Publications by authors named "Rudi Beyaert"

100Publications

Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity.

iScience 2020 Oct 12;23(10):101557. Epub 2020 Sep 12.

Center for Inflammation Research, VIB, Technologiepark-Zwijnaarde 71, 9052 Ghent, Belgium.

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http://dx.doi.org/10.1016/j.isci.2020.101557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522757PMC
October 2020

Recognition by Dendritic Cells Negatively Regulates Allergic Lung Inflammation Through a TLR2/MyD88 Pathway.

Am J Respir Cell Mol Biol 2020 Sep 24. Epub 2020 Sep 24.

Sciensano, 54513, Infectious Human Diseases. Service Immune Response, Brussels, Belgium.

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http://dx.doi.org/10.1165/rcmb.2020-0083OCDOI Listing
September 2020

Defining the combinatorial space of PKC::CARD-CC signal transduction nodes.

FEBS J 2020 Aug 13. Epub 2020 Aug 13.

Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1111/febs.15522DOI Listing
August 2020

Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors.

Front Immunol 2020 13;11:1422. Epub 2020 Jul 13.

Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.

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http://dx.doi.org/10.3389/fimmu.2020.01422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370943PMC
July 2020

Taking the STING Out of Sepsis?

Cell Host Microbe 2020 04;27(4):491-493

Center for Inflammation Research, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2020.03.016DOI Listing
April 2020

Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases.

Biochem Pharmacol 2020 05 20;175:113866. Epub 2020 Feb 20.

VIB-UGent Center for Inflammation Research, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2020.113866DOI Listing
May 2020

Fragility can be a good thing in cancer.

Nat Immunol 2020 01;21(1):11-13

Center for Inflammation Research, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1038/s41590-019-0564-1DOI Listing
January 2020

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages William W Agace Nima Aghaeepour Mübeccel Akdis Matthieu Allez Larissa Nogueira Almeida Giorgia Alvisi Graham Anderson Immanuel Andrä Francesco Annunziato Achille Anselmo Petra Bacher Cosima T Baldari Sudipto Bari Vincenzo Barnaba Joana Barros-Martins Luca Battistini Wolfgang Bauer Sabine Baumgart Nicole Baumgarth Dirk Baumjohann Bianka Baying Mary Bebawy Burkhard Becher Wolfgang Beisker Vladimir Benes Rudi Beyaert Alfonso Blanco Dominic A Boardman Christian Bogdan Jessica G Borger Giovanna Borsellino Philip E Boulais Jolene A Bradford Dirk Brenner Ryan R Brinkman Anna E S Brooks Dirk H Busch Martin Büscher Timothy P Bushnell Federica Calzetti Garth Cameron Ilenia Cammarata Xuetao Cao Susanna L Cardell Stefano Casola Marco A Cassatella Andrea Cavani Antonio Celada Lucienne Chatenoud Pratip K Chattopadhyay Sue Chow Eleni Christakou Luka Čičin-Šain Mario Clerici Federico S Colombo Laura Cook Anne Cooke Andrea M Cooper Alexandra J Corbett Antonio Cosma Lorenzo Cosmi Pierre G Coulie Ana Cumano Ljiljana Cvetkovic Van Duc Dang Chantip Dang-Heine Martin S Davey Derek Davies Sara De Biasi Genny Del Zotto Gelo Victoriano Dela Cruz Michael Delacher Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing James P Di Santo Andreas Diefenbach Francesco Dieli Andreas Dolf Thomas Dörner Regine J Dress Diana Dudziak Michael Dustin Charles-Antoine Dutertre Friederike Ebner Sidonia B G Eckle Matthias Edinger Pascale Eede Götz R A Ehrhardt Marcus Eich Pablo Engel Britta Engelhardt Anna Erdei Charlotte Esser Bart Everts Maximilien Evrard Christine S Falk Todd A Fehniger Mar Felipo-Benavent Helen Ferry Markus Feuerer Andrew Filby Kata Filkor Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Britta Frehse Paul S Frenette Stefan Frischbutter Wolfgang Fritzsche David W Galbraith Anastasia Gangaev Natalio Garbi Brice Gaudilliere Ricardo T Gazzinelli Jens Geginat Wilhelm Gerner Nicholas A Gherardin Kamran Ghoreschi Lara Gibellini Florent Ginhoux Keisuke Goda Dale I Godfrey Christoph Goettlinger Jose M González-Navajas Carl S Goodyear Andrea Gori Jane L Grogan Daryl Grummitt Andreas Grützkau Claudia Haftmann Jonas Hahn Hamida Hammad Günter Hämmerling Leo Hansmann Goran Hansson Christopher M Harpur Susanne Hartmann Andrea Hauser Anja E Hauser David L Haviland David Hedley Daniela C Hernández Guadalupe Herrera Martin Herrmann Christoph Hess Thomas Höfer Petra Hoffmann Kristin Hogquist Tristan Holland Thomas Höllt Rikard Holmdahl Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Fang-Ping Huang Johanna E Huber Jochen Huehn Michael Hundemer Christopher A Hunter William Y K Hwang Anna Iannone Florian Ingelfinger Sabine M Ivison Hans-Martin Jäck Peter K Jani Beatriz Jávega Stipan Jonjic Toralf Kaiser Tomas Kalina Thomas Kamradt Stefan H E Kaufmann Baerbel Keller Steven L C Ketelaars Ahad Khalilnezhad Srijit Khan Jan Kisielow Paul Klenerman Jasmin Knopf Hui-Fern Koay Katja Kobow Jay K Kolls Wan Ting Kong Manfred Kopf Thomas Korn Katharina Kriegsmann Hendy Kristyanto Thomas Kroneis Andreas Krueger Jenny Kühne Christian Kukat Désirée Kunkel Heike Kunze-Schumacher Tomohiro Kurosaki Christian Kurts Pia Kvistborg Immanuel Kwok Jonathan Landry Olivier Lantz Paola Lanuti Francesca LaRosa Agnès Lehuen Salomé LeibundGut-Landmann Michael D Leipold Leslie Y T Leung Megan K Levings Andreia C Lino Francesco Liotta Virginia Litwin Yanling Liu Hans-Gustaf Ljunggren Michael Lohoff Giovanna Lombardi Lilly Lopez Miguel López-Botet Amy E Lovett-Racke Erik Lubberts Herve Luche Burkhard Ludewig Enrico Lugli Sebastian Lunemann Holden T Maecker Laura Maggi Orla Maguire Florian Mair Kerstin H Mair Alberto Mantovani Rudolf A Manz Aaron J Marshall Alicia Martínez-Romero Glòria Martrus Ivana Marventano Wlodzimierz Maslinski Giuseppe Matarese Anna Vittoria Mattioli Christian Maueröder Alessio Mazzoni James McCluskey Mairi McGrath Helen M McGuire Iain B McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Stephen D Miller Kingston H G Mills Hans Minderman Jenny Mjösberg Jonni Moore Barry Moran Lorenzo Moretta Tim R Mosmann Susann Müller Gabriele Multhoff Luis Enrique Muñoz Christian Münz Toshinori Nakayama Milena Nasi Katrin Neumann Lai Guan Ng Antonia Niedobitek Sussan Nourshargh Gabriel Núñez José-Enrique O'Connor Aaron Ochel Anna Oja Diana Ordonez Alberto Orfao Eva Orlowski-Oliver Wenjun Ouyang Annette Oxenius Raghavendra Palankar Isabel Panse Kovit Pattanapanyasat Malte Paulsen Dinko Pavlinic Livius Penter Pärt Peterson Christian Peth Jordi Petriz Federica Piancone Winfried F Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Zhiyong Poon Katharina Pracht Immo Prinz Carlo E M Pucillo Sally A Quataert Linda Quatrini Kylie M Quinn Helena Radbruch Tim R D J Radstake Susann Rahmig Hans-Peter Rahn Bartek Rajwa Gevitha Ravichandran Yotam Raz Jonathan A Rebhahn Diether Recktenwald Dorothea Reimer Caetano Reis e Sousa Ester B M Remmerswaal Lisa Richter Laura G Rico Andy Riddell Aja M Rieger J Paul Robinson Chiara Romagnani Anna Rubartelli Jürgen Ruland Armin Saalmüller Yvan Saeys Takashi Saito Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Inga Sandrock Angela Santoni Ramon Bellmàs Sanz Marina Saresella Catherine Sautes-Fridman Birgit Sawitzki Linda Schadt Alexander Scheffold Hans U Scherer Matthias Schiemann Frank A Schildberg Esther Schimisky Andreas Schlitzer Josephine Schlosser Stephan Schmid Steffen Schmitt Kilian Schober Daniel Schraivogel Wolfgang Schuh Thomas Schüler Reiner Schulte Axel Ronald Schulz Sebastian R Schulz Cristiano Scottá Daniel Scott-Algara David P Sester T Vincent Shankey Bruno Silva-Santos Anna Katharina Simon Katarzyna M Sitnik Silvano Sozzani Daniel E Speiser Josef Spidlen Anders Stahlberg Alan M Stall Natalie Stanley Regina Stark Christina Stehle Tobit Steinmetz Hannes Stockinger Yousuke Takahama Kiyoshi Takeda Leonard Tan Attila Tárnok Gisa Tiegs Gergely Toldi Julia Tornack Elisabetta Traggiai Mohamed Trebak Timothy I M Tree Joe Trotter John Trowsdale Maria Tsoumakidou Henning Ulrich Sophia Urbanczyk Willem van de Veen Maries van den Broek Edwin van der Pol Sofie Van Gassen Gert Van Isterdael René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Anouk von Borstel Konrad von Volkmann Ari Waisman Rachael V Walker Paul K Wallace Sa A Wang Xin M Wang Michael D Ward Kirsten A Ward-Hartstonge Klaus Warnatz Gary Warnes Sarah Warth Claudia Waskow James V Watson Carsten Watzl Leonie Wegener Thomas Weisenburger Annika Wiedemann Jürgen Wienands Anneke Wilharm Robert John Wilkinson Gerald Willimsky James B Wing Rieke Winkelmann Thomas H Winkler Oliver F Wirz Alicia Wong Peter Wurst Jennie H M Yang Juhao Yang Maria Yazdanbakhsh Liping Yu Alice Yue Hanlin Zhang Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky

Eur J Immunol 2019 Oct;49(10):1457-1973

Max Planck Institute for Infection Biology, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201970107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350392PMC
October 2019

Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site.

Biotechniques 2019 06 24;66(6):254-259. Epub 2019 May 24.

VIB-UGent Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.

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http://dx.doi.org/10.2144/btn-2019-0014DOI Listing
June 2019

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation.

J Allergy Clin Immunol 2019 07 13;144(1):204-215. Epub 2019 Mar 13.

Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193034
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http://dx.doi.org/10.1016/j.jaci.2019.02.028DOI Listing
July 2019

Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation.

Mol Cell Proteomics 2019 05 26;18(5):909-922. Epub 2019 Feb 26.

From the ‡Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, Ghent, Belgium;

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http://www.mcponline.org/lookup/doi/10.1074/mcp.RA119.001316
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http://dx.doi.org/10.1074/mcp.RA119.001316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495253PMC
May 2019

Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells.

Cell Immunol 2019 06 1;340:103877. Epub 2018 Dec 1.

Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Unit of Molecular Signal Transduction in Inflammation, Center for Inflammation Research, VIB, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2018.11.001DOI Listing
June 2019

Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function.

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, VIB, 9052 Ghent, Belgium.

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http://www.mdpi.com/1420-3049/23/12/3144
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http://dx.doi.org/10.3390/molecules23123144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320945PMC
November 2018

Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation.

ChemMedChem 2018 11 23;13(21):2317-2331. Epub 2018 Oct 23.

Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, 1190, Vienna, Austria.

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http://doi.wiley.com/10.1002/cmdc.201800505
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http://dx.doi.org/10.1002/cmdc.201800505DOI Listing
November 2018

IL-33 signalling contributes to pollutant-induced allergic airway inflammation.

Clin Exp Allergy 2018 12 19;48(12):1665-1675. Epub 2018 Sep 19.

Department of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1111/cea.13261DOI Listing
December 2018

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications.

Cells 2018 Aug 29;7(9). Epub 2018 Aug 29.

VIB-UGent Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, 9052 Ghent, Belgium.

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http://dx.doi.org/10.3390/cells7090122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162478PMC
August 2018

Psoriasis Plays a Wild CARD.

J Invest Dermatol 2018 09;138(9):1903-1905

Unit of Molecular Signal Transduction in Inflammation, Center for Inflammation Research, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.05.001DOI Listing
September 2018

Lipid A structural characterization from the LPS of the Siberian psychro-tolerant Psychrobacter arcticus 273-4 grown at low temperature.

Extremophiles 2018 Nov 20;22(6):955-963. Epub 2018 Aug 20.

Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126, Naples, Italy.

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http://dx.doi.org/10.1007/s00792-018-1051-6DOI Listing
November 2018

Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.

Chem Sci 2018 Apr 15;9(16):3957-3963. Epub 2018 Mar 15.

Department of Chemistry , University of Natural Resources and Life Sciences , Muthgasse 18 , A-1190 Vienna , Austria . Email:

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http://dx.doi.org/10.1039/c7sc05323aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941199PMC
April 2018

Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study.

Front Cell Dev Biol 2018 10;6:40. Epub 2018 Apr 10.

Unit of Molecular Signal Transduction in Inflammation, Department of Biomedical Molecular Biology, VIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.3389/fcell.2018.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932415PMC
April 2018

How Good Roommates Can Protect against Microbial Sepsis.

Cell Host Microbe 2018 03;23(3):283-285

VIB Center for Inflammation Research, Ghent, Belgium; Department Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.02.007DOI Listing
March 2018

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling.

Biochem Pharmacol 2018 07 31;153:292-298. Epub 2018 Jan 31.

Center for Inflammation Research, VIB, Unit of Molecular Signal Transduction in Inflammation, Technologiepark 927, Zwijnaarde, Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde, Ghent 9052, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.01.039DOI Listing
July 2018

Dichotomous function of IL-33 in health and disease: From biology to clinical implications.

Biochem Pharmacol 2018 02 5;148:238-252. Epub 2018 Jan 5.

Center for Inflammation Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.01.010DOI Listing
February 2018

Interleukin-17 signaling triggers degradation of the constitutive NF-κB inhibitor ABIN-1.

Immunohorizons 2017 Sep;1(7):133-141

Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.4049/immunohorizons.1700035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370333PMC
September 2017

A20 Restrains Thymic Regulatory T Cell Development.

J Immunol 2017 10 25;199(7):2356-2365. Epub 2017 Aug 25.

Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität, 81675 Munich, Germany;

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http://dx.doi.org/10.4049/jimmunol.1602102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617121PMC
October 2017

A20 deletion in T cells modulates acute graft-versus-host disease in mice.

Eur J Immunol 2017 11 15;47(11):1982-1988. Epub 2017 Sep 15.

Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1002/eji.201646911DOI Listing
November 2017

Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome.

Nat Immunol 2017 Jul;18(8):861-869

Unit of Molecular Signal Transduction in Inflammation, Center for Inflammation Research, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1038/ni.3772DOI Listing
July 2017

Unusual Lipid A from a Cold-Adapted Bacterium: Detailed Structural Characterization.

Chembiochem 2017 09 27;18(18):1845-1854. Epub 2017 Jul 27.

Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126, Naples, Italy.

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http://dx.doi.org/10.1002/cbic.201700287DOI Listing
September 2017

Abscisic Acid as Pathogen Effector and Immune Regulator.

Front Plant Sci 2017 19;8:587. Epub 2017 Apr 19.

Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, VIBGhent, Belgium.

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http://dx.doi.org/10.3389/fpls.2017.00587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395610PMC
April 2017

Patterns, Receptors, and Signals: Regulation of Phagosome Maturation.

Trends Immunol 2017 06 14;38(6):407-422. Epub 2017 Apr 14.

Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Current address: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR8204 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.it.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455985PMC
June 2017

CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different.

Cell Death Differ 2017 07 31;24(7):1172-1183. Epub 2017 Mar 31.

Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, Ghent University-VIB, Ghent, Belgium.

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http://dx.doi.org/10.1038/cdd.2017.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520167PMC
July 2017

CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis.

J Invest Dermatol 2017 03 8;137(3):569-575. Epub 2016 Dec 8.

Interfaculty Institute for Biochemistry, Eberhard Karls University of Tuebingen, Tuebingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.09.031DOI Listing
March 2017

Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung.

Immunity 2016 12 6;45(6):1285-1298. Epub 2016 Dec 6.

Department of Pulmonary Medicine, Erasmus University Medical Center Rotterdam, Rotterdam 3015 GJ, the Netherlands; Laboratory of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, Ghent 9050, Belgium; Department of Pulmonary Medicine, Ghent University, Ghent 9000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.10.031DOI Listing
December 2016

Monitoring Ubiquitin-Coated Bacteria via Confocal Microscopy.

Methods Mol Biol 2016 ;1449:243-50

Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1007/978-1-4939-3756-1_14DOI Listing
January 2018

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

J Exp Med 2016 09 22;213(10):1973-81. Epub 2016 Aug 22.

Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center, 9052 Ghent, Belgium Department of Rheumatology, Ghent University, Ghent University Hospital, 9000 Ghent, Belgium

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http://dx.doi.org/10.1084/jem.20151065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030796PMC
September 2016

The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes.

EMBO Rep 2016 06 25;17(6):914-27. Epub 2016 Apr 25.

Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center VIB, Ghent, Belgium Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium

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http://dx.doi.org/10.15252/embr.201642109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278603PMC
June 2016

TRAF2 multitasking in TNF receptor-induced signaling to NF-κB, MAP kinases and cell death.

Biochem Pharmacol 2016 09 16;116:1-10. Epub 2016 Mar 16.

Inflammation Research Center, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2016.03.009DOI Listing
September 2016

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages.

Immunity 2016 Apr 15;44(4):755-68. Epub 2016 Mar 15.

Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.02.017DOI Listing
April 2016

Trabid epigenetically drives expression of IL-12 and IL-23.

Nat Immunol 2016 Mar;17(3):227-8

Inflammation Research Center (VIB), and the Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1038/ni.3388DOI Listing
March 2016

Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?

Trends Mol Med 2016 Feb 17;22(2):135-150. Epub 2016 Jan 17.

Inflammation Research Center, Unit of Molecular Signal Transduction in Inflammation, Vlaams Instituut voor Biotechnologie (VIB), 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2015.12.004DOI Listing
February 2016

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.

Eur J Immunol 2016 Apr 15;46(4):971-80. Epub 2016 Jan 15.

Inflammation Research Center, Unit of Cellular and Molecular (Patho)physiology, Ghent, Belgium.

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http://dx.doi.org/10.1002/eji.201545863DOI Listing
April 2016

A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.

Mol Endocrinol 2016 Jan 10;30(1):48-61. Epub 2015 Dec 10.

Université Libre de Bruxelles Center for Diabetes Research (M.F., K.M., D.D., E.C.V., A.K.C.), Free University Brussels, 1070 Brussels, Belgium; Copenhagen Diabetes Research Center (C.A.B., L.B.N., M.L.A., H.B.M., F.P., J.S.), Department of Pediatrics E, Copenhagen University Hospital Herlev, DL-2730 Herlev, Denmark; Inflammation Research Center (L.C., R.B., G.v.L.), Vlaams Instituut voor Biotechnologie, 9052 Gent, Belgium; Department of Biomedical Molecular Biology (L.C., R.B., G.v.L.), 9052 Gent University, Gent, Belgium; Laboratory of Endocrine Pancreas and Metabolism (E.C.V.), Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, 13083-970 Campinas, Brazil; and Department of Development and Cellular Biology (F.O.), Institute of Biomedical Sciences, 05508-900 São Paulo University, São Paulo, Brazil.

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http://dx.doi.org/10.1210/me.2015-1176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414657PMC
January 2016

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling.

FEBS J 2016 Feb 26;283(3):403-12. Epub 2015 Nov 26.

Inflammation Research Center, Unit of Molecular Signal Transduction in Inflammation, VIB, Department of Biomedical Molecular Biology, Ghent University, Belgium.

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http://dx.doi.org/10.1111/febs.13597DOI Listing
February 2016

MALT1 is not alone after all: identification of novel paracaspases.

Cell Mol Life Sci 2016 Mar 16;73(5):1103-16. Epub 2015 Sep 16.

Inflammation Research Center, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00018-015-2041-9DOI Listing
March 2016

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells.

Science 2015 Sep;349(6252):1106-10

Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium. Department of Internal Medicine, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1126/science.aac6623DOI Listing
September 2015

Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites.

Immunity 2015 Aug;43(2):318-30

VIB Inflammation Research Center (IRC), Gent University, Zwijnaarde 9052B, Belgium; Department of Respiratory Medicine, Gent University Hospital, Gent 9000, Belgium; Department of Pulmonary Medicine, ErasmusMC, Rotterdam 3015CD, the Netherlands.

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http://dx.doi.org/10.1016/j.immuni.2015.07.015DOI Listing
August 2015

XEDAR activates the non-canonical NF-κB pathway.

Biochem Biophys Res Commun 2015 Sep 8;465(2):275-80. Epub 2015 Aug 8.

Inflammation Research Center, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.08.019DOI Listing
September 2015

The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination.

Immunol Rev 2015 Jul;266(1):208-21

Inflammation Research Center, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1111/imr.12307DOI Listing
July 2015

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme.

Immunity 2015 Jun;42(6):991-1004

Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center, VIB, Technologiepark 927, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.06.003DOI Listing
June 2015

MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression.

FEBS J 2015 Sep 10;282(17):3286-97. Epub 2015 Jun 10.

Inflammation Research Center, Unit of Molecular Signal Transduction in Inflammation, VIB, Department of Biomedical Molecular Biology, Ghent University, Belgium.

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http://dx.doi.org/10.1111/febs.13325DOI Listing
September 2015

Role of the Bacterial Type VI Secretion System in the Modulation of Mammalian Host Cell Immunity.

Curr Med Chem 2015 ;22(14):1734-44

Department for Biomedical Molecular Biology, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium.

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http://dx.doi.org/10.2174/0929867322666150417123744DOI Listing
June 2016

Chemical synthesis of Burkholderia Lipid A modified with glycosyl phosphodiester-linked 4-amino-4-deoxy-β-L-arabinose and its immunomodulatory potential.

Chemistry 2015 Mar 28;21(10):4102-14. Epub 2015 Jan 28.

Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, 1190 Vienna (Austria).

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http://dx.doi.org/10.1002/chem.201406058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517147PMC
March 2015

Receptor proximal kinases in NF-κB signaling as potential therapeutic targets in cancer and inflammation.

Biochem Pharmacol 2014 Dec 7;92(4):519-29. Epub 2014 Nov 7.

Inflammation Research Center, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.10.017DOI Listing
December 2014

A20 controls intestinal homeostasis through cell-specific activities.

Nat Commun 2014 Sep 30;5:5103. Epub 2014 Sep 30.

1] Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center, VIB, Technologiepark 927, B-9052 Ghent, Belgium [2] Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium [3].

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http://dx.doi.org/10.1038/ncomms6103DOI Listing
September 2014

Development of αGlcN(1↔1)αMan-based lipid A mimetics as a novel class of potent Toll-like receptor 4 agonists.

J Med Chem 2014 Oct 25;57(19):8056-71. Epub 2014 Sep 25.

Department of Chemistry, University of Natural Resources and Life Sciences , Muthgasse 18, A-1190 Vienna, Austria.

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http://dx.doi.org/10.1021/jm500946rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191062PMC
October 2014

Priming IKKβ kinase for action.

Biochem J 2014 Oct;463(1):e1-2

*Division of Immune Cell Biology, Medical Research Council National Institute for Medical Research, London, U.K.

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http://dx.doi.org/10.1042/BJ20140989DOI Listing
October 2014

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

J Neuroinflammation 2014 Jul 21;11:124. Epub 2014 Jul 21.

Inflammation Research Center, Unit of Molecular Signal Transduction in Inflammation, VIB, Technologiepark 927, B-9052 Ghent, Belgium.

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http://dx.doi.org/10.1186/1742-2094-11-124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112826PMC
July 2014

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells.

Proc Natl Acad Sci U S A 2014 Jul 14;111(30):11115-20. Epub 2014 Jul 14.

Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University (UM 2), Case 906, 13288 Marseille Cedex 9, France;Institut National de la Santé et de la Recherche Médicale, U1104, 13288 Marseille, France;Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7280, 13288 Marseille, France;

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http://dx.doi.org/10.1073/pnas.1406259111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121810PMC
July 2014

A20: attractive without showing cleavage.

EMBO Rep 2014 Jul 30;15(7):734-5. Epub 2014 May 30.

Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center VIB, Ghent, Belgium.

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http://dx.doi.org/10.15252/embr.201439014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196973PMC
July 2014

An E3 ubiquitin ligase-independent role of LUBAC.

Authors:
Rudi Beyaert

Blood 2014 Apr;123(14):2131-3

GHENT UNIVERSITY;

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http://dx.doi.org/10.1182/blood-2014-02-556076DOI Listing
April 2014

A20-deficient mast cells exacerbate inflammatory responses in vivo.

PLoS Biol 2014 Jan 14;12(1):e1001762. Epub 2014 Jan 14.

Molecular Immunology and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1371/journal.pbio.1001762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891641PMC
January 2014

A20 in inflammation and autoimmunity.

Trends Immunol 2014 Jan 15;35(1):22-31. Epub 2013 Nov 15.

Inflammation Research Center, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium. Electronic address:

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http://www.cell.com/trends/immunology/pdf/S1471-4906(13)0015
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http://linkinghub.elsevier.com/retrieve/pii/S147149061300158
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http://dx.doi.org/10.1016/j.it.2013.10.005DOI Listing
January 2014

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology.

Trends Mol Med 2013 Oct 2;19(10):604-13. Epub 2013 Sep 2.

Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium.

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http://dx.doi.org/10.1016/j.molmed.2013.08.001DOI Listing
October 2013

Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.

J Immunol 2013 Mar 11;190(6):2896-903. Epub 2013 Feb 11.

Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium.

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http://dx.doi.org/10.4049/jimmunol.1201351DOI Listing
March 2013

IκB kinase ε (IKKε): a therapeutic target in inflammation and cancer.

Biochem Pharmacol 2013 Apr 17;85(7):873-80. Epub 2013 Jan 17.

Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Zwijnaarde (Ghent), Belgium.

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http://dx.doi.org/10.1016/j.bcp.2013.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111187PMC
April 2013

Structure and function of the Type III secretion system of Pseudomonas aeruginosa.

Curr Protein Pept Sci 2012 Dec;13(8):831-42

Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706959PMC
http://dx.doi.org/10.2174/138920312804871210DOI Listing
December 2012