Publications by authors named "Rosella Tiberio"

2 Publications

  • Page 1 of 1

miR-21 is overexpressed in NPM1-mutant acute myeloid leukemias.

Leuk Res 2015 Feb 18;39(2):221-8. Epub 2014 Nov 18.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

MicroRNAs (miRs) play a key role in the pathogenesis of human malignancies and particularly in acute myeloid leukemias (AMLs) and are increasingly recognized as potential biomarkers and therapeutic targets. miR-21 is dysregulated in several types of cancers, including some hematologic malignancies, and plays a key role in carcinogenesis, disease recurrence and metastasis. However, no studies have specifically investigated the role of miR-21 in AMLs. In this study we analyzed the expression of miR-21 and of its target PDCD4 (Programmed Cell Death 4) during normal hematopoietic differentiation and in AMLs. Our results showed that: (i) miR-21 expression is strongly up-modulated during normal granulo/monocytic differentiation, while PDCD4 protein level is concomitantly downmodulated; (ii) miR-21 is frequently overexpressed in AML blasts, in association with a marked PDCD4 protein downmodulation; (iii) miR-21 expression level is particularly elevated in NPM1mutant AMLs. Together, these findings suggest that deregulated miR-21 expression may contribute to disease pathogenesis in NPM1-mutated AMLs.
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http://dx.doi.org/10.1016/j.leukres.2014.11.001DOI Listing
February 2015

Human cord blood-derived hemogenic endothelium generates mast cells.

Blood Cells Mol Dis 2015 Feb 15;54(2):195-7. Epub 2014 Nov 15.

Department of Hmatology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2014.11.002DOI Listing
February 2015