Publications by authors named "Rudolf Hagen"

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Impact and Modulations of Peripheral and Edaphic B Cell Subpopulations in Chronic Rhinosinusitis With Nasal Polyposis.
Clin Exp Otorhinolaryngol 2018 Jun 8;11(2):133-140. Epub 2018 Feb 8.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Wuerzburg, Germany.

A polydopamine peptide coating enables adipose-derived stem cell growth on the silicone surface of cochlear implant electrode arrays.
J Biomed Mater Res B Appl Biomater 2018 May 22;106(4):1431-1438. Epub 2017 Jun 22.
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Carl von Ossietzky-University, Oldenburg, Germany.

Patterned semiconductor structures modulate neuronal outgrowth: Implication for the development of a neurobionic interface.
J Biomed Mater Res A 2018 Jan 26;106(1):65-72. Epub 2017 Sep 26.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery and the Comprehensive Hearing Center, University of Wuerzburg, Würzburg, Germany.


Time-Dependent Toxic and Genotoxic Effects of Zinc Oxide Nanoparticles after Long-Term and Repetitive Exposure to Human Mesenchymal Stem Cells.
Int J Environ Res Public Health 2017 Dec 18;14(12). Epub 2017 Dec 18.
Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, 97080 Würzburg, Germany.

Management of CSF leakage after microsurgery for vestibular schwannoma via the middle cranial fossa approach.
Eur Arch Otorhinolaryngol 2016 Oct 9;273(10):2975-81. Epub 2016 Jan 9.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital of Wuerzburg, Josef-Schneider-Strasse 11, 97080, Würzburg, Germany.

Long-term Stability of the Active Middle-ear Implant with Floating-mass Transducer Technology: A Single-center Study.
Otol Neurotol 2016 Mar;37(3):252-66
*Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Comprehensive Hearing Center, University of Wuerzburg, Würzburg †Department of Oto-Rhino-Laryngology, Head and Neck Surgery "Otto Körner," University Medical Center Rostock, Rostock, Germany.

Effects of salinomycin and CGP37157 on head and neck squamous cell carcinoma cell lines in vitro.
Mol Med Rep 2015 Sep 22;12(3):4455-61. Epub 2015 Jun 22.
Department of Oto‑Rhino‑Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius‑Maximilian‑University of Wuerzburg, Wuerzburg D‑97080, Germany.

Standardized Active Middle-Ear Implant Coupling to the Short Incus Process.
Otol Neurotol 2015 Sep;36(8):1390-8
*Department of Otorhinolaryngology, Head and Neck Surgery "Otto Koerner" University Medical Center Rostock, Rostock; †Department of Otolaryngology, Section of Physiological Acoustics and Communication, University of Tübingen, Tübingen; and ‡Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Comprehensive Hearing Center, University of Würzburg, Würzburg, Germany.

Cochlear nucleus whole mount explants promote the differentiation of neuronal stem cells from the cochlear nucleus in co-culture experiments.
Brain Res 2015 Aug 8;1616:58-70. Epub 2015 May 8.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery and the Comprehensive Hearing Center, University of Wuerzburg, Wuerzburg, Germany.

Assessment of HEMA and TEGDMA induced DNA damage by multiple genotoxicological endpoints in human lymphocytes.
Dent Mater 2015 Aug 27;31(8):865-76. Epub 2015 May 27.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital of Wuerzburg, Josef-Schneider-Str. 11, D-97080 Wuerzburg, Germany.

Human mesenchymal stem cells enhance cancer cell proliferation via IL-6 secretion and activation of ERK1/2.
Int J Oncol 2015 Jul 18;47(1):391-7. Epub 2015 May 18.
Department of Oto-Rhino-Laryngology Plastic, Aesthetic and Reconstructive, Head and Neck Surgery, Julius-Maximilian-University Wuerzburg, D-97080 Wuerzburg, Germany.

Geno- and cytotoxicity of salinomycin in human nasal mucosa and peripheral blood lymphocytes.
Toxicol In Vitro 2015 Jun 10;29(4):813-8. Epub 2015 Mar 10.
Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Josef-Schneider-Str. 11, D-97080 Wuerzburg, Germany. Electronic address:

Mosaic pattern of Cre recombinase expression in cochlear outer hair cells of the Brn3.1 Cre mouse.
Neuroreport 2015 Apr;26(6):309-13
aDepartment of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery and the Comprehensive Hearing Center bInstitute for Clinical Neurobiology, University of Wuerzburg, Wuerzburg cDepartment of Oto-Rhino-Laryngology, University of Duesseldorf, Duesseldorf dDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery 'Otto Koerner', Rostock University Medical Center, Rostock, Germany.

Reinforced active middle ear implant fixation in incus vibroplasty.
Ear Hear 2015 Jan;36(1):72-81
1Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Otto Koerner Rostock University Medical Center, Rostock, Germany; 2Department of Otolaryngology, Section of Physiological Acoustics and Communication, University of Tübingen, Tübingen, Germany; and 3Department of Oto-Rhino-Laryngology, Plastic, Aesthetic, and Reconstructive Head and Neck Surgery, Comprehensive Hearing Center, University of Wuerzburg, Würzburg, Germany.


Vibro-EAS: a proposal for electroacoustic stimulation.
Otol Neurotol 2015 Jan;36(1):22-7
*Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Comprehensive Hearing Center, University of Würzburg, Würzburg, Germany, †Department of Oto-Rhino-Laryngology, Head and Neck Surgery, "Otto Koerner," Rostock University Medical Center, Rostock, Germany; ‡Department of Otolaryngology, Section of Physiological Acoustics and Communication, University of Tübingen, Tübingen, Germany; and §Department of Neuroradiology, University of Würzburg, Würzburg, Germany.

Neurotrophic effects of taurine on spiral ganglion neurons in vitro.
Neuroreport 2014 Nov;25(16):1250-4
aDepartment of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Comprehensive Hearing Center bInstitute for Clinical Neurobiology, University of Wuerzburg cDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery 'Otto Körner', Rostock University Medical Center, Rostock, Germany.

Nicotine derived genotoxic effects in human primary parotid gland cells as assessed in vitro by comet assay, cytokinesis-block micronucleus test and chromosome aberrations test.
Toxicol In Vitro 2014 Aug 31;28(5):838-46. Epub 2014 Mar 31.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital of Wuerzburg, Josef-Schneider-Str. 11, D-97080 Wuerzburg, Germany. Electronic address:

Effects of the neurotrophic factors BDNF, NT-3, and FGF2 on dissociated neurons of the cochlear nucleus.
Neuroreport 2014 Aug;25(12):960-4
aDepartment of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Comprehensive Hearing Center bInstitute for Clinical Neurobiology, University of Wuerzburg, Wuerzburg, Germany.

Nicotine causes genotoxic damage but is not metabolized during long-term exposure of human nasal miniorgan cultures.
Toxicol Lett 2014 Aug 29;229(1):303-10. Epub 2014 Jun 29.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius-Maximilian University Würzburg, Josef-Schneider-Str. 11, D-97080 Würzburg, Germany.

A hydrogel coating for cochlear implant arrays with encapsulated adipose-derived stem cells allows brain-derived neurotrophic factor delivery.
Acta Otolaryngol 2014 May 19;134(5):497-505. Epub 2014 Mar 19.
Comprehensive Hearing Center, Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg , Germany.

Nanoparticle-induced photocatalytic head and neck squamous cell carcinoma cell death is associated with autophagy.
Nanomedicine (Lond) 2014 Jan 3;9(1):21-33. Epub 2013 Jun 3.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic & Reconstructive Head & Neck Surgery, University Hospital of Wuerzburg, Germany.

Mutation of the TBCE gene causes disturbance of microtubules in the auditory nerve and cochlear outer hair cell degeneration accompanied by progressive hearing loss in the pmn/pmn mouse.
Exp Neurol 2013 Dec 10;250:333-40. Epub 2013 Oct 10.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Germany; Comprehensive Hearing Center, University of Wuerzburg, Germany.

Chromosomal aberrations and deoxyribonucleic acid single-strand breaks in adipose-derived stem cells during long-term expansion in vitro.
Cytotherapy 2013 Jul 1;15(7):767-81. Epub 2013 May 1.
Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Germany.

Dynamic changes of the neurogenic potential in the rat cochlear nucleus during post-natal development.
Exp Brain Res 2013 May 2;226(3):393-406. Epub 2013 Mar 2.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Comprehensive Hearing Center, University of Wuerzburg, Josef-Schneider-Strasse 11, 97080 Wuerzburg, Germany.

Outcome on hearing and facial nerve function in microsurgical treatment of small vestibular schwannoma via the middle cranial fossa approach.
Eur Arch Otorhinolaryngol 2013 Mar 22;270(4):1209-16. Epub 2012 Jun 22.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital of Wuerzburg, Josef-Schneider-Str. 11, 97080 Wuerzburg, Germany.

Influence of different growth factors on chondrogenic differentiation of adipose-derived stem cells in polyurethane-fibrin composites.
Int J Artif Organs 2012 Dec;35(12):1047-60
Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, 97080 Wuerzburg, Germany.


Antitumor activity of photo-stimulated zinc oxide nanoparticles combined with paclitaxel or cisplatin in HNSCC cell lines.
J Photochem Photobiol B 2012 Sep 29;114:87-93. Epub 2012 May 29.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Germany.

Use of flexible CO₂ laser fiber in microsurgery for vestibular schwannoma via the middle cranial fossa approach.
Eur Arch Otorhinolaryngol 2012 May 4;269(5):1417-23. Epub 2011 Oct 4.
Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital of Wuerzburg, Josef-Schneider-Strasse 11, 97080 Wuerzburg, Germany.

Analysis of nicotine-induced DNA damage in cells of the human respiratory tract.
Toxicol Lett 2012 Jan 5;208(1):23-9. Epub 2011 Oct 5.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius-Maximilian University Wuerzburg, Josef-Schneider-Str. 11, D-97080 Wuerzburg, Germany.

The effect of wound fluid on adipose-derived stem cells in vitro: a study in human cell materials.
Tissue Eng Part C Methods 2011 Aug 16;17(8):809-17. Epub 2011 May 16.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius-Maximilian-University Würzburg, Würzburg, Germany.

Repetitive exposure to zinc oxide nanoparticles induces dna damage in human nasal mucosa mini organ cultures.
Environ Mol Mutagen 2011 Aug 22;52(7):582-9. Epub 2011 Jul 22.
Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Germany.

Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro.
Toxicol In Vitro 2011 Apr 11;25(3):657-63. Epub 2011 Jan 11.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Josef-Schneider-Str. 11, D-97080 Wuerzburg, Germany.

Isolation and characterization of neural stem cells from the neonatal rat cochlear nucleus.
Cell Tissue Res 2011 Mar 22;343(3):499-508. Epub 2011 Jan 22.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery and the Comprehensive Hearing Center, University of Wuerzburg, Josef-Schneider-Straße 11, 97080 Wuerzburg, Germany.

Silver nanoparticles: evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cells.
Toxicol Lett 2011 Feb 8;201(1):27-33. Epub 2010 Dec 8.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Josef-Schneider-Str. 11, D-97080 Wuerzburg, Germany.

Clinical trial results with the MED-EL fine structure processing coding strategy in experienced cochlear implant users.
ORL J Otorhinolaryngol Relat Spec 2012 18;74(4):185-98. Epub 2012 Jul 18.
Department of Otorhinolaryngology, Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Ludwig-Maximilians-Universität München, Munich, Germany.

Plasma-assisted hydrophilization of cochlear implant electrode array surfaces enables adhesion of neurotrophin-secreting cells.
ORL J Otorhinolaryngol Relat Spec 2014 20;76(5):257-65. Epub 2014 Nov 20.
Comprehensive Hearing Center, Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Würzburg, Würzburg, Germany.


Coupling of an active middle-ear implant to the long process of the incus using an elastic clip attachment.
Hear Res 2016 10 13;340:179-184. Epub 2016 Apr 13.
Department of Otolaryngology, Section of Physiological Acoustics and Communication, University of Tübingen, Elfriede-Aulhorn-Straße 5, D-72076 Tübingen, Germany.

Cochlear Implantation Improves Spatial Release From Masking and Restores Localization Abilities in Single-sided Deaf Patients.
Otol Neurotol 2016 07;37(6):658-64
*Comprehensive Hearing Center, Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Würzburg, Würzburg†MED-EL Deutschland GmbH, Starnberg‡Department of Oto-Rhino-Laryngology, Head and Neck Surgery "Otto Körner," Rostock University Medical Center, Rostock, Germany.



Stable Longitudinal Performance of Adult Cochlear Implant Users for More Than 10 Years.
Otol Neurotol 2017 10;38(9):e315-e319
*Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery and the Comprehensive Hearing Center, University of Wuerzburg, Wuerzburg †Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Oldenburg, Oldenburg, Germany.

Cardiac and renal dysfunction is associated with progressive hearing loss in patients with Fabry disease.
PLoS One 2017 21;12(11):e0188103. Epub 2017 Nov 21.
Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Comprehensive Hearing Center, University Hospital Würzburg, Würzburg, Germany.

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