Rudolf Jaenisch

Rudolf Jaenisch

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Rudolf Jaenisch

Publications by authors named "Rudolf Jaenisch"

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99Publications

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Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs.

Mol Cell 2019 Sep 15;75(5):905-920.e6. Epub 2019 Aug 15.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731151PMC
September 2019

Whsc1 links pluripotency exit with mesendoderm specification.

Nat Cell Biol 2019 Jul 24;21(7):824-834. Epub 2019 Jun 24.

Center for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41556-019-0342-1DOI Listing
July 2019

Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs.

Cell Stem Cell 2019 May 18;24(5):724-735.e5. Epub 2019 Apr 18.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509360PMC
May 2019

Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.

Cell 2019 Feb 31;176(4):928-943.e22. Epub 2019 Jan 31.

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Systems Biology Harvard Medical School, Boston, MA 02125, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193003
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http://dx.doi.org/10.1016/j.cell.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402800PMC
February 2019

Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype.

Cell Rep 2018 10;25(2):368-382.e5

Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, MIT, 31 Ames Street, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183147
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http://dx.doi.org/10.1016/j.celrep.2018.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392048PMC
October 2018

Stem Cells, Genome Editing, and the Path to Translational Medicine.

Cell 2018 10;175(3):615-632

The Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 31 Ames Street, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183118
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http://dx.doi.org/10.1016/j.cell.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461399PMC
October 2018

Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation.

Stem Cell Reports 2018 05 29;10(5):1445-1452. Epub 2018 Mar 29.

Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995271PMC
May 2018

Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas.

Proc Natl Acad Sci U S A 2018 04 29;115(15):3924-3929. Epub 2018 Mar 29.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142;

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http://dx.doi.org/10.1073/pnas.1702059115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899428PMC
April 2018

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.

Cell 2018 02 15;172(5):979-992.e6. Epub 2018 Feb 15.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183004
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http://dx.doi.org/10.1016/j.cell.2018.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375087PMC
February 2018

Monitoring Dynamics of DNA Methylation at Single-Cell Resolution during Development and Disease.

Cold Spring Harb Symp Quant Biol 2015 2;80:199-206. Epub 2015 Oct 2.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142.

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http://dx.doi.org/10.1101/sqb.2015.80.027334DOI Listing
January 2018

YY1 Is a Structural Regulator of Enhancer-Promoter Loops.

Cell 2017 Dec 7;171(7):1573-1588.e28. Epub 2017 Dec 7.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785279PMC
December 2017

Mechanisms of gene regulation in human embryos and pluripotent stem cells.

Development 2017 12;144(24):4496-4509

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA

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http://dx.doi.org/10.1242/dev.157404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769625PMC
December 2017

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models.

Cell Rep 2017 Nov;21(8):2171-2182

Departments of Molecular Medicine and Neuroscience and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121, USA; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705204PMC
November 2017

Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation.

Stem Cell Reports 2017 10 28;9(4):1291-1303. Epub 2017 Sep 28.

The Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 91904, Israel; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639460PMC
October 2017

An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells.

Stem Cell Reports 2017 10 28;9(4):1304-1314. Epub 2017 Sep 28.

Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639459PMC
October 2017

Human Embryo Editing: Opportunities and Importance of Transnational Cooperation.

Cell Stem Cell 2017 10;21(4):423-426

California Institute of Technology, Pasadena, CA 91125, USA; Organizing Committee for the International Summit on Human Gene Editing.

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http://dx.doi.org/10.1016/j.stem.2017.09.010DOI Listing
October 2017

Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells.

Nat Commun 2017 10 23;8(1):1096. Epub 2017 Oct 23.

Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-017-01076-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653659PMC
October 2017

Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors.

Neuropsychopharmacology 2017 Jul 11;42(8):1657-1669. Epub 2017 Jan 11.

Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/npp.2017.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518912PMC
July 2017

Induction of Expansion and Folding in Human Cerebral Organoids.

Cell Stem Cell 2017 03 29;20(3):385-396.e3. Epub 2016 Dec 29.

The Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 31 Ames Street, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461394PMC
March 2017

Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation.

Cell Stem Cell 2017 01 15;20(1):87-101. Epub 2016 Dec 15.

Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218861PMC
January 2017

CNS disease models with human pluripotent stem cells in the CRISPR age.

Curr Opin Cell Biol 2016 12 19;43:96-103. Epub 2016 Oct 19.

Whitehead Institute for Biomedical Research, 9Cambridge Center, Cambridge, MA 02142, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2016.10.001DOI Listing
December 2016

Stem cells and interspecies chimaeras.

Nature 2016 12;540(7631):51-59

Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature20573DOI Listing
December 2016

Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome.

Proc Natl Acad Sci U S A 2016 11 1;113(46):E7287-E7296. Epub 2016 Nov 1.

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1615330113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135376PMC
November 2016

Molecular Criteria for Defining the Naive Human Pluripotent State.

Cell Stem Cell 2016 10 14;19(4):502-515. Epub 2016 Jul 14.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065525PMC
October 2016

Parent-of-Origin DNA Methylation Dynamics during Mouse Development.

Cell Rep 2016 09;16(12):3167-3180

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119552PMC
September 2016

Editing DNA Methylation in the Mammalian Genome.

Cell 2016 Sep;167(1):233-247.e17

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062609PMC
http://dx.doi.org/10.1016/j.cell.2016.08.056DOI Listing
September 2016

Induced Pluripotent Stem Cells Meet Genome Editing.

Cell Stem Cell 2016 05;18(5):573-86

The Whitehead Institute for Biomedical Research and Department of Biology, MIT, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.stem.2016.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871596PMC
May 2016

Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation.

Mol Cell Biol 2016 02 23;36(3):452-61. Epub 2015 Nov 23.

Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany

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http://dx.doi.org/10.1128/MCB.00587-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719427PMC
February 2016

3D Chromosome Regulatory Landscape of Human Pluripotent Cells.

Cell Stem Cell 2016 Feb 10;18(2):262-75. Epub 2015 Dec 10.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(15)00505-6
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http://www.cell.com/cms/attachment/2045959822/2057172160/mmc
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http://dx.doi.org/10.1016/j.stem.2015.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848748PMC
February 2016

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.

Proc Natl Acad Sci U S A 2016 Feb 25;113(6):1570-5. Epub 2016 Jan 25.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142

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http://dx.doi.org/10.1073/pnas.1525518113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760776PMC
February 2016

Induced Pluripotency and Epigenetic Reprogramming.

Cold Spring Harb Perspect Biol 2015 Dec 1;7(12). Epub 2015 Dec 1.

Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142.

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http://dx.doi.org/10.1101/cshperspect.a019448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665075PMC
December 2015

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice.

Cell Rep 2015 Nov 12;13(8):1692-704. Epub 2015 Nov 12.

Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, University of Miami, Miami, FL 33136, USA; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764044PMC
November 2015

A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity.

Stem Cell Reports 2015 Nov;5(5):763-775

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649293PMC
November 2015

A conversation with Rudolf Jaenisch.

J Clin Invest 2015 Sep 1;125(9):3305-7. Epub 2015 Sep 1.

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http://dx.doi.org/10.1172/JCI82629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588280PMC
September 2015

Hallmarks of pluripotency.

Nature 2015 Sep;525(7570):469-78

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature15515DOI Listing
September 2015

Failure to replicate the STAP cell phenomenon.

Nature 2015 Sep;525(7570):E6-9

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature15513DOI Listing
September 2015

Tracing dynamic changes of DNA methylation at single-cell resolution.

Cell 2015 Sep;163(1):218-29

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583717PMC
September 2015

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Proc Natl Acad Sci U S A 2015 Aug 20;112(31):E4281-7. Epub 2015 Jul 20.

Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1512289112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534235PMC
August 2015

TET1 is a tumor suppressor of hematopoietic malignancy.

Nat Immunol 2015 Jun 13;16(6):653-62. Epub 2015 Apr 13.

1] Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, New York, USA. [2] NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1038/ni.3148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545281PMC
June 2015

Stem Cell Research: Promise and Progress.

Authors:
Rudolf Jaenisch

Stem Cell Reports 2015 Jun;4(6):953-4

ISSCR President, 2014-2015.

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http://dx.doi.org/10.1016/j.stemcr.2015.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471823PMC
June 2015

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Nat Commun 2015 Jun 16;6:7314. Epub 2015 Jun 16.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms8314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490410PMC
June 2015

An interview with Rudolf Jaenisch.

Development 2015 Jun;142(12):2085-7

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http://dx.doi.org/10.1242/dev.126128DOI Listing
June 2015

Dissecting risk haplotypes in sporadic Alzheimer's disease.

Cell Stem Cell 2015 Apr;16(4):341-2

The Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 31 Ames Street, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.03.010DOI Listing
April 2015

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions.

Proc Natl Acad Sci U S A 2015 Mar 9;112(12):3841-6. Epub 2015 Mar 9.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1502971112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378427PMC
March 2015

SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.

Cell Stem Cell 2015 Jan 20;16(1):33-8. Epub 2014 Nov 20.

TSI Laboratory, University Heart Center Hamburg, Martinistrasse 52, 20246 Hamburg, Germany; Cardiovascular Research Center Hamburg (CVRC) and DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Martinistrasse 52, 20246 Hamburg, Germany; Stanford Cardiovascular Institute and Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.11.003DOI Listing
January 2015

Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells.

Stem Cell Reports 2014 Dec 6;3(6):948-56. Epub 2014 Nov 6.

The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264067PMC
December 2014

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.

Nature 2014 Oct 17;514(7523):513-7. Epub 2014 Aug 17.

1] Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, New York 10016, USA [2] NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/nature13605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209203PMC
October 2014

The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.

Cell Stem Cell 2014 Sep;15(3):295-309

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Skolkovo Institute of Science and Technology (Skoltech), Novaya strazha 100, Skolkovo Moscow Region 143025, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170792PMC
September 2014

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering.

Nat Protoc 2014 Aug 24;9(8):1956-68. Epub 2014 Jul 24.

1] Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA. [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2014.134DOI Listing
August 2014

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells.

Nat Biotechnol 2014 Jul 20;32(7):670-6. Epub 2014 Apr 20.

1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145672PMC
July 2014

Restarting stalled autophagy a potential therapeutic approach for the lipid storage disorder, Niemann-Pick type C1 disease.

Autophagy 2014 Jun;10(6):1137-40

Whitehead Institute for Biomedical Research; Massachusetts Institute of Technology; Cambridge, MA USA; Skolkovo Institute of Science and Technology (Skoltech); Skolkovo, Moscow Region, Russia.

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http://dx.doi.org/10.4161/auto.28623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091173PMC
June 2014

Molecular control of induced pluripotency.

Cell Stem Cell 2014 Jun;14(6):720-34

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112734PMC
June 2014

Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.

Stem Cell Reports 2014 Jun 15;2(6):866-80. Epub 2014 May 15.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA ; Skolkovo Institute of Science and Technology (Skoltech), Novaya Street 100, Skolkovo 143025, Moscow Region, Russia ; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.stemcr.2014.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050353PMC
June 2014

Transcriptional profiling of cells sorted by RNA abundance.

Nat Methods 2014 May 30;11(5):549-551. Epub 2014 Mar 30.

Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.

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http://dx.doi.org/10.1038/nmeth.2910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174458PMC
May 2014

Loss of Tet enzymes compromises proper differentiation of embryonic stem cells.

Dev Cell 2014 Apr;29(1):102-11

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035811PMC
April 2014

A stochastic model dissects cell states in biological transition processes.

Sci Rep 2014 Jan 17;4:3692. Epub 2014 Jan 17.

Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/srep03692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894565PMC
January 2014

Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease.

Cell Rep 2013 Dec 27;5(5):1302-15. Epub 2013 Nov 27.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957429PMC
December 2013

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system.

Cell Res 2013 Oct 27;23(10):1163-71. Epub 2013 Aug 27.

1] Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA [2] Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/cr.2013.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790238PMC
October 2013

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering.

Cell 2013 Sep 29;154(6):1370-9. Epub 2013 Aug 29.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.cell.2013.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961003PMC
September 2013

Tet1 is critical for neuronal activity-regulated gene expression and memory extinction.

Neuron 2013 Sep;79(6):1109-1122

The Picower Institute for Learning and Memory, 77 Massachusetts Avenue, Cambridge, MA, 02139.

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http://dx.doi.org/10.1016/j.neuron.2013.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543319PMC
September 2013

Mechanisms and models of somatic cell reprogramming.

Nat Rev Genet 2013 Jun;14(6):427-39

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nrg3473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060150PMC
June 2013