Publications by authors named "Ruben Fernández-Santiago"

44Publications

Disrupted Mitochondrial and Metabolic Plasticity Underlie Comorbidity between Age-Related and Degenerative Disorders as Parkinson Disease and Type 2 Diabetes Mellitus.

Antioxidants (Basel) 2020 Oct 30;9(11). Epub 2020 Oct 30.

Laboratory of Muscle Research and Mitochondrial Function, Department of Internal Medicine-Hospital Clínic of Barcelona (HCB), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Faculty of Medicine and Health Science, University of Barcelona (UB), 08036 Barcelona, Spain.

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http://dx.doi.org/10.3390/antiox9111063DOI Listing
October 2020

Peripheral insulin and amylin levels in Parkinson's disease.

Parkinsonism Relat Disord 2020 Aug 25;79:91-96. Epub 2020 Aug 25.

Parkinson's Disease and Movement Disorders Unit. Department of Neurology. Hospital Clinic of Barcelona, Spain; Institut de Neurociències, Maeztu Center, University of Barcelona, Spain; Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED: CB06/05/0018-ISCIII) Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2020.08.018DOI Listing
August 2020

MicroRNA Deregulation in Blood Serum Identifies Multiple System Atrophy Altered Pathways.

Mov Disord 2020 10 20;35(10):1873-1879. Epub 2020 Jul 20.

Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders: Clinical and Experimental Research; Department of Neurology, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1002/mds.28143DOI Listing
October 2020

Transcriptomic differences in MSA clinical variants.

Sci Rep 2020 06 25;10(1):10310. Epub 2020 Jun 25.

Parkinson's Disease & Movement Disorders Unit, Hospital Clínic/IDIBAPS/CIBERNED/European Reference Network for Rare Neurological Diseases (ERN-RND)/Institut de Neurociències, University of Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1038/s41598-020-66221-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316739PMC
June 2020

The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight.

Authors:
Sara Bandres-Ciga Sarah Ahmed Marya S Sabir Cornelis Blauwendraat Astrid D Adarmes-Gómez Inmaculada Bernal-Bernal Marta Bonilla-Toribio Dolores Buiza-Rueda Fátima Carrillo Mario Carrión-Claro Pilar Gómez-Garre Silvia Jesús Miguel A Labrador-Espinosa Daniel Macias Carlota Méndez-Del-Barrio Teresa Periñán-Tocino Cristina Tejera-Parrado Laura Vargas-González Monica Diez-Fairen Ignacio Alvarez Juan Pablo Tartari Mariateresa Buongiorno Miquel Aguilar Ana Gorostidi Jesús Alberto Bergareche Elisabet Mondragon Ana Vinagre-Aragon Ioana Croitoru Javier Ruiz-Martínez Oriol Dols-Icardo Jaime Kulisevsky Juan Marín-Lahoz Javier Pagonabarraga Berta Pascual-Sedano Mario Ezquerra Ana Cámara Yaroslau Compta Manel Fernández Rubén Fernández-Santiago Esteban Muñoz Eduard Tolosa Francesc Valldeoriola Isabel Gonzalez-Aramburu Antonio Sanchez Rodriguez María Sierra Manuel Menéndez-González Marta Blazquez Ciara Garcia Esther Suarez-San Martin Pedro García-Ruiz Juan Carlos Martínez-Castrillo Lydia Vela-Desojo Clara Ruz Francisco Javier Barrero Francisco Escamilla-Sevilla Adolfo Mínguez-Castellanos Debora Cerdan Cesar Tabernero Maria Jose Gomez Heredia Francisco Perez Errazquin Manolo Romero-Acebal Cici Feliz Jose Luis Lopez-Sendon Marina Mata Irene Martínez Torres Jonggeol Jeffrey Kim Clifton L Dalgard Janet Brooks Sara Saez-Atienzar J Raphael Gibbs Rafael Jorda Juan A Botia Luis Bonet-Ponce Karen E Morrison Carl Clarke Manuela Tan Huw Morris Connor Edsall Dena Hernandez Javier Simon-Sanchez Mike A Nalls Sonja W Scholz Adriano Jimenez-Escrig Jacinto Duarte Francisco Vives Raquel Duran Janet Hoenicka Victoria Alvarez Jon Infante Maria José Marti Jordi Clarimón Adolfo López de Munain Pau Pastor Pablo Mir Andrew Singleton

Mov Disord 2019 12 29;34(12):1851-1863. Epub 2019 Oct 29.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/mds.27864DOI Listing
December 2019

Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease.

EBioMedicine 2019 Oct 17;48:554-567. Epub 2019 Oct 17.

Neurobiology Unit, Institut d'Investigacions Biomèdiques de Barcelona, Consejo Superior de Investigaciones Científicas (CSIC), Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838390PMC
October 2019

HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease.

Neurol Neuroimmunol Neuroinflamm 2019 11 12;6(6). Epub 2019 Aug 12.

From the Service of Neurology (C.G., A.I., J.S.), Hospital Clinic, Barcelona, Spain; Multidisciplinary Sleep Disorders Unit (C.G., A.I., J.S.), Hospital Clinic, Barcelona, Spain; Department of Immunology (G.E., E.P.), Hospital Clínic, Barcelona, Spain; Institute of Biotechnology and Biomedicine (X.D.), Universitat Autònoma de Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA) (X.D., J.D.), Barcelona, Spain; Laboratory of Parkinson Disease and Other Neurodegenerative Movement Disorders (M.E., R.F.-S.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Neuroimmunology Program (L.S., J.D., F.G.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Institute for Sleep Medicine and Neuromuscular Disorders (A.H.), University Hospital Muenster, Muenster, Germany; Department of Neurology (B.H.), Medical University of Innsbruck, Innsbruck, Austria; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1212/NXI.0000000000000605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705627PMC
November 2019

Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson's disease patients.

Clin Epigenetics 2019 07 23;11(1):108. Epub 2019 Jul 23.

Department of Neurology, Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Faculty of Medicine (UB), University of Barcelona, Casanova 143, Floor 3B, 08036, Barcelona, Spain.

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http://dx.doi.org/10.1186/s13148-019-0701-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651999PMC
July 2019

CCAAT/enhancer binding protein δ is a transcriptional repressor of α-synuclein.

Cell Death Differ 2020 02 17;27(2):509-524. Epub 2019 Jun 17.

Department of Biomedical Sciences, School of Medicine, Biochemistry and Molecular Biology Unit, University of Barcelona, IDIBAPS, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41418-019-0368-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206087PMC
February 2020

Mitochondrial and autophagic alterations in skin fibroblasts from Parkinson disease patients with Parkin mutations.

Aging (Albany NY) 2019 06;11(11):3750-3767

Laboratory of Muscle Research and Mitochondrial Function, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona (UB), Department of Internal Medicine, Hospital Clínic of Barcelona (HCB), Barcelona 08036, Spain.

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http://dx.doi.org/10.18632/aging.102014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594812PMC
June 2019

Parkinson's disease as a systemic pathology.

Aging (Albany NY) 2019 02;11(4):1081-1082

Laboratory of Neurodegenerative Disorders, Department of Neurology-Hospital Clínic of Barcelona, IDIBAPS, UB, 08036 Barcelona, Catalonia.

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http://dx.doi.org/10.18632/aging.101824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402515PMC
February 2019

MTOR Pathway-Based Discovery of Genetic Susceptibility to L-DOPA-Induced Dyskinesia in Parkinson's Disease Patients.

Mol Neurobiol 2019 Mar 10;56(3):2092-2100. Epub 2018 Jul 10.

Department of Biomedicine, Unit of Biochemistry, Faculty of Medicine, Universitat de Barcelona, 08036, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1007/s12035-018-1219-1DOI Listing
March 2019

MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients.

Neurobiol Aging 2018 09 31;69:283-291. Epub 2018 May 31.

Department of Neurology, Laboratory of Parkinson Disease and Other Neurodegenerative Movement Disorders, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona (UB), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183020
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.05.032DOI Listing
September 2018

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 -Parkinson's disease.

J Transl Med 2018 06 8;16(1):160. Epub 2018 Jun 8.

Laboratory of Muscle Research and Mitochondrial Function-CELLEX, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Internal Medicine-Hospital Clínic of Barcelona, Faculty of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Spain.

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http://dx.doi.org/10.1186/s12967-018-1526-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994110PMC
June 2018

Transcriptional alterations in skin fibroblasts from Parkinson's disease patients with parkin mutations.

Neurobiol Aging 2018 05 7;65:206-216. Epub 2018 Feb 7.

Laboratory of Muscle Research and Mitochondrial Function-CELLEX, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Faculty of Medicine and Health Sciences, University of Barcelona (UB), Department of Internal Medicine-Hospital Clínic of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.01.021DOI Listing
May 2018

α-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain.

Mov Disord 2018 04 23;33(4):637-641. Epub 2018 Feb 23.

Laboratory of Parkinson Disease and Other Neurodegenerative Movement Disorders, Clinical and Experimental Research, Department of Neurology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1002/mds.27295DOI Listing
April 2018

The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.

Mol Neurobiol 2018 Sep 10;55(9):7533-7552. Epub 2018 Feb 10.

Department of Biochemistry and Molecular Biology, Institut de Neurociències, Faculty of Medicine, M2, Universitat Autònoma de Barcelona (UAB), Bellaterra Campus, Cerdanyola del Vallés, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-018-0881-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096980PMC
September 2018

Discovering the 3' UTR-mediated regulation of alpha-synuclein.

Nucleic Acids Res 2017 Dec;45(22):12888-12903

Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1093/nar/gkx1048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728410PMC
December 2017

A Novel p.Glu298Lys Mutation in the ACMSD Gene in Sporadic Parkinson's Disease.

J Parkinsons Dis 2017 ;7(3):459-463

Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.

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http://dx.doi.org/10.3233/JPD-171146DOI Listing
April 2018

association with REM sleep behavior disorder.

Neurol Genet 2017 Feb 13;3(1):e131. Epub 2017 Jan 13.

Laboratory of Neurodegenerative Disorders (R.F.-S., M.F., E.T., M.E.), Multidisciplinary Sleep Unit (A.I., C.G., M.S., J.S.), Movement Disorders Unit (E.T.), Department of Neurology, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) (R.F.-S., A.I., C.G., M.S., M.F., E.T., J.S., M.E.), Madrid; and Movement Disorders Unit (P.P.), Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain.

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http://ng.neurology.org/lookup/doi/10.1212/NXG.0000000000000
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http://dx.doi.org/10.1212/NXG.0000000000000131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238706PMC
February 2017

A Common Variant in the MC1R Gene (p.V92M) is associated with Alzheimer's Disease Risk.

J Alzheimers Dis 2017 ;56(3):1065-1074

Dermatology Department, Melanoma Unit, Hospital Clinic & IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain.

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http://dx.doi.org/10.3233/JAD-161113DOI Listing
February 2018

CSF microRNA Profiling in Alzheimer's Disease: a Screening and Validation Study.

Mol Neurobiol 2017 11 13;54(9):6647-6654. Epub 2016 Oct 13.

Alzheimer's disease and other cognitive disorders unit, Neurology Service, Hospital Clínic i Universitari-, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, Barcelona, 08036, Spain.

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http://dx.doi.org/10.1007/s12035-016-0106-xDOI Listing
November 2017

Reply.

Ann Neurol 2016 May 22;79(5):868. Epub 2016 Mar 22.

Dermatology Department, Melanoma Unit, Hospital Clínic and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.

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http://doi.wiley.com/10.1002/ana.24629
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http://dx.doi.org/10.1002/ana.24629DOI Listing
May 2016

Absence of LRRK2 mutations in a cohort of patients with idiopathic REM sleep behavior disorder.

Neurology 2016 Mar 8;86(11):1072-3. Epub 2016 Jan 8.

From the Laboratory of Neurodegenerative Disorders (R.F.-S., M.F., E.T., M.E.), Multidisciplinary Sleep Unit (A.I., C.G., M.S., J.S.), and Movement Disorders Unit (E.T.), Department of Neurology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona; and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (R.F.-S., A.I., C.G., M.S., M.F., E.T., J.S., M.E.), Madrid, Spain.

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http://dx.doi.org/10.1212/WNL.0000000000002304DOI Listing
March 2016

Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models.

Stem Cells Int 2016 30;2016:9464591. Epub 2015 Nov 30.

Laboratory of Neurodegenerative Disorders, Department of Clinical and Experimental Neurology, Hospital Clinic of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), University of Barcelona (UB), 08036 Barcelona, Spain ; Centre for Networked Biomedical Research in Neurodegenerative Disorders (CIBERNED), 28031 Madrid, Spain ; Cell Therapy Program, Faculty of Medicine, University of Barcelona (UB), 08036 Barcelona, Spain.

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http://dx.doi.org/10.1155/2016/9464591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677257PMC
December 2015

Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients.

EMBO Mol Med 2015 Dec;7(12):1529-46

Laboratory of Neurodegenerative Disorders, Department of Neurology, Hospital Clínic of Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) University of Barcelona (UB), Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain Cell Therapy Program, Faculty of Medicine, University of Barcelona (UB), Barcelona, Spain Movement Disorders Unit, Department of Neurology, Hospital Clínic of Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) University of Barcelona (UB), Barcelona, Spain.

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http://dx.doi.org/10.15252/emmm.201505439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693505PMC
December 2015

Reply.

Ann Neurol 2016 Jan 12;79(1):161-3. Epub 2015 Dec 12.

Dermatology Department, Melanoma Unit, Hospital Clinic and August Pi i Sunyer Biomedical Research Institute.

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http://dx.doi.org/10.1002/ana.24526DOI Listing
January 2016

Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers.

PLoS One 2015 15;10(7):e0132368. Epub 2015 Jul 15.

Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions BiomediquesAugust Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132368PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503402PMC
May 2016

Reply: To PMID 25631192.

Ann Neurol 2015 Jul 25;78(1):153-4. Epub 2015 May 25.

Dermatology Department, Melanoma Unit, Hospital Clínic and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.

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http://dx.doi.org/10.1002/ana.24418DOI Listing
July 2015

MicroRNA association with synucleinopathy conversion in rapid eye movement behavior disorder.

Ann Neurol 2015 May 13;77(5):895-901. Epub 2015 Mar 13.

Laboratory of Neurodegenerative Disorders, Department of Neurology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona; Center for Biomedical Research in Neurodegenerative Diseases, Madrid.

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http://dx.doi.org/10.1002/ana.24384DOI Listing
May 2015

The MC1R melanoma risk variant p.R160W is associated with Parkinson disease.

Ann Neurol 2015 May 13;77(5):889-94. Epub 2015 Mar 13.

Dermatology, Department, Melanoma Unit, Hospital Clínic and August Pi i Sunyer Biomedical Research Institute (IDIBAPS); Center for Biomedical Network Research on Rare Diseases (CIBERER), Carlos III Health Institute (ISCIII).

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http://dx.doi.org/10.1002/ana.24373DOI Listing
May 2015

Identification of blood serum micro-RNAs associated with idiopathic and LRRK2 Parkinson's disease.

J Neurosci Res 2014 Aug 20;92(8):1071-7. Epub 2014 Mar 20.

Laboratory of Neurodegenerative Disorders, Department of Neurology, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Centro de Investigación sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1002/jnr.23377DOI Listing
August 2014

Age at onset in LRRK2-associated PD is modified by SNCA variants.

J Mol Neurosci 2012 Sep 6;48(1):245-7. Epub 2012 Jun 6.

Parkinson's Disease and Movement Disorders Unit, Neurology Service-Hospital Clínic, Institut de Neurociències and Department of Medicine, Universitat de Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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http://dx.doi.org/10.1007/s12031-012-9820-7DOI Listing
September 2012

Mutant superoxide dismutase-1 indistinguishable from wild-type causes ALS.

Hum Mol Genet 2012 Aug 16;21(16):3568-74. Epub 2012 May 16.

Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen 72076, Germany.

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http://dx.doi.org/10.1093/hmg/dds188DOI Listing
August 2012

The human G93A SOD1 phenotype closely resembles sporadic amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2010 Jul 22;81(7):764-7. Epub 2010 Feb 22.

Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, Hoppe-Seyler-Str 3, University of Tübingen, Tübingen 72076, Germany.

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http://jnnp.bmj.com/cgi/doi/10.1136/jnnp.2009.181719
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http://dx.doi.org/10.1136/jnnp.2009.181719DOI Listing
July 2010

No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort.

Neurobiol Aging 2011 Mar 22;32(3):551.e1-4. Epub 2009 May 22.

Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Otfried-Müller-Strasse 27, 72076, Tuebingen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01974580090014
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http://dx.doi.org/10.1016/j.neurobiolaging.2009.04.018DOI Listing
March 2011