Roshan Borkar

Roshan Borkar

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Roshan Borkar

Roshan Borkar

Publications by authors named "Roshan Borkar"

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Formulation and evaluation of cyclodextrin complexes for improved anticancer activity of repurposed drug: Niclosamide.

Carbohydr Polym 2019 May 13;212:252-259. Epub 2019 Feb 13.

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2019.02.041DOI Listing
May 2019

Isolation and structural characterization of degradation products of afatinib dimaleate by LC-Q-TOF/MS/MS and NMR: cytotoxicity evaluation of afatinib and isolated degradation products.

J Pharm Biomed Anal 2019 Mar 7;166:139-146. Epub 2019 Jan 7.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research, IDPL R&D Campus, Balanagar, Hyderabad- 500 037. India. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2019.01.004DOI Listing
March 2019

IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo.

Oncogene 2019 01 30;38(4):581-595. Epub 2018 Aug 30.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hyderabad, TS, India.

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http://dx.doi.org/10.1038/s41388-018-0446-2DOI Listing
January 2019

Identification and characterization of stress degradation products of sumatriptan succinate by using LC/Q-TOF-ESI-MS/MS and NMR: Toxicity evaluation of degradation products.

J Mass Spectrom 2018 Oct 15;53(10):963-975. Epub 2018 Aug 15.

Analytical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.

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http://dx.doi.org/10.1002/jms.4266DOI Listing
October 2018

Identification and structural characterization of in vivo metabolites of balofloxacin in rat plasma, urine and feces samples using Q-TOF/LC/ESI/MS/MS : In silico toxicity studies.

J Pharm Biomed Anal 2018 Sep 28;159:200-211. Epub 2018 Jun 28.

Analytical Department, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.06.050DOI Listing
September 2018

Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles.

Drug Deliv 2017 Nov;24(1):224-232

a Medicinal Chemistry & Pharmacology Division, CSIR-Indian Institute of Chemical Technology , Hyderabad , India.

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http://dx.doi.org/10.1080/10717544.2016.1245366DOI Listing
November 2017

Novel Sulfur Metabolites of Garlic Attenuate Cardiac Hypertrophy and Remodeling through Induction of Na/K-ATPase Expression.

Front Pharmacol 2017 30;8:18. Epub 2017 Jan 30.

Division of Medicinal Chemistry and Pharmacology, Indian Institute of Chemical TechnologyHyderabad, India; Drug Discovery Research Center, Translational Health Science and Technology InstituteFaridabad, India.

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http://journal.frontiersin.org/article/10.3389/fphar.2017.00
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http://dx.doi.org/10.3389/fphar.2017.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5276815PMC
January 2017

Lower Vitamin D Metabolites Levels Were Associated With Increased Coronary Artery Diseases in Type 2 Diabetes Patients in India.

Sci Rep 2016 11 24;6:37593. Epub 2016 Nov 24.

Drug Discovery Research Center, Translational Health Science and Technology Institute (THSTI), Faridabad, HR-121001 (RA, SKB), India.

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http://dx.doi.org/10.1038/srep37593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121614PMC
November 2016

An evaluation of the CYP2D6 and CYP3A4 inhibition potential of metoprolol metabolites and their contribution to drug-drug and drug-herb interaction by LC-ESI/MS/MS.

Biomed Chromatogr 2016 Oct 19;30(10):1556-72. Epub 2016 Apr 19.

National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.

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http://dx.doi.org/10.1002/bmc.3721DOI Listing
October 2016

In vivo metabolic investigation of silodosin using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites.

J Mass Spectrom 2016 Oct;51(10):867-882

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad (NIPER-H), Balanagar, Hyderabad, 500037, Telangana, India.

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http://dx.doi.org/10.1002/jms.3795DOI Listing
October 2016

Identification of leads for antiproliferative activity on MDA-MB-435 human breast cancer cells through pharmacophore and CYP1A1-mediated metabolism.

Eur J Med Chem 2016 Jun 3;115:82-93. Epub 2016 Mar 3.

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab, India.

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http://dx.doi.org/10.1016/j.ejmech.2016.02.061DOI Listing
June 2016

Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice.

Life Sci 2016 Jan 29;144:8-18. Epub 2015 Nov 29.

Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad-500 007, India. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2015.11.018DOI Listing
January 2016

Characterization of degradation products of ivabradine by LC-HR-MS/MS: a typical case of exhibition of different degradation behaviour in HCl and H2SO4 acid hydrolysis.

J Mass Spectrom 2015 Feb;50(2):344-53

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, 500037, Telangana, India.

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http://dx.doi.org/10.1002/jms.3533DOI Listing
February 2015

Plasma protein binding, pharmacokinetics, tissue distribution and CYP450 biotransformation studies of fidarestat by ultra high performance liquid chromatography-high resolution mass spectrometry.

J Pharm Biomed Anal 2015 Jan 19;102:386-99. Epub 2014 Oct 19.

National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad 500 037, India. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2014.10.008DOI Listing
January 2015

Liquid chromatography electrospray ionization tandem mass spectrometry study of nilutamide and its stress degradation products: in silico toxicity prediction of degradation products.

Biomed Chromatogr 2014 Jun;28(6):788-93

National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.

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http://doi.wiley.com/10.1002/bmc.3119
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http://dx.doi.org/10.1002/bmc.3119DOI Listing
June 2014

Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection.

Toxicol Appl Pharmacol 2014 May 14;277(1):8-20. Epub 2014 Mar 14.

Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X140009
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http://dx.doi.org/10.1016/j.taap.2014.02.022DOI Listing
May 2014

Characterization of forced degradation products of ketorolac tromethamine using LC/ESI/Q/TOF/MS/MS and in silico toxicity prediction.

J Mass Spectrom 2014 May;49(5):380-91

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, 500037, AP, India.

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http://dx.doi.org/10.1002/jms.3351DOI Listing
May 2014

Identification of forced degradation products of tamsulosin using liquid chromatography/electrospray ionization tandem mass spectrometry.

J Pharm Biomed Anal 2014 Jan 12;88:245-55. Epub 2013 Sep 12.

National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad 500037, India.

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http://dx.doi.org/10.1016/j.jpba.2013.08.052DOI Listing
January 2014

Development and validation of liquid chromatography-mass spectrometric method for simultaneous determination of moxifloxacin and ketorolac in rat plasma: application to pharmacokinetic study.

Biomed Chromatogr 2012 Nov 15;26(11):1341-7. Epub 2012 Feb 15.

National Centre for Mass Spectrometry, Indian Institute of Chemical Technology, Hyderabad, 500 007, India.

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http://doi.wiley.com/10.1002/bmc.2701
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http://dx.doi.org/10.1002/bmc.2701DOI Listing
November 2012

In vivo metabolic investigation of moxifloxacin using liquid chromatography/electrospray ionization tandem mass spectrometry in combination with online hydrogen/deuterium exchange experiments.

Rapid Commun Mass Spectrom 2012 Aug;26(16):1817-31

National Centre for Mass Spectrometry, Indian Institute of Chemical Technology, Hyderabad, 500 007, India.

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http://dx.doi.org/10.1002/rcm.6288DOI Listing
August 2012

Identification and structural characterization of in vivo metabolites of ketorolac using liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS).

J Mass Spectrom 2012 Jul;47(7):919-31

National Centre for Mass Spectrometry, Indian Institute of Chemical Technology, Hyderabad, 500 007, India.

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http://dx.doi.org/10.1002/jms.3043DOI Listing
July 2012

Identification and characterization of stressed degradation products of metoprolol using LC/Q-TOF-ESI-MS/MS and MS(n) experiments.

Biomed Chromatogr 2012 Jun 12;26(6):720-36. Epub 2011 Oct 12.

National Centre for Mass Spectrometry, Indian Institute of Chemical Technology, Hyderabad, 500 607, India.

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http://doi.wiley.com/10.1002/bmc.1721
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http://dx.doi.org/10.1002/bmc.1721DOI Listing
June 2012