Publications by authors named "Roy Zent"

100Publications

Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate Transport in Primary Renal Tubule Cells.

Tissue Eng Part A 2020 Oct;26(19-20):1091-1098

Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1089/ten.TEA.2019.0294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580646PMC
October 2020

Small proline-rich repeat 3 is a novel coordinator of PDGFRβ and integrin β1 crosstalk to augment proliferation and matrix synthesis by cardiac fibroblasts.

FASEB J 2020 Jun 16;34(6):7885-7904. Epub 2020 Apr 16.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1096/fj.201902815RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302973PMC
June 2020

Basement membrane ligands initiate distinct signalling networks to direct cell shape.

Matrix Biol 2020 08 6;90:61-78. Epub 2020 Mar 6.

Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327512PMC
August 2020

Methylselenol producing selenocompounds enhance the efficiency of mammaglobin-A peptide vaccination against breast cancer cells.

Oncol Lett 2019 Dec 18;18(6):6891-6898. Epub 2019 Oct 18.

Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA.

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http://dx.doi.org/10.3892/ol.2019.11010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876340PMC
December 2019

Identification of matrix physicochemical properties required for renal epithelial cell tubulogenesis by using synthetic hydrogels.

J Cell Sci 2019 10 21;132(20). Epub 2019 Oct 21.

Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332, USA

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http://dx.doi.org/10.1242/jcs.226639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826008PMC
October 2019

Diaspora linkages benefit both sides: a single partnership experience.

Glob Health Action 2019 ;12(1):1645558

b Division of Nephrology and Hypertension, Department of Medicine , Nashville , TN , USA.

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http://dx.doi.org/10.1080/16549716.2019.1645558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711129PMC
December 2019

Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner.

Am J Physiol Endocrinol Metab 2019 06 5;316(6):E1118-E1135. Epub 2019 Mar 5.

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine , Nashville, Tennessee.

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http://dx.doi.org/10.1152/ajpendo.00496.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732653PMC
June 2019

Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.

Tissue Eng Part A 2019 07 14;25(13-14):1013-1022. Epub 2019 Jun 14.

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1089/ten.TEA.2018.0182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648172PMC
July 2019

NIX-mediated mitophagy protects against proteinuria-induced tubular cell apoptosis and renal injury.

Am J Physiol Renal Physiol 2019 02 12;316(2):F382-F395. Epub 2018 Sep 12.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.

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http://dx.doi.org/10.1152/ajprenal.00360.2018DOI Listing
February 2019

The laminin binding α3 and α6 integrins cooperate to promote epithelial cell adhesion and growth.

Matrix Biol 2019 04 4;77:101-116. Epub 2018 Sep 4.

Division of Nephrology and Hypertension, Department of Medicine, Nashville, TN 37232, USA; Department of Cancer Biology, Nashville, TN 37232, USA; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Veterans Affairs Hospital, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399080PMC
April 2019

Lkb1 deficiency confers glutamine dependency in polycystic kidney disease.

Nat Commun 2018 02 26;9(1):814. Epub 2018 Feb 26.

Departments of Molecular Biology and Internal Medicine, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://www.nature.com/articles/s41467-018-03036-y
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http://dx.doi.org/10.1038/s41467-018-03036-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827653PMC
February 2018

Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains.

Sci Rep 2018 02 13;8(1):2916. Epub 2018 Feb 13.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232-2372, USA.

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http://dx.doi.org/10.1038/s41598-018-21231-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811549PMC
February 2018

Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of GPCRs.

Cell Signal 2018 Jan 11;42:259-269. Epub 2017 Nov 11.

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732042PMC
January 2018

Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.

Development 2017 11 9;144(22):4148-4158. Epub 2017 Oct 9.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA

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http://dx.doi.org/10.1242/dev.149914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719244PMC
November 2017

Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.

J Cell Biol 2017 11 14;216(11):3785-3798. Epub 2017 Sep 14.

Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1083/jcb.201701176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674885PMC
November 2017

Clustering of integrin α5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells.

Mol Biol Cell 2017 May 29;28(10):1288-1300. Epub 2017 Mar 29.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232

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http://dx.doi.org/10.1091/mbc.E16-12-0852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426844PMC
May 2017

Integrin alpha6 maintains the structural integrity of the kidney collecting system.

Matrix Biol 2017 01 30;57-58:244-257. Epub 2016 Dec 30.

Division of Nephrology and Hypertension and Vanderbilt Center for Kidney Disease, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Veterans Affairs Hospital, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330664PMC
January 2017

Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis.

Matrix Biol 2017 01 1;57-58:258-271. Epub 2016 Dec 1.

Department of Medicine (Division of Nephrology), Vanderbilt University, Nashville, TN, United States; Veterans Affairs Hospitals, Nashville, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2016.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329129PMC
January 2017

Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance.

Diabetes 2017 02 29;66(2):325-334. Epub 2016 Nov 29.

Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.

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http://dx.doi.org/10.2337/db16-0484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248997PMC
February 2017

Progression of chronic kidney disease: too much cellular talk causes damage.

Kidney Int 2017 03 20;91(3):552-560. Epub 2016 Oct 20.

Division of Nephrology, Department of Medicine, Vanderbilt Medical Center, Nashville, Tennessee, USA; Veterans Affairs Medical Center, Nashville, Tennessee, USA; Department of Cancer Biology, Vanderbilt Medical Center, Nashville, Tennessee, USA; Department of Molecular Physiology and Biophysics, Vanderbilt Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1016/j.kint.2016.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313325PMC
March 2017

Extracellular chloride signals collagen IV network assembly during basement membrane formation.

J Cell Biol 2016 05;213(4):479-94

Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232 Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232 Center for Matrix Biology, Vanderbilt University Medical Center, Nashville, TN 37232 Aspirnaut Program, Vanderbilt University Medical Center, Nashville, TN 37232 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232 Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232

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http://dx.doi.org/10.1083/jcb.201510065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878091PMC
May 2016

Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice.

Diabetes 2016 06 5;65(6):1590-600. Epub 2016 Apr 5.

Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, TN.

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http://dx.doi.org/10.2337/db15-1434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878430PMC
June 2016

Deleting the TGF-β receptor in proximal tubules impairs HGF signaling.

Am J Physiol Renal Physiol 2016 Mar 6;310(6):F499-510. Epub 2016 Jan 6.

Department of Research, Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee; and Division of Nephrology, Department of Medicine, Vanderbilt Medical Center, Nashville, Tennessee; Department of Cell and Developmental Biology, Vanderbilt Medical Center, Nashville, Tennessee;

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http://ajprenal.physiology.org/content/ajprenal/early/2016/0
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http://ajprenal.physiology.org/lookup/doi/10.1152/ajprenal.0
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http://dx.doi.org/10.1152/ajprenal.00446.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796273PMC
March 2016

Cell Receptor-Basement Membrane Interactions in Health and Disease: A Kidney-Centric View.

Curr Top Membr 2015 ;76:231-53

Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Veterans Administration Hospital, Nashville, TN, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10635823150006
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http://dx.doi.org/10.1016/bs.ctm.2015.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913201PMC
September 2016

Extracellular rigidity sensing by talin isoform-specific mechanical linkages.

Nat Cell Biol 2015 Dec 2;17(12):1597-606. Epub 2015 Nov 2.

Max Planck Institute of Biochemistry, Group of Molecular Mechanotransduction, Martinsried D-82152, Germany.

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http://dx.doi.org/10.1038/ncb3268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662888PMC
December 2015

Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.

J Cell Sci 2015 Dec 21;128(23):4293-305. Epub 2015 Oct 21.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA

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http://dx.doi.org/10.1242/jcs.164509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712811PMC
December 2015

A Murine Model of K-RAS and β-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor.

J Urol 2015 Dec 29;194(6):1762-70. Epub 2015 Apr 29.

Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2015.04.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782590PMC
December 2015

Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt.

Mol Biol Cell 2015 May 25;26(10):1857-74. Epub 2015 Mar 25.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 Veterans Affairs Hospital, Nashville, TN 37232

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http://dx.doi.org/10.1091/mbc.E14-07-1203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436831PMC
May 2015

The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites.

J Cell Sci 2015 Mar 20;128(5):1023-33. Epub 2015 Jan 20.

Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.162545
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http://dx.doi.org/10.1242/jcs.162545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342583PMC
March 2015

p47(phox) contributes to albuminuria and kidney fibrosis in mice.

Kidney Int 2015 May 7;87(5):948-62. Epub 2015 Jan 7.

1] Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA [2] Department of Medicine, Veterans Affairs Hospitals, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/ki.2014.386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425591PMC
May 2015

Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization.

Development 2014 Dec 13;141(24):4751-62. Epub 2014 Nov 13.

Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232, USA Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA Nashville Veterans Affairs Medical Center, Nashville, TN 37232, USA

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http://dx.doi.org/10.1242/dev.117200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299273PMC
December 2014

The kidney research predicament.

J Am Soc Nephrol 2014 May 20;25(5):898-903. Epub 2014 Mar 20.

Division of Nephrology, Department of Medicine, Jesse Brown Veterans Affairs Medical Center and Edward Hines Jr. Veterans Affairs Hospital, Chicago, Illinois; and Division of Nephrology, Department of Medicine, University of Illinois Hospital and Health Sciences Center, Chicago, Illinois.

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http://dx.doi.org/10.1681/ASN.2013121313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005318PMC
May 2014

Glomerular cell cross-talk influences composition and assembly of extracellular matrix.

J Am Soc Nephrol 2014 May 16;25(5):953-66. Epub 2014 Jan 16.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences and Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom;

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http://dx.doi.org/10.1681/ASN.2013070795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005312PMC
May 2014

PPARα activation can help prevent and treat non-small cell lung cancer.

Cancer Res 2014 Jan 3;74(2):621-31. Epub 2013 Dec 3.

Authors' Affiliations: Departments of Medicine, Division of Nephrology, Cancer Biology, and Biochemistry, Vanderbilt University; Department of Medicine, Veterans Affairs Hospital, Nashville, Tennessee; and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://cancerres.aacrjournals.org/content/early/2013/12/03/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-1928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902646PMC
January 2014

Cdc42 promotes host defenses against fatal infection.

Infect Immun 2013 Aug 20;81(8):2714-23. Epub 2013 May 20.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1128/IAI.01114-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719566PMC
August 2013

Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice.

J Biol Chem 2013 Jun 8;288(26):18863-71. Epub 2013 May 8.

Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1074/jbc.M113.470476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696662PMC
June 2013

Integrins in kidney disease.

J Am Soc Nephrol 2013 Jun 2;24(7):1034-9. Epub 2013 May 2.

Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 27232, USA.

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http://dx.doi.org/10.1681/ASN.2013010012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699832PMC
June 2013

Deleting the TGF-β receptor attenuates acute proximal tubule injury.

J Am Soc Nephrol 2012 Dec 15;23(12):2001-11. Epub 2012 Nov 15.

Department of Research, Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1681/ASN.2012020139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507360PMC
December 2012

Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.

Mol Pharmacol 2013 Jan 18;83(1):206-16. Epub 2012 Oct 18.

Division of Nephrology, Vanderbilt University School of Medicine, S3223 MCN, 1161 21st Avenue, Nashville, TN 37232-2372, USA.

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http://dx.doi.org/10.1124/mol.112.080473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533480PMC
January 2013

EP1 disruption attenuates end-organ damage in a mouse model of hypertension.

Hypertension 2012 Nov 24;60(5):1184-91. Epub 2012 Sep 24.

Department of Pharmacology, Vanderbilt University Medical Center, 1161 21 Ave, Medical Center North # B3214, Nashville, TN 37232-2372, USA.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.112.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.199026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478772PMC
November 2012

Connecting the segments.

J Am Soc Nephrol 2012 Oct 13;23(10):1603-5. Epub 2012 Sep 13.

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http://dx.doi.org/10.1681/ASN.2012080850DOI Listing
October 2012

Nonmuscle myosin II regulation of lung epithelial morphology.

Dev Dyn 2012 Nov 25;241(11):1770-81. Epub 2012 Sep 25.

Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1002/dvdy.23866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484380PMC
November 2012

How does TGF-β mediate tubulointerstitial fibrosis?

Semin Nephrol 2012 May;32(3):228-35

Department of Research, Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, TN, USA.

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http://dx.doi.org/10.1016/j.semnephrol.2012.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948283PMC
May 2012

CD98 increases renal epithelial cell proliferation by activating MAPKs.

PLoS One 2012 29;7(6):e40026. Epub 2012 Jun 29.

Department of Medicine (Division of Nephrology), Vanderbilt University Medical Center, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040026PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386947PMC
November 2012

The mammalian kidney.

Exp Cell Res 2012 May;318(9)

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http://dx.doi.org/10.1016/S0014-4827(12)00185-1DOI Listing
May 2012

Inhibition of integrin α2β1 ameliorates glomerular injury.

J Am Soc Nephrol 2012 Jun 22;23(6):1027-38. Epub 2012 Mar 22.

Departments of Medicine and Cancer Biology, Division of Nephrology and Hypertension, Vanderbilt University, Medical Center North, Nashville, TN 37232, USA.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2011040367
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http://dx.doi.org/10.1681/ASN.2011040367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358756PMC
June 2012

Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy.

Kidney Int 2012 Jun 1;81(11):1086-97. Epub 2012 Feb 1.

Division of Nephrology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1038/ki.2011.474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345314PMC
June 2012

Bicelles at low concentrations.

Mol Pharm 2012 Apr 20;9(4):752-61. Epub 2012 Jan 20.

Department of Biochemistry, Center for Structural Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1021/mp2004687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319193PMC
April 2012

Hold tight or you'll fall off: CD151 helps podocytes stick in high-pressure situations.

J Clin Invest 2012 Jan 27;122(1):13-6. Epub 2011 Dec 27.

Division of Nephrology, Department of Medicine, Vanderbilt Medical Center and VA Medical Center, Nashville, Tennessee 37232-2372, USA.

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http://dx.doi.org/10.1172/JCI61858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248315PMC
January 2012

β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.

Am J Pathol 2011 Dec 8;179(6):3045-55. Epub 2011 Oct 8.

Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2765, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260797PMC
December 2011

Renal collecting system growth and function depend upon embryonic γ1 laminin expression.

Development 2011 Oct 8;138(20):4535-44. Epub 2011 Sep 8.

Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1242/dev.071266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177319PMC
October 2011

Integrins in renal development.

Pediatr Nephrol 2012 Jun 21;27(6):891-900. Epub 2011 May 21.

Department of Medicine (Division of Nephrology), Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1007/s00467-011-1890-1DOI Listing
June 2012

Extracellular matrix receptors in branched organs.

Curr Opin Cell Biol 2011 Oct 9;23(5):547-53. Epub 2011 May 9.

Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Hospital, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.ceb.2011.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181278PMC
October 2011

TGF-β sequestration by mesangial cell integrin αvβ8: A novel mechanism of glomerular endothelial cell regulation.

Am J Pathol 2011 Feb;178(2):485-9

Department of Medicine, Division of Nephrology, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1016/j.ajpath.2010.10.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069894PMC
February 2011

Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase.

J Biol Chem 2010 Dec 12;285(51):40114-24. Epub 2010 Oct 12.

Department of Medicine, Division of Nephrology, Vanderbilt University, Nashville, Tennessee 37212-2372, USA.

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http://dx.doi.org/10.1074/jbc.M110.156729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000994PMC
December 2010

Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products.

Wiley Interdiscip Rev Syst Biol Med 2009 Sep-Oct;1(2):254-272

Department of Medicine, Veterans Affairs Hospital, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1002/wsbm.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789245PMC
January 2011

Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.

Development 2010 Oct;137(19):3233-43

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1242/dev.052845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934735PMC
October 2010

MT1-MMP-mediated basement membrane remodeling modulates renal development.

Exp Cell Res 2010 Oct 19;316(17):2993-3005. Epub 2010 Aug 19.

Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.yexcr.2010.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945451PMC
October 2010

TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis.

J Urol 2010 Sep 21;184(3):1166-74. Epub 2010 Jul 21.

Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2765, USA.

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http://dx.doi.org/10.1016/j.juro.2010.04.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963111PMC
September 2010

TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis.

J Am Soc Nephrol 2010 Aug 24;21(8):1334-43. Epub 2010 Jun 24.

Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1681/ASN.2010020147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938601PMC
August 2010

The role of a recombinant fragment of laminin-332 in integrin alpha3beta1-dependent cell binding, spreading and migration.

Biomaterials 2010 Jul 27;31(19):5110-21. Epub 2010 Mar 27.

Department of Cancer Biology, Vanderbilt University Medical Center, 771 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232 6840, United States.

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http://dx.doi.org/10.1016/j.biomaterials.2010.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861493PMC
July 2010

Sirt1 activation protects the mouse renal medulla from oxidative injury.

J Clin Invest 2010 Apr 24;120(4):1056-68. Epub 2010 Mar 24.

Nephrology Division, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee 37232, USA.

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http://www.jci.org/articles/view/41563
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http://dx.doi.org/10.1172/JCI41563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846063PMC
April 2010

Integrin-linked kinase is an adaptor with essential functions during mouse development.

Nature 2009 Oct;461(7266):1002-6

Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.

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http://dx.doi.org/10.1038/nature08468DOI Listing
October 2009

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.

Blood 2009 Nov 29;114(23):4897-906. Epub 2009 Sep 29.

Department of Pathology, Anatomy, and Cell Biology, and Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1182/blood-2009-02-207134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786295PMC
November 2009

The role of integrin alpha8beta1 in fetal lung morphogenesis and injury.

Dev Biol 2009 Nov 19;335(2):407-17. Epub 2009 Sep 19.

Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-0493, USA.

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http://dx.doi.org/10.1016/j.ydbio.2009.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783258PMC
November 2009

Distinct roles for basal and induced COX-2 in podocyte injury.

J Am Soc Nephrol 2009 Sep 30;20(9):1953-62. Epub 2009 Jul 30.

Division of Nephrology, Vanderbilt University School of Medicine and Nashville Veterans Affairs Hospital, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1681/ASN.2009010039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736764PMC
September 2009

Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions.

J Am Soc Nephrol 2009 Oct 16;20(10):2119-25. Epub 2009 Jul 16.

Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1681/ASN.2008080900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754111PMC
October 2009

The tail of integrins, talin, and kindlins.

Science 2009 May;324(5929):895-9

Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1126/science.1163865DOI Listing
May 2009