Ross Levine

Ross Levine

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Ross Levine

Publications by authors named "Ross Levine"

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Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.

Cell Stem Cell 2019 Aug 30. Epub 2019 Aug 30.

Human Oncology and Pathogenesis Program and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193033
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http://dx.doi.org/10.1016/j.stem.2019.08.003DOI Listing
August 2019

Risk of disease progression in low-risk MDS is linked to distinct epigenetic subtypes.

Leukemia 2019 Jul 22. Epub 2019 Jul 22.

Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1038/s41375-019-0518-5DOI Listing
July 2019

Unfolding the Role of Calreticulin in Myeloproliferative Neoplasm Pathogenesis.

Clin Cancer Res 2019 May 17;25(10):2956-2962. Epub 2019 Jan 17.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522317PMC
May 2019

Next-generation sequencing in the diagnosis and minimal residual disease assessment of acute myeloid leukemia.

Haematologica 2019 May 28;104(5):868-871. Epub 2019 Mar 28.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

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http://dx.doi.org/10.3324/haematol.2018.205955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518900PMC
May 2019

Genetic and epigenetic determinants of AML pathogenesis.

Semin Hematol 2019 Apr 22;56(2):84-89. Epub 2018 Aug 22.

Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY.

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https://linkinghub.elsevier.com/retrieve/pii/S00371963183009
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http://dx.doi.org/10.1053/j.seminhematol.2018.08.001DOI Listing
April 2019

Radioactive Iodine-Related Clonal Hematopoiesis in Thyroid Cancer Is Common and Associated With Decreased Survival.

J Clin Endocrinol Metab 2018 11;103(11):4216-4223

Division of Endocrinology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1210/jc.2018-00803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194804PMC
November 2018

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 Mice.

Circ Res 2018 11;123(11):e35-e47

From the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309796PMC
November 2018

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.

Cancer Cell 2018 10 27;34(4):643-658.e5. Epub 2018 Sep 27.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179449PMC
October 2018

Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil.

Stem Cells 2018 09 8;36(9):1287-1294. Epub 2018 Jun 8.

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1002/stem.2845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125185PMC
September 2018

Cohesin mutations in myeloid malignancies made simple.

Curr Opin Hematol 2018 03;25(2):61-66

Human Oncology & Pathogenesis Program, Center for Hematologic Malignancies, and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601335PMC
March 2018

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies.

Cell Stem Cell 2018 02;22(2):157-170

Human Oncology and Pathogenesis Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183001
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http://dx.doi.org/10.1016/j.stem.2018.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804896PMC
February 2018

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer Cell 2018 01 14;33(1):29-43.e7. Epub 2017 Dec 14.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760343PMC
January 2018

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.

Cancer Cell 2018 01 21;33(1):44-59.e8. Epub 2017 Dec 21.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108173051
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http://dx.doi.org/10.1016/j.ccell.2017.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760367PMC
January 2018

TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis.

Cell Rep 2018 01;22(5):1250-1262

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183003
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http://dx.doi.org/10.1016/j.celrep.2018.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971064PMC
January 2018

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation.

EBioMedicine 2017 Dec 21;26:112-125. Epub 2017 Nov 21.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832629PMC
December 2017

Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.

Cell Stem Cell 2017 10 28;21(4):489-501.e7. Epub 2017 Sep 28.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847260PMC
October 2017

Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes.

Cell Stem Cell 2017 09 10;21(3):374-382.e4. Epub 2017 Aug 10.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591073PMC
September 2017

Gain of chromosome 1q portends worse prognosis in multiple myeloma despite novel agent-based induction regimens and autologous transplantation.

Leuk Lymphoma 2017 08 12;58(8):1823-1831. Epub 2017 Jan 12.

b Department of Medicine, Adult Bone Marrow Transplant Service , Memorial Sloan Kettering Cancer Center, NY Presbyterian Hospital - Weill Cornell Medical College , New York , NY , USA.

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http://dx.doi.org/10.1080/10428194.2016.1260126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554510PMC
August 2017

TET2 in Normal and Malignant Hematopoiesis.

Cold Spring Harb Perspect Med 2017 Aug 1;7(8). Epub 2017 Aug 1.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021.

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http://dx.doi.org/10.1101/cshperspect.a026518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538403PMC
August 2017

Overview of Transgenic Mouse Models of Myeloproliferative Neoplasms (MPNs).

Curr Protoc Pharmacol 2017 Jun 22;77:14.40.1-14.40.19. Epub 2017 Jun 22.

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York City, New York.

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http://dx.doi.org/10.1002/cpph.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352313PMC
June 2017

Cardiovascular disease: Commonality with cancer.

Nature 2017 03 22;543(7643):45-47. Epub 2017 Feb 22.

Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://www.nature.com/articles/nature21505
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http://dx.doi.org/10.1038/nature21505DOI Listing
March 2017

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.

Nat Commun 2016 12 21;7:13829. Epub 2016 Dec 21.

Department of Genetic Medicine, Ansary Stem Cell Institute, Weill Cornell Medical College, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/ncomms13829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187502PMC
December 2016

An Unexpected Chink in the Transcriptional Armor of Plasmacytoid Dendritic Neoplasms.

Cancer Cell 2016 11;30(5):659-660

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.10.016DOI Listing
November 2016

Telomere length and associations with somatic mutations and clinical outcomes in acute myeloid leukemia.

Leuk Res 2016 10 25;49:62-5. Epub 2016 Jul 25.

Leukemia Service, Department of Medicine, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, United States.

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http://dx.doi.org/10.1016/j.leukres.2016.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526052PMC
October 2016

LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis.

Circ Res 2016 Sep 18;119(6):e91-e103. Epub 2016 Jul 18.

From the Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY (W.W., Y.T., Y.W., L.T., C.W., A.R.T., N.W.); Division of Hematology, Children's Hospital of Philadelphia, PA (W.T.); Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia (J.B., W.T.); and Human Oncology and Pathogenesis Program (R.L.L.) and Leukemia Service, Department of Medicine (R.L.L.), Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016083PMC
September 2016

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Cancer Cell 2016 08 14;30(2):337-348. Epub 2016 Jul 14.

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada; The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022794PMC
August 2016

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.

Mol Cell 2016 08 28;63(4):711-719. Epub 2016 Jul 28.

Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992443PMC
August 2016

Roads Diverge--A Robert Frost View of Leukemia Development.

N Engl J Med 2016 Jun;374(23):2282-4

From the Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.

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http://dx.doi.org/10.1056/NEJMe1603420DOI Listing
June 2016

A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia.

JCI Insight 2016 Jun;1(9)

Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.87323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951094PMC
June 2016

Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms.

Cell Biosci 2016 23;6:34. Epub 2016 May 23.

College of Life Sciences, Wuhan University, 16 Luo-Jia-Shan Road, Wuhan, 430072 Hubei People's Republic of China.

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http://dx.doi.org/10.1186/s13578-016-0097-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877759PMC
May 2016

Epigenetic regulators and their impact on therapy in acute myeloid leukemia.

Haematologica 2016 Mar;101(3):269-78

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA

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http://dx.doi.org/10.3324/haematol.2015.140822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815718PMC
March 2016

Acute myeloid leukaemia.

Nat Rev Dis Primers 2016 03 10;2:16010. Epub 2016 Mar 10.

Department of Haematology, University College London, UCL Cancer Institute, 72 Huntley Street, London WC1E 6DD, UK.

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http://dx.doi.org/10.1038/nrdp.2016.10DOI Listing
March 2016