Ruben van Boxtel

Ruben van Boxtel

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Ruben van Boxtel

Ruben van Boxtel

Publications by authors named "Ruben van Boxtel"

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39Publications

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Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer.

Genome Res 2019 07 20;29(7):1067-1077. Epub 2019 Jun 20.

Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands.

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http://dx.doi.org/10.1101/gr.246223.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633256PMC
July 2019

Characterizing Mutational Load and Clonal Composition of Human Blood.

J Vis Exp 2019 Jul 11(149). Epub 2019 Jul 11.

Princess Máxima Center for Pediatric Oncology;

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http://dx.doi.org/10.3791/59846DOI Listing
July 2019

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.

Cell Stem Cell 2019 Jun 23;24(6):927-943.e6. Epub 2019 May 23.

Oncode Institute, Utrecht, the Netherlands; Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands; The Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; University Medical Center Utrecht, Cancer Genomics Netherlands, 3584CX Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.04.017DOI Listing
June 2019

Portrait of a cancer: mutational signature analyses for cancer diagnostics.

BMC Cancer 2019 May 15;19(1):457. Epub 2019 May 15.

Center for Molecular Medicine and Oncode Institute, University Medical Centre Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s12885-019-5677-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521503PMC
May 2019

Early divergence of mutational processes in human fetal tissues.

Sci Adv 2019 May 29;5(5):eaaw1271. Epub 2019 May 29.

Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, Netherlands.

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http://dx.doi.org/10.1126/sciadv.aaw1271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541467PMC
May 2019

MutationalPatterns: comprehensive genome-wide analysis of mutational processes.

Genome Med 2018 04 25;10(1):33. Epub 2018 Apr 25.

Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584, CG, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s13073-018-0539-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922316PMC
April 2018

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures.

Nat Protoc 2018 Jan 7;13(1):59-78. Epub 2017 Dec 7.

Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nprot.2017.111DOI Listing
January 2018

Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.

Proc Natl Acad Sci U S A 2017 12 13;114(52):E11190-E11198. Epub 2017 Dec 13.

Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences, 3584 CT Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1714145115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748200PMC
December 2017

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

Science 2017 10 14;358(6360):234-238. Epub 2017 Sep 14.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, 3584CT Utrecht, Netherlands.

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http://dx.doi.org/10.1126/science.aao3130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038908PMC
October 2017

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids.

Proc Natl Acad Sci U S A 2017 03 7;114(12):E2357-E2364. Epub 2017 Mar 7.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center (UMC) Utrecht, 3584 CT Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1701219114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373343PMC
March 2017

The forkhead transcription factor FOXP1 represses human plasma cell differentiation.

Blood 2015 Oct 19;126(18):2098-109. Epub 2015 Aug 19.

Department of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Academic Medical Center, Amsterdam, The Netherlands;

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http://dx.doi.org/10.1182/blood-2015-02-626176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626252PMC
October 2015

Sequential cancer mutations in cultured human intestinal stem cells.

Nature 2015 May 29;521(7550):43-7. Epub 2015 Apr 29.

1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nature14415DOI Listing
May 2015

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells.

Blood 2014 Nov 29;124(23):3431-40. Epub 2014 Sep 29.

Department of Pathology and Lymphoma and Myeloma Center Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

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http://dx.doi.org/10.1182/blood-2014-01-553412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246697PMC
November 2014

Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

Cell 2014 Sep 4;159(1):163-175. Epub 2014 Sep 4.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772677PMC
September 2014

Forkhead Box P family members at the crossroad between tolerance and immunity: a balancing act.

Int Rev Immunol 2014 Mar 25;33(2):94-109. Epub 2013 Jul 25.

Department of Cell Biology, University Medical Center Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.3109/08830185.2013.816698DOI Listing
March 2014

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.

Obesity (Silver Spring) 2012 Mar 28;20(3):612-21. Epub 2011 Apr 28.

Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/oby.2011.81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286758PMC
March 2012

Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.

Am J Pathol 2011 Oct 18;179(4):1616-22. Epub 2011 Aug 18.

Hubrecht Institute for Developmental Biology and Stem Cell Research, Cancer Genomics Center, KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.

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http://www.criver.com/about-us/eureka/wp-content/uploads/ACT
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http://transposagenbio.com/pdf/p53-TGEN-Am-J-Path-2011.pdf
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S000294401100657
Publisher Site
http://dx.doi.org/10.1016/j.ajpath.2011.06.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181367PMC
October 2011

Generation of genetically modified rodents using random ENU mutagenesis.

Methods Mol Biol 2011 ;693:295-308

Royal Netherlands Academy of Sciences, Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/978-1-60761-974-1_18DOI Listing
March 2011

Rat traps: filling the toolbox for manipulating the rat genome.

Genome Biol 2010 29;11(9):217. Epub 2010 Sep 29.

Hubrecht Institute for Developmental Biology and Stem Cell Research, Cancer Genomics Center, Royal Netherlands Academy of Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/gb-2010-11-9-217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965381PMC
February 2011

Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples.

Nat Methods 2010 Nov 17;7(11):913-5. Epub 2010 Oct 17.

Hubrecht Institute, Developmental Biology and Stem Cell Research, Royal Netherlands Academy of Arts and Sciences and the University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nmeth.1516DOI Listing
November 2010

ENU mutagenesis to generate genetically modified rat models.

Methods Mol Biol 2010 ;597:151-67

Hubrect Institute, Niob Knaw, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/978-1-60327-389-3_11DOI Listing
February 2010

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.

BMC Genomics 2008 Oct 7;9:460. Epub 2008 Oct 7.

Hubrecht Institute for Developmental Biology and Stem Cell Research, Cancer Genomics Center, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
Publisher Site
http://dx.doi.org/10.1186/1471-2164-9-460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567347PMC
October 2008

Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.

Carcinogenesis 2008 Jun 15;29(6):1290-7. Epub 2008 Apr 15.

Hubrecht Institute for Developmental Biology and Stem Cell Research, Cancer Genomics Center, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/carcin/bgn094DOI Listing
June 2008