Ross Lazarus

Ross Lazarus

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Ross Lazarus

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RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells.

Food Funct 2015 Aug 26;6(8):2507-24. Epub 2015 Jun 26.

Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1039/c5fo00467eDOI Listing
August 2015

Experimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq.

BMC Genomics 2015 Jul 25;16:548. Epub 2015 Jul 25.

Department of Biomedicine, Aarhus University, 6, Bartholins Allé, Aarhus C, Aarhus, 8000, Denmark.

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http://dx.doi.org/10.1186/s12864-015-1767-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515013PMC
July 2015

Development of novel activin-targeted therapeutics.

Mol Ther 2015 Mar 17;23(3):434-44. Epub 2014 Nov 17.

1] MIMR-PHI Institute of Medical Research, Clayton, Australia [2] Department of Physiology, Monash University, Clayton, Australia [3] Department of Molecular and Translational Sciences, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1038/mt.2014.221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351455PMC
March 2015

Non-referenced genome assembly from epigenomic short-read data.

Epigenetics 2014 Oct;9(10):1329-38

a Epigenetics in Human Health and Disease Laboratory ; Baker IDI Heart and Diabetes Institute ; The Alfred Medical Research and Education Precinct ; Melbourne , Victoria , Australia ;

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http://dx.doi.org/10.4161/15592294.2014.969610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622496PMC
October 2014

Time course-dependent changes in the transcriptome of human skeletal muscle during recovery from endurance exercise: from inflammation to adaptive remodeling.

J Appl Physiol (1985) 2014 Feb 5;116(3):274-87. Epub 2013 Dec 5.

Emerging Field Oxidative Stress and DNA Stability, Research Platform Active Aging, and Department of Nutritional Sciences, University of Vienna, Austria;

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http://dx.doi.org/10.1152/japplphysiol.00909.2013DOI Listing
February 2014

Transcriptome analysis of neutrophils after endurance exercise reveals novel signaling mechanisms in the immune response to physiological stress.

J Appl Physiol (1985) 2013 Jun 11;114(12):1677-88. Epub 2013 Apr 11.

Emerging Field Oxidative Stress and DNA Stability, and Research Platform Active Aging, Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1152/japplphysiol.00143.2013DOI Listing
June 2013

Harnessing electronic health records for public health surveillance.

Online J Public Health Inform 2011 22;3(3). Epub 2011 Dec 22.

Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.

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http://dx.doi.org/10.5210/ojphi.v3i3.3794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615793PMC
April 2013

Automated detection and classification of type 1 versus type 2 diabetes using electronic health record data.

Diabetes Care 2013 Apr 27;36(4):914-21. Epub 2012 Nov 27.

Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2337/dc12-0964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609529PMC
April 2013

Motif analysis in DNAse hypersensitivity regions uncovers distal cis elements associated with gene expression.

Bioinformation 2013 21;9(4):212-5. Epub 2013 Feb 21.

Epigenetics in Human Health and Disease Laboratory ; Epigenomics Profiling Facility, Baker IDI Heart & Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

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http://www.bioinformation.net/009/97320630009212.pdf
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http://www.bioinformation.net/009/97320630009212.htm
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http://dx.doi.org/10.6026/97320630009212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602893PMC
March 2013

Creating reusable tools from scripts: the Galaxy Tool Factory.

Bioinformatics 2012 Dec 28;28(23):3139-40. Epub 2012 Sep 28.

Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1093/bioinformatics/bts573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509488PMC
December 2012

A pipeline for the identification and characterization of chromatin modifications derived from ChIP-Seq datasets.

Biochimie 2012 Nov 13;94(11):2353-9. Epub 2012 Jun 13.

Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1016/j.biochi.2012.06.002DOI Listing
November 2012

Integrating clinical practice and public health surveillance using electronic medical record systems.

Am J Prev Med 2012 Jun;42(6 Suppl 2):S154-62

Harvard Medical School and Harvard Pilgrim Health Care Institute, Department of Population Medicine, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1016/j.amepre.2012.04.005DOI Listing
June 2012

Quantifying differential gene connectivity between disease states for objective identification of disease-relevant genes.

BMC Syst Biol 2011 May 31;5:89. Epub 2011 May 31.

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston MA 02115, USA.

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http://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0
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http://dx.doi.org/10.1186/1752-0509-5-89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128864PMC
May 2011

A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.

Kidney Int 2010 Oct 28;78(7):698-704. Epub 2010 Jul 28.

Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ki.2010.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001190PMC
October 2010

Distributed health data networks: a practical and preferred approach to multi-institutional evaluations of comparative effectiveness, safety, and quality of care.

Med Care 2010 Jun;48(6 Suppl):S45-51

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1097/MLR.0b013e3181d9919fDOI Listing
June 2010

Galaxy: a web-based genome analysis tool for experimentalists.

Curr Protoc Mol Biol 2010 Jan;Chapter 19:Unit 19.10.1-21

The Huck Institutes for the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.

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http://dx.doi.org/10.1002/0471142727.mb1910s89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264107PMC
January 2010

Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.

Hum Mol Genet 2009 Dec 10;18(23):4677-87. Epub 2009 Sep 10.

Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/hmg/ddp428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773275PMC
December 2009

Design of a national distributed health data network.

Ann Intern Med 2009 Sep 28;151(5):341-4. Epub 2009 Jul 28.

Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.7326/0003-4819-151-5-200909010-00139DOI Listing
September 2009

The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids.

J Allergy Clin Immunol 2009 Jun 28;123(6):1376-83.e7. Epub 2009 Feb 28.

Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.01.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317788PMC
June 2009

Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

Am J Respir Crit Care Med 2009 Jun 5;179(12):1084-90. Epub 2009 Mar 5.

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1164/rccm.200812-1860OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695495PMC
June 2009

Electronic Support for Public Health: validated case finding and reporting for notifiable diseases using electronic medical data.

J Am Med Inform Assoc 2009 Jan-Feb;16(1):18-24. Epub 2008 Oct 24.

Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA.

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http://dx.doi.org/10.1197/jamia.M2848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605594PMC
January 2009

Developing a distributed research network to conduct population-based studies and safety surveillance.

AMIA Annu Symp Proc 2008 Nov 6:973. Epub 2008 Nov 6.

University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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November 2008

A marginal mixture model for selecting differentially expressed genes across two types of tissue samples.

Int J Biostat 2008 Oct 9;4(1):Article 20. Epub 2008 Oct 9.

Brigham and Women's Hospital and Harvard Medical School.

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http://dx.doi.org/10.2202/1557-4679.1093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835454PMC
October 2008

Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma.

Pharmacogenet Genomics 2008 Aug;18(8):733-7

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3282fe6ebfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225071PMC
August 2008

Balancing selection is the main force shaping the evolution of innate immunity genes.

J Immunol 2008 Jul;181(2):1315-22

Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Unitat de Biologia Evolutiva, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.4049/jimmunol.181.2.1315DOI Listing
July 2008

Automated identification of acute hepatitis B using electronic medical record data to facilitate public health surveillance.

PLoS One 2008 Jul 9;3(7):e2626. Epub 2008 Jul 9.

Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002626PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440348PMC
July 2008

FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma.

J Allergy Clin Immunol 2007 Dec 5;120(6):1285-91. Epub 2007 Nov 5.

Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2007.09.005DOI Listing
December 2007

Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.

Cancer Epidemiol Biomarkers Prev 2007 Oct;16(10):1982-9

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-07-0325DOI Listing
October 2007

Genetic determinants of emphysema distribution in the national emphysema treatment trial.

Am J Respir Crit Care Med 2007 Jul 15;176(1):42-8. Epub 2007 Mar 15.

Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1164/rccm.200612-1797OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2049064PMC
July 2007

Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations.

Hum Genet 2007 May 8;121(3-4):389-400. Epub 2007 Feb 8.

Genetics Laboratory, Division of Translational Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s00439-006-0308-9DOI Listing
May 2007

GGtools: analysis of genetics of gene expression in bioconductor.

Bioinformatics 2007 Feb 8;23(4):522-3. Epub 2006 Dec 8.

Channing Laboratory, Brigham and Women's Hospital, 75 Francis Street, Boston 02115, USA.

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http://dx.doi.org/10.1093/bioinformatics/btl628DOI Listing
February 2007

A new multimarker test for family-based association studies.

Genet Epidemiol 2007 Jan;31(1):9-17

Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.

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http://doi.wiley.com/10.1002/gepi.20186
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http://dx.doi.org/10.1002/gepi.20186DOI Listing
January 2007

Pathologic outcome of laparoscopic and open radical prostatectomy.

Urology 2006 Dec 4;68(6):1253-6. Epub 2006 Dec 4.

Department of Urology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.urology.2006.08.1054DOI Listing
December 2006

Lack of Association Between Genetic Variation in 9 Innate Immunity Genes and Baseline CRP Levels.

Ann Hum Genet 2006 Sep;70(5):574-586

Division of Hematology, Brigham and Women's Hospital, Boston, MADivision of Preventive Medicine and Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MADonald W. Reynolds Cardiovascular Clinical Research Center on Atherosclerosis at Harvard Medical School, Boston, MAChanning Laboratory, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1111/j.1469-1809.2005.00256.xDOI Listing
September 2006

Distributed data processing for public health surveillance.

BMC Public Health 2006 Sep 19;6:235. Epub 2006 Sep 19.

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/1471-2458-6-235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618842PMC
September 2006

Health outcomes of patients undergoing cardiac surgery: repeated measures using Short Form-36 and 15 Dimensions of Quality of Life questionnaire.

Heart Lung 2006 Jul-Aug;35(4):245-51

Faculty of Nursing, Midwifery and Health, University of Technology, Sydney, Australia.

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http://dx.doi.org/10.1016/j.hrtlng.2005.10.004DOI Listing
August 2006

Genetic determinants of functional impairment in chronic obstructive pulmonary disease.

Proc Am Thorac Soc 2006 Aug;3(6):476

Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1513/pats.200603-039MSDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647635PMC
August 2006

Proxy respondents reliably assessed the quality of life of elective cardiac surgery patients.

J Clin Epidemiol 2006 Feb;59(2):153-9

Faculty of Nursing and Midwifery, The University of Sydney, Australia.

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http://dx.doi.org/10.1016/j.jclinepi.2005.06.010DOI Listing
February 2006

Eotaxin polymorphisms and serum total IgE levels in children with asthma.

J Allergy Clin Immunol 2006 Feb;117(2):298-305

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2005.10.041DOI Listing
February 2006

Lung function in type 2 diabetes: the Normative Aging Study.

Respir Med 2005 Dec 26;99(12):1583-90. Epub 2005 Apr 26.

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.rmed.2005.03.023DOI Listing
December 2005

Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer.

Cancer Res 2005 Dec;65(24):11771-8

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-2078DOI Listing
December 2005

Genomic screening in family-based association testing.

BMC Genet 2005 Dec 30;6 Suppl 1:S115. Epub 2005 Dec 30.

Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866823PMC
December 2005

Comparison of linkage and association strategies for quantitative traits using the COGA dataset.

BMC Genet 2005 Dec 30;6 Suppl 1:S96. Epub 2005 Dec 30.

Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/1471-2156-6-S1-S96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866683PMC
December 2005

Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes.

Am J Respir Crit Care Med 2005 Sep 23;172(6):687-92. Epub 2005 Jun 23.

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1164/rccm.200501-122OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718550PMC
September 2005

Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma.

Respir Res 2005 Jun 3;6:52. Epub 2005 Jun 3.

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/1465-9921-6-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180474PMC
June 2005

Association of vitamin D receptor gene polymorphisms with childhood and adult asthma.

Am J Respir Crit Care Med 2004 Nov 28;170(10):1057-65. Epub 2004 Jul 28.

Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200404-447OC
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http://dx.doi.org/10.1164/rccm.200404-447OCDOI Listing
November 2004

The IL12B gene is associated with asthma.

Am J Hum Genet 2004 Oct 20;75(4):709-15. Epub 2004 Aug 20.

Channing Laboratory, Brigham and Women's Hospital, Department of Anesthesia, Children's Hospital, and Harvard Medical School, Boston, MA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000292970762723
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http://dx.doi.org/10.1086/424886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182059PMC
October 2004

TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples.

Am J Respir Crit Care Med 2004 Sep 16;170(6):594-600. Epub 2004 Jun 16.

Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1164/rccm.200404-491OCDOI Listing
September 2004

ADAM33 polymorphisms and phenotype associations in childhood asthma.

J Allergy Clin Immunol 2004 Jun;113(6):1071-8

Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2004.03.035DOI Listing
June 2004

A generalized linear mixed models approach for detecting incident clusters of disease in small areas, with an application to biological terrorism.

Am J Epidemiol 2004 Feb;159(3):217-24

Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA 02215-3920, USA.

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http://dx.doi.org/10.1093/aje/kwh029DOI Listing
February 2004

Minimal haplotype tagging.

Proc Natl Acad Sci U S A 2003 Aug 4;100(17):9900-5. Epub 2003 Aug 4.

Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.

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http://dx.doi.org/10.1073/pnas.1633613100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187880PMC
August 2003

Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes.

Hum Mol Genet 2003 Aug;12(16):1973-9

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/hmg/ddg208DOI Listing
August 2003

Is smoking an indirect risk factor for the development of ulcerative colitis? An age- and sex-matched case-control study.

J Gastroenterol Hepatol 2003 Feb;18(2):139-46

Department of Colorectal Surgery, University of Sydney and Royal Prince Alfred Hospital, Sydney, Australia.

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http://dx.doi.org/10.1046/j.1440-1746.2003.02953.xDOI Listing
February 2003