Publications by authors named "Ruby Yun-Ju Huang"

47Publications

Spotlight on the Granules (Grainyhead-Like Proteins) - From an Evolutionary Conserved Controller of Epithelial Trait to Pioneering the Chromatin Landscape.

Front Mol Biosci 2020 21;7:213. Epub 2020 Aug 21.

Department of Obstetrics and Gynaecology, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.3389/fmolb.2020.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471608PMC
August 2020

Functional reservoir microcapsules generated via microfluidic fabrication for long-term cardiovascular therapeutics.

Lab Chip 2020 08 1;20(15):2756-2764. Epub 2020 Jul 1.

Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, 04-08, 117583, Singapore.

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http://dx.doi.org/10.1039/d0lc00296hDOI Listing
August 2020

Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).

Authors:
Aline Talhouk Joshy George Chen Wang Timothy Budden Tuan Zea Tan Derek S Chiu Stefan Kommoss Huei San Leong Stephanie Chen Maria P Intermaggio Blake Gilks Tayyebeh M Nazeran Mila Volchek Wafaa Elatre Rex C Bentley Janine Senz Amy Lum Veronica Chow Hanwei Sudderuddin Robertson Mackenzie Samuel C Y Leong Geyi Liu Dustin Johnson Billy Chen Aocs Group Jennifer Alsop Susana N Banerjee Sabine Behrens Clara Bodelon Alison H Brand Louise Brinton Michael E Carney Yoke-Eng Chiew Kara L Cushing-Haugen Cezary Cybulski Darren Ennis Sian Fereday Renée T Fortner Jesús García-Donas Aleksandra Gentry-Maharaj Rosalind Glasspool Teodora Goranova Casey S Greene Paul Haluska Holly R Harris Joy Hendley Brenda Y Hernandez Esther Herpel Mercedes Jimenez-Linan Chloe Karpinskyj Scott H Kaufmann Gary L Keeney Catherine J Kennedy Martin Köbel Jennifer M Koziak Melissa C Larson Jenny Lester Liz-Anne Lewsley Jolanta Lissowska Jan Lubiński Hugh Luk Geoff Macintyre Sven Mahner Iain A McNeish Janusz Menkiszak Nikilyn Nevins Ana Osorio Oleg Oszurek José Palacios Samantha Hinsley Celeste L Pearce Malcolm C Pike Anna M Piskorz Isabelle Ray-Coquard Valerie Rhenius Cristina Rodriguez-Antona Raghwa Sharma Mark E Sherman Dilrini De Silva Naveena Singh Peter Sinn Dennis Slamon Honglin Song Helen Steed Euan A Stronach Pamela J Thompson Aleksandra Tołoczko Britton Trabert Nadia Traficante Chiu-Chen Tseng Martin Widschwendter Lynne R Wilkens Stacey J Winham Boris Winterhoff Alicia Beeghly-Fadiel Javier Benitez Andrew Berchuck James D Brenton Robert Brown Jenny Chang-Claude Georgia Chenevix-Trench Anna deFazio Peter A Fasching María J García Simon A Gayther Marc T Goodman Jacek Gronwald Michelle J Henderson Beth Y Karlan Linda E Kelemen Usha Menon Sandra Orsulic Paul D P Pharoah Nicolas Wentzensen Anna H Wu Joellen M Schildkraut Mary Anne Rossing Gottfried E Konecny David G Huntsman Ruby Yun-Ju Huang Ellen L Goode Susan J Ramus Jennifer A Doherty David D Bowtell Michael S Anglesio

Clin Cancer Res 2020 Oct 17;26(20):5411-5423. Epub 2020 Jun 17.

British Columbia's Gynecological Cancer Research Program (OVCARE), BC Cancer, Vancouver General Hospital, and University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-20-0103DOI Listing
October 2020

SNAI1-Driven Sequential EMT Changes Attributed by Selective Chromatin Enrichment of RAD21 and GRHL2.

Cancers (Basel) 2020 May 2;12(5). Epub 2020 May 2.

Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.

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http://dx.doi.org/10.3390/cancers12051140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281482PMC
May 2020

Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Oxidative Stress and Iron-Sulfur Cluster Biogenesis Deficit.

Antioxid Redox Signal 2020 May 19. Epub 2020 May 19.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1089/ars.2019.7850DOI Listing
May 2020

Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective.

Cancers (Basel) 2020 Jan 18;12(1). Epub 2020 Jan 18.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593 Singapore, Singapore.

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http://dx.doi.org/10.3390/cancers12010238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017214PMC
January 2020

Activation of STAT3 and STAT5 Signaling in Epithelial Ovarian Cancer Progression: Mechanism and Therapeutic Opportunity.

Cancers (Basel) 2019 Dec 19;12(1). Epub 2019 Dec 19.

Department of Obstetrics & Gynecology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 10002, Taiwan.

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http://dx.doi.org/10.3390/cancers12010024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017004PMC
December 2019

Analysis of gene expression signatures identifies prognostic and functionally distinct ovarian clear cell carcinoma subtypes.

EBioMedicine 2019 Dec 21;50:203-210. Epub 2019 Nov 21.

Center for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, #12-01, Singapore 117599, Singapore; School of Medicine, College of Medicine, National Taiwan University, No. 1 Ren Ai Road Sec. 1, Taipei 100, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921362PMC
December 2019

Stopping transformed cancer cell growth by rigidity sensing.

Nat Mater 2020 Feb 28;19(2):239-250. Epub 2019 Oct 28.

Mechanobiology Institute, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41563-019-0507-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477912PMC
February 2020

The role of GRHL2 and epigenetic remodeling in epithelial-mesenchymal plasticity in ovarian cancer cells.

Commun Biol 2019 24;2:272. Epub 2019 Jul 24.

1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599 Singapore.

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http://dx.doi.org/10.1038/s42003-019-0506-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656769PMC
May 2020

SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition.

Sci Rep 2019 06 5;9(1):8295. Epub 2019 Jun 5.

Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, 14 Medical Drive, MD6 #12-01, 117599, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41598-019-44826-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549180PMC
June 2019

Epithelial-to-mesenchymal transition: lessons from development, insights into cancer and the potential of EMT-subtype based therapeutic intervention.

Phys Biol 2019 05 7;16(4):041004. Epub 2019 May 7.

Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, United States of America.

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http://dx.doi.org/10.1088/1478-3975/ab157aDOI Listing
May 2019

Reply to Pontus Eriksson and Gottfrid Sjödahl's Letter to the Editor re: Tuan Zea Tan, Mathieu Rouanne, Kien Thiam Tan, Ruby Yun-Ju Huang, Jean-Paul Thiery. Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors. Eur Urol 2019;75:423-32.

Eur Urol 2019 04 5;75(4):e108-e109. Epub 2018 Dec 5.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou, People's Republic of China; CNRS Emeritus CNRS UMR 7057 Matter and Complex Systems, University Paris Denis Diderot, Paris, France; INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.11.048DOI Listing
April 2019

Decoding transcriptomic intra-tumour heterogeneity to guide personalised medicine in ovarian cancer.

J Pathol 2019 03 18;247(3):305-319. Epub 2018 Dec 18.

Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore.

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http://doi.wiley.com/10.1002/path.5191
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http://dx.doi.org/10.1002/path.5191DOI Listing
March 2019

Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors.

Eur Urol 2019 03 10;75(3):423-432. Epub 2018 Sep 10.

Biochemistry Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou, People's Republic of China; CNRS Emeritus CNRS UMR 7057 Matter and Complex Systems, University Paris Denis Diderot, Paris, France; INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, EPHE, PSL, Fac. de Médecine - University Paris-Sud, Université Paris-Saclay, Villejuif, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183061
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http://dx.doi.org/10.1016/j.eururo.2018.08.027DOI Listing
March 2019

Dual role of autophagy in hallmarks of cancer.

Oncogene 2018 03 19;37(9):1142-1158. Epub 2017 Dec 19.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41388-017-0046-6DOI Listing
March 2018

Loss of discoidin domain receptor 1 (DDR1) via CpG methylation during EMT in epithelial ovarian cancer.

Gene 2017 Nov 5;635:9-15. Epub 2017 Sep 5.

Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, 117599, Singapore; Department of Obstetrics & Gynaecology, National University Hospital of Singapore, 5 Lower Kent Ridge Road, 119074, Singapore; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, 117594, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2017.09.001DOI Listing
November 2017

AXL-Driven EMT State as a Targetable Conduit in Cancer.

Cancer Res 2017 07 30;77(14):3725-3732. Epub 2017 Jun 30.

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0392DOI Listing
July 2017

Targeting the AXL signaling pathway in ovarian cancer.

Mol Cell Oncol 2017 28;4(2):e1263716. Epub 2016 Nov 28.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1080/23723556.2016.1263716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383361PMC
November 2016

A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets.

Cancer Lett 2016 11 5;382(2):203-214. Epub 2016 Sep 5.

Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077659PMC
http://dx.doi.org/10.1016/j.canlet.2016.09.001DOI Listing
November 2016

A new dimension in drug discovery: reversing epithelial-mesenchymal transition (EMT).

Cell Death Dis 2016 10 13;7(10):e2417. Epub 2016 Oct 13.

Department of Biology, University of California, San Diego, CA 92092, USA.

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http://dx.doi.org/10.1038/cddis.2016.316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133983PMC
October 2016

The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer.

Sci Signal 2016 10 4;9(448):ra97. Epub 2016 Oct 4.

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. Department of Obstetrics and Gynecology, National University Health System, Singapore 119228, Singapore. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1126/scisignal.aaf8175DOI Listing
October 2016

EMT: 2016.

Cell 2016 Jun;166(1):21-45

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore; Institute of Molecular and Cell Biology, A-STAR, Singapore 138673, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.06.028DOI Listing
June 2016

GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.

Sci Rep 2016 Feb 18;6:19943. Epub 2016 Feb 18.

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, #12-01, Singapore 117599.

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http://dx.doi.org/10.1038/srep19943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757891PMC
February 2016

CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype.

Oncotarget 2015 Dec;6(41):43843-52

Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore 117599.

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https://www.csi.nus.edu.sg/ws/wp-content/uploads/12-In-the-s
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http://www.oncotarget.com/abstract/5983
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http://dx.doi.org/10.18632/oncotarget.5983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791271PMC
December 2015

The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions.

Hum Pathol 2015 Jan 16;46(1):1-8. Epub 2014 Oct 16.

Cancer Science Institute (CSI), Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 117599 Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 117599 Singapore; Institute of Molecular and Cell Biology (IMCB) A*STAR, Proteos 138673, Singapore.

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https://linkinghub.elsevier.com/retrieve/pii/S00468177140041
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http://dx.doi.org/10.1016/j.humpath.2014.10.004DOI Listing
January 2015

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients.

EMBO Mol Med 2014 Oct;6(10):1279-93

Cancer Science Institute of Singapore, National University of Singapore, Singapore Institute of Molecular and Cell Biology, A*STAR, Singapore Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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http://dx.doi.org/10.15252/emmm.201404208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287932PMC
October 2014

A spatiotemporally defined in vitro microenvironment for controllable signal delivery and drug screening.

Analyst 2014 Oct;139(19):4846-54

Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan, Republic of China.

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http://dx.doi.org/10.1039/c4an00936cDOI Listing
October 2014

Lgr5 marks stem/progenitor cells in ovary and tubal epithelia.

Nat Cell Biol 2014 Aug 6;16(8):745-57. Epub 2014 Jul 6.

1] A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore [2] Centre for Regenerative Medicine, 47 Little France Crescent, University of Edinburgh, EH16 4TJ, UK [3] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore.

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http://dx.doi.org/10.1038/ncb3000DOI Listing
August 2014

Modeling of cancer metastasis and drug resistance via biomimetic nano-cilia and microfluidics.

Biomaterials 2014 Feb 22;35(5):1562-71. Epub 2013 Nov 22.

Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2013.11.008DOI Listing
February 2014

Rapid prototyping of concave microwells for the formation of 3D multicellular cancer aggregates for drug screening.

Adv Healthc Mater 2014 Apr 27;3(4):609-16. Epub 2013 Aug 27.

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology (SMART) Center, 1 CREATE Way, #04-13/14 Enterprise, Wing, Singapore, 138602, Singapore.

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http://dx.doi.org/10.1002/adhm.201300151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038742PMC
April 2014

Early events in cell adhesion and polarity during epithelial-mesenchymal transition.

J Cell Sci 2012 Oct;125(Pt 19):4417-22

Department of Obstetrics and Gynaecology, National University Hospital, 119074, Singapore.

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http://dx.doi.org/10.1242/jcs.099697DOI Listing
October 2012

Targeting pathways contributing to epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer.

Curr Drug Targets 2012 Dec;13(13):1649-53

Department of Obstetrics & Gynaecology, National University Hospital, Singapore.

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http://dx.doi.org/10.2174/138945012803530044DOI Listing
December 2012

Lysophosphatidic acid modulates the association of PTP1B with N-cadherin/catenin complex in SKOV3 ovarian cancer cells.

Cell Biol Int 2012 Sep;36(9):833-41

Department of Obstetrics and Gynaecology, National University Hospital of Singapore, Singapore.

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http://dx.doi.org/10.1042/CBI20110687DOI Listing
September 2012

Target cell movement in tumor and cardiovascular diseases based on the epithelial-mesenchymal transition concept.

Adv Drug Deliv Rev 2011 Jul 16;63(8):558-67. Epub 2011 Feb 16.

Institute of Molecular Cell Biology, Experimental Therapeutic Centre, Biopolis A*STAR, Cancer Science Institute National University of Singapore and Department of Obstetrics and Gynaecology, National University Hospital, Singapore, Republic of Singapore.

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http://dx.doi.org/10.1016/j.addr.2011.02.003DOI Listing
July 2011

Lysophosphatidic acid induces ovarian cancer cell dispersal by activating Fyn kinase associated with p120-catenin.

Int J Cancer 2008 Aug;123(4):801-9

Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://doi.wiley.com/10.1002/ijc.23579
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http://dx.doi.org/10.1002/ijc.23579DOI Listing
August 2008