Ross A Soo

Ross A Soo

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Ross A Soo

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The evolving immuno-oncology landscape in advanced lung cancer: first-line treatment of non-small cell lung cancer.

Ther Adv Med Oncol 2019 28;11:1758835919870360. Epub 2019 Aug 28.

Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228, Singapore.

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http://dx.doi.org/10.1177/1758835919870360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716180PMC
August 2019

Somatic mutations and immune checkpoint biomarkers.

Respirology 2019 Mar 12;24(3):215-226. Epub 2019 Jan 12.

Department of Haematology-Oncology, National University Hospital, Singapore.

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http://doi.wiley.com/10.1111/resp.13463
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http://dx.doi.org/10.1111/resp.13463DOI Listing
March 2019

Prognostic significance of immune cells in non-small cell lung cancer: meta-analysis.

Oncotarget 2018 May 15;9(37):24801-24820. Epub 2018 May 15.

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.18632/oncotarget.24835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973851PMC
May 2018

Treatment of EGFR T790M-Positive Non-Small Cell Lung Cancer.

Target Oncol 2018 04;13(2):141-156

Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 7, Singapore, 119228, Singapore.

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http://dx.doi.org/10.1007/s11523-018-0554-5DOI Listing
April 2018

Acquired resistance to EGFR targeted therapy in non-small cell lung cancer: Mechanisms and therapeutic strategies.

Cancer Treat Rev 2018 Apr 20;65:1-10. Epub 2018 Feb 20.

Department of Haematology-Oncology, National University Health System, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2018.02.006DOI Listing
April 2018

Management of epidermal growth factor receptor tyrosine kinase inhibitor-related cutaneous and gastrointestinal toxicities.

Asia Pac J Clin Oncol 2018 Feb 2;14(1):23-31. Epub 2017 May 2.

Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore.

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http://dx.doi.org/10.1111/ajco.12687DOI Listing
February 2018

Third generation EGFR TKIs: current data and future directions.

Mol Cancer 2018 02 19;17(1):29. Epub 2018 Feb 19.

Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 7, Singapore, 119228, Singapore.

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http://dx.doi.org/10.1186/s12943-018-0778-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817792PMC
February 2018

Immune checkpoint inhibitors in epidermal growth factor receptor mutant non-small cell lung cancer: Current controversies and future directions.

Lung Cancer 2018 01 13;115:12-20. Epub 2017 Nov 13.

Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1016/j.lungcan.2017.11.009DOI Listing
January 2018

De-novo and acquired resistance to immune checkpoint targeting.

Lancet Oncol 2017 12;18(12):e731-e741

Department of Haematology-Oncology, National University Cancer Institute, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(17)30607-1DOI Listing
December 2017

Validation of ALK/ROS1 Dual Break Apart FISH Probe probe in non-small-cell lung cancer.

Lung Cancer 2017 09 12;111:79-83. Epub 2017 Jul 12.

Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002173039
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http://dx.doi.org/10.1016/j.lungcan.2017.07.016DOI Listing
September 2017

Treatment options for EGFR mutant NSCLC with CNS involvement-Can patients BLOOM with the use of next generation EGFR TKIs?

Lung Cancer 2017 06 22;108:29-37. Epub 2017 Feb 22.

Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; School of Surgery, The University of Western Australia, Perth, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.02.012DOI Listing
June 2017

Predicting Clinical Outcomes Using Proteomics in Non-Small Cell Lung Cancer-The Past, Present, and Future.

J Thorac Oncol 2017 04;12(4):602-606

Department of Oncology, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.jtho.2017.01.025DOI Listing
April 2017

The KEY to the end of chemotherapy in non-small cell lung cancer?

Ann Transl Med 2017 Apr;5(7):166

Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.

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http://dx.doi.org/10.21037/atm.2017.03.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401674PMC
April 2017

Nivolumab in the treatment of metastatic squamous non-small cell lung cancer: a review of the evidence.

Ther Adv Respir Dis 2016 10 31;10(5):444-54. Epub 2016 Jul 31.

Department of Haematology-Oncology, National University Cancer Institute, National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228

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http://dx.doi.org/10.1177/1753465816661091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933620PMC
October 2016

Profile of nivolumab in the treatment of metastatic squamous non-small-cell lung cancer.

Onco Targets Ther 2016 30;9:3187-95. Epub 2016 May 30.

Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Surgery, University of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.2147/OTT.S84356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892831PMC
August 2016

Dacomitinib in lung cancer: a "lost generation" EGFR tyrosine-kinase inhibitor from a bygone era?

Drug Des Devel Ther 2015 15;9:5641-53. Epub 2015 Oct 15.

National University Health System and Cancer Science Institute of Singapore, Singapore.

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http://dx.doi.org/10.2147/DDDT.S52787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610796PMC
July 2016

Next-generation epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor -mutant non-small cell lung cancer.

Lung Cancer 2016 Mar 8;93:59-68. Epub 2016 Jan 8.

Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; School of Surgery, The University of Western Australia, Perth, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2016.01.003DOI Listing
March 2016

A rapid MZI-IDA sensor system for EGFR mutation testing in non-small cell lung cancer (NSCLC).

Biosens Bioelectron 2015 Dec 26;74:865-71. Epub 2015 Jul 26.

Institute of Microelectronics, A⁎STAR (Agency for Science, Technology and Research), 11 Science Park Road, Singapore Science Park II, 117685 Singapore; Asan Institute for Life Science, Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympicro-43gil, Songpa-gu, Seoul, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2015.07.055DOI Listing
December 2015

Shedding light on the molecular determinants of response to anti-PD-1 therapy.

Authors:
Ross A Soo

Transl Lung Cancer Res 2015 Dec;4(6):816-9

1 Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore ; 2 Cancer Science Institute of Singapore, National University of Singapore, Singapore ; 3 Department of Surgery, University of Western Australia, Western Australia, Australia.

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http://dx.doi.org/10.3978/j.issn.2218-6751.2015.05.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700224PMC
December 2015

Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells.

PLoS One 2014 7;9(7):e99409. Epub 2014 Jul 7.

Mechanobiology Institute, National University of Singapore, Singapore, Singapore; BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore; Clearbridge BioMedics Pte Ltd, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099409PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085042PMC
November 2015

Best practice in the treatment of advanced squamous cell lung cancer.

Ther Adv Respir Dis 2015 Oct 22;9(5):224-35. Epub 2015 Apr 22.

Department of Hematology-Oncology, National University Cancer Institute, National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228

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http://dx.doi.org/10.1177/1753465815581147DOI Listing
October 2015

Rapid and label-free amplification and detection assay for genotyping of cancer biomarker.

Biosens Bioelectron 2015 Jun 18;68:107-114. Epub 2014 Dec 18.

Institute of Microelectronics, A*STAR (Agency for Science, Technology and Research), 11 Science Park Road, Singapore Science Park II, Singapore 117685, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2014.12.039DOI Listing
June 2015

Molecular targeted therapy in the treatment of advanced stage non-small cell lung cancer (NSCLC).

Respirology 2015 Apr 17;20(3):370-8. Epub 2015 Feb 17.

Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore.

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http://dx.doi.org/10.1111/resp.12490DOI Listing
April 2015

Erratum to: does saturable formation of gemcitabine triphosphate occur in patients?

Cancer Chemother Pharmacol 2015 Mar;75(3):657

Department of Hematology-Oncology, National University Hospital, Singapore, Singapore,

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http://dx.doi.org/10.1007/s00280-015-2678-yDOI Listing
March 2015

Nivolumab in NSCLC: latest evidence and clinical potential.

Ther Adv Med Oncol 2015 Mar;7(2):85-96

Department of Haematology-Oncology, National University Cancer Institute, National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228.

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http://journals.sagepub.com/doi/10.1177/1758834014567470
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http://dx.doi.org/10.1177/1758834014567470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346216PMC
March 2015

Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer.

J Clin Oncol 2015 Feb 5;33(5):433-41. Epub 2015 Jan 5.

Suresh S. Ramalingam and Taofeek K. Owonikoko, Winship Cancer Institute of Emory University, Atlanta, GA; Mikhail Shtivelband, Ironwood Cancer and Research Centers, Chandler, AZ; Ross A. Soo, National University Cancer Institute, National University Health System, Singapore, Singapore; Carlos H. Barrios, Pontifícia Universidade Católica do Rio Grande do Sul School of Medicine, Porto Alegre; José G.M. Segalla, Hospital Amaral Carvalho, Jau; Jose R. Pereira, Instituto Brasileiro de Cancerologia Toracica, Sao Paulo, Brazil; Anatoly Makhson, Moscow City Oncology Hospital No. 62; Vera A. Gorbunova, N.N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia; Kenneth B. Pittman, The Queen Elizabeth Hospital, Woodville, South Australia, Australia; Petr Kolman, Hospital Kyjov, Kyjov, Czech Republic; Gordan Srkalovic, Sparrow Regional Cancer Center, Lansing, MI; Chandra P. Belani, Penn State Hershey Cancer Institute, Hershey; Rita Axelrod, Thomas Jefferson University Hospital, Philadelphia, PA; Qin Qin, Jiang Qian, Evelyn M. McKeegan, Viswanath Devanarayan, Mark D. McKee, Justin L. Ricker, and Dawn M. Carlson, AbbVie, North Chicago, IL.

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http://dx.doi.org/10.1200/JCO.2014.55.7173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478045PMC
February 2015

β-catenin contributes to lung tumor development induced by EGFR mutations.

Cancer Res 2014 Oct 27;74(20):5891-902. Epub 2014 Aug 27.

Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Harvard Stem Cell Institute, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199914PMC
October 2014

Immunotherapy in the treatment of non-small cell lung cancer.

Lung Cancer 2014 Aug 14;85(2):101-9. Epub 2014 May 14.

Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Surgery, University of Western Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2014.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332778PMC
August 2014

An ultra-high-throughput spiral microfluidic biochip for the enrichment of circulating tumor cells.

Analyst 2014 Jul;139(13):3245-55

BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore.

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http://dx.doi.org/10.1039/c4an00355aDOI Listing
July 2014

Isolation and retrieval of circulating tumor cells using centrifugal forces.

Sci Rep 2013 12;3:1259. Epub 2013 Feb 12.

Department of Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/srep01259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569917PMC
August 2013

Personalized therapy on the horizon for squamous cell carcinoma of the lung.

Lung Cancer 2013 Jun 13;80(3):249-55. Epub 2013 Mar 13.

Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1016/j.lungcan.2013.02.015DOI Listing
June 2013

Role of FGF receptors as an emerging therapeutic target in lung squamous cell carcinoma.

Future Oncol 2013 Mar;9(3):377-86

Department of Internal Medicine, Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, Seoul 120-752, Korea.

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http://dx.doi.org/10.2217/fon.12.190DOI Listing
March 2013

Targeting ROS1 with anaplastic lymphoma kinase inhibitors: a promising therapeutic strategy for a newly defined molecular subset of non-small-cell lung cancer.

J Thorac Oncol 2012 Nov;7(11):1625-30

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1097/JTO.0b013e31826baf83DOI Listing
November 2012

Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation.

Mol Cancer Ther 2012 Oct 13;11(10):2254-64. Epub 2012 Aug 13.

Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, Republic of Korea.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0311DOI Listing
October 2012

Systemic therapies for pancreatic cancer--the role of pharmacogenetics.

Curr Drug Targets 2012 Jun;13(6):811-28

Department of Hematology-Oncology, National University Health System, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795429PMC
http://dx.doi.org/10.2174/138945012800564068DOI Listing
June 2012

ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway.

Expert Rev Anticancer Ther 2012 Apr;12(4):447-56

Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, Orange, CA 92868, USA.

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http://dx.doi.org/10.1586/era.12.17DOI Listing
April 2012

Differences in outcome and toxicity between Asian and caucasian patients with lung cancer treated with systemic therapy.

Future Oncol 2012 Apr;8(4):451-62

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.2217/fon.12.25DOI Listing
April 2012

Rare subtypes of adenocarcinoma of the lung.

Expert Rev Anticancer Ther 2011 Oct;11(10):1535-42

Department of Medicine, Division of Hematology Oncology, Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, 101 City Drive, Building 56, Orange, CA 92868, USA.

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http://dx.doi.org/10.1586/era.11.99DOI Listing
October 2011

How many adenocarcinoma lung cancers come from bronchioloalveolar carcinoma?

Thorac Cancer 2011 05;2(2):54-60

Department of Hematology-Oncology, National University Hospital, National University Health System, Singapore Department of Diagnostic Imaging, National University Hospital, National University Health System, Singapore Cancer Science Institute of Singapore, National University of Singapore, Singapore Department of Pathology, National University Hospital, National University Health System, Singapore.

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http://doi.wiley.com/10.1111/j.1759-7714.2011.00041.x
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http://dx.doi.org/10.1111/j.1759-7714.2011.00041.xDOI Listing
May 2011

Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.

Cancer Biol Ther 2011 Mar 15;11(6):599-608. Epub 2011 Mar 15.

Cancer Science Institute of Singapore, Center for Life Sciences, National University of Singapore, Singapore.

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http://dx.doi.org/10.4161/cbt.11.6.14670DOI Listing
March 2011

Targeting the tumor vascular supply with vascular disrupting agents.

Authors:
Ross A Soo

J Thorac Dis 2010 Dec;2(4):192-3

Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore;

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http://dx.doi.org/10.3978/j.issn.2072-1439.2010.11.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256470PMC
December 2010

The role of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of advanced stage non-small cell lung cancer.

J Thorac Dis 2010 Sep;2(3):144-53

Department of Hematology-Oncology, National University Cancer Institute, National University Health System, Singapore;

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http://www.jthoracdis.com/article/view/106/187
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http://dx.doi.org/10.3978/j.issn.2072-1439.2010.02.03.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256457PMC
September 2010

Targeted therapy at the end of life for patients with lung cancer.

J Palliat Med 2010 Aug;13(8):945-8

Department of Hematology-Oncology, National University Hospital, National University Health System, Singapore, Singapore.

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http://dx.doi.org/10.1089/jpm.2010.0084DOI Listing
August 2010

The role of monoclonal antibody in combination with first-line chemotherapy in Asian patients with advanced non-small cell lung cancer.

Yonsei Med J 2010 Jan 29;51(1):1-8. Epub 2009 Dec 29.

Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

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https://synapse.koreamed.org/DOIx.php?id=10.3349/ymj.2010.51
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http://dx.doi.org/10.3349/ymj.2010.51.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799980PMC
January 2010

First-line systemic treatment of advanced stage non-small-cell lung cancer in Asia: consensus statement from the Asian Oncology Summit 2009.

Lancet Oncol 2009 Nov;10(11):1102-10

Department of Haematology-Oncology, National University Hospital, and Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1016/S1470-2045(09)70238-4DOI Listing
November 2009

Clinical pharmacology and pharmacogenetics of gemcitabine.

Drug Metab Rev 2009 ;41(2):77-88

Department of Hematology-Oncology, National University Hospital, Singapore.

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http://dx.doi.org/10.1080/03602530902741828DOI Listing
September 2009

Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients.

Lung Cancer 2009 Jan 5;63(1):121-7. Epub 2008 Jun 5.

Department of Haematology-Oncology, National University of Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.

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http://dx.doi.org/10.1016/j.lungcan.2008.04.010DOI Listing
January 2009

Does saturable formation of gemcitabine triphosphate occur in patients?

Cancer Chemother Pharmacol 2008 Dec 28;63(1):55-64. Epub 2008 Feb 28.

Department of Hematology-Oncology, National University Hospital, Singapore.

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http://dx.doi.org/10.1007/s00280-008-0707-9DOI Listing
December 2008

Phase I trial of fixed dose-rate gemcitabine in combination with carboplatin in chemonaive advanced non-small-cell lung cancer: a Cancer Therapeutics Research Group study.

Cancer Chemother Pharmacol 2003 Aug 16;52(2):153-8. Epub 2003 May 16.

Department of Hematology-Oncology, National University Hospital, 5 Lower Kent Ridge Road, 119074, Singapore.

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http://dx.doi.org/10.1007/s00280-003-0637-5DOI Listing
August 2003