Dr Ruangelie Edrada-Ebel, PhD - University of Strathclyde - Senior Lecturer

Dr Ruangelie Edrada-Ebel

PhD

University of Strathclyde

Senior Lecturer

Glasgow | United Kingdom

Main Specialties: Biotechnology, Chemistry

ORCID logohttps://orcid.org/0000-0003-2420-1117


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Dr Ruangelie Edrada-Ebel, PhD - University of Strathclyde - Senior Lecturer

Dr Ruangelie Edrada-Ebel

PhD

Introduction

Dr Edrada-Ebel received her Dr. rer. Nat degree in Pharmaceutical Biology from Julius- Maximillians-Universität Würzburg, Germany, did a postdoctoral fellowship at the Department of Chemistry, University of California Santa Cruz and was a senior research fellow at the Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Germany. She is currently a Senior Lecturer at the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, UK and heads the Natural Products Metabolomics Group (NPMG) and is currently author of more than 140 publications (h-index=40) for 2019 and four patents on the topic marine natural products. She referees articles on marine natural products on more than 10 peer-reviewed journals and is a member of the editorial board for Marine Drugs and Scientific Reports. Her expertise comprises both natural products isolation and structure elucidation with modern spectroscopic techniques. At present, she has a series of on-going projects on the application of metabolomics to identify and biotechnologically optimize the production of bioactive secondary metabolites in marine-derived microorganisms. She was awarded an International Visiting Fellowship by the Royal Melbourne Institute of Technology for the academic year 2017/2018.

Primary Affiliation: University of Strathclyde - Glasgow , United Kingdom

Specialties:

Research Interests:


View Dr Ruangelie Edrada-Ebel’s Resume / CV

Education

Jan 2000
University of California Santa Cruz
PostDoc
Jun 1998
Julius- Maximillians-Universität Würzburg
PhD

Publications

71Publications

1486Reads

20Profile Views

Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt.

PLoS One 2019 30;14(12):e0226959. Epub 2019 Dec 30.

Strathclyde Institute of Pharmacy and Biomedical Sciences, Faculty of Science, University of Strathclyde, Glasgow, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226959PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936774PMC
April 2020
3.234 Impact Factor

Metabolomic tools used in marine natural product drug discovery.

Expert Opin Drug Discov 2020 Apr 6;15(4):499-522. Epub 2020 Feb 6.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

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http://dx.doi.org/10.1080/17460441.2020.1722636DOI Listing
April 2020
3.467 Impact Factor

Metabolomics-Guided Isolation of Anti-Trypanosomal Compounds from Endophytic Fungi of the Mangrove plant .

Curr Med Chem 2020 ;27(11):1815-1835

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom.

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http://dx.doi.org/10.2174/0929867326666190704130105DOI Listing
January 2020
3.853 Impact Factor

Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy.

ACS Chem Neurosci 2019 04 6;10(4):1992-2003. Epub 2018 Nov 6.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences , University of Leuven , Leuven 3000 , Belgium.

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00281
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http://dx.doi.org/10.1021/acschemneuro.8b00281DOI Listing
April 2019
47 Reads
4.362 Impact Factor

Isolation of anticancer and anti-trypanosome secondary metabolites from the endophytic fungus Aspergillus flocculus via bioactivity guided isolation and MS based metabolomics.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Feb 6;1106-1107:71-83. Epub 2019 Jan 6.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2018.12.032DOI Listing
February 2019
19 Reads
2.729 Impact Factor

Metabolomics-Coupled Functional Pharmacology of Chlorophyll Compounds Isolated From the Leaves of Ficus Exasperata Vahl (Moraceae) Provides Novel Pathways on Myometrial Activity.

Reprod Sci 2018 06 26;25(6):923-937. Epub 2017 Sep 26.

1 Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom.

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http://journals.sagepub.com/doi/10.1177/1933719117732159
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http://dx.doi.org/10.1177/1933719117732159DOI Listing
June 2018
14 Reads
2.230 Impact Factor

Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge Stylissa carteri.

Z Naturforsch C J Biosci 2018 Apr;73(5-6):199-210

Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1515/znc-2017-0161DOI Listing
April 2018
12 Reads

Metabolomic-Guided Isolation of Bioactive Natural Products from Curvularia sp., an Endophytic Fungus of Terminalia laxiflora.

Planta Med 2018 Feb 28;84(3):182-190. Epub 2017 Aug 28.

Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, United Kingdom.

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http://dx.doi.org/10.1055/s-0043-118807DOI Listing
February 2018
27 Reads
2.152 Impact Factor

Isolation of Petrocidin A, a New Cytotoxic Cyclic Dipeptide from the Marine Sponge-Derived Bacterium Streptomyces sp. SBT348.

Mar Drugs 2017 Dec 6;15(12). Epub 2017 Dec 6.

Department of Botany II, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, D-97082 Würzburg, Germany.

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http://dx.doi.org/10.3390/md15120383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742843PMC
December 2017
11 Reads
2.853 Impact Factor

Erratum to: Isolation, Purification, and Characterization of Five Active Diketopiperazine Derivatives from Endophytic SUK 25 with Antimicrobial and Cytotoxic Activities.

J Microbiol Biotechnol 2017 11;27(11):2074

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, Scotland.

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http://dx.doi.org/10.4014/jmb.2017.2711.2074DOI Listing
November 2017
6 Reads
1.525 Impact Factor

Metabolomic Tools to Assess the Chemistry and Bioactivity of Endophytic Aspergillus Strain.

Chem Biodivers 2017 Oct 4;14(10). Epub 2017 Oct 4.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, G4 0NR, UK.

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http://dx.doi.org/10.1002/cbdv.201700040DOI Listing
October 2017
34 Reads
1.515 Impact Factor

Characterisation of the antiproliferative constituents and activity of Ficus exasperata (Vahl) on ovarian cancer cells -a preliminary investigation.

Nat Prod Res 2017 Sep 17;31(18):2164-2168. Epub 2017 Jan 17.

a Strathclyde Institute of Pharmacy and Biomedical Sciences , University of Strathclyde , Glasgow , United Kingdom.

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http://dx.doi.org/10.1080/14786419.2016.1277348DOI Listing
September 2017
8 Reads
0.919 Impact Factor

Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba.

Sci Rep 2017 08 15;7(1):8247. Epub 2017 Aug 15.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK.

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http://dx.doi.org/10.1038/s41598-017-07495-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557935PMC
August 2017
16 Reads
5.078 Impact Factor

Isolation, Purification, and Characterization of Five Active Diketopiperazine Derivatives from Endophytic SUK 25 with Antimicrobial and Cytotoxic Activities.

J Microbiol Biotechnol 2017 07;27(7):1249-1256

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, Scotland.

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http://dx.doi.org/10.4014/jmb.1608.08032DOI Listing
July 2017
16 Reads
1.525 Impact Factor

Toward Understanding Myometrial Regulation: Metabolomic Investigation Reveals New Pathways of Oxytocin and Ritodrine Activity on the Myometrium.

Reprod Sci 2017 05 27;24(5):691-705. Epub 2016 Sep 27.

1 Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom.

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http://dx.doi.org/10.1177/1933719116667224DOI Listing
May 2017
8 Reads
2.230 Impact Factor

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic SUK10.

Drug Des Devel Ther 2017 8;11:351-363. Epub 2017 Feb 8.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

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https://www.dovepress.com/gancidin-w-a-potential-low-toxicit
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http://dx.doi.org/10.2147/DDDT.S121283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308589PMC
May 2017
6 Reads
3.028 Impact Factor

Isolation and characterization of cyclo-(tryptophanyl-prolyl) and chloramphenicol from Streptomyces sp. SUK 25 with antimethicillin-resistant Staphylococcus aureus activity.

Drug Des Devel Ther 2016 31;10:1817-27. Epub 2016 May 31.

Programme of Biomedical Science, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

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https://www.dovepress.com/isolation-and-characterization-of-
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http://dx.doi.org/10.2147/DDDT.S101212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896468PMC
April 2017
6 Reads
3.028 Impact Factor

Metabolomics-Guided Isolation of Anti-trypanosomal Metabolites from the Endophytic Fungus Lasiodiplodia theobromae.

Planta Med 2017 Apr 19;83(6):565-573. Epub 2016 Oct 19.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-118601
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http://dx.doi.org/10.1055/s-0042-118601DOI Listing
April 2017
5 Reads
2.152 Impact Factor

Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants.

Sci Rep 2016 07 7;6:29265. Epub 2016 Jul 7.

AsterBioChem Team, Laboratory of Pharmacognosy, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo. Av. do Café s/n, Monte Alegre, Ribeirão Preto, SP, 14040-903, Brazil.

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http://www.nature.com/articles/srep29265
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http://dx.doi.org/10.1038/srep29265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935878PMC
July 2016
3 Reads
5.078 Impact Factor

Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges.

PLoS One 2015 25;10(9):e0138528. Epub 2015 Sep 25.

Dept. of Botany II, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Würzburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138528PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583450PMC
June 2016
8 Reads
3.234 Impact Factor

Draft genome sequences of three chemically rich actinomycetes isolated from Mediterranean sponges.

Mar Genomics 2015 Dec 20;24 Pt 3:285-7. Epub 2015 Oct 20.

Department of Marine Microbiology, GEOMAR Helmholtz Centre for Ocean Research, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.margen.2015.10.003DOI Listing
December 2015
7 Reads
1.792 Impact Factor

The 9th European Conference on Marine Natural Products.

Mar Drugs 2015 Dec 3;13(12):7150-249. Epub 2015 Dec 3.

Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen, AB24 3UE, Scotland, UK.

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http://www.mdpi.com/1660-3397/13/12/7059
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http://dx.doi.org/10.3390/md13127059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698589PMC
December 2015
3 Reads
2.853 Impact Factor

In vivo antimalarial activity of the endophytic actinobacteria, Streptomyces SUK 10.

J Microbiol 2015 Dec 2;53(12):847-55. Epub 2015 Dec 2.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, United Kingdom.

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http://link.springer.com/10.1007/s12275-015-5076-6
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http://dx.doi.org/10.1007/s12275-015-5076-6DOI Listing
December 2015
3 Reads
1.439 Impact Factor

Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes.

Nanomedicine 2015 Aug 29;11(6):1445-54. Epub 2015 Apr 29.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2015.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509555PMC
August 2015
30 Reads
6.155 Impact Factor

A Metabolomic Approach to Target Compounds from the Asteraceae Family for Dual COX and LOX Inhibition.

Metabolites 2015 Jul 8;5(3):404-30. Epub 2015 Jul 8.

University of Strathclyde, the John Arbuthnott Building, 161 Cathedral Street, Glasgow G4 0RE, UK.

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http://dx.doi.org/10.3390/metabo5030404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588803PMC
July 2015
2 Reads

Prediction of Anti-inflammatory Plants and Discovery of Their Biomarkers by Machine Learning Algorithms and Metabolomic Studies.

Planta Med 2015 Apr 23;81(6):450-8. Epub 2015 Jan 23.

AsterBioChem Research Team, Laboratory of Pharmacognosy, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.

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http://dx.doi.org/10.1055/s-0034-1396206DOI Listing
April 2015
57 Reads
2.152 Impact Factor

Antichlamydial sterol from the Red Sea sponge Callyspongia aff. implexa.

Planta Med 2015 Mar 17;81(5):382-7. Epub 2015 Mar 17.

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

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https://www.thieme-connect.com/products/ejournals/pdf/10.105
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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1545721
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http://dx.doi.org/10.1055/s-0035-1545721DOI Listing
March 2015
18 Reads
2.152 Impact Factor

The re-emergence of natural products for drug discovery in the genomics era.

Nat Rev Drug Discov 2015 Feb 23;14(2):111-29. Epub 2015 Jan 23.

Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia.

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http://www.nature.com/nrd/journal/v14/n2/pdf/nrd4510.pdf?WT.
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http://dx.doi.org/10.1038/nrd4510DOI Listing
February 2015
16 Reads
41.908 Impact Factor

Metabolomics of the bio-degradation process of aflatoxin B1 by actinomycetes at an initial pH of 6.0.

Toxins (Basel) 2015 Feb 4;7(2):439-56. Epub 2015 Feb 4.

Fermentation Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.

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http://dx.doi.org/10.3390/toxins7020439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344634PMC
February 2015
7 Reads
2.480 Impact Factor

The isolation of antiprotozoal compounds from Libyan propolis.

Phytother Res 2014 Dec 9;28(12):1756-60. Epub 2014 Jul 9.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow, G4 0NR, UK.

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http://doi.wiley.com/10.1002/ptr.5194
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http://dx.doi.org/10.1002/ptr.5194DOI Listing
December 2014
23 Reads
2.397 Impact Factor

Two new antioxidant actinosporin analogues from the calcium alginate beads culture of sponge-associated Actinokineospora sp. strain EG49.

Bioorg Med Chem Lett 2014 Nov 6;24(21):5089-92. Epub 2014 Sep 6.

Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.08.068DOI Listing
November 2014
55 Reads
2.420 Impact Factor

Metabolomic profiling and genomic study of a marine sponge-associated Streptomyces sp.

Mar Drugs 2014 Jun 2;12(6):3323-51. Epub 2014 Jun 2.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UK.

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http://dx.doi.org/10.3390/md12063323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071579PMC
June 2014
78 Reads
2.853 Impact Factor

Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge Haliclona simulans.

Mar Drugs 2014 May 16;12(5):2937-52. Epub 2014 May 16.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UK.

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http://dx.doi.org/10.3390/md12052937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052325PMC
May 2014
35 Reads
2.853 Impact Factor

Chromatographic analysis with different detectors in the chemical characterisation and dereplication of African propolis.

Talanta 2014 Mar 11;120:181-90. Epub 2013 Dec 11.

University of Strathclyde, Department of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Science, 27 Taylor Street, Glasgow G4 0NR, UK.

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http://dx.doi.org/10.1016/j.talanta.2013.11.094DOI Listing
March 2014
1 Read
3.545 Impact Factor

Metabolomics and dereplication strategies in natural products.

Methods Mol Biol 2013 ;1055:227-44

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

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http://dx.doi.org/10.1007/978-1-62703-577-4_17DOI Listing
March 2014
89 Reads

Dereplication strategies for targeted isolation of new antitrypanosomal actinosporins A and B from a marine sponge associated-Actinokineospora sp. EG49.

Mar Drugs 2014 Mar 6;12(3):1220-44. Epub 2014 Mar 6.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow G4 0NR, UK.

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http://dx.doi.org/10.3390/md12031220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967206PMC
March 2014
22 Reads
2.853 Impact Factor

Streptomyces kebangsaanensis sp. nov., an endophytic actinomycete isolated from an ethnomedicinal plant, which produces phenazine-1-carboxylic acid.

Int J Syst Evol Microbiol 2013 Oct 3;63(Pt 10):3733-3738. Epub 2013 May 3.

Programme of Biomedical Science, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia 50300 Kuala Lumpur, Malaysia.

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http://ijs.microbiologyresearch.org/content/journal/ijsem/10
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http://dx.doi.org/10.1099/ijs.0.047878-0DOI Listing
October 2013
25 Reads
2.511 Impact Factor

A new bioactive sesquiterpenoid quinone from the Mediterranean Sea marine sponge Dysidea avara.

Nat Prod Commun 2013 Mar;8(3):289-92

Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany.

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March 2013
12 Reads

The leaves of Ficus exasperata Vahl (Moraceae) generates uterine active chemical constituents.

J Ethnopharmacol 2013 Feb 21;145(3):803-12. Epub 2012 Dec 21.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S037887411200854
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http://dx.doi.org/10.1016/j.jep.2012.12.020DOI Listing
February 2013
62 Reads
2.998 Impact Factor

Natural products isolation in modern drug discovery programs.

Methods Mol Biol 2012 ;864:515-34

Natural Products Research Laboratories, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

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http://dx.doi.org/10.1007/978-1-61779-624-1_20DOI Listing
June 2012
2 Reads

Perfusion culture enhanced human endometrial stromal cell growth in alginate-multivalent integrin α5β1 ligand scaffolds.

J Biomed Mater Res A 2011 Nov 16;99(2):211-20. Epub 2011 Aug 16.

Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/jbm.a.33177DOI Listing
November 2011
4 Reads
3.369 Impact Factor

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex.

Nanomedicine 2011 Oct 17;7(5):615-23. Epub 2011 Feb 17.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.

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http://dx.doi.org/10.1016/j.nano.2011.01.016DOI Listing
October 2011
51 Reads
6.155 Impact Factor

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex.

Biomaterials 2011 Sep 18;32(25):5889-99. Epub 2011 May 18.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.

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http://dx.doi.org/10.1016/j.biomaterials.2011.04.079DOI Listing
September 2011
7 Reads
8.557 Impact Factor

NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum.

Bioorg Med Chem 2011 Jan 17;19(1):414-21. Epub 2010 Nov 17.

Heinrich-Heine-Universität, Institut für Pharmazeutische Biologie und Biotechnologie, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1016/j.bmc.2010.11.012DOI Listing
January 2011
72 Reads
2.793 Impact Factor

Isolation of recombinant proteins from culture broth by co-precipitation with an amino acid carrier to form stable dry powders.

Biotechnol Bioeng 2010 Aug;106(5):764-73

Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, UK.

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http://dx.doi.org/10.1002/bit.22730DOI Listing
August 2010
1 Read
4.126 Impact Factor

Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa.

Bioorg Med Chem 2010 Jul 11;18(14):4947-56. Epub 2010 Jun 11.

Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Geb. 26.23, Universitätsstrasse 1, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1016/j.bmc.2010.06.012DOI Listing
July 2010
3 Reads
2.793 Impact Factor

Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA.

J Control Release 2010 Apr 26;143(2):215-21. Epub 2009 Nov 26.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, United Kingdom.

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http://dx.doi.org/10.1016/j.jconrel.2009.11.015DOI Listing
April 2010
19 Reads
7.705 Impact Factor

From anti-fouling to biofilm inhibition: new cytotoxic secondary metabolites from two Indonesian Agelas sponges.

Bioorg Med Chem 2010 Feb 12;18(3):1297-311. Epub 2010 Jan 12.

Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr 1, Geb 26.23, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1016/j.bmc.2009.12.028DOI Listing
February 2010
19 Reads
2.793 Impact Factor

Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the mangrove plant Sonneratia alba.

J Nat Prod 2009 Nov;72(11):2053-7

Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1021/np900417gDOI Listing
November 2009
51 Reads
3.798 Impact Factor

A new tetrahydrofuran derivative from the endophytic fungus Chaetomium sp. isolated from Otanthus maritimus.

Z Naturforsch C J Biosci 2009 May-Jun;64(5-6):350-4

Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universittät, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1515/znc-2009-5-608DOI Listing
September 2009
16 Reads

Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula.

J Nat Prod 2009 Sep;72(9):1585-8

Institut fur Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universitat Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany.

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http://dx.doi.org/10.1021/np900220rDOI Listing
September 2009
22 Reads
3.798 Impact Factor

Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.

J Nat Prod 2009 Apr;72(4):626-31

Institut fur Pharmazeutische Biologie and Biotechnologie, Heinrich-Heine-Universitat, Dusseldorf, Germany.

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http://dx.doi.org/10.1021/np8004997DOI Listing
April 2009
46 Reads
3.798 Impact Factor

Dihydrostilbene derivatives from the Mongolian medicinal plant Scorzonera radiata.

J Nat Prod 2009 Apr;72(4):671-5

Institut fur Pharmazeutische Biologie and Biotechnologie, Heinrich-Heine-Universitat Dusseldorf, Dusseldorf, Germany.

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http://dx.doi.org/10.1021/np800782fDOI Listing
April 2009
4 Reads
3.798 Impact Factor

Side-on binding of p-sulphonatocalix[4]arene to the dinuclear platinum complex trans-[{PtCl(NH3)2}2mu-dpzm]2+ and its implications for anticancer drug delivery.

J Inorg Biochem 2009 Mar 27;103(3):448-54. Epub 2008 Dec 27.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, United Kingdom.

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http://dx.doi.org/10.1016/j.jinorgbio.2008.12.011DOI Listing
March 2009
5 Reads
3.444 Impact Factor

Dibromopyrrole alkaloids from the marine sponge Acanthostylotella sp.

Nat Prod Commun 2009 Jan;4(1):47-52

Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany.

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January 2009
6 Reads

Diacarperoxides, norterpene cyclic peroxides from the sponge Diacarnus megaspinorhabdosa.

J Nat Prod 2008 Aug 2;71(8):1358-64. Epub 2008 Aug 2.

Institut für Pharmazeutische Biologie and Biotechnologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1021/np800102uDOI Listing
August 2008
29 Reads
3.798 Impact Factor

Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.

J Nat Prod 2008 Jun 22;71(6):972-80. Epub 2008 May 22.

Institut für Pharmazeutische Biologie and Biotechnologie, Heinrich-Heine-Universität, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1021/np070447mDOI Listing
June 2008
55 Reads
3.798 Impact Factor

Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides.

Phytochemistry 2008 May 8;69(8):1716-25. Epub 2008 Apr 8.

Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1016/j.phytochem.2008.02.013DOI Listing
May 2008
38 Reads
2.547 Impact Factor

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