Publications by authors named "Ross L Levine"

100Publications

Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML.

Cancer Discov 2020 Sep 16. Epub 2020 Sep 16.

Division of Hematology/Oncology, Weill Cornell Medicine, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0897DOI Listing
September 2020

Cancer did not stay home for COVID-19.

Authors:
Ross L Levine

Sci Adv 2020 09 11;6(37). Epub 2020 Sep 11.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Email:

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http://dx.doi.org/10.1126/sciadv.abd7487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485988PMC
September 2020

The clinical implications of clonal hematopoiesis in hematopoietic cell transplantation.

Blood Rev 2020 Aug 24:100744. Epub 2020 Aug 24.

Department of Medicine, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, USA; Department of Medicine, Weill Cornell Medical College, USA. Electronic address:

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http://dx.doi.org/10.1016/j.blre.2020.100744DOI Listing
August 2020

Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions.

Cell Syst 2020 Jul 2;11(1):86-94.e5. Epub 2020 Jul 2.

Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2020.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428059PMC
July 2020

Drug modulation by nuclear condensates.

Science 2020 06;368(6497):1314-1315

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1126/science.abc5318DOI Listing
June 2020

COVID-19 impact on early career investigators: a call for action.

Nat Rev Cancer 2020 07;20(7):357-358

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1038/s41568-020-0279-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273376PMC
July 2020

The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor.

JAMA Cardiol 2020 May 27. Epub 2020 May 27.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamacardio.2020.1271DOI Listing
May 2020

The Role of Somatic Mutations in Acute Myeloid Leukemia Pathogenesis.

Cold Spring Harb Perspect Med 2020 May 12. Epub 2020 May 12.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1101/cshperspect.a034975DOI Listing
May 2020

ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms.

Cell Rep 2020 03;30(10):3397-3410.e5

Institut National de la Santé et de la Recherche Médicale (INSERM) U1065, Université Côte d'Azur, Centre Méditerranéen de Médecine Moléculaire (C3M), Atip-Avenir, Fédération Hospitalo-Universitaire (FHU) Oncoage, 06204 Nice, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.02.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473128PMC
March 2020

Detection of Marker-Free Precision Genome Editing and Genetic Variation through the Capture of Genomic Signatures.

Cell Rep 2020 03;30(10):3280-3295.e6

Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.02.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108696PMC
March 2020

The Clinical Management of Clonal Hematopoiesis: Creation of a Clonal Hematopoiesis Clinic.

Hematol Oncol Clin North Am 2020 Apr 18;34(2):357-367. Epub 2020 Jan 18.

Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.hoc.2019.11.006DOI Listing
April 2020

Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe Mice.

Cardiovasc Drugs Ther 2020 04;34(2):145-152

Division of Molecular Medicine, Department of Medicine, Columbia University Medical Center, 630 W. 168th Street, New York, NY, 10032, USA.

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http://dx.doi.org/10.1007/s10557-020-06943-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125070PMC
April 2020

Driver mutations in acute myeloid leukemia.

Curr Opin Hematol 2020 Mar;27(2):49-57

Human Oncology and Pathogenesis Program.

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http://dx.doi.org/10.1097/MOH.0000000000000567DOI Listing
March 2020

Inhibition of the mutated c-KIT kinase in AML1-ETO-positive leukemia cells restores sensitivity to PARP inhibitor.

Blood Adv 2019 12;3(23):4050-4054

Sol Sherry Thrombosis Research Center and Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

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http://dx.doi.org/10.1182/bloodadvances.2019000756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963253PMC
December 2019

Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.

Cell Stem Cell 2019 11 5;25(5):682-696.e8. Epub 2019 Sep 5.

Human Oncology and Pathogenesis Program and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193033
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http://dx.doi.org/10.1016/j.stem.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842438PMC
November 2019

Risk of disease progression in low-risk MDS is linked to distinct epigenetic subtypes.

Leukemia 2019 11 22;33(11):2753-2757. Epub 2019 Jul 22.

Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1038/s41375-019-0518-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842085PMC
November 2019

Genetic and epigenetic determinants of AML pathogenesis.

Semin Hematol 2019 04 22;56(2):84-89. Epub 2018 Aug 22.

Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY.

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https://linkinghub.elsevier.com/retrieve/pii/S00371963183009
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http://dx.doi.org/10.1053/j.seminhematol.2018.08.001DOI Listing
April 2019

Next-generation sequencing in the diagnosis and minimal residual disease assessment of acute myeloid leukemia.

Haematologica 2019 05 28;104(5):868-871. Epub 2019 Mar 28.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

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http://dx.doi.org/10.3324/haematol.2018.205955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518900PMC
May 2019

Unfolding the Role of Calreticulin in Myeloproliferative Neoplasm Pathogenesis.

Clin Cancer Res 2019 05 17;25(10):2956-2962. Epub 2019 Jan 17.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522317PMC
May 2019

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 Mice.

Circ Res 2018 11;123(11):e35-e47

From the Division of Molecular Medicine, Department of Medicine (W.W., W.L., T.F., Y.W., Y.T., C.W., B.C., I.T., A.R.T., N.W.), Columbia University Medical Center, New York, NY.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309796PMC
November 2018

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.

Cancer Cell 2018 10 27;34(4):643-658.e5. Epub 2018 Sep 27.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179449PMC
October 2018

Radioactive Iodine-Related Clonal Hematopoiesis in Thyroid Cancer Is Common and Associated With Decreased Survival.

J Clin Endocrinol Metab 2018 11;103(11):4216-4223

Division of Endocrinology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1210/jc.2018-00803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194804PMC
November 2018

Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil.

Stem Cells 2018 09 8;36(9):1287-1294. Epub 2018 Jun 8.

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1002/stem.2845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125185PMC
September 2018

LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone.

Hemasphere 2018 Jun 8;2(3):e54. Epub 2018 Jun 8.

Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Center for Tumor Biology, Freiburg, Germany.

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http://dx.doi.org/10.1097/HS9.0000000000000054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745991PMC
June 2018

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies.

Cell Stem Cell 2018 02;22(2):157-170

Human Oncology and Pathogenesis Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183001
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http://dx.doi.org/10.1016/j.stem.2018.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804896PMC
February 2018

TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis.

Cell Rep 2018 01;22(5):1250-1262

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183003
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http://dx.doi.org/10.1016/j.celrep.2018.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971064PMC
January 2018

Cohesin mutations in myeloid malignancies made simple.

Curr Opin Hematol 2018 03;25(2):61-66

Human Oncology & Pathogenesis Program, Center for Hematologic Malignancies, and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601335PMC
March 2018

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.

Cancer Cell 2018 01 21;33(1):44-59.e8. Epub 2017 Dec 21.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108173051
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http://dx.doi.org/10.1016/j.ccell.2017.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760367PMC
January 2018

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer Cell 2018 01 14;33(1):29-43.e7. Epub 2017 Dec 14.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760343PMC
January 2018

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation.

EBioMedicine 2017 Dec 21;26:112-125. Epub 2017 Nov 21.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832629PMC
December 2017

Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.

Cell Stem Cell 2017 10 28;21(4):489-501.e7. Epub 2017 Sep 28.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847260PMC
October 2017

Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes.

Cell Stem Cell 2017 09 10;21(3):374-382.e4. Epub 2017 Aug 10.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591073PMC
September 2017

TET2 in Normal and Malignant Hematopoiesis.

Cold Spring Harb Perspect Med 2017 Aug 1;7(8). Epub 2017 Aug 1.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021.

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http://dx.doi.org/10.1101/cshperspect.a026518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538403PMC
August 2017

Cardiovascular disease: Commonality with cancer.

Nature 2017 03 22;543(7643):45-47. Epub 2017 Feb 22.

Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://www.nature.com/articles/nature21505
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http://dx.doi.org/10.1038/nature21505DOI Listing
March 2017

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.

Nat Commun 2016 12 21;7:13829. Epub 2016 Dec 21.

Department of Genetic Medicine, Ansary Stem Cell Institute, Weill Cornell Medical College, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/ncomms13829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187502PMC
December 2016

An Unexpected Chink in the Transcriptional Armor of Plasmacytoid Dendritic Neoplasms.

Cancer Cell 2016 11;30(5):659-660

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.10.016DOI Listing
November 2016

Telomere length and associations with somatic mutations and clinical outcomes in acute myeloid leukemia.

Leuk Res 2016 10 25;49:62-5. Epub 2016 Jul 25.

Leukemia Service, Department of Medicine, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, United States.

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http://dx.doi.org/10.1016/j.leukres.2016.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526052PMC
October 2016