Dr. Rostyslav V Bubnov, MD, PhD - Clinical Hospital “Pheophania” of State Affairs Department - Dr.

Dr. Rostyslav V Bubnov

MD, PhD

Clinical Hospital “Pheophania” of State Affairs Department

Dr.

Kyiv | Ukraine

Main Specialties: Abdominal Radiology, Gastroenterology, Muscoskeletal Radiology, Neuromuscular Medicine, Oncology, Pain Medicine, Physical Medicine & Rehabilitation, Radiology-Diagnostic, Sports Medicine

ORCID logohttps://orcid.org/0000-0003-3148-9884

Dr. Rostyslav V Bubnov, MD, PhD - Clinical Hospital “Pheophania” of State Affairs Department - Dr.

Dr. Rostyslav V Bubnov

MD, PhD

Education

Jan 2013 - May 2016
International Solomon University
LL.B.
law, medical law
Oct 2009 - May 2012
Kharkiv Medical Academy of Postgraduate Education
PhD
Radiology
Oct 2009 - May 2012
Kharkiv Medical Academy of Postgraduate Education
PhD
Radiology
Aug 1994 - Jun 2000
Horbachevsky Ternopil State Medical University
MD
medicine
Jun 2000
Gorbachevsky Ternopil medical academy
M.D.

Experience

Nov 2014
The EPMA Journal (Springer Nature)
Associate Editor
Jul 2011
European Association for Predictive, Preventive and Personalized Medicine (EPMA)
National Representative in Ukraine of the European Association for Predictive, Preventive and Personalized Medicine (EPMA)
Dec 2012
Zabolotny Institute of Microbiology, Virology, National Academy of sciences of Ukraine
researcher
Interferon
Jun 2005
Clinical Hospital ‘Pheophania’ of State Affairs Department
medical doctor
Ultrasound

Publications

116Publications

730Reads

833Profile Views

228PubMed Central Citations

Specific properties of probiotic strains: relevance and benefits for the host.

EPMA J 2018 Jun 13;9(2):205-223. Epub 2018 Apr 13.

1Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny str., 154, Kyiv, 03143 Ukraine.

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http://dx.doi.org/10.1007/s13167-018-0132-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972142PMC
June 2018
29 Reads

High regenerative capacity of the liver and irreversible injury of male reproductive system in carbon tetrachloride-induced liver fibrosis rat model.

EPMA J 2018 Mar 11;9(1):59-75. Epub 2017 Oct 11.

3Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Zabolotny str., 150, Kyiv, 03143 Ukraine.

Background: Liver fibrosis (LF) is a chronic disease, associated with many collateral diseases including reproductive dysfunction. Although the normal liver has a large regenerative capacity the complications of LF could be severe and irreversible. Hormone and sex-related issues of LF development and interactions with male reproductive have not been finally studied. The aim was to study the reproductive function of male rats in experimental CCl-induced liver fibrosis rat model, and the capability for restoration of both the liver and male reproduction system.

Materials: Studies were conducted on 20 3-month old Wistar male rats. The experimental animals were injected with freshly prepared 50% olive oil solution of carbohydrate tetrachloride (CCl). On the 8th week after injection we noted the manifestations of liver fibrosis. The rats were left to self-healing of the liver for 8 weeks. All male rats underwent ultrasound and biopsy of the liver and testes on the 8th and 16th weeks. The male rats were mated with healthy females before CCl injection, after modeling LF on the 8th week, and after self-healing of the liver. Pregnancy was monitored on ultrasound.

Results: On the 8th week of experiment we observed ultrasound manifestation of advanced liver fibrosis, including hepatosplenomegaly, portal hypertension. Ultrasound exam of the rat testes showed testicular degeneration, hydrocele, fibrosis, scarring, petrifications, size reduction, and restriction of testicular descent; testes size decreased from 1.24 ± 0.62 ml to 0.61 ± 0.13,  < 0.01. Liver histology showed granular dystrophy of hepatocytes, necrotic areas, lipid inclusions in parenchyma. Rats with liver fibrosis demonstrated severe injury of the reproductive system and altering of fertility: the offspring of male rats with advanced LF was 4.71 ± 0.53 born alive vs 9.55 ± 0.47 born from mating with healthy males,  < 0.001. Eight weeks after last CCl injection, we revealed signs of liver regeneration, significant recovery of its structure. The ALT and AST levels significantly decreased and reached background measurements. As a result of the second interbreeding after liver self-healing no significant difference was found vs previous mating.

Conclusion: Carbohydrate tetrachloride induces injury of liver parenchyma evoking fast and severe liver fibrosis, and is associated with irreversible structural and functional changes in testes, reducing fertility, decreasing potential pregnancy rate, and affecting its development. Liver showed high potential to regenerate, however the self-restoring after liver fibrosis was not accompanied with recovery of the reproductive system.

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http://dx.doi.org/10.1007/s13167-017-0115-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833895PMC
March 2018
10 Reads
3.900 Impact Factor

Innovative payer engagement strategies: will the convergence lead to better value creation in personalized medicine?

EPMA J 2017 12 13;8(1):5-15. Epub 2017 Feb 13.

Clinical Hospital "Pheophania" of State Affairs Department, Zabolotny Str., 21, Kyiv, 03680 Ukraine ; 0000 0004 0385 8977grid.418751.eZabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, Kyiv, 03680 Ukraine.

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http://dx.doi.org/10.1007/s13167-017-0078-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306421PMC
December 2017
19 Reads
3 Citations

Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model-comparative study.

EPMA J 2017 Dec 16;8(4):377-390. Epub 2017 Jun 16.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, Kyiv, 03143 Ukraine.

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http://dx.doi.org/10.1007/s13167-017-0098-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700020PMC
December 2017
21 Reads
2 Citations

Comparative study of probiotic effects of and strains on cholesterol levels, liver morphology and the gut microbiota in obese mice.

EPMA J 2017 Dec 10;8(4):357-376. Epub 2017 Oct 10.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, Kyiv, 03143 Ukraine.

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http://dx.doi.org/10.1007/s13167-017-0117-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700021PMC
December 2017
45 Reads
2 Citations

How do probiotics and prebiotics function at distant sites?

Benef Microbes 2017 Aug 20;8(4):521-533. Epub 2017 Jul 20.

16 Winclove Probiotics, Hulstweg 11, 1032 LB Amsterdam, the Netherlands.

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http://dx.doi.org/10.3920/BM2016.0222DOI Listing
August 2017
25 Reads
4 Citations
1.500 Impact Factor

Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats.

Biomed Pharmacother 2017 Jun 12;90:608-614. Epub 2017 Apr 12.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.

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http://dx.doi.org/10.1016/j.biopha.2017.03.099DOI Listing
June 2017
21 Reads
2 Citations
2.023 Impact Factor

"Pre-metastatic niches" in breast cancer: are they created by or prior to the tumour onset? "Flammer Syndrome" relevance to address the question.

EPMA J 2017 Jun 2;8(2):141-157. Epub 2017 May 2.

Radiological Clinic, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany.

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http://dx.doi.org/10.1007/s13167-017-0092-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486540PMC
June 2017
33 Reads
14 Citations

EPMA-World Congress 2015: Bonn, Germany. 3-5 September 2015.

Abraham J, Golubnitschaja O, Akhmetov I, Andrews RJ, Quintana L, Andrews RJ, Baban B, Liu JY, Qin X, Wang T, Mozaffari MS, Bati VV, Meleshko TV, Levchuk OB, Boyko NV, Bauer J, Boerner E, Podbielska H, Bomba A, Petrov VO, The Epma Journal, 2016, vol. 7, no. Suppl 1, 2016

http://europepmc.org/abstract/PMC/PMC4896262

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2016
13 Reads

Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016.

EPMA J 2016 25;7:23. Epub 2016 Oct 25.

European Association for Predictive, Preventive and Personalised Medicine, Brussels, Belgium ; European Medical Association, Brussels, Belgium.

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http://dx.doi.org/10.1186/s13167-016-0072-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078893PMC
October 2016
17 Reads
40 Citations

A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.

Int Orthop 2016 Aug 30;40(8):1755-1765. Epub 2016 Mar 30.

The Centre of Ultrasound Diagnostics and Interventional Sonography, Clinical Hospital "Pheophania" of State Affairs Department, Zabolotny Street, 21, 03680, Kyiv, Ukraine.

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http://dx.doi.org/10.1007/s00264-016-3162-yDOI Listing
August 2016
17 Reads
8 Citations
2.020 Impact Factor

Aims and Scope/Editorial Board

Pathogenesis

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May 2016
12 Reads

Thank You to Our 2015 Viral Immunology Reviewers

Viral Immunology

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January 2016
6 Reads

Assessing value of innovative molecular diagnostic tests in the concept of predictive, preventive, and personalized medicine.

EPMA J 2015 30;6:19. Epub 2015 Sep 30.

Clinical Hospital "Pheophania" of State Affairs Department, Zabolotny Str., 21, Kyiv, 03680 Ukraine ; Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, Kyiv, 03680 Ukraine.

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http://dx.doi.org/10.1186/s13167-015-0041-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588236PMC
October 2015
13 Reads
4 Citations

Probiotics and immunity: provisional role for personalized diets and disease prevention.

EPMA J 2015 14;6(1):14. Epub 2015 Jul 14.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Zabolotny St., Kyiv, 03680 Ukraine ; Cassovia Life Sciences, Palárikova 4, 04011 Košice, Slovak Republiс

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http://dx.doi.org/10.1186/s13167-015-0036-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517425PMC
July 2015
28 Reads
11 Citations

The role of beneficial bacteria wall elasticity in regulating innate immune response.

EPMA J 2015 19;6(1):13. Epub 2015 Jun 19.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Zabolotny st., Kyiv, D03680 Ukraine ; LCL «Diaprof», Svitlycky Str., 35, Kyiv, 04123 Ukraine.

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http://dx.doi.org/10.1186/s13167-015-0035-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479350PMC
June 2015
19 Reads
6 Citations

Antioxidative effects of cerium dioxide nanoparticles ameliorate age-related male infertility: optimistic results in rats and the review of clinical clues for integrative concept of men health and fertility.

EPMA J 2015 10;6(1):12. Epub 2015 Jun 10.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, Kyiv, 03680 Ukraine ; LCL "DIAPROF", Svitlycky Str., 35, Kyiv, 04123 Ukraine.

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http://dx.doi.org/10.1186/s13167-015-0034-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475301PMC
June 2015
19 Reads
6 Citations

EPMA position paper in cancer: current overview and future perspectives.

EPMA J 2015 15;6(1). Epub 2015 Apr 15.

Department of Neurology, University of Tennessee Center for Health Science, Memphis, USA.

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http://dx.doi.org/10.1186/s13167-015-0030-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407842PMC
April 2015
13 Reads
26 Citations

Nanocrystalline cerium dioxide efficacy for gastrointestinal motility: potential for prokinetic treatment and prevention in elderly.

EPMA J 2015 11;6(1). Epub 2015 Mar 11.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str., 154, 03680 Kyiv, Ukraine ; Clinical Hospital 'Pheophania' of State Affairs Department, Zabolotny Str., 21, 03680 Kyiv, Ukraine.

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http://dx.doi.org/10.1186/s13167-015-0029-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374531PMC
March 2015
28 Reads
4 Citations

Introduction to sonosurgery.

Pilecki Z, Pilecki G, Bubnov R, The Epma Journal, 2014, vol. 5, no. Suppl 1, pp. A66-A66

http://europepmc.org/abstract/PMC/PMC4125956

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2014
8 Reads

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention.

EPMA J 2014 Jan 13;5(1). Epub 2014 Jan 13.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str,, 154, Kyiv 03680, Ukraine.

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http://dx.doi.org/10.1186/1878-5085-5-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922789PMC
January 2014
49 Reads
16 Citations

Gold nanoparticles - the theranostic challenge for PPPM: nanocardiology application

Mykola Ya Spivak, Rostyslav V Bubnov, Ilya M Yemets, Liudmyla M Lazarenko, Natalia O Tymoshok, Zoia R Ulberg, 2013, 'Gold nanoparticles - the theranostic challenge for PPPM: nanocardiology application', EPMA Journal, vol. 4, no. 1, p. 18

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2013
5 Reads

Predictive diagnosis of endometrial hyperplasia and personalized therapeutic strategy in women of fertile age.

EPMA J 2013 Dec 6;4(1):24. Epub 2013 Dec 6.

Clinical Hospital 'Pheophania' of State Affairs Department, Zabolotny str,, 21, Kyiv 03680, Ukraine.

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http://dx.doi.org/10.1186/1878-5085-4-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866390PMC
December 2013
19 Reads
8 Citations

Development and testing of gold nanoparticles for drug delivery and treatment of heart failure: a theranostic potential for PPP cardiology.

Spivak MY, Bubnov RV, Yemets IM, Lazarenko LM, Tymoshok NO, Ulberg ZR: Development and testing of gold nanoparticles for drug delivery and treatment of heart failure: a theranostic potential for PPP cardiology. EPMA J. 2013 Jun 24;4(1):20

http://www.epmajournal.com/content/4/1/20/abstract

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July 2013
7 Reads

Development and testing of gold nanoparticles for drug delivery and treatment of heart failure: a theranostic potential for PPP cardiology.

EPMA J 2013 Jul 29;4(1):20. Epub 2013 Jul 29.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny str,, 154, Kyiv 03680, Ukraine.

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http://link.springer.com/content/pdf/10.1186%2F1878-5085-4-2
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http://www.epmajournal.com/content/4/1/20
Publisher Site
http://dx.doi.org/10.1186/1878-5085-4-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751918PMC
July 2013
36 Reads
15 Citations

Gold nanoparticles - the theranostic challenge for PPPM: nanocardiology application.

EPMA J 2013 Jun 24;4(1):18. Epub 2013 Jun 24.

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Zabolotny Str,, 154, Kyiv 03680, Ukraine.

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http://dx.doi.org/10.1186/1878-5085-4-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702527PMC
June 2013
19 Reads
11 Citations

Ultrasound guided injections of platelets rich plasma for muscle injury in professional athletes. Comparative study.

Med Ultrason 2013 Jun;15(2):101-5

Centre of Ultrasound Diagnostics and Interventional Sonography, Clinical Hospital "Pheophania", Kyiv, Ukraine.

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June 2013
12 Reads
12 Citations

Ultrasound guided injections of platelets rich plasma for muscle injury in professional athletes. Comparative study

Rostyslav Bubnov, 2013, 'Ultrasound guided injections of Platelets Rich Plasma for muscle injury in professional athletes. Comparative study', Medical Ultrasonography, vol. 15, no. 2, pp. 101-105

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June 2013
6 Reads

Evidence-based pain management: is the concept of integrative medicine applicable?

EPMA J 2012 Oct 22;3(1):13. Epub 2012 Oct 22.

The Centre of Ultrasound Diagnostics and Interventional Sonography, Clinical Hospital 'Pheophania' of State Affairs Department, Zabolotny str,, 21, Kyiv, 03680, Ukraine.

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http://dx.doi.org/10.1186/1878-5085-3-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533862PMC
October 2012
17 Reads
13 Citations

The methods of fractal analysis of diagnostic images. initial clinical experience.

Lik Sprava 2011 Apr-Jun(3-4):108-13

The Center of Ultrasound Diagnostics and Interventional Sonography, Clinical Hospital "Pheophania" of State Affairs Department.

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April 2012
8 Reads
2 Citations

[Comparative study of performance of lower extremities blocks under ultrasonography and nerve stimulator guidance].

Lik Sprava 2011 Jan-Mar(1-2):126-31

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October 2011
11 Reads
1 Citation

EPMA-World Congress 2011

EPMA Journal

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August 2011

[Main sonographic parameters of regional anesthesia conduction in the lower extremities under ultrasound guidance].

Lik Sprava 2010 Oct-Dec(7-8):97-107

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July 2011
8 Reads
1 Citation

The use of trigger point "dry" needling under ultrasound guidance for the treatment of myofascial pain (technological innovation and literature review).

Lik Sprava 2010 Jul-Sep(5-6):56-64

The Center Ultrasound Diagnostics and Interventional Sonography, Clinical Hospital Pheophania of State Affairs Department.

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May 2011
48 Reads
5 Citations

Evidence-based pain management: is the concept of integrative medicine applicable?

Rostyslav V Bubnov, 2012, 'Evidence-based pain management: is the concept of integrative medicine applicable?', EPMA Journal, vol. 3, no. 1

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1969
5 Reads