Royston C Copley

Royston C B Copley

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Royston C Copley

Royston C B Copley

Publications by authors named "Royston C B Copley"

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1PubMed Central Citations

Thermal and photochemical annulation of vinyl azides to 2-aminoimidazoles.

Org Biomol Chem 2019 07 24;17(27):6566-6569. Epub 2019 Jun 24.

Medicinal Chemistry, GlaxoSmithKline, 1250 South Collegeville Rd, PO Box 5089, Collegeville, PA 19426-0989, USA.

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http://xlink.rsc.org/?DOI=C9OB01100E
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http://dx.doi.org/10.1039/c9ob01100eDOI Listing
July 2019

Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists.

J Med Chem 2018 03 28;61(6):2518-2532. Epub 2018 Feb 28.

Neurosciences Therapeutic Area Unit , GSK Pharmaceuticals R&D , 898 Halei Road, Zhangjiang Hi-Tech Park , Pudong , Shanghai 201203 , P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01854DOI Listing
March 2018

Conversion of a Benzofuran Ester to an Amide through an Enamine Lactone Pathway: Synthesis of HCV Polymerase Inhibitor GSK852A.

J Org Chem 2015 Oct 30;80(19):9610-9. Epub 2015 Sep 30.

Product Development, GlaxoSmithKline , 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.

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http://dx.doi.org/10.1021/acs.joc.5b01598DOI Listing
October 2015

Solid-state NMR analysis of a complex crystalline phase of ronacaleret hydrochloride.

J Phys Chem B 2014 Aug 18;118(34):10266-84. Epub 2014 Aug 18.

Product Development, GlaxoSmithKline plc. 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.

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http://dx.doi.org/10.1021/jp505061jDOI Listing
August 2014

Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.

Org Biomol Chem 2014 Mar;12(11):1779-92

Allergy & Inflammation DPU, Respiratory TAU, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.

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http://dx.doi.org/10.1039/c3ob42443jDOI Listing
March 2014

One-phase crystal disorder in pharmaceutical solids and its implication for solid-state stability.

J Pharm Sci 2011 Oct 16;100(10):4302-16. Epub 2011 May 16.

Product Development, GlaxoSmithKline plc., King of Prussia, Pennsylvania 19406.

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http://dx.doi.org/10.1002/jps.22621DOI Listing
October 2011

Elucidating the pathways of degradation of denagliptin.

J Pharm Sci 2010 Jul;99(7):3030-40

Analytical Sciences, Chemical Development, Five Moore Drive, PO Box 13398, GlaxoSmithKline, RTP, North Carolina 27709, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002235491532565
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http://dx.doi.org/10.1002/jps.22069DOI Listing
July 2010

Studying the origin of the antiferromagnetic to spin-canting transition in the beta-p-NCC6F4CNSSN* molecular magnet.

Chemistry 2010 Mar;16(9):2741-50

Departament de Química Física & IQTCUB, Universitat de Barcelona, Martí i Franquès 1, 08028, Barcelona, Spain.

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http://dx.doi.org/10.1002/chem.200903221DOI Listing
March 2010

An investigation into the electrophilic cyclisation of N-acyl-pyrrolidinium ions: a facile synthesis of pyrrolo-tetrahydroisoquinolones and pyrrolo-benzazepinones.

Org Biomol Chem 2009 Sep 9;7(17):3561-71. Epub 2009 Jul 9.

Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.

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http://dx.doi.org/10.1039/b907400gDOI Listing
September 2009

An investigation of the absolute configuration of the potent histamine H3 receptor antagonist GT-2331 using vibrational circular dichroism.

Chirality 2007 Sep;19(9):731-40

GlaxoSmithKline, Discovery Research, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1002/chir.20431DOI Listing
September 2007

Absolute stereochemistry of ibhayinol from a South African sea hare.

J Nat Prod 2002 Apr;65(4):580-2

Department of Chemistry, Rhodes University, Grahamstown, South Africa.

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http://dx.doi.org/10.1021/np010403sDOI Listing
April 2002