Rou-Shayn Chen

Rou-Shayn Chen

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Rou-Shayn Chen

Publications by authors named "Rou-Shayn Chen"

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Nonmotor symptoms of 820 Taiwanese patients with Parkinson's disease: an exploratory-comparative study.

J Neurol 2020 Feb 5. Epub 2020 Feb 5.

Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

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http://dx.doi.org/10.1007/s00415-020-09708-4DOI Listing
February 2020

Generation of induced pluripotent stem cells from a young-onset Parkinson's disease patient carrying the compound heterozygous PLA2G6 p.D331Y/p.M358IfsX mutations.

Stem Cell Res 2019 10 27;40:101552. Epub 2019 Aug 27.

College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2019.101552DOI Listing
October 2019

Analysis and Discrimination of Surface Electromyographic Features for Parkinson's Disease during Elbow Flexion Movements.

J Mot Behav 2019 Sep 20:1-9. Epub 2019 Sep 20.

Neuroscience Research Center and Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine , Taoyuan , Taiwan .

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http://dx.doi.org/10.1080/00222895.2019.1666081DOI Listing
September 2019

Inter-cortical modulation from premotor to motor plasticity.

J Physiol 2018 09 5;596(17):4207-4217. Epub 2018 Jul 5.

Neuroscience Research Center, Healthy Ageing Research Center, and Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, 33305, Taiwan.

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http://dx.doi.org/10.1113/JP276276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117544PMC
September 2018

Effects of Wrist Weights on Kinematic and Myographic Movement Characteristics During a Reaching Task in Individuals With Parkinson Disease.

Arch Phys Med Rehabil 2018 07 22;99(7):1303-1310. Epub 2017 Dec 22.

Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Tao-yuan, Taiwan; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.apmr.2017.11.009DOI Listing
July 2018

Sleep disturbances in Taiwanese patients with Parkinson's disease.

Brain Behav 2017 10 21;7(10):e00806. Epub 2017 Sep 21.

Department of Neurology LinKou Chang Gung Memorial Hospital Taoyuan Taiwan.

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http://dx.doi.org/10.1002/brb3.806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651390PMC
October 2017

Abnormal Somatosensory Synchronization in Patients With Paroxysmal Kinesigenic Dyskinesia: A Magnetoencephalographic Study.

Clin EEG Neurosci 2017 Jul 11;48(4):288-294. Epub 2016 Aug 11.

1 Brain Research Center, National Yang-Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.1177/1550059416662575DOI Listing
July 2017

Abnormal blink reflex recovery cycle in manifesting and nonmanifesting carriers of the DYT1 gene mutation.

Neuroreport 2016 Sep;27(14):1046-9

aDepartment of Neurology, Movement Disorder Division bNeuroscience Research Center, Chang Gung Memorial Hospital at Linkou cSchool of Medicine, Chang Gung University dInstitute of Cognitive Neuroscience, College of Health Science and Technology, National Central University, Taoyuan, Taiwan eDepartment of Cell Sciences, St George's University of London fSobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1097/WNR.0000000000000653DOI Listing
September 2016

PDD-5S: A useful screening tool for Parkinson's disease dementia.

Parkinsonism Relat Disord 2016 Apr 3;25:85-90. Epub 2016 Feb 3.

Faculty of Medicine, National Yang-Ming University Schools of Medicine, Taipei, Taiwan; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2016.02.001DOI Listing
April 2016

Reduced functional connectivity of somatosensory network in writer's cramp patients.

Brain Behav 2016 03 26;6(3):e00433. Epub 2016 Jan 26.

Institute of Physiology National Yang-Ming University Taipei Taiwan; Laboratory of Neurophysiology Taipei Veterans General Hospital Taipei Taiwan; Institute of Brain Science National Yang-Ming University Taipei Taiwan; Department of Neurology Taipei Veterans General Hospital Taipei Taiwan.

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http://dx.doi.org/10.1002/brb3.433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726822PMC
March 2016

THE USE OF THE TRADITIONAL CHINESE VERSION OF THE UNIVERSITY OF PENNSYLVANIA SMELL IDENTIFICATION TEST AND THE SMELL THRESHOLD TEST FOR HEALTHY YOUNG AND OLD ADULTS IN TAIWAN.

Percept Mot Skills 2015 Jun 1;120(3):928-43. Epub 2015 Jun 1.

5 Department of Otolaryngology, Head, and Neck Surgery, Chang Gung Memorial Hospital.

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http://dx.doi.org/10.2466/27.03.pms.120v17x5DOI Listing
June 2015

Reduced motor cortex deactivation in individuals who suffer from writer's cramp.

PLoS One 2014 15;9(5):e97561. Epub 2014 May 15.

Institute of Physiology, National Yang-Ming University, Taipei, Taiwan; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Laboratory of Neurophysiology, Taipei Veterans General Hospital, Taipei, Taiwan; Integrated Brain Research Laboratory, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097561PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022529PMC
January 2015

Comparison of activities of daily living impairments in Parkinson's disease patients as defined by the Pill Questionnaire and assessments by neurologists.

J Neurol Neurosurg Psychiatry 2014 Sep 11;85(9):969-73. Epub 2013 Nov 11.

Faculty of Medicine, National Yang-Ming University Schools of Medicine, Taipei, Taiwan Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1136/jnnp-2013-306381DOI Listing
September 2014

Reduced cortical plasticity and GABAergic modulation in essential tremor.

Mov Disord 2014 Apr 21;29(4):501-7. Epub 2014 Jan 21.

Movement Disorder Section, Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

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http://dx.doi.org/10.1002/mds.25809DOI Listing
April 2014

Altered inhibitory modulation of somatosensory cortices in paroxysmal kinesigenic dyskinesia.

Mov Disord 2013 Oct 20;28(12):1728-31. Epub 2013 Sep 20.

Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; Laboratory of Neurophysiology, Taipei Veterans General Hospital, Taipei, Taiwan; Integrated Brain Research Laboratory, Taipei Veterans General Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1002/mds.25656DOI Listing
October 2013

Reduced postmovement cortical inhibition in patients with paroxysmal kinesigenic dyskinesia.

Neurology 2013 Jul 21;81(4):353-60. Epub 2013 Jun 21.

Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.1212/WNL.0b013e31829c5e61DOI Listing
July 2013

Screening for C9orf72 repeat expansions in parkinsonian syndromes.

Neurobiol Aging 2013 Apr 11;34(4):1311.e3-4. Epub 2012 Oct 11.

Section of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University, Taoyuan, Taiwan.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022748PMC
April 2013

Modulation of the disturbed motor network in dystonia by multisession suppression of premotor cortex.

PLoS One 2012 10;7(10):e47574. Epub 2012 Oct 10.

Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047574PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468590PMC
February 2013

Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: a replication study in a Taiwanese cohort.

Parkinsonism Relat Disord 2013 Feb 20;19(2):251-5. Epub 2012 Nov 20.

Human Molecular Genetics Laboratory, Department of Medical Research, Chang Gung Memorial Hospital and Chang Gung University, Kweishan, Taoyuan, Taiwan.

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http://dx.doi.org/10.1016/j.parkreldis.2012.10.019DOI Listing
February 2013

Familial paroxysmal nonkinesigenic dyskinesia: clinical and genetic analysis of a Taiwanese family.

J Neurol Sci 2012 Dec 8;323(1-2):80-4. Epub 2012 Sep 8.

Section of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center, Taiwan.

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http://dx.doi.org/10.1016/j.jns.2012.08.015DOI Listing
December 2012

PLA2G6 mutations in PARK14-linked young-onset parkinsonism and sporadic Parkinson's disease.

Am J Med Genet B Neuropsychiatr Genet 2012 Mar 27;159B(2):183-91. Epub 2011 Dec 27.

Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center, Taoyuan, Taiwan.

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http://dx.doi.org/10.1002/ajmg.b.32012DOI Listing
March 2012

Abnormal bidirectional plasticity-like effects in Parkinson's disease.

Brain 2011 Aug 8;134(Pt 8):2312-20. Epub 2011 Jul 8.

Department of Neurology, Chang Gung Memorial Hospital, Taipei 10507, Taiwan.

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http://dx.doi.org/10.1093/brain/awr158DOI Listing
August 2011

The theoretical model of theta burst form of repetitive transcranial magnetic stimulation.

Clin Neurophysiol 2011 May;122(5):1011-8

Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei 10507, Taiwan.

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http://dx.doi.org/10.1016/j.clinph.2010.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046904PMC
May 2011

Asymmetric involvement in sporadic creutzfeldt-jakob disease: clinical, brain imaging, and electroencephalographic studies.

Eur Neurol 2010 3;64(2):74-9. Epub 2010 Jul 3.

Department of Neurology, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1159/000315148DOI Listing
November 2010

Large SGCE deletion contributes to Taiwanese myoclonus-dystonia syndrome.

Parkinsonism Relat Disord 2010 Nov 30;16(9):585-9. Epub 2010 Aug 30.

Department of Neurology, Saint Paul's Hospital, Chang Gung University, Taoyuan, Taiwan.

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http://dx.doi.org/10.1016/j.parkreldis.2010.06.016DOI Listing
November 2010

Reversal of plasticity-like effects in the human motor cortex.

J Physiol 2010 Oct 26;588(Pt 19):3683-93. Epub 2010 Jul 26.

Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei 10507, Taiwan.

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http://dx.doi.org/10.1113/jphysiol.2010.191361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997480PMC
October 2010

Acute neuroborreliosis with involvement of the central nervous system.

J Neurol Sci 2010 Aug 18;295(1-2):10-5. Epub 2010 Jun 18.

Department of Neurology, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, 199, Tung Hwa North Road, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.jns.2010.05.004DOI Listing
August 2010

Microstructural changes in patients with progressive supranuclear palsy: a diffusion tensor imaging study.

J Magn Reson Imaging 2010 Jul;32(1):69-75

Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taiwan.

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http://dx.doi.org/10.1002/jmri.22229DOI Listing
July 2010

Neuronal intranuclear inclusion disease: two cases of dopa-responsive juvenile parkinsonism with drug-induced dyskinesia.

Mov Disord 2010 Jul;25(9):1274-9

Neuroscience Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

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http://dx.doi.org/10.1002/mds.22876DOI Listing
July 2010

High frequency of multiexonic deletion of the GCH1 gene in a Taiwanese cohort of dopa-response dystonia.

Am J Med Genet B Neuropsychiatr Genet 2010 Jun;153B(4):903-8

Human Molecular Genetics Laboratory, Department of Medical Research, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/ajmg.b.31058DOI Listing
June 2010

Restoration of motor inhibition through an abnormal premotor-motor connection in dystonia.

Mov Disord 2010 Apr;25(6):696-703

Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1002/mds.22814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000921PMC
April 2010

The prevalence of restless legs syndrome in Taiwanese adults.

Psychiatry Clin Neurosci 2010 Apr;64(2):170-8

Sleep Center, Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taiwan.

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http://dx.doi.org/10.1111/j.1440-1819.2010.02067.xDOI Listing
April 2010

The effect of continuous theta burst stimulation over premotor cortex on circuits in primary motor cortex and spinal cord.

Clin Neurophysiol 2009 Apr 23;120(4):796-801. Epub 2009 Feb 23.

Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.clinph.2009.01.003DOI Listing
April 2009

Spinal cord infarction in Chinese patients. Clinical features, risk factors, imaging and prognosis.

Cerebrovasc Dis 2008 23;26(5):502-8. Epub 2008 Sep 23.

Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1159/000155988DOI Listing
January 2009

Analysis of the LRRK2 Gly2385Arg variant in primary dystonia and multiple system atrophy in Taiwan.

Parkinsonism Relat Disord 2008 2;14(5):393-6. Epub 2008 May 2.

Section of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University, No. 5, Fu-Shin Street, Kweishan, Taoyuan 33305, Taiwan.

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http://dx.doi.org/10.1016/j.parkreldis.2008.03.004DOI Listing
November 2008

The LRRK2 Arg1628Pro variant is a risk factor for Parkinson's disease in the Chinese population.

Neurogenetics 2008 Oct 21;9(4):271-6. Epub 2008 Aug 21.

Neuroscience Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.

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http://dx.doi.org/10.1007/s10048-008-0140-6DOI Listing
October 2008

Abnormal cortical excitability with preserved brainstem and spinal reflexes in sialidosis type I.

Clin Neurophysiol 2008 May 17;119(5):1042-50. Epub 2008 Mar 17.

Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 199, Dunhwa North Road, Taipei 10507, Taiwan.

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http://dx.doi.org/10.1016/j.clinph.2008.01.023DOI Listing
May 2008

Effect of physiological activity on an NMDA-dependent form of cortical plasticity in human.

Cereb Cortex 2008 Mar 14;18(3):563-70. Epub 2007 Jun 14.

Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei 10507, Taiwan.

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http://dx.doi.org/10.1093/cercor/bhm087DOI Listing
March 2008

[Restless legs syndrome].

Acta Neurol Taiwan 2008 Mar;17(1):54-65

Movement Disorders Section, Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan.

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March 2008

PINK1 mutation in Taiwanese early-onset parkinsonism : clinical, genetic, and dopamine transporter studies.

J Neurol 2007 Oct 15;254(10):1347-55. Epub 2007 Oct 15.

Neuroscience Research Center, Dept. of Neurology, Chang Gung Memorial Hospital and Chang Gung University, 33305, 5 Fu-Shin St., Kweishan, Taoyuan, Taiwan.

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http://dx.doi.org/10.1007/s00415-007-0534-7DOI Listing
October 2007

The after-effect of human theta burst stimulation is NMDA receptor dependent.

Clin Neurophysiol 2007 May 23;118(5):1028-32. Epub 2007 Mar 23.

Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei 10507, Taiwan.

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http://dx.doi.org/10.1016/j.clinph.2007.01.021DOI Listing
May 2007

DYT1 mutation in a cohort of Taiwanese primary dystonias.

Parkinsonism Relat Disord 2006 Jan 29;12(1):15-9. Epub 2005 Sep 29.

Movement Disorders Unit, Department of Neurology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan.

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http://dx.doi.org/10.1016/j.parkreldis.2005.08.002DOI Listing
January 2006

Taiwanese cases of SCA2 are derived from a single founder.

Mov Disord 2005 Dec;20(12):1633-6

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20952, USA.

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http://dx.doi.org/10.1002/mds.20638DOI Listing
December 2005

Pallidotomy effect on the cortical excitability in patients with severe Parkinson's disease.

Mov Disord 2005 Apr;20(4):463-70

Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan, Republic of China.

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http://dx.doi.org/10.1002/mds.20344DOI Listing
April 2005

Autonomic dysfunction in Machado-Joseph disease.

Arch Neurol 2005 Apr;62(4):630-6

First Department of Neurology and Human Molecular Genetic Laboratory, Chang Gung Memorial Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1001/archneur.62.4.630DOI Listing
April 2005

Sensitivity and specificity of 99mTc-TRODAT-1 SPECT imaging in differentiating patients with idiopathic Parkinson's disease from healthy subjects.

J Nucl Med 2004 Mar;45(3):393-401

Movement Disorders Unit, the First Department of Neurology, Chang Gung Memorial Hospital and Medical College, Taipei, Taiwan.

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http://jnm.snmjournals.org/content/45/3/393.full.pdf
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March 2004

99mTc-TRODAT-1 imaging of multiple system atrophy.

J Nucl Med 2004 Jan;45(1):49-55

First Department of Neurology, Chang Gung Memorial Hospital at Taipei, Taipei, Taiwan.

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January 2004

Dopa-responsive parkinsonism phenotype of spinocerebellar ataxia type 2.

Mov Disord 2002 Sep;17(5):1046-51

Department of Neurology, Chang Gung Memorial Hospital and School of Medicine, Chang Gung University, Taiwan.

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http://doi.wiley.com/10.1002/mds.10243
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http://dx.doi.org/10.1002/mds.10243DOI Listing
September 2002

Dopamine transporter concentration is reduced in asymptomatic Machado-Joseph disease gene carriers.

J Nucl Med 2002 Feb;43(2):153-9

Department of Nuclear Medicine, Chang Gung Memorial Hospital at Lin-kou and Kee-long, Chang Gung University, Taiwan.

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February 2002