Publications by authors named "Ross Overman"

19Publications

A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding.

Authors:
Alexander Pflug Marianne Schimpl J Willem M Nissink Ross C Overman Philip B Rawlins Caroline Truman Elizabeth Underwood Juli Warwicker Jon Winter-Holt William McCoull

Biochem J 2020 Nov;477(22):4443-4452

Oncology R&D, AstraZeneca, Cambridge, U.K.

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November 2020

Plant-made dengue virus-like particles produced by co-expression of structural and non-structural proteins induce a humoral immune response in mice.

Authors:
Daniel Ponndorf Yulia Meshcheriakova Eva C Thuenemann Albor Dobon Alonso Ross Overman Nicholas Holton Stuart Dowall Emma Kennedy Martin Stocks George P Lomonossoff Hadrien Peyret

Plant Biotechnol J 2020 Oct 25. Epub 2020 Oct 25.

Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, UK.

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October 2020

Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.

Authors:
Erica Banks Michael Grondine Deepa Bhavsar Evan Barry Jason G Kettle Venkatesh Pilla Reddy Crystal Brown Haiyun Wang Jerome T Mettetal Teresa Collins Oladipupo Adeyemi Ross Overman Deborah Lawson Alexander R Harmer Corinne Reimer Lisa Drew Martin J Packer Sabina Cosulich Rhys DO Jones Wenlin Shao David Wilson Sylvie Guichard Stephen Fawell Rana Anjum

Sci Transl Med 2020 Apr;12(541)

Bioscience, Oncology R&D, AstraZeneca, 35 Gatehouse Park, Boston, MA 02451, USA.

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April 2020

The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif.

Authors:
Taiana Maia de Oliveira Victoria Korboukh Sarah Caswell Jon J Winter Holt Michelle Lamb Alexander W Hird Ross Overman

Biochem J 2020 01;477(1):275-284

Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.

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January 2020

Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo.

Authors:
Nikki Heath Xabier Osteikoetxea Taiana Mia de Oliveria Elisa Lázaro-Ibáñez Olga Shatnyeva Christina Schindler Natalie Tigue Lorenz M Mayr Niek Dekker Ross Overman Rick Davies

Nanomedicine (Lond) 2019 11 14;14(21):2799-2814. Epub 2019 Nov 14.

Discovery Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Alderley Park, UK.

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November 2019

Introduction of a C-terminal hexa-lysine tag increases thermal stability of the LacDiNac binding adhesin (LabA) exodomain from Helicobacter pylori.

Authors:
Vasiliki Paraskevopoulou Verónica García Artiaga Rachel Rowlinson G Sebastiaan Winkler Paul Gellert Snow Stolnik Ross Overman Franco H Falcone

Protein Expr Purif 2019 11 1;163:105446. Epub 2019 Jul 1.

School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom. Electronic address:

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November 2019

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.

Authors:
Nicolas Bery Sandrine Legg Judit Debreczeni Jason Breed Kevin Embrey Christopher Stubbs Paulina Kolasinska-Zwierz Nathalie Barrett Rose Marwood Jo Watson Jon Tart Ross Overman Ami Miller Christopher Phillips Ralph Minter Terence H Rabbitts

Nat Commun 2019 06 13;10(1):2607. Epub 2019 Jun 13.

Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

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June 2019

Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.

Authors:
Jason G Kettle Rana Anjum Evan Barry Deepa Bhavsar Crystal Brown Scott Boyd Andrew Campbell Kristin Goldberg Michael Grondine Sylvie Guichard Christopher J Hardy Tom Hunt Rhys D O Jones Xiuwei Li Olga Moleva Derek Ogg Ross C Overman Martin J Packer Stuart Pearson Marianne Schimpl Wenlin Shao Aaron Smith James M Smith Darren Stead Steve Stokes Michael Tucker Yang Ye

J Med Chem 2018 10 24;61(19):8797-8810. Epub 2018 Sep 24.

Pharmaron Beijing Co., Ltd. , 6 Taihe Road BDA , Beijing 100176 , P. R. China.

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October 2018

Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography.

Authors:
Nikki Heath Lois Grant Taiana Maia De Oliveira Rachel Rowlinson Xabier Osteikoetxea Niek Dekker Ross Overman

Sci Rep 2018 04 10;8(1):5730. Epub 2018 Apr 10.

Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK.

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April 2018

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.

Authors:
Sandrine Guillard Paulina Kolasinska-Zwierz Judit Debreczeni Jason Breed Jing Zhang Nicolas Bery Rose Marwood Jon Tart Ross Overman Pawel Stocki Bina Mistry Christopher Phillips Terence Rabbitts Ronald Jackson Ralph Minter

Nat Commun 2017 07 14;8:16111. Epub 2017 Jul 14.

Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, UK.

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July 2017

A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases.

Authors:
Alvin Kung Marianne Schimpl Arunika Ekanayake Ying-Chu Chen Ross Overman Chao Zhang

ACS Chem Biol 2017 06 8;12(6):1499-1503. Epub 2017 May 8.

Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca , Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom.

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June 2017

Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3.

Authors:
Alvin Kung Ying-Chu Chen Marianne Schimpl Feng Ni Jianfa Zhu Maurice Turner Henrik Molina Ross Overman Chao Zhang

J Am Chem Soc 2016 08 11;138(33):10554-60. Epub 2016 Aug 11.

Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca , Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.

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August 2016

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.

Authors:
Anna A Marusiak Natalie L Stephenson Hayeon Baik Eleanor W Trotter Yaoyong Li Karen Blyth Susan Mason Phil Chapman Lorena A Puto Jon A Read Claire Brassington Hannah K Pollard Chris Phillips Isabelle Green Ross Overman Matthew Collier Ewelina Testoni Crispin J Miller Tony Hunter Owen J Sansom John Brognard

Cancer Res 2016 Feb 4;76(3):724-35. Epub 2015 Dec 4.

Signalling Networks in Cancer Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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February 2016

Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA.

Authors:
Naim Hage Tina Howard Chris Phillips Claire Brassington Ross Overman Judit Debreczeni Paul Gellert Snow Stolnik G Sebastiaan Winkler Franco H Falcone

Sci Adv 2015 Aug 14;1(7):e1500315. Epub 2015 Aug 14.

School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

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August 2015

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.

Authors:
Jon J G Winter Malcolm Anderson Kevin Blades Claire Brassington Alexander L Breeze Christine Chresta Kevin Embrey Gary Fairley Paul Faulder M Raymond V Finlay Jason G Kettle Thorsten Nowak Ross Overman S Joe Patel Paula Perkins Loredana Spadola Jonathan Tart Julie A Tucker Gail Wrigley

J Med Chem 2015 Mar 26;58(5):2265-74. Epub 2015 Feb 26.

AstraZeneca , Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom.

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March 2015

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4.

Authors:
Julie A Tucker Tobias Klein Jason Breed Alexander L Breeze Ross Overman Chris Phillips Richard A Norman

Structure 2014 Dec 20;22(12):1764-1774. Epub 2014 Nov 20.

Discovery Sciences, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. Electronic address:

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December 2014

Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein.

Authors:
Adam B Shapiro Ning Gao Nichole O'Connell Jun Hu Jason Thresher Rong-Fang Gu Ross Overman Ian M Hardern Graham G Sproat

Virol J 2014 Nov 19;11:191. Epub 2014 Nov 19.

Biology Department, Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA.

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November 2014

Completing the structural family portrait of the human EphB tyrosine kinase domains.

Authors:
Ross C Overman Judit E Debreczeni Caroline M Truman Mark S McAlister Teresa K Attwood

Protein Sci 2014 May 11;23(5):627-38. Epub 2014 Mar 11.

AstraZeneca PLC, Alderley Park, Cheshire, SK10 4TG, United Kingdom.

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May 2014

Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles.

Authors:
Ross C Overman Judit E Debreczeni Caroline M Truman Mark S McAlister Teresa K Attwood

Biosci Rep 2013 Jun 5;33(3). Epub 2013 Jun 5.

AstraZeneca PLC, Alderley Park, Cheshire, SK10 4TG, UK.

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June 2013