Roy Perlis

Roy Perlis

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Roy Perlis

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What do patients learn about psychotropic medications on the web? A natural language processing study.

J Affect Disord 2020 Jan 10;260:366-371. Epub 2019 Sep 10.

Center for Quantitative Health, Massachusetts General Hospital, 185 Cambridge Street, 6th Floor, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.09.043DOI Listing
January 2020

Evaluating Machine Learning Articles.

JAMA 2019 11;322(18):1777-1779

Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jama.2019.17304DOI Listing
November 2019

Gender Trends in Authorship in Psychiatry Journals From 2008 to 2018.

Biol Psychiatry 2019 Oct 19;86(8):639-646. Epub 2019 Feb 19.

Center for Quantitative Health, Division of Clinical Research, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699930PMC
October 2019

Evidence of Low Adherence to Stimulant Medication Among Children and Youths With ADHD: An Electronic Health Records Study.

Psychiatr Serv 2019 Oct 27;70(10):874-880. Epub 2019 Jun 27.

Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston (J. Biederman, Fried, DiSalvo, Storch, Pulli, Woodworth, I. Biederman); Department of Psychiatry, Harvard Medical School, Boston (J. Biederman, Fried, Perlis); Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York, and K.G. Jebsen Centre for Psychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway (Faraone); Center for Quantitative Health, Massachusetts General Hospital, Boston (Perlis).

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http://dx.doi.org/10.1176/appi.ps.201800515DOI Listing
October 2019

Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA).

Mol Cell Neurosci 2019 Sep 14;99:103386. Epub 2019 Jun 14.

Chemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, United States of America; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States of America; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2019.06.006DOI Listing
September 2019

Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett Syndrome.

Hum Mol Genet 2019 Sep 13. Epub 2019 Sep 13.

Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114 USA.

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http://dx.doi.org/10.1093/hmg/ddz208DOI Listing
September 2019

Characterizing DSM-5 and ICD-11 personality disorder features in psychiatric inpatients at scale using electronic health records.

Psychol Med 2019 Sep 23:1-9. Epub 2019 Sep 23.

Center for Quantitative Health, Division of Clinical Research and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1017/S0033291719002320DOI Listing
September 2019

Can electronic health records revive central nervous system clinical trials?

Mol Psychiatry 2019 08;24(8):1096-1098

Center for Quantitative Health, Massachusetts General Hospital, Boston, MA, 02114, USA.

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http://www.nature.com/articles/s41380-018-0278-z
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http://dx.doi.org/10.1038/s41380-018-0278-zDOI Listing
August 2019

Attention-Deficit/Hyperactivity Disorder, Hypomania, and Bipolar Disorder in Youth.

JAMA Psychiatry 2019 Aug 14. Epub 2019 Aug 14.

Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamapsychiatry.2019.1926DOI Listing
August 2019

Translating Discoveries in Attention-Deficit/Hyperactivity Disorder Genomics to an Outpatient Child and Adolescent Psychiatric Cohort.

J Am Acad Child Adolesc Psychiatry 2019 Aug 14. Epub 2019 Aug 14.

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA; Massachusetts General Hospital, Boston, MA, and Harvard Medical School, Massachusetts General Hospital, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.08.004DOI Listing
August 2019

Prevalence of Financial Considerations Documented in Primary Care Encounters as Identified by Natural Language Processing Methods.

JAMA Netw Open 2019 Aug 2;2(8):e1910399. Epub 2019 Aug 2.

Mossavar-Rahmani Center for Business and Government, Harvard Kennedy School, Cambridge, Massachusetts.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.10399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724154PMC
August 2019

Genome-wide association study identifies 30 loci associated with bipolar disorder.

Authors:
Eli A Stahl Gerome Breen Andreas J Forstner Andrew McQuillin Stephan Ripke Vassily Trubetskoy Manuel Mattheisen Yunpeng Wang Jonathan R I Coleman Héléna A Gaspar Christiaan A de Leeuw Stacy Steinberg Jennifer M Whitehead Pavlides Maciej Trzaskowski Enda M Byrne Tune H Pers Peter A Holmans Alexander L Richards Liam Abbott Esben Agerbo Huda Akil Diego Albani Ney Alliey-Rodriguez Thomas D Als Adebayo Anjorin Verneri Antilla Swapnil Awasthi Judith A Badner Marie Bækvad-Hansen Jack D Barchas Nicholas Bass Michael Bauer Richard Belliveau Sarah E Bergen Carsten Bøcker Pedersen Erlend Bøen Marco P Boks James Boocock Monika Budde William Bunney Margit Burmeister Jonas Bybjerg-Grauholm William Byerley Miquel Casas Felecia Cerrato Pablo Cervantes Kimberly Chambert Alexander W Charney Danfeng Chen Claire Churchhouse Toni-Kim Clarke William Coryell David W Craig Cristiana Cruceanu David Curtis Piotr M Czerski Anders M Dale Simone de Jong Franziska Degenhardt Jurgen Del-Favero J Raymond DePaulo Srdjan Djurovic Amanda L Dobbyn Ashley Dumont Torbjørn Elvsåshagen Valentina Escott-Price Chun Chieh Fan Sascha B Fischer Matthew Flickinger Tatiana M Foroud Liz Forty Josef Frank Christine Fraser Nelson B Freimer Louise Frisén Katrin Gade Diane Gage Julie Garnham Claudia Giambartolomei Marianne Giørtz Pedersen Jaqueline Goldstein Scott D Gordon Katherine Gordon-Smith Elaine K Green Melissa J Green Tiffany A Greenwood Jakob Grove Weihua Guan José Guzman-Parra Marian L Hamshere Martin Hautzinger Urs Heilbronner Stefan Herms Maria Hipolito Per Hoffmann Dominic Holland Laura Huckins Stéphane Jamain Jessica S Johnson Anders Juréus Radhika Kandaswamy Robert Karlsson James L Kennedy Sarah Kittel-Schneider James A Knowles Manolis Kogevinas Anna C Koller Ralph Kupka Catharina Lavebratt Jacob Lawrence William B Lawson Markus Leber Phil H Lee Shawn E Levy Jun Z Li Chunyu Liu Susanne Lucae Anna Maaser Donald J MacIntyre Pamela B Mahon Wolfgang Maier Lina Martinsson Steve McCarroll Peter McGuffin Melvin G McInnis James D McKay Helena Medeiros Sarah E Medland Fan Meng Lili Milani Grant W Montgomery Derek W Morris Thomas W Mühleisen Niamh Mullins Hoang Nguyen Caroline M Nievergelt Annelie Nordin Adolfsson Evaristus A Nwulia Claire O'Donovan Loes M Olde Loohuis Anil P S Ori Lilijana Oruc Urban Ösby Roy H Perlis Amy Perry Andrea Pfennig James B Potash Shaun M Purcell Eline J Regeer Andreas Reif Céline S Reinbold John P Rice Fabio Rivas Margarita Rivera Panos Roussos Douglas M Ruderfer Euijung Ryu Cristina Sánchez-Mora Alan F Schatzberg William A Scheftner Nicholas J Schork Cynthia Shannon Weickert Tatyana Shehktman Paul D Shilling Engilbert Sigurdsson Claire Slaney Olav B Smeland Janet L Sobell Christine Søholm Hansen Anne T Spijker David St Clair Michael Steffens John S Strauss Fabian Streit Jana Strohmaier Szabolcs Szelinger Robert C Thompson Thorgeir E Thorgeirsson Jens Treutlein Helmut Vedder Weiqing Wang Stanley J Watson Thomas W Weickert Stephanie H Witt Simon Xi Wei Xu Allan H Young Peter Zandi Peng Zhang Sebastian Zöllner Rolf Adolfsson Ingrid Agartz Martin Alda Lena Backlund Bernhard T Baune Frank Bellivier Wade H Berrettini Joanna M Biernacka Douglas H R Blackwood Michael Boehnke Anders D Børglum Aiden Corvin Nicholas Craddock Mark J Daly Udo Dannlowski Tõnu Esko Bruno Etain Mark Frye Janice M Fullerton Elliot S Gershon Michael Gill Fernando Goes Maria Grigoroiu-Serbanescu Joanna Hauser David M Hougaard Christina M Hultman Ian Jones Lisa A Jones René S Kahn George Kirov Mikael Landén Marion Leboyer Cathryn M Lewis Qingqin S Li Jolanta Lissowska Nicholas G Martin Fermin Mayoral Susan L McElroy Andrew M McIntosh Francis J McMahon Ingrid Melle Andres Metspalu Philip B Mitchell Gunnar Morken Ole Mors Preben Bo Mortensen Bertram Müller-Myhsok Richard M Myers Benjamin M Neale Vishwajit Nimgaonkar Merete Nordentoft Markus M Nöthen Michael C O'Donovan Ketil J Oedegaard Michael J Owen Sara A Paciga Carlos Pato Michele T Pato Danielle Posthuma Josep Antoni Ramos-Quiroga Marta Ribasés Marcella Rietschel Guy A Rouleau Martin Schalling Peter R Schofield Thomas G Schulze Alessandro Serretti Jordan W Smoller Hreinn Stefansson Kari Stefansson Eystein Stordal Patrick F Sullivan Gustavo Turecki Arne E Vaaler Eduard Vieta John B Vincent Thomas Werge John I Nurnberger Naomi R Wray Arianna Di Florio Howard J Edenberg Sven Cichon Roel A Ophoff Laura J Scott Ole A Andreassen John Kelsoe Pamela Sklar

Nat Genet 2019 05 1;51(5):793-803. Epub 2019 May 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://www.nature.com/articles/s41588-019-0397-8
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http://dx.doi.org/10.1038/s41588-019-0397-8DOI Listing
May 2019

Trends in Proportion of Women as Authors of Medical Journal Articles, 2008-2018.

JAMA Intern Med 2019 May 28. Epub 2019 May 28.

Center for Quantitative Health, Division of Clinical Research, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamainternmed.2019.0907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547141PMC
May 2019

Association between child psychiatric emergency room outcomes and dimensions of psychopathology.

Gen Hosp Psychiatry 2019 Jul - Aug;59:1-6. Epub 2019 Apr 16.

Center for Quantitative Health, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02114, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01638343183043
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http://dx.doi.org/10.1016/j.genhosppsych.2019.04.009DOI Listing
April 2019

Conflict of interest and citation impact among dermatology guideline authors.

J Am Acad Dermatol 2019 03 24;80(3):813-815. Epub 2018 Oct 24.

Temple University Medical School, Keystone Dermatology Partners, King of Prussia, Pennsylvania. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183279
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http://dx.doi.org/10.1016/j.jaad.2018.10.028DOI Listing
March 2019

Risk tolerance measured by probability discounting among individuals with primary mood and psychotic disorders.

Neuropsychology 2019 Mar 28;33(3):417-424. Epub 2019 Jan 28.

Massachusetts General Hospital and Harvard Medical School.

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http://dx.doi.org/10.1037/neu0000506DOI Listing
March 2019

Psychosis with Methylphenidate or Amphetamine in Patients with ADHD.

N Engl J Med 2019 03;380(12):1128-1138

From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston (L.V.M., S.S.); the Division of Psychotic Disorders, McLean Hospital, Belmont, MA (L.V.M., D.O.); and the Department of Health Care Policy (J.H.), Harvard Medical School (L.V.M., D.O., J.H., R.H.P., S.S.), the Mongan Institute Health Policy Center (J.H.) and the Center for Quantitative Health, Department of Psychiatry (R.H.P.), Massachusetts General Hospital, and Partners Research Computing, Partners HealthCare System (V.M.C.) - all in Boston.

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http://dx.doi.org/10.1056/NEJMoa1813751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543546PMC
March 2019

Genomewide Association Study of Fracture Nonunion Using Electronic Health Records.

JBMR Plus 2019 Jan 20;3(1):23-28. Epub 2018 Jun 20.

Center for Quantitative Health Massachusetts General Hospital and Harvard Medical School Boston MA USA.

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http://doi.wiley.com/10.1002/jbm4.10063
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http://dx.doi.org/10.1002/jbm4.10063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339539PMC
January 2019

Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8.

Transl Psychiatry 2019 01 29;9(1):45. Epub 2019 Jan 29.

Center for Quantitative Health, Division of Clinical Research and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41398-019-0386-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351652PMC
January 2019

Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls.

Transl Psychiatry 2019 01 29;9(1):37. Epub 2019 Jan 29.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41398-019-0378-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351610PMC
January 2019

Advancing Health and Health Care Using Machine Learning: JAMA Network Open Call for Papers.

JAMA Netw Open 2018 12 7;1(8):e187176. Epub 2018 Dec 7.

Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.7176DOI Listing
December 2018

Assessment of Time-Series Machine Learning Methods for Forecasting Hospital Discharge Volume.

JAMA Netw Open 2018 11 2;1(7):e184087. Epub 2018 Nov 2.

Center for Quantitative Health, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.4087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324591PMC
November 2018

Prevalence and Nature of Financial Considerations Documented in Narrative Clinical Records in Intensive Care Units.

JAMA Netw Open 2018 11 2;1(7):e184178. Epub 2018 Nov 2.

Center for Quantitative Health, Division of Clinical Research and Center for Genomic Medicine, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.4178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324587PMC
November 2018

Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study.

Depress Anxiety 2018 10 7;35(10):946-952. Epub 2018 May 7.

Graduate School of Business, Stanford University, Stanford, CA, USA.

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http://doi.wiley.com/10.1002/da.22742
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http://dx.doi.org/10.1002/da.22742DOI Listing
October 2018

Cohort study of the relationship between individual psychotherapy and pregnancy outcomes.

J Affect Disord 2018 10 6;239:253-257. Epub 2018 Jul 6.

Center for Experimental Drugs and Diagnostics, Center for Human Genetic Research and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, Unites States. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2018.05.083DOI Listing
October 2018

Temporal Trends and Characteristics of Reportable Health Data Breaches, 2010-2017.

JAMA 2018 09;320(12):1282-1284

Center for Quantitative Health, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jama.2018.9222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233611PMC
September 2018

Genome-wide association identifies a novel locus for delirium risk.

Neurobiol Aging 2018 08 10;68:160.e9-160.e14. Epub 2018 Mar 10.

Center for Quantitative Health, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993590PMC
August 2018

High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health Records.

Biol Psychiatry 2018 06 26;83(12):997-1004. Epub 2018 Feb 26.

Center for Quantitative Health and Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.biopsych.2018.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972065PMC
June 2018

Genome-wide Association Study of Dimensional Psychopathology Using Electronic Health Records.

Biol Psychiatry 2018 06 26;83(12):1005-1011. Epub 2018 Feb 26.

Center for Quantitative Health and Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.biopsych.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972060PMC
June 2018

Anxiety About Antidepressants.

Authors:
Roy H Perlis

Am J Psychiatry 2018 06 25;175(6):500-501. Epub 2018 Apr 25.

From the Department of Psychiatry, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1176/appi.ajp.2018.18040399DOI Listing
June 2018

No Association Between Antidepressant Efficacy and rs28365143 in Corticotropin-Releasing Hormone Binding Protein in a Large Meta-Analysis.

Am J Psychiatry 2018 06;175(6):575-576

From the Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; the Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London; the Department of Psychiatry, Center for Experimental Drugs and Diagnostics, Massachusetts General Hospital, Boston; and the Department of Psychiatry, Dalhousie University, Halifax, N.S., Canada.

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http://dx.doi.org/10.1176/appi.ajp.2018.18010070DOI Listing
June 2018

Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study.

Depress Anxiety 2018 10 7;35(10):946-952. Epub 2018 May 7.

Graduate School of Business, Stanford University, Stanford, CA, USA.

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http://doi.wiley.com/10.1002/da.22742
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http://dx.doi.org/10.1002/da.22742DOI Listing
October 2018

Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders.

NPJ Schizophr 2018 May 28;4(1). Epub 2018 May 28.

Department of Psychiatry, Center for Quantitative Health, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41537-018-0050-z
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http://dx.doi.org/10.1038/s41537-018-0050-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972152PMC
May 2018

Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder.

Authors:
Céline S Reinbold Andreas J Forstner Julian Hecker Janice M Fullerton Per Hoffmann Liping Hou Urs Heilbronner Franziska Degenhardt Mazda Adli Kazufumi Akiyama Nirmala Akula Raffaella Ardau Bárbara Arias Lena Backlund Antonio Benabarre Susanne Bengesser Abesh K Bhattacharjee Joanna M Biernacka Armin Birner Cynthia Marie-Claire Pablo Cervantes Guo-Bo Chen Hsi-Chung Chen Caterina Chillotti Scott R Clark Francesc Colom David A Cousins Cristiana Cruceanu Piotr M Czerski Alexandre Dayer Bruno Étain Peter Falkai Louise Frisén Sébastien Gard Julie S Garnham Fernando S Goes Paul Grof Oliver Gruber Ryota Hashimoto Joanna Hauser Stefan Herms Stéphane Jamain Esther Jiménez Jean-Pierre Kahn Layla Kassem Sarah Kittel-Schneider Sebastian Kliwicki Barbara König Ichiro Kusumi Nina Lackner Gonzalo Laje Mikael Landén Catharina Lavebratt Marion Leboyer Susan G Leckband Carlos A López Jaramillo Glenda MacQueen Mirko Manchia Lina Martinsson Manuel Mattheisen Michael J McCarthy Susan L McElroy Marina Mitjans Francis M Mondimore Palmiero Monteleone Caroline M Nievergelt Urban Ösby Norio Ozaki Roy H Perlis Andrea Pfennig Daniela Reich-Erkelenz Guy A Rouleau Peter R Schofield K Oliver Schubert Barbara W Schweizer Florian Seemüller Giovanni Severino Tatyana Shekhtman Paul D Shilling Kazutaka Shimoda Christian Simhandl Claire M Slaney Jordan W Smoller Alessio Squassina Thomas J Stamm Pavla Stopkova Sarah K Tighe Alfonso Tortorella Gustavo Turecki Julia Volkert Stephanie H Witt Adam J Wright L Trevor Young Peter P Zandi James B Potash J Raymond DePaulo Michael Bauer Eva Reininghaus Tomáš Novák Jean-Michel Aubry Mario Maj Bernhard T Baune Philip B Mitchell Eduard Vieta Mark A Frye Janusz K Rybakowski Po-Hsiu Kuo Tadafumi Kato Maria Grigoroiu-Serbanescu Andreas Reif Maria Del Zompo Frank Bellivier Martin Schalling Naomi R Wray John R Kelsoe Martin Alda Francis J McMahon Thomas G Schulze Marcella Rietschel Markus M Nöthen Sven Cichon

Front Psychiatry 2018 31;9:207. Epub 2018 May 31.

Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.3389/fpsyt.2018.00207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991073PMC
May 2018

Enhancing Delirium Case Definitions in Electronic Health Records Using Clinical Free Text.

Psychosomatics 2017 Mar - Apr;58(2):113-120. Epub 2016 Oct 27.

Division of Clinical Research, Center for Quantitative Health, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1016/j.psym.2016.10.007DOI Listing
November 2017

Efficient genome-wide association in biobanks using topic modeling identifies multiple novel disease loci.

Mol Med 2017 11 31;23:285-294. Epub 2017 Aug 31.

Center for Quantitative Health, Division of Clinical Research and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114.

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http://www.molmed.org/content/pdfstore/17_100_McCoy.pdf
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http://dx.doi.org/10.2119/molmed.2017.00100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681697PMC
November 2017

Validation of Polygenic Scores for QT Interval in Clinical Populations.

Circ Cardiovasc Genet 2017 Oct;10(5)

From the University of Colorado School of Medicine, Aurora (M.A.R.); Massachusetts General Hospital, Boston (S.A.L., G.K., V.M.C., P.H., P.T.E., R.H.P., C.N.-C.); and Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, MA (H.L.).

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679734PMC
October 2017

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.

Authors:
Nese Direk Stephanie Williams Jennifer A Smith Stephan Ripke Tracy Air Azmeraw T Amare Najaf Amin Bernhard T Baune David A Bennett Douglas H R Blackwood Dorret Boomsma Gerome Breen Henriette N Buttenschøn Enda M Byrne Anders D Børglum Enrique Castelao Sven Cichon Toni-Kim Clarke Marilyn C Cornelis Udo Dannlowski Philip L De Jager Ayse Demirkan Enrico Domenici Cornelia M van Duijn Erin C Dunn Johan G Eriksson Tonu Esko Jessica D Faul Luigi Ferrucci Myriam Fornage Eco de Geus Michael Gill Scott D Gordon Hans Jörgen Grabe Gerard van Grootheest Steven P Hamilton Catharina A Hartman Andrew C Heath Karin Hek Albert Hofman Georg Homuth Carsten Horn Jouke Jan Hottenga Sharon L R Kardia Stefan Kloiber Karestan Koenen Zoltán Kutalik Karl-Heinz Ladwig Jari Lahti Douglas F Levinson Cathryn M Lewis Glyn Lewis Qingqin S Li David J Llewellyn Susanne Lucae Kathryn L Lunetta Donald J MacIntyre Pamela Madden Nicholas G Martin Andrew M McIntosh Andres Metspalu Yuri Milaneschi Grant W Montgomery Ole Mors Thomas H Mosley Joanne M Murabito Bertram Müller-Myhsok Markus M Nöthen Dale R Nyholt Michael C O'Donovan Brenda W Penninx Michele L Pergadia Roy Perlis James B Potash Martin Preisig Shaun M Purcell Jorge A Quiroz Katri Räikkönen John P Rice Marcella Rietschel Margarita Rivera Thomas G Schulze Jianxin Shi Stanley Shyn Grant C Sinnamon Johannes H Smit Jordan W Smoller Harold Snieder Toshiko Tanaka Katherine E Tansey Alexander Teumer Rudolf Uher Daniel Umbricht Sandra Van der Auwera Erin B Ware David R Weir Myrna M Weissman Gonneke Willemsen Jingyun Yang Wei Zhao Henning Tiemeier Patrick F Sullivan

Biol Psychiatry 2017 09 8;82(5):322-329. Epub 2016 Dec 8.

Department of Psychiatry, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Psychiatric Genomics, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.

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http://dx.doi.org/10.1016/j.biopsych.2016.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462867PMC
September 2017

Underreporting of Delirium in Statewide Claims Data: Implications for Clinical Care and Predictive Modeling.

Psychosomatics 2016 Sep-Oct;57(5):480-8. Epub 2016 Jun 4.

Department of Psychiatry, Center for Human Genetic Research, Center for Experimental Drugs and Diagnostics, Massachusetts General Hospital, Boston, MA. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S003331821630056
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http://dx.doi.org/10.1016/j.psym.2016.06.001DOI Listing
August 2017

Physician Payments from Industry Are Associated with Greater Medicare Part D Prescribing Costs.

PLoS One 2016 16;11(5):e0155474. Epub 2016 May 16.

Department of Dermatology, Temple University Health System, Philadelphia, Pennsylvania, United States of America.

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July 2017

Frequency of non-right-handedness in bipolar disorder and schizophrenia.

Psychiatry Res 2017 07 5;253:267-269. Epub 2017 Apr 5.

Program for Neuropsychiatric Research, McLean Hospital, 115 Mill Street, Belmont, MA, USA; Harvard Medical School, Department of Psychiatry, 25 Shattuck Street, Boston, MA, USA; Psychotic Disorders Division, McLean Hospital, 115 Mill Street, Belmont, MA, USA.

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http://dx.doi.org/10.1016/j.psychres.2017.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510165PMC
July 2017

Improving discrimination in antepartum depression screening using the Edinburgh Postnatal Depression Scale.

J Affect Disord 2017 May 24;214:1-7. Epub 2017 Feb 24.

Center for Experimental Drugs and Diagnostics, Dept. of Psychiatry, Massachusetts General Hospital, Boston, MA, United States; Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.jad.2017.01.042DOI Listing
May 2017

Characterizing and predicting rates of delirium across general hospital settings.

Gen Hosp Psychiatry 2017 05 26;46:1-6. Epub 2017 Jan 26.

Center for Quantitative Health, Division of Clinical Research, Massachusetts General Hospital, Simches Research Building 6th Floor, 185 Cambridge St, Boston, MA 20114, United States.

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May 2017

Tissue Type-Specific Bioenergetic Abnormalities in Adults with Major Depression.

Neuropsychopharmacology 2017 Mar 2;42(4):876-885. Epub 2016 Sep 2.

Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/npp.2016.180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312061PMC
March 2017

Abandoning personalization to get to precision in the pharmacotherapy of depression.

Authors:
Roy H Perlis

World Psychiatry 2016 Oct;15(3):228-235

Center for Experimental Drugs and Diagnostics, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/wps.20345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032508PMC
October 2016

Validation of a risk stratification tool for fall-related injury in a state-wide cohort.

BMJ Open 2017 02 6;7(2):e012189. Epub 2017 Feb 6.

Department of Psychiatry, Center for Experimental Drugs and Diagnostics, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/bmjopen-2016-012189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293982PMC
February 2017

Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment.

Soc Cogn Affect Neurosci 2016 12 6;11(12):1872-1881. Epub 2016 Aug 6.

Department of Psychology, Harvard University, 02138, Cambridge, MA, USA.

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http://dx.doi.org/10.1093/scan/nsw103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141955PMC
December 2016

Abandoning personalization to get to precision in the pharmacotherapy of depression.

Authors:
Roy H Perlis

World Psychiatry 2016 Oct;15(3):228-235

Center for Experimental Drugs and Diagnostics, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/wps.20345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032508PMC
October 2016

Abandoning personalization to get to precision in the pharmacotherapy of depression.

Authors:
Roy H Perlis

World Psychiatry 2016 Oct;15(3):228-235

Center for Experimental Drugs and Diagnostics, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/wps.20345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032508PMC
October 2016

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.

Nat Genet 2016 09 1;48(9):1031-6. Epub 2016 Aug 1.

Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Pfizer, Inc., Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706769PMC
September 2016

Autism and antidepressant use in pregnancy.

Authors:
Roy H Perlis

J Pediatr 2016 07;174:278

Harvard University, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jpeds.2016.04.072DOI Listing
July 2016

Pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy.

Pediatr Allergy Immunol 2016 06 26;27(4):413-8. Epub 2016 Feb 26.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/pai.12532DOI Listing
June 2016

Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models.

Mol Cell Neurosci 2016 06 28;73:104-15. Epub 2016 Jan 28.

Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, United States; Center for Experimental Drugs & Diagnostics, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, United States; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, United States.

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http://dx.doi.org/10.1016/j.mcn.2016.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292010PMC
June 2016

Sentiment Measured in Hospital Discharge Notes Is Associated with Readmission and Mortality Risk: An Electronic Health Record Study.

PLoS One 2015 24;10(8):e0136341. Epub 2015 Aug 24.

Center for Experimental Drugs and Diagnostics, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, 6th Floor, Boston, MA 02114, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136341PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547711PMC
May 2016

Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth.

Obstet Gynecol 2016 05;127(5):926-33

Department of Obstetrics and Gynecology, Massachusetts General Hospital and Brigham and Women's Hospital, the Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, and the Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, and the Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/AOG.0000000000001397DOI Listing
May 2016

A Systematic Evaluation of the QTc Interval and Antidepressants in Youth: An Electronic Health Record Study.

J Dev Behav Pediatr 2015 Jul-Aug;36(6):434-9

*Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA; †Partners Research Computing, Partners HealthCare System, Boston, MA; ‡Department of Pediatrics, Massachusetts General Hospital, Boston, MA; §Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA; ‖Center for Experimental Drugs and Diagnostics, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/DBP.0000000000000188DOI Listing
April 2016

Stratifying Risk for Renal Insufficiency Among Lithium-Treated Patients: An Electronic Health Record Study.

Neuropsychopharmacology 2016 Mar 21;41(4):1138-43. Epub 2015 Aug 21.

Center for Experimental Drugs and Diagnostics, Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

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http://www.nature.com/articles/npp2015254
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http://dx.doi.org/10.1038/npp.2015.254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748438PMC
March 2016

Antidepressant nonadherence in routine clinical settings determined from discarded blood samples.

J Clin Psychiatry 2016 Mar;77(3):359-62

Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.4088/JCP.14m09612DOI Listing
March 2016

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.

Authors:
Liping Hou Urs Heilbronner Franziska Degenhardt Mazda Adli Kazufumi Akiyama Nirmala Akula Raffaella Ardau Bárbara Arias Lena Backlund Claudio E M Banzato Antoni Benabarre Susanne Bengesser Abesh Kumar Bhattacharjee Joanna M Biernacka Armin Birner Clara Brichant-Petitjean Elise T Bui Pablo Cervantes Guo-Bo Chen Hsi-Chung Chen Caterina Chillotti Sven Cichon Scott R Clark Francesc Colom David A Cousins Cristiana Cruceanu Piotr M Czerski Clarissa R Dantas Alexandre Dayer Bruno Étain Peter Falkai Andreas J Forstner Louise Frisén Janice M Fullerton Sébastien Gard Julie S Garnham Fernando S Goes Paul Grof Oliver Gruber Ryota Hashimoto Joanna Hauser Stefan Herms Per Hoffmann Andrea Hofmann Stephane Jamain Esther Jiménez Jean-Pierre Kahn Layla Kassem Sarah Kittel-Schneider Sebastian Kliwicki Barbara König Ichiro Kusumi Nina Lackner Gonzalo Laje Mikael Landén Catharina Lavebratt Marion Leboyer Susan G Leckband Carlos A López Jaramillo Glenda MacQueen Mirko Manchia Lina Martinsson Manuel Mattheisen Michael J McCarthy Susan L McElroy Marina Mitjans Francis M Mondimore Palmiero Monteleone Caroline M Nievergelt Markus M Nöthen Urban Ösby Norio Ozaki Roy H Perlis Andrea Pfennig Daniela Reich-Erkelenz Guy A Rouleau Peter R Schofield K Oliver Schubert Barbara W Schweizer Florian Seemüller Giovanni Severino Tatyana Shekhtman Paul D Shilling Kazutaka Shimoda Christian Simhandl Claire M Slaney Jordan W Smoller Alessio Squassina Thomas Stamm Pavla Stopkova Sarah K Tighe Alfonso Tortorella Gustavo Turecki Julia Volkert Stephanie Witt Adam Wright L Trevor Young Peter P Zandi James B Potash J Raymond DePaulo Michael Bauer Eva Z Reininghaus Tomas Novák Jean-Michel Aubry Mario Maj Bernhard T Baune Philip B Mitchell Eduard Vieta Mark A Frye Janusz K Rybakowski Po-Hsiu Kuo Tadafumi Kato Maria Grigoroiu-Serbanescu Andreas Reif Maria Del Zompo Frank Bellivier Martin Schalling Naomi R Wray John R Kelsoe Martin Alda Marcella Rietschel Francis J McMahon Thomas G Schulze

Lancet 2016 Mar 22;387(10023):1085-1093. Epub 2016 Jan 22.

Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA; Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)00143-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814312PMC
March 2016

Discriminating Between Bipolar Disorder and Major Depressive Disorder.

Psychiatr Clin North Am 2016 Mar;39(1):1-10

Department of Psychiatry, Center for Experimental Drugs and Diagnostics, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.psc.2015.10.001DOI Listing
March 2016

Getting Past Proof of Concept For New Treatments.

Authors:
Roy H Perlis

Am J Psychiatry 2015 Oct;172(10):937-8

From the Center for Experimental Drugs and Diagnostics, the Department of Psychiatry, and the Center for Human Genetic Research, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1176/appi.ajp.2015.15070906DOI Listing
October 2015

A Naturalistic Study of the Effectiveness of Pharmacogenetic Testing to Guide Treatment in Psychiatric Patients With Mood and Anxiety Disorders.

Prim Care Companion CNS Disord 2015 16;17(2). Epub 2015 Apr 16.

Genomind, Inc, King of Prussia, Pennsylvania (Drs Brennan, Lombard, and Scott and Ms Gardner); Department of Psychiatry, Massachusetts General Hospital, Boston (Drs Perlis and Fava); and North Carolina Elderly Psychiatric Services, Raleigh (Dr Harris).

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http://dx.doi.org/10.4088/PCC.14m01717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560190PMC
October 2015

Lifetime prevalence of anxiety disorders in people with bipolar disorder: a systematic review and meta-analysis.

Lancet Psychiatry 2015 Aug 23;2(8):710-717. Epub 2015 Jun 23.

Nova Scotia Health Authority, Halifax, NS, Canada; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.

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http://www.thelancet.com/pdfs/journals/lanpsy/PIIS2215-0366(
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http://linkinghub.elsevier.com/retrieve/pii/S221503661500112
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http://dx.doi.org/10.1016/S2215-0366(15)00112-1DOI Listing
August 2015

Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder.

Bipolar Disord 2015 Jun 26;17(4):403-8. Epub 2015 Feb 26.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/bdi.12289DOI Listing
June 2015

Monotherapy Antidepressant Treatment is Not Associated With Mania in Bipolar I Disorder.

Am J Psychiatry 2015 Jun;172(6):586

From the Department of Psychiatry, VA Palo Alto Health Care System, Palo Alto, Calif. and the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston; and the Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1176/appi.ajp.2015.14111443DOI Listing
June 2015

Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist.

Molecules 2015 May 26;20(6):9550-9. Epub 2015 May 26.

Department of Radiology, Harvard Medical School, Division of Nuclear Medicine and Molecular Imaging and Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.3390/molecules20069550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870226PMC
May 2015

A clinical perspective on the relevance of research domain criteria in electronic health records.

Am J Psychiatry 2015 Apr;172(4):316-20

From the Center for Experimental Drugs and Diagnostics, the Department of Psychiatry, and the Center for Human Genetic Research, Massachusetts General Hospital, Boston; and the Department of Medicine, Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1176/appi.ajp.2014.14091177DOI Listing
April 2015

Validation of electronic health record phenotyping of bipolar disorder cases and controls.

Am J Psychiatry 2015 Apr 12;172(4):363-72. Epub 2014 Dec 12.

From Research Information Systems and Computing, Partners HealthCare System, Boston; the Laboratory of Computer Science, the Department of Neurology, the Department of Psychiatry, the Center for Anxiety and Traumatic Stress Disorders, the Center for Experimental Drugs and Diagnostics, and the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston; the Center for Biomedical Informatics, Harvard Medical School, Boston; the Department of Biostatistics, Harvard School of Public Health, Boston; the Psychotic Disorders Division, McLean Hospital, Belmont, Mass.; the Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland; and the Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York.

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http://dx.doi.org/10.1176/appi.ajp.2014.14030423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441333PMC
April 2015

Association of a brain methylation site with clinical outcomes in depression does not replicate across populations.

Am J Psychiatry 2015 Apr;172(4):395-7

From the Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada; King's College London, Institute of Psychiatry, Psychology & Neuroscience, MRC Social, Genetic and Developmental Psychiatry Centre, London; Broad Institute, Cambridge, Mass.; Massachusetts General Hospital, Boston; Institute of Translational Medicine, University of Liverpool, United Kingdom; Max Planck Institute of Psychiatry, Munich, Germany; and Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

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http://dx.doi.org/10.1176/appi.ajp.2015.14101348DOI Listing
April 2015

A tool to utilize adverse effect profiles to identify brain-active medications for repurposing.

Int J Neuropsychopharmacol 2015 Feb 11;18(3). Epub 2015 Feb 11.

Center for Experimental Drugs and Diagnostics, Massachusetts General Hospital Department of Psychiatry and Harvard Medical School, Boston, MA (Drs McCoy and Perlis).

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http://dx.doi.org/10.1093/ijnp/pyu078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360243PMC
February 2015

From bench to bedlam.

Authors:
Roy H Perlis

Am J Psychiatry 2014 Dec;171(12):1233-5

From the Center for Experimental Drugs and Diagnostics, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1176/appi.ajp.2014.14091198DOI Listing
December 2014

Use of large data sets and the future of personalized treatment.

Authors:
Roy H Perlis

Depress Anxiety 2014 Nov;31(11):916-9

Center for Experimental Drugs and Diagnostics, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Simches Research Building 6th Floor, 185 Cambridge St, Boston, MA, 20114.

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http://doi.wiley.com/10.1002/da.22321
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http://dx.doi.org/10.1002/da.22321DOI Listing
November 2014

Stratification of risk for hospital admissions for injury related to fall: cohort study.

BMJ 2014 Oct 24;349:g5863. Epub 2014 Oct 24.

Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building 6th Floor, 185 Cambridge St, Boston, MA 20114, USA Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Simches Research Building 6th Floor, 185 Cambridge St, Boston, MA 02114, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208628PMC
http://dx.doi.org/10.1136/bmj.g5863DOI Listing
October 2014

Rare copy number variation in treatment-resistant major depressive disorder.

Biol Psychiatry 2014 Oct 19;76(7):536-41. Epub 2014 Jan 19.

Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts; Partners HealthCare System, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2013.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104153PMC
October 2014

Autism spectrum disorder severity reflects the average contribution of de novo and familial influences.

Proc Natl Acad Sci U S A 2014 Oct 6;111(42):15161-5. Epub 2014 Oct 6.

Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142;

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http://dx.doi.org/10.1073/pnas.1409204111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210299PMC
October 2014

Bipolar polygenic loading and bipolar spectrum features in major depressive disorder.

Bipolar Disord 2014 Sep 12;16(6):608-16. Epub 2014 Apr 12.

Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Boston, MA, USA; Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Boston, MA, USA.

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http://dx.doi.org/10.1111/bdi.12201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427243PMC
September 2014

An electronic health records study of long-term weight gain following antidepressant use.

JAMA Psychiatry 2014 Aug;71(8):889-96

Center for Experimental Drugs and Diagnostics, Department of Psychiatry, Massachusetts General Hospital, Boston2Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jamapsychiatry.2014.414DOI Listing
August 2014

Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV.

Depress Anxiety 2014 Jun 22;31(6):459-71. Epub 2013 Nov 22.

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada; Institute of Psychiatry, King's College London, London, UK.

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http://dx.doi.org/10.1002/da.22217DOI Listing
June 2014

Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association.

Bipolar Disord 2014 Mar 27;16(2):199-203. Epub 2013 Dec 27.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.

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http://dx.doi.org/10.1111/bdi.12143DOI Listing
March 2014

Pharmacogenomic testing and personalized treatment of depression.

Authors:
Roy H Perlis

Clin Chem 2014 Jan 26;60(1):53-9. Epub 2013 Nov 26.

Center for Experimental Drugs and Diagnostics, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1373/clinchem.2013.204446DOI Listing
January 2014