 2019 Sep 2.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Box 30.001, 9700 RB, Groningen, The Netherlands.

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July 2020

Consideration of breast cancer subtype in targeting the androgen receptor.

Pharmacol Ther 2019 08 8;200:135-147. Epub 2019 May 8.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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August 2019

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

BMC Cancer 2019 04 25;19(1):390. Epub 2019 Apr 25.

Department of Surgery, Catharina Hospital, PO Box 1350, 5602 ZA, Eindhoven, Netherlands.

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April 2019

Transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells.

Exp Hematol 2019 05 13;73:38-49.e7. Epub 2019 Apr 13.

Department of Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

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May 2019

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.

Nat Commun 2019 01 9;10(1):100. Epub 2019 Jan 9.

Department of Medical Oncology, University Medical Center Groningen, Cancer Research Center Groningen, University of Groningen, Hanzeplein 1, 9713GZ, Groningen, The Netherlands.

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January 2019

Quantitative proteomics analysis identifies MUC1 as an effect sensor of EGFR inhibition.

Oncogene 2019 02 10;38(9):1477-1488. Epub 2018 Oct 10.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713GZ, Groningen, Netherlands.

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February 2019

TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells.

Oncogene 2019 02 3;38(6):852-867. Epub 2018 Sep 3.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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February 2019

Considering the biology of late recurrences in selecting patients for extended endocrine therapy in breast cancer.

Cancer Treat Rev 2018 Nov 26;70:118-126. Epub 2018 Jul 26.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

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November 2018

Glypican 3 Overexpression across a Broad Spectrum of Tumor Types Discovered with Functional Genomic mRNA Profiling of a Large Cancer Database.

Am J Pathol 2018 09 21;188(9):1973-1981. Epub 2018 Jun 21.

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

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September 2018

Data-Driven Prioritization and Review of Targets for Molecular-Based Theranostic Approaches in Pancreatic Cancer.

J Nucl Med 2017 12 19;58(12):1899-1903. Epub 2017 Oct 19.

Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands; and.

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December 2017

Theranostics Using Antibodies and Antibody-Related Therapeutics.

J Nucl Med 2017 09;58(Suppl 2):83S-90S

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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September 2017

Identification of novel therapeutic targets in anaplastic thyroid carcinoma using functional genomic mRNA-profiling: Paving the way for new avenues?

Surgery 2017 01 16;161(1):202-211. Epub 2016 Nov 16.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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January 2017

Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer.

J Natl Cancer Inst 2017 01 13;109(1). Epub 2016 Oct 13.

Affiliations of authors: Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (RDB, MATMvV, EGEdV, CPS, RSNF); Department of Medical Oncology and Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium (CS, MJPG); Division of Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands (JBAGH).

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January 2017

Functional genomic mRNA profiling of a large cancer data base demonstrates mesothelin overexpression in a broad range of tumor types.

Oncotarget 2015 Sep;6(29):28164-72

University of Groningen, University Medical Center Groningen, Department of Medical Oncology, Groningen, The Netherlands.

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September 2015

Regulators of homologous recombination repair as novel targets for cancer treatment.

Front Genet 2015 20;6:96. Epub 2015 Mar 20.

Department of Medical Oncology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen Groningen, Netherlands.

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April 2015

Growth differentiation factor 15 (GDF-15) plasma levels increase during bleomycin- and cisplatin-based treatment of testicular cancer patients and relate to endothelial damage.

PLoS One 2015 15;10(1):e0115372. Epub 2015 Jan 15.

Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.

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December 2015

Treatment with high-dose simvastatin inhibits geranylgeranylation in AML blast cells in a subset of AML patients.

Exp Hematol 2012 Mar 25;40(3):177-186.e6. Epub 2011 Nov 25.

Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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March 2012

MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects.

Bioinformatics 2011 Aug 7;27(15):2104-11. Epub 2011 Jun 7.

Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.

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August 2011

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:
Carl A Anderson Gabrielle Boucher Charlie W Lees Andre Franke Mauro D'Amato Kent D Taylor James C Lee Philippe Goyette Marcin Imielinski Anna Latiano Caroline Lagacé Regan Scott Leila Amininejad Suzannah Bumpstead Leonard Baidoo Robert N Baldassano Murray Barclay Theodore M Bayless Stephan Brand Carsten Büning Jean-Frédéric Colombel Lee A Denson Martine De Vos Marla Dubinsky Cathryn Edwards David Ellinghaus Rudolf S N Fehrmann James A B Floyd Timothy Florin Denis Franchimont Lude Franke Michel Georges Jürgen Glas Nicole L Glazer Stephen L Guthery Talin Haritunians Nicholas K Hayward Jean-Pierre Hugot Gilles Jobin Debby Laukens Ian Lawrance Marc Lémann Arie Levine Cecile Libioulle Edouard Louis Dermot P McGovern Monica Milla Grant W Montgomery Katherine I Morley Craig Mowat Aylwin Ng William Newman Roel A Ophoff Laura Papi Orazio Palmieri Laurent Peyrin-Biroulet Julián Panés Anne Phillips Natalie J Prescott Deborah D Proctor Rebecca Roberts Richard Russell Paul Rutgeerts Jeremy Sanderson Miquel Sans Philip Schumm Frank Seibold Yashoda Sharma Lisa A Simms Mark Seielstad A Hillary Steinhart Stephan R Targan Leonard H van den Berg Morten Vatn Hein Verspaget Thomas Walters Cisca Wijmenga David C Wilson Harm-Jan Westra Ramnik J Xavier Zhen Z Zhao Cyriel Y Ponsioen Vibeke Andersen Leif Torkvist Maria Gazouli Nicholas P Anagnou Tom H Karlsen Limas Kupcinskas Jurgita Sventoraityte John C Mansfield Subra Kugathasan Mark S Silverberg Jonas Halfvarson Jerome I Rotter Christopher G Mathew Anne M Griffiths Richard Gearry Tariq Ahmad Steven R Brant Mathias Chamaillard Jack Satsangi Judy H Cho Stefan Schreiber Mark J Daly Jeffrey C Barrett Miles Parkes Vito Annese Hakon Hakonarson Graham Radford-Smith Richard H Duerr Séverine Vermeire Rinse K Weersma John D Rioux

Nat Genet 2011 Mar 6;43(3):246-52. Epub 2011 Feb 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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March 2011

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.

Authors:
Nona Sotoodehnia Aaron Isaacs Paul I W de Bakker Marcus Dörr Christopher Newton-Cheh Ilja M Nolte Pim van der Harst Martina Müller Mark Eijgelsheim Alvaro Alonso Andrew A Hicks Sandosh Padmanabhan Caroline Hayward Albert Vernon Smith Ozren Polasek Steven Giovannone Jingyuan Fu Jared W Magnani Kristin D Marciante Arne Pfeufer Sina A Gharib Alexander Teumer Man Li Joshua C Bis Fernando Rivadeneira Thor Aspelund Anna Köttgen Toby Johnson Kenneth Rice Mark P S Sie Ying A Wang Norman Klopp Christian Fuchsberger Sarah H Wild Irene Mateo Leach Karol Estrada Uwe Völker Alan F Wright Folkert W Asselbergs Jiaxiang Qu Aravinda Chakravarti Moritz F Sinner Jan A Kors Astrid Petersmann Tamara B Harris Elsayed Z Soliman Patricia B Munroe Bruce M Psaty Ben A Oostra L Adrienne Cupples Siegfried Perz Rudolf A de Boer André G Uitterlinden Henry Völzke Timothy D Spector Fang-Yu Liu Eric Boerwinkle Anna F Dominiczak Jerome I Rotter Gé van Herpen Daniel Levy H-Erich Wichmann Wiek H van Gilst Jacqueline C M Witteman Heyo K Kroemer W H Linda Kao Susan R Heckbert Thomas Meitinger Albert Hofman Harry Campbell Aaron R Folsom Dirk J van Veldhuisen Christine Schwienbacher Christopher J O'Donnell Claudia Beu Volpato Mark J Caulfield John M Connell Lenore Launer Xiaowen Lu Lude Franke Rudolf S N Fehrmann Gerard te Meerman Harry J M Groen Rinse K Weersma Leonard H van den Berg Cisca Wijmenga Roel A Ophoff Gerjan Navis Igor Rudan Harold Snieder James F Wilson Peter P Pramstaller David S Siscovick Thomas J Wang Vilmundur Gudnason Cornelia M van Duijn Stephan B Felix Glenn I Fishman Yalda Jamshidi Bruno H Ch Stricker Nilesh J Samani Stefan Kääb Dan E Arking

Nat Genet 2010 Dec 14;42(12):1068-76. Epub 2010 Nov 14.

Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.

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December 2010

Evidence based selection of housekeeping genes.

PLoS One 2007 Sep 19;2(9):e898. Epub 2007 Sep 19.

Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, Groningen, The Netherlands.

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September 2007

Profiling studies in ovarian cancer: a review.

Oncologist 2007 Aug;12(8):960-6

Department of Medical Oncology, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

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August 2007