Publications Authored by Rosalind Eeles

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations.

BJU Int 2019 Feb 22;123(2):284-292. Epub 2018 Jun 22.

Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Download full-text PDF	Source
http://dx.doi.org/10.1111/bju.14412	DOI Listing

February 2019

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:

Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2019 Feb;51(2):363

Institute of Cancer Research, London, UK.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41588-018-0330-6	Publisher Site
http://dx.doi.org/10.1038/s41588-018-0330-6	DOI Listing

February 2019

Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel.

Authors:

Daniel A Leongamornlert Edward J Saunders Sarah Wakerell Ian Whitmore Tokhir Dadaev Clara Cieza-Borrella Sarah Benafif Mark N Brook Jenny L Donovan Freddie C Hamdy David E Neal Kenneth Muir Koveela Govindasami David V Conti Zsofia Kote-Jarai Rosalind A Eeles

Eur Urol 2019 Feb 15. Epub 2019 Feb 15.

Oncogenetics, Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, London, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.eururo.2019.01.050	DOI Listing

February 2019

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.

Authors:

Charleen D Adams Rebecca Richmond Diana L Santos Ferreira Wes Spiller Vanessa Tan Jie Zheng Peter Würtz Jenny Donovan Freddie Hamdy David Neal J Athene Lane George Davey Smith Caroline Relton Rosalind A Eeles Christopher A Haiman ZSofia Kote-Jarai Fredrick R Schumacher Ali Amin Al Olama Sara Benlloch Kenneth Muir Sonja I Berndt David V Conti Fredrik Wiklund Stephen J Chanock Susan Gapstur Victoria L Stevens Catherine M Tangen Jyotsna Batra Judith A Clements Henrik Gronberg Nora Pashayan Johanna Schleutker Demetrius Albanes Alicja Wolk Catharine M L West Lorelei A Mucci Géraldine Cancel-Tassin Stella Koutros Karina Dalsgaard Sorensen Lovise Maehle Ruth C Travis Robert J Hamilton Sue Ann Ingles Barry S Rosenstein Yong-Jie Lu Graham G Giles Adam S Kibel Ana Vega Manolis Kogevinas Kathryn L Penney Jong Y Park Janet L Stanford Cezary Cybulski Børge G Nordestgaard Hermann Brenner Christiane Maier Jeri Kim Esther M John Manuel R Teixeira Susan L Neuhausen Kim De Ruyck Azad Razack Lisa F Newcomb Davor Lessel Radka P Kaneva Nawaid Usmani Frank Claessens Paul A Townsend Manuela Gago Dominguez Monique J Roobol Florence Menegaux Kay-Tee Khaw Lisa A Cannon-Albright Hardev Pandha Stephen N Thibodeau Richard M Martin

Cancer Epidemiol Biomarkers Prev 2019 Jan 23;28(1):208-216. Epub 2018 Oct 23.

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.

View Article

Download full-text PDF	Source
http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP	Publisher Site
http://dx.doi.org/10.1158/1055-9965.EPI-18-0079	DOI Listing

January 2019

Author Correction: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions.

Authors:

Nicholas Mancuso Simon Gayther Alexander Gusev Wei Zheng Kathryn L Penney Zsofia Kote-Jarai Rosalind Eeles Matthew Freedman Christopher Haiman Bogdan Pasaniuc

Nat Commun 2019 01 8;10(1):171. Epub 2019 Jan 8.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, 90095, CA, USA.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41467-018-08108-7	Publisher Site
http://dx.doi.org/10.1038/s41467-018-08108-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325152	PMC

January 2019

Author Correction: Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.

Nat Commun 2019 01 8;10(1):157. Epub 2019 Jan 8.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41467-018-08105-w	Publisher Site
http://dx.doi.org/10.1038/s41467-018-08105-w	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325156	PMC

January 2019

Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.

Authors:

Molly Went Amit Sud Asta Försti Britt-Marie Halvarsson Niels Weinhold Scott Kimber Mark van Duin Gudmar Thorleifsson Amy Holroyd David C Johnson Ni Li Giulia Orlando Philip J Law Mina Ali Bowang Chen Jonathan S Mitchell Daniel F Gudbjartsson Rowan Kuiper Owen W Stephens Uta Bertsch Peter Broderick Chiara Campo Obul R Bandapalli Hermann Einsele Walter A Gregory Urban Gullberg Jens Hillengass Per Hoffmann Graham H Jackson Karl-Heinz Jöckel Ellinor Johnsson Sigurður Y Kristinsson Ulf-Henrik Mellqvist Hareth Nahi Douglas Easton Paul Pharoah Alison Dunning Julian Peto Federico Canzian Anthony Swerdlow Rosalind A Eeles Zsofia Kote-Jarai Kenneth Muir Nora Pashayan Jolanta Nickel Markus M Nöthen Thorunn Rafnar Fiona M Ross Miguel Inacio da Silva Filho Hauke Thomsen Ingemar Turesson Annette Vangsted Niels Frost Andersen Anders Waage Brian A Walker Anna-Karin Wihlborg Annemiek Broyl Faith E Davies Unnur Thorsteinsdottir Christian Langer Markus Hansson Hartmut Goldschmidt Martin Kaiser Pieter Sonneveld Kari Stefansson Gareth J Morgan Kari Hemminki Björn Nilsson Richard S Houlston

Nat Commun 2019 01 10;10(1):213. Epub 2019 Jan 10.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41467-018-08107-8	Publisher Site
http://dx.doi.org/10.1038/s41467-018-08107-8	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328616	PMC

January 2019

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

Authors:

Marco Matejcic Edward J Saunders Tokhir Dadaev Mark N Brook Kan Wang Xin Sheng Ali Amin Al Olama Fredrick R Schumacher Sue A Ingles Koveela Govindasami Sara Benlloch Sonja I Berndt Demetrius Albanes Stella Koutros Kenneth Muir Victoria L Stevens Susan M Gapstur Catherine M Tangen Jyotsna Batra Judith Clements Henrik Gronberg Nora Pashayan Johanna Schleutker Alicja Wolk Catharine West Lorelei Mucci Peter Kraft Géraldine Cancel-Tassin Karina D Sorensen Lovise Maehle Eli M Grindedal Sara S Strom David E Neal Freddie C Hamdy Jenny L Donovan Ruth C Travis Robert J Hamilton Barry Rosenstein Yong-Jie Lu Graham G Giles Adam S Kibel Ana Vega Jeanette T Bensen Manolis Kogevinas Kathryn L Penney Jong Y Park Janet L Stanford Cezary Cybulski Børge G Nordestgaard Hermann Brenner Christiane Maier Jeri Kim Manuel R Teixeira Susan L Neuhausen Kim De Ruyck Azad Razack Lisa F Newcomb Davor Lessel Radka Kaneva Nawaid Usmani Frank Claessens Paul A Townsend Manuela Gago-Dominguez Monique J Roobol Florence Menegaux Kay-Tee Khaw Lisa A Cannon-Albright Hardev Pandha Stephen N Thibodeau Daniel J Schaid Fredrik Wiklund Stephen J Chanock Douglas F Easton Rosalind A Eeles Zsofia Kote-Jarai David V Conti Christopher A Haiman

Nat Commun 2019 01 17;10(1):382. Epub 2019 Jan 17.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90033, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-019-08293-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336778	PMC

January 2019

Author Correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.

Nat Commun 2019 01 21;10(1):419. Epub 2019 Jan 21.

Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41467-018-08106-9	Publisher Site
http://dx.doi.org/10.1038/s41467-018-08106-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341085	PMC

January 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:

Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-018-08054-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624	PMC

January 2019

DESNT: A Poor Prognosis Category of Human Prostate Cancer.

Eur Urol Focus 2018 12 6;4(6):842-850. Epub 2017 Mar 6.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, UK. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.euf.2017.01.016	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669460	PMC

December 2018

AA9int: SNP interaction pattern search using non-hierarchical additive model set.

Bioinformatics 2018 Dec;34(24):4141-4150

Department of Cancer Epidemiology Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/bioinformatics/bty461	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289141	PMC

December 2018

Homeobox B13 G84E Mutation and Prostate Cancer Risk.

Authors:

Tommy Nyberg Koveela Govindasami Goska Leslie Tokhir Dadaev Elizabeth Bancroft Holly Ni Raghallaigh Mark N Brook Nafisa Hussain Diana Keating Andrew Lee Romayne McMahon Angela Morgan Andrea Mullen Andrea Osborne Reshma Rageevakumar Zsofia Kote-Jarai Rosalind Eeles Antonis C Antoniou

Eur Urol 2018 Dec 7. Epub 2018 Dec 7.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF	Source
https://linkinghub.elsevier.com/retrieve/pii/S03022838183087	Publisher Site
http://dx.doi.org/10.1016/j.eururo.2018.11.015	DOI Listing

December 2018

Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study.

Int J Epidemiol 2018 Dec 28. Epub 2018 Dec 28.

Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.

View Article

Download full-text PDF	Source
https://academic.oup.com/ije/advance-article/doi/10.1093/ije	Publisher Site
http://dx.doi.org/10.1093/ije/dyy284	DOI Listing

December 2018

Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.

Blood 2018 Nov 7;132(19):2040-2052. Epub 2018 Sep 7.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1182/blood-2018-06-855296	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236462	PMC

November 2018

Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

Authors:

Marco Matejcic Edward J Saunders Tokhir Dadaev Mark N Brook Kan Wang Xin Sheng Ali Amin Al Olama Fredrick R Schumacher Sue A Ingles Koveela Govindasami Sara Benlloch Sonja I Berndt Demetrius Albanes Stella Koutros Kenneth Muir Victoria L Stevens Susan M Gapstur Catherine M Tangen Jyotsna Batra Judith Clements Henrik Gronberg Nora Pashayan Johanna Schleutker Alicja Wolk Catharine West Lorelei Mucci Peter Kraft Géraldine Cancel-Tassin Karina D Sorensen Lovise Maehle Eli M Grindedal Sara S Strom David E Neal Freddie C Hamdy Jenny L Donovan Ruth C Travis Robert J Hamilton Barry Rosenstein Yong-Jie Lu Graham G Giles Adam S Kibel Ana Vega Jeanette T Bensen Manolis Kogevinas Kathryn L Penney Jong Y Park Janet L Stanford Cezary Cybulski Børge G Nordestgaard Hermann Brenner Christiane Maier Jeri Kim Manuel R Teixeira Susan L Neuhausen Kim De Ruyck Azad Razack Lisa F Newcomb Davor Lessel Radka Kaneva Nawaid Usmani Frank Claessens Paul A Townsend Manuela Gago-Dominguez Monique J Roobol Florence Menegaux Kay-Tee Khaw Lisa A Cannon-Albright Hardev Pandha Stephen N Thibodeau Daniel J Schaid Fredrik Wiklund Stephen J Chanock Douglas F Easton Rosalind A Eeles Zsofia Kote-Jarai David V Conti Christopher A Haiman

Nat Commun 2018 11 5;9(1):4616. Epub 2018 Nov 5.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90033, USA.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41467-018-06863-1	Publisher Site
http://dx.doi.org/10.1038/s41467-018-06863-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218483	PMC

November 2018

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions.

Authors:

Nicholas Mancuso Simon Gayther Alexander Gusev Wei Zheng Kathryn L Penney Zsofia Kote-Jarai Rosalind Eeles Matthew Freedman Christopher Haiman Bogdan Pasaniuc

Nat Commun 2018 10 4;9(1):4079. Epub 2018 Oct 4.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, 90095, CA, USA.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41467-018-06302-1	Publisher Site
http://dx.doi.org/10.1038/s41467-018-06302-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172280	PMC

October 2018

Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology.

Eur Urol 2018 09 21;74(3):248-252. Epub 2018 Jun 21.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; William Harvey Research Institute, Queen Mary University, London, UK; Department of Clinical Genetics, Guys and St Thomas NHS Foundation Trust, London, UK; Public Health England, National Cancer Registration and Analysis Service, London, UK. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.eururo.2018.05.036	DOI Listing

September 2018

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.

Authors:

Molly Went Amit Sud Asta Försti Britt-Marie Halvarsson Niels Weinhold Scott Kimber Mark van Duin Gudmar Thorleifsson Amy Holroyd David C Johnson Ni Li Giulia Orlando Philip J Law Mina Ali Bowang Chen Jonathan S Mitchell Daniel F Gudbjartsson Rowan Kuiper Owen W Stephens Uta Bertsch Peter Broderick Chiara Campo Obul R Bandapalli Hermann Einsele Walter A Gregory Urban Gullberg Jens Hillengass Per Hoffmann Graham H Jackson Karl-Heinz Jöckel Ellinor Johnsson Sigurður Y Kristinsson Ulf-Henrik Mellqvist Hareth Nahi Douglas Easton Paul Pharoah Alison Dunning Julian Peto Federico Canzian Anthony Swerdlow Rosalind A Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan Jolanta Nickel Markus M Nöthen Thorunn Rafnar Fiona M Ross Miguel Inacio da Silva Filho Hauke Thomsen Ingemar Turesson Annette Vangsted Niels Frost Andersen Anders Waage Brian A Walker Anna-Karin Wihlborg Annemiek Broyl Faith E Davies Unnur Thorsteinsdottir Christian Langer Markus Hansson Hartmut Goldschmidt Martin Kaiser Pieter Sonneveld Kari Stefansson Gareth J Morgan Kari Hemminki Björn Nilsson Richard S Houlston

Nat Commun 2018 09 13;9(1):3707. Epub 2018 Sep 13.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41467-018-04989-w	Publisher Site
http://dx.doi.org/10.1038/s41467-018-04989-w	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137048	PMC

September 2018

A Review of Prostate Cancer Genome-Wide Association Studies (GWAS).

Authors:

Sarah Benafif Zsofia Kote-Jarai Rosalind A Eeles

Cancer Epidemiol Biomarkers Prev 2018 Aug 18;27(8):845-857. Epub 2018 Jan 18.

The Institute of Cancer Research, Sutton, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/1055-9965.EPI-16-1046	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051932	PMC

August 2018

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:

Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2018 Jul 11;50(7):928-936. Epub 2018 Jun 11.

Institute of Cancer Research, London, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41588-018-0142-8	DOI Listing

July 2018

Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease.

Authors:

Martina Mijuskovic Edward J Saunders Daniel A Leongamornlert Sarah Wakerell Ian Whitmore Tokhir Dadaev Clara Cieza-Borrella Koveela Govindasami Mark N Brook Christopher A Haiman David V Conti Rosalind A Eeles Zsofia Kote-Jarai

Br J Cancer 2018 Jul 19;119(1):96-104. Epub 2018 Jun 19.

Oncogenetics, Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41416-018-0141-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035259	PMC

July 2018

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

Authors:

Tokhir Dadaev Edward J Saunders Paul J Newcombe Ezequiel Anokian Daniel A Leongamornlert Mark N Brook Clara Cieza-Borrella Martina Mijuskovic Sarah Wakerell Ali Amin Al Olama Fredrick R Schumacher Sonja I Berndt Sara Benlloch Mahbubl Ahmed Chee Goh Xin Sheng Zhuo Zhang Kenneth Muir Koveela Govindasami Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Hakansson Catharine West Alison M Dunning Neil Burnet Lorelei Mucci Edward Giovannucci Gerald Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry Rosenstein Sarah Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Laura Fachal Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weisher Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Chavdar Slavov Vanio Mitev Matthew Parliament Sandeep Singhal Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Andrzej Kierzek Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Peter Kraft Matthew Freedman Fredrik Wiklund Stephen Chanock Brian E Henderson Douglas F Easton Christopher A Haiman Rosalind A Eeles David V Conti Zsofia Kote-Jarai

Nat Commun 2018 06 11;9(1):2256. Epub 2018 Jun 11.

The Institute of Cancer Research, London, SW7 3RP, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-018-04109-8	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995836	PMC

June 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Authors:

David C Wedge Gunes Gundem Thomas Mitchell Dan J Woodcock Inigo Martincorena Mohammed Ghori Jorge Zamora Adam Butler Hayley Whitaker Zsofia Kote-Jarai Ludmil B Alexandrov Peter Van Loo Charlie E Massie Stefan Dentro Anne Y Warren Clare Verrill Dan M Berney Nening Dennis Sue Merson Steve Hawkins William Howat Yong-Jie Lu Adam Lambert Jonathan Kay Barbara Kremeyer Katalin Karaszi Hayley Luxton Niedzica Camacho Luke Marsden Sandra Edwards Lucy Matthews Valeria Bo Daniel Leongamornlert Stuart McLaren Anthony Ng Yongwei Yu Hongwei Zhang Tokhir Dadaev Sarah Thomas Douglas F Easton Mahbubl Ahmed Elizabeth Bancroft Cyril Fisher Naomi Livni David Nicol Simon Tavaré Pelvender Gill Christopher Greenman Vincent Khoo Nicholas Van As Pardeep Kumar Christopher Ogden Declan Cahill Alan Thompson Erik Mayer Edward Rowe Tim Dudderidge Vincent Gnanapragasam Nimish C Shah Keiran Raine David Jones Andrew Menzies Lucy Stebbings Jon Teague Steven Hazell Cathy Corbishley Johann de Bono Gerhardt Attard William Isaacs Tapio Visakorpi Michael Fraser Paul C Boutros Robert G Bristow Paul Workman Chris Sander Freddie C Hamdy Andrew Futreal Ultan McDermott Bissan Al-Lazikani Andrew G Lynch G Steven Bova Christopher S Foster Daniel S Brewer David E Neal Colin S Cooper Rosalind A Eeles

Nat Genet 2018 May 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/s41588-018-0086-z	Publisher Site
http://dx.doi.org/10.1038/s41588-018-0086-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064	PMC

May 2018

Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.

Nat Commun 2018 04 9;9(1):1340. Epub 2018 Apr 9.

Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-018-03178-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890276	PMC

April 2018

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.

Br J Cancer 2018 Mar 13;118(6):e9. Epub 2018 Feb 13.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/bjc.2017.468	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877430	PMC

March 2018

Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium.

Br J Cancer 2018 Mar 13;118(6):e16. Epub 2018 Feb 13.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/bjc.2018.6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877441	PMC

March 2018

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition.

Authors:

Christos Mikropoulos Christina G Hutten Selkirk Sibel Saya Elizabeth Bancroft Emily Vertosick Tokhir Dadaev Charles Brendler Elizabeth Page Alexander Dias D Gareth Evans Jeanette Rothwell Lovise Maehle Karol Axcrona Kate Richardson Diana Eccles Thomas Jensen Palle J Osther Christi J van Asperen Hans Vasen Lambertus A Kiemeney Janneke Ringelberg Cezary Cybulski Dominika Wokolorczyk Rachel Hart Wayne Glover Jimmy Lam Louise Taylor Monica Salinas Lidia Feliubadaló Rogier Oldenburg Ruben Cremers Gerald Verhaegh Wendy A van Zelst-Stams Jan C Oosterwijk Jackie Cook Derek J Rosario Saundra S Buys Tom Conner Susan Domchek Jacquelyn Powers Margreet G E M Ausems Manuel R Teixeira Sofia Maia Louise Izatt Rita Schmutzler Kerstin Rhiem William D Foulkes Talia Boshari Rosemarie Davidson Marielle Ruijs Apollonia T J M Helderman-van den Enden Lesley Andrews Lisa Walker Katie Snape Alex Henderson Irene Jobson Geoffrey J Lindeman Annelie Liljegren Marion Harris Muriel A Adank Judy Kirk Amy Taylor Rachel Susman Rakefet Chen-Shtoyerman Nicholas Pachter Allan Spigelman Lucy Side Janez Zgajnar Josefina Mora Carole Brewer Neus Gadea Angela F Brady David Gallagher Theo van Os Alan Donaldson Vigdis Stefansdottir Julian Barwell Paul A James Declan Murphy Eitan Friedman Nicola Nicolai Lynn Greenhalgh Elias Obeid Vedang Murthy Lucia Copakova John McGrath Soo-Hwang Teo Sara Strom Karin Kast Daniel A Leongamornlert Anthony Chamberlain Jenny Pope Anna C Newlin Neil Aaronson Audrey Ardern-Jones Chris Bangma Elena Castro David Dearnaley Jorunn Eyfjord Alison Falconer Christopher S Foster Henrik Gronberg Freddie C Hamdy Oskar Johannsson Vincent Khoo Jan Lubinski Eli Marie Grindedal Joanne McKinley Kylie Shackleton Anita V Mitra Clare Moynihan Gad Rennert Mohnish Suri Karen Tricker Sue Moss Zsofia Kote-Jarai Andrew Vickers Hans Lilja Brian T Helfand Rosalind A Eeles

Br J Cancer 2018 Mar 6;118(6):e17. Epub 2018 Mar 6.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/bjc.2018.11	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877440	PMC

March 2018

Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.

Authors:

Chey Loveday Kevin Litchfield Max Levy Amy Holroyd Peter Broderick Zsofia Kote-Jarai Alison M Dunning Kenneth Muir Julian Peto Rosalind Eeles Douglas F Easton Darshna Dudakia Nick Orr Nora Pashayan Alison Reid Robert A Huddart Richard S Houlston Clare Turnbull

Oncotarget 2018 Feb 7;9(16):12630-12638. Epub 2017 Dec 7.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.18632/oncotarget.23117	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849160	PMC

February 2018

Men with a susceptibility to prostate cancer and the role of genetic based screening.

Authors:

Rosalind Eeles Holly Ni Raghallaigh

Transl Androl Urol 2018 Feb;7(1):61-69

Division of Genetics & Epidemiology, Institute of Cancer Research, Sutton, London, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.21037/tau.2017.12.30	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861282	PMC

February 2018

RAZOR: A Phase II Open Randomized Trial of Screening Plus Goserelin and Raloxifene Versus Screening Alone in Premenopausal Women at Increased Risk of Breast Cancer.

Authors:

Anthony Howell Linda Ashcroft Lesley Fallowfield Diana M Eccles Rosalind A Eeles Ann Ward Adam R Brentnall Mitchell Dowsett Jack M Cuzick Rosemary Greenhalgh Caroline Boggis Jamie Motion Jamie C Sergeant Judith Adams D Gareth Evans

Cancer Epidemiol Biomarkers Prev 2018 01 2;27(1):58-66. Epub 2017 Nov 2.

Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester, Manchester, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/1055-9965.EPI-17-0158	DOI Listing

January 2018

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition.

Authors:

Christos Mikropoulos Christina G Hutten Selkirk Sibel Saya Elizabeth Bancroft Emily Vertosick Tokhir Dadaev Charles Brendler Elizabeth Page Alexander Dias D Gareth Evans Jeanette Rothwell Lovise Maehle Karol Axcrona Kate Richardson Diana Eccles Thomas Jensen Palle J Osther Christi J van Asperen Hans Vasen Lambertus A Kiemeney Janneke Ringelberg Cezary Cybulski Dominika Wokolorczyk Rachel Hart Wayne Glover Jimmy Lam Louise Taylor Monica Salinas Lidia Feliubadaló Rogier Oldenburg Ruben Cremers Gerald Verhaegh Wendy A van Zelst-Stams Jan C Oosterwijk Jackie Cook Derek J Rosario Saundra S Buys Tom Conner Susan Domchek Jacquelyn Powers Margreet Gem Ausems Manuel R Teixeira Sofia Maia Louise Izatt Rita Schmutzler Kerstin Rhiem William D Foulkes Talia Boshari Rosemarie Davidson Marielle Ruijs Apollonia Tjm Helderman-van den Enden Lesley Andrews Lisa Walker Katie Snape Alex Henderson Irene Jobson Geoffrey J Lindeman Annelie Liljegren Marion Harris Muriel A Adank Judy Kirk Amy Taylor Rachel Susman Rakefet Chen-Shtoyerman Nicholas Pachter Allan Spigelman Lucy Side Janez Zgajnar Josefina Mora Carole Brewer Neus Gadea Angela F Brady David Gallagher Theo van Os Alan Donaldson Vigdis Stefansdottir Julian Barwell Paul A James Declan Murphy Eitan Friedman Nicola Nicolai Lynn Greenhalgh Elias Obeid Vedang Murthy Lucia Copakova John McGrath Soo-Hwang Teo Sara Strom Karin Kast Daniel A Leongamornlert Anthony Chamberlain Jenny Pope Anna C Newlin Neil Aaronson Audrey Ardern-Jones Chris Bangma Elena Castro David Dearnaley Jorunn Eyfjord Alison Falconer Christopher S Foster Henrik Gronberg Freddie C Hamdy Oskar Johannsson Vincent Khoo Jan Lubinski Eli Marie Grindedal Joanne McKinley Kylie Shackleton Anita V Mitra Clare Moynihan Gad Rennert Mohnish Suri Karen Tricker Sue Moss Zsofia Kote-Jarai Andrew Vickers Hans Lilja Brian T Helfand Rosalind A Eeles

Br J Cancer 2018 01 4;118(2):266-276. Epub 2018 Jan 4.

The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/bjc.2017.429	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785754	PMC

January 2018

Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.

Authors:

Tyler M Seibert Chun Chieh Fan Yunpeng Wang Verena Zuber Roshan Karunamuni J Kellogg Parsons Rosalind A Eeles Douglas F Easton ZSofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Garcia Kenneth Muir Henrik Grönberg Fredrik Wiklund Markus Aly Johanna Schleutker Csilla Sipeky Teuvo Lj Tammela Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg M Andreas Røder Peter Iversen Tim J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul Pharoah Nora Pashayan Kay-Tee Khaw Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Dominika Wokolorczyk Wojciech Kluzniak Lisa Cannon-Albright Hermann Brenner Katarina Cuk Kai-Uwe Saum Jong Y Park Thomas A Sellers Chavdar Slavov Radka Kaneva Vanio Mitev Jyotsna Batra Judith A Clements Amanda Spurdle Manuel R Teixeira Paula Paulo Sofia Maia Hardev Pandha Agnieszka Michael Andrzej Kierzek David S Karow Ian G Mills Ole A Andreassen Anders M Dale

BMJ 2018 01 10;360:j5757. Epub 2018 Jan 10.

Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA

View Article

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759091	PMC
http://dx.doi.org/10.1136/bmj.j5757	DOI Listing

January 2018

Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis.

JAMA Oncol 2017 12;3(12):1634-1639

Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1001/jamaoncol.2017.1968	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824277	PMC

December 2017

Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.

Nat Commun 2017 12 1;8(1):1892. Epub 2017 Dec 1.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41467-017-00320-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711884	PMC

December 2017

Effect on Overall Survival of Locoregional Treatment in a Cohort of De Novo Metastatic Prostate Cancer Patients: A Single Institution Retrospective Analysis From the Royal Marsden Hospital.

Clin Genitourin Cancer 2017 10 26;15(5):e801-e807. Epub 2017 Apr 26.

The Institute of Cancer Research, London, United Kingdom. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.clgc.2017.04.013	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647264	PMC

October 2017

Quantifying the Genetic Correlation between Multiple Cancer Types.

Cancer Epidemiol Biomarkers Prev 2017 09 21;26(9):1427-1435. Epub 2017 Jun 21.

Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/1055-9965.EPI-17-0211	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582139	PMC

September 2017

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data.

Authors:

Niedzica Camacho Peter Van Loo Sandra Edwards Jonathan D Kay Lucy Matthews Kerstin Haase Jeremy Clark Nening Dennis Sarah Thomas Barbara Kremeyer Jorge Zamora Adam P Butler Gunes Gundem Sue Merson Hayley Luxton Steve Hawkins Mohammed Ghori Luke Marsden Adam Lambert Katalin Karaszi Gill Pelvender Charlie E Massie Zsofia Kote-Jarai Keiran Raine David Jones William J Howat Steven Hazell Naomi Livni Cyril Fisher Christopher Ogden Pardeep Kumar Alan Thompson David Nicol Erik Mayer Tim Dudderidge Yongwei Yu Hongwei Zhang Nimish C Shah Vincent J Gnanapragasam William Isaacs Tapio Visakorpi Freddie Hamdy Dan Berney Clare Verrill Anne Y Warren David C Wedge Andrew G Lynch Christopher S Foster Yong Jie Lu G Steven Bova Hayley C Whitaker Ultan McDermott David E Neal Rosalind Eeles Colin S Cooper Daniel S Brewer

PLoS Genet 2017 Sep 25;13(9):e1007001. Epub 2017 Sep 25.

Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1371/journal.pgen.1007001	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628936	PMC

September 2017

Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium.

Br J Cancer 2017 Aug 1;117(5):734-743. Epub 2017 Aug 1.

Centre of Epidemiology, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/bjc.2017.231	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572182	PMC

August 2017

Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.

Authors:

David V Conti Kan Wang Xin Sheng Jeannette T Bensen Dennis J Hazelett Michael B Cook Sue A Ingles Rick A Kittles Sara S Strom Benjamin A Rybicki Barbara Nemesure William B Isaacs Janet L Stanford Wei Zheng Maureen Sanderson Esther M John Jong Y Park Jianfeng Xu Victoria L Stevens Sonja I Berndt Chad D Huff Zhaoming Wang Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Thomas A Sellers Kosj Yamoah Adam B Murphy Dana C Crawford Susan M Gapstur William S Bush Melinda C Aldrich Olivier Cussenot Gyorgy Petrovics Jennifer Cullen Christine Neslund-Dudas Mariana C Stern Zsofia-Kote Jarai Koveela Govindasami Anand P Chokkalingam Ann W Hsing Phyllis J Goodman Thomas Hoffmann Bettina F Drake Jennifer J Hu Peter E Clark Stephen K Van Den Eeden Pascal Blanchet Jay H Fowke Graham Casey Anselm J M Hennis Ying Han Alexander Lubwama Ian M Thompson Robin Leach Douglas F Easton Fredrick Schumacher David J Van den Berg Susan M Gundell Alex Stram Peggy Wan Lucy Xia Loreall C Pooler James L Mohler Elizabeth T H Fontham Gary J Smith Jack A Taylor Shiv Srivastava Rosalind A Eeles John Carpten Adam S Kibel Luc Multigner Marie-Elise Parent Florence Menegaux Geraldine Cancel-Tassin Eric A Klein Laurent Brureau Daniel O Stram Stephen Watya Stephen J Chanock John S Witte William J Blot Brian E Henderson Christopher A Haiman

J Natl Cancer Inst 2017 08;109(8)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/jnci/djx084	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448553	PMC

August 2017

Baseline results from the UK SIGNIFY study: a whole-body MRI screening study in TP53 mutation carriers and matched controls.

Fam Cancer 2017 07;16(3):433-440

The Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, London, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1007/s10689-017-9965-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487773	PMC

July 2017

Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor.

Nat Genet 2017 Jul 12;49(7):1133-1140. Epub 2017 Jun 12.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/ng.3896	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016736	PMC

July 2017

Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium.

Authors:

Reka Toth Dominique Scherer Linda E Kelemen Angela Risch Aditi Hazra Yesilda Balavarca Jean-Pierre J Issa Victor Moreno Rosalind A Eeles Shuji Ogino Xifeng Wu Yuanqing Ye Rayjean J Hung Ellen L Goode Cornelia M Ulrich

Cancer Epidemiol Biomarkers Prev 2017 06 23;26(6):816-825. Epub 2017 Jan 23.

National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/1055-9965.EPI-16-0728	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054308	PMC

June 2017

gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels.

Genet Epidemiol 2017 05 16;41(4):297-308. Epub 2017 Feb 16.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1002/gepi.22036	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397327	PMC

May 2017

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Authors:

Philip C Haycock Stephen Burgess Aayah Nounu Jie Zheng George N Okoli Jack Bowden Kaitlin Hazel Wade Nicholas J Timpson David M Evans Peter Willeit Abraham Aviv Tom R Gaunt Gibran Hemani Massimo Mangino Hayley Patricia Ellis Kathreena M Kurian Karen A Pooley Rosalind A Eeles Jeffrey E Lee Shenying Fang Wei V Chen Matthew H Law Lisa M Bowdler Mark M Iles Qiong Yang Bradford B Worrall Hugh Stephen Markus Rayjean J Hung Chris I Amos Amanda B Spurdle Deborah J Thompson Tracy A O'Mara Brian Wolpin Laufey Amundadottir Rachael Stolzenberg-Solomon Antonia Trichopoulou N Charlotte Onland-Moret Eiliv Lund Eric J Duell Federico Canzian Gianluca Severi Kim Overvad Marc J Gunter Rosario Tumino Ulrika Svenson Andre van Rij Annette F Baas Matthew J Bown Nilesh J Samani Femke N G van t'Hof Gerard Tromp Gregory T Jones Helena Kuivaniemi James R Elmore Mattias Johansson James Mckay Ghislaine Scelo Robert Carreras-Torres Valerie Gaborieau Paul Brennan Paige M Bracci Rachel E Neale Sara H Olson Steven Gallinger Donghui Li Gloria M Petersen Harvey A Risch Alison P Klein Jiali Han Christian C Abnet Neal D Freedman Philip R Taylor John M Maris Katja K Aben Lambertus A Kiemeney Sita H Vermeulen John K Wiencke Kyle M Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew-Kee Low Krina T Zondervan Grant W Montgomery Dale R Nyholt David A van Heel Karen Hunt Dan E Arking Foram N Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand Mary E Comeau W Mark Brown Edwin K Silverman John E Hokanson Michael H Cho Jennie Hui Manuel A Ferreira Philip J Thompson Alanna C Morrison Janine F Felix Nicholas L Smith Angela M Christiano Lynn Petukhova Regina C Betz Xing Fan Xuejun Zhang Caihong Zhu Carl D Langefeld Susan D Thompson Feijie Wang Xu Lin David A Schwartz Tasha Fingerlin Jerome I Rotter Mary Frances Cotch Richard A Jensen Matthias Munz Henrik Dommisch Arne S Schaefer Fang Han Hanna M Ollila Ryan P Hillary Omar Albagha Stuart H Ralston Chenjie Zeng Wei Zheng Xiao-Ou Shu Andre Reis Steffen Uebe Ulrike Hüffmeier Yoshiya Kawamura Takeshi Otowa Tsukasa Sasaki Martin Lloyd Hibberd Sonia Davila Gang Xie Katherine Siminovitch Jin-Xin Bei Yi-Xin Zeng Asta Försti Bowang Chen Stefano Landi Andre Franke Annegret Fischer David Ellinghaus Carlos Flores Imre Noth Shwu-Fan Ma Jia Nee Foo Jianjun Liu Jong-Won Kim David G Cox Olivier Delattre Olivier Mirabeau Christine F Skibola Clara S Tang Merce Garcia-Barcelo Kai-Ping Chang Wen-Hui Su Yu-Sun Chang Nicholas G Martin Scott Gordon Tracey D Wade Chaeyoung Lee Michiaki Kubo Pei-Chieng Cha Yusuke Nakamura Daniel Levy Masayuki Kimura Shih-Jen Hwang Steven Hunt Tim Spector Nicole Soranzo Ani W Manichaikul R Graham Barr Bratati Kahali Elizabeth Speliotes Laura M Yerges-Armstrong Ching-Yu Cheng Jost B Jonas Tien Yin Wong Isabella Fogh Kuang Lin John F Powell Kenneth Rice Caroline L Relton Richard M Martin George Davey Smith

JAMA Oncol 2017 May;3(5):636-651

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1001/jamaoncol.2016.5945	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638008	PMC

May 2017

SNP interaction pattern identifier (SIPI): an intensive search for SNP-SNP interaction patterns.

Bioinformatics 2017 03;33(6):822-833

Department of Cancer Epidemiology, Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/bioinformatics/btw762	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860469	PMC

March 2017

seXY: a tool for sex inference from genotype arrays.

Authors:

David C Qian Jonathan A Busam Xiangjun Xiao Tracy A O'Mara Rosalind A Eeles Frederick R Schumacher Catherine M Phelan Christopher I Amos

Bioinformatics 2017 02;33(4):561-563

Department of Biomedical Data Science, Dartmouth Geisel School of Medicine, Lebanon, NH 03756, USA.

View Article

Download full-text PDF	Source
https://academic.oup.com/bioinformatics/article-lookup/doi/1	Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btw696	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041889	PMC

February 2017

Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study.

Int J Cancer 2017 Jan 8;140(1):75-85. Epub 2016 Oct 8.

School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1002/ijc.30436	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111609	PMC

January 2017

The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.

Authors:

Christopher I Amos Joe Dennis Zhaoming Wang Jinyoung Byun Fredrick R Schumacher Simon A Gayther Graham Casey David J Hunter Thomas A Sellers Stephen B Gruber Alison M Dunning Kyriaki Michailidou Laura Fachal Kimberly Doheny Amanda B Spurdle Yafang Li Xiangjun Xiao Jane Romm Elizabeth Pugh Gerhard A Coetzee Dennis J Hazelett Stig E Bojesen Charlisse Caga-Anan Christopher A Haiman Ahsan Kamal Craig Luccarini Daniel Tessier Daniel Vincent François Bacot David J Van Den Berg Stefanie Nelson Stephen Demetriades David E Goldgar Fergus J Couch Judith L Forman Graham G Giles David V Conti Heike Bickeböller Angela Risch Melanie Waldenberger Irene Brüske-Hohlfeld Belynda D Hicks Hua Ling Lesley McGuffog Andrew Lee Karoline Kuchenbaecker Penny Soucy Judith Manz Julie M Cunningham Katja Butterbach Zsofia Kote-Jarai Peter Kraft Liesel FitzGerald Sara Lindström Marcia Adams James D McKay Catherine M Phelan Sara Benlloch Linda E Kelemen Paul Brennan Marjorie Riggan Tracy A O'Mara Hongbing Shen Yongyong Shi Deborah J Thompson Marc T Goodman Sune F Nielsen Andrew Berchuck Sylvie Laboissiere Stephanie L Schmit Tameka Shelford Christopher K Edlund Jack A Taylor John K Field Sue K Park Kenneth Offit Mads Thomassen Rita Schmutzler Laura Ottini Rayjean J Hung Jonathan Marchini Ali Amin Al Olama Ulrike Peters Rosalind A Eeles Michael F Seldin Elizabeth Gillanders Daniela Seminara Antonis C Antoniou Paul D P Pharoah Georgia Chenevix-Trench Stephen J Chanock Jacques Simard Douglas F Easton

Cancer Epidemiol Biomarkers Prev 2017 01 3;26(1):126-135. Epub 2016 Oct 3.

Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/1055-9965.EPI-16-0106	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224974	PMC

January 2017

Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis.

Int J Cancer 2017 Jan 26;140(2):322-328. Epub 2016 Oct 26.

MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1002/ijc.30462	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132137	PMC

January 2017

Telomere structure and maintenance gene variants and risk of five cancer types.

Authors:

Sara Karami Younghun Han Mala Pande Iona Cheng James Rudd Brandon L Pierce Ellen L Nutter Fredrick R Schumacher Zsofia Kote-Jarai Sara Lindstrom John S Witte Shenying Fang Jiali Han Peter Kraft David J Hunter Fengju Song Rayjean J Hung James McKay Stephen B Gruber Stephen J Chanock Angela Risch Hongbing Shen Christopher A Haiman Lisa Boardman Cornelia M Ulrich Graham Casey Ulrike Peters Ali Amin Al Olama Andrew Berchuck Sonja I Berndt Stephane Bezieau Paul Brennan Hermann Brenner Louise Brinton Neil Caporaso Andrew T Chan Jenny Chang-Claude David C Christiani Julie M Cunningham Douglas Easton Rosalind A Eeles Timothy Eisen Manish Gala Steven J Gallinger Simon A Gayther Ellen L Goode Henrik Grönberg Brian E Henderson Richard Houlston Amit D Joshi Sébastien Küry Mari T Landi Loic Le Marchand Kenneth Muir Polly A Newcomb Jenny Permuth-Wey Paul Pharoah Catherine Phelan John D Potter Susan J Ramus Harvey Risch Joellen Schildkraut Martha L Slattery Honglin Song Nicolas Wentzensen Emily White Fredrik Wiklund Brent W Zanke Thomas A Sellers Wei Zheng Nilanjan Chatterjee Christopher I Amos Jennifer A Doherty

Int J Cancer 2016 Dec 8;139(12):2655-2670. Epub 2016 Sep 8.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1002/ijc.30288	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198774	PMC

December 2016

Use of a Novel Nonparametric Version of DEPTH to Identify Genomic Regions Associated with Prostate Cancer Risk.

Cancer Epidemiol Biomarkers Prev 2016 12 18;25(12):1619-1624. Epub 2016 Aug 18.

Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/1055-9965.EPI-16-0301	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5232414	PMC

December 2016

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.

Authors:

Melissa C Southey David E Goldgar Robert Winqvist Katri Pylkäs Fergus Couch Marc Tischkowitz William D Foulkes Joe Dennis Kyriaki Michailidou Elizabeth J van Rensburg Tuomas Heikkinen Heli Nevanlinna John L Hopper Thilo Dörk Kathleen Bm Claes Jorge Reis-Filho Zhi Ling Teo Paolo Radice Irene Catucci Paolo Peterlongo Helen Tsimiklis Fabrice A Odefrey James G Dowty Marjanka K Schmidt Annegien Broeks Frans B Hogervorst Senno Verhoef Jane Carpenter Christine Clarke Rodney J Scott Peter A Fasching Lothar Haeberle Arif B Ekici Matthias W Beckmann Julian Peto Isabel Dos-Santos-Silva Olivia Fletcher Nichola Johnson Manjeet K Bolla Elinor J Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Federik Marme Barbara Burwinkel Rongxi Yang Pascal Guénel Thérèse Truong Florence Menegaux Marie Sanchez Stig Bojesen Sune F Nielsen Henrik Flyger Javier Benitez M Pilar Zamora Jose Ignacio Arias Perez Primitiva Menéndez Hoda Anton-Culver Susan Neuhausen Argyrios Ziogas Christina A Clarke Hermann Brenner Volker Arndt Christa Stegmaier Hiltrud Brauch Thomas Brüning Yon-Dschun Ko Taru A Muranen Kristiina Aittomäki Carl Blomqvist Natalia V Bogdanova Natalia N Antonenkova Annika Lindblom Sara Margolin Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Amanda B Spurdle kConFab Investigators Els Wauters Dominiek Smeets Benoit Beuselinck Giuseppe Floris Jenny Chang-Claude Anja Rudolph Petra Seibold Dieter Flesch-Janys Janet E Olson Celine Vachon Vernon S Pankratz Catriona McLean Christopher A Haiman Brian E Henderson Fredrick Schumacher Loic Le Marchand Vessela Kristensen Grethe Grenaker Alnæs Wei Zheng David J Hunter Sara Lindstrom Susan E Hankinson Peter Kraft Irene Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Arja Jukkola-Vuorinen Mervi Grip Saila Kauppila Peter Devilee Robert A E M Tollenaar Caroline Seynaeve Antoinette Hollestelle Montserrat Garcia-Closas Jonine Figueroa Stephen J Chanock Jolanta Lissowska Kamila Czene Hatef Darabi Mikael Eriksson Diana M Eccles Sajjad Rafiq William J Tapper Sue M Gerty Maartje J Hooning John W M Martens J Margriet Collée Madeleine Tilanus-Linthorst Per Hall Jingmei Li Judith S Brand Keith Humphreys Angela Cox Malcolm W R Reed Craig Luccarini Caroline Baynes Alison M Dunning Ute Hamann Diana Torres Hans Ulrich Ulmer Thomas Rüdiger Anna Jakubowska Jan Lubinski Katarzyna Jaworska Katarzyna Durda Susan Slager Amanda E Toland Christine B Ambrosone Drakoulis Yannoukakos Anthony Swerdlow Alan Ashworth Nick Orr Michael Jones Anna González-Neira Guillermo Pita M Rosario Alonso Nuria Álvarez Daniel Herrero Daniel C Tessier Daniel Vincent Francois Bacot Jacques Simard Martine Dumont Penny Soucy Rosalind Eeles Kenneth Muir Fredrik Wiklund Henrik Gronberg Johanna Schleutker Børge G Nordestgaard Maren Weischer Ruth C Travis David Neal Jenny L Donovan Freddie C Hamdy Kay-Tee Khaw Janet L Stanford William J Blot Stephen Thibodeau Daniel J Schaid Joseph L Kelley Christiane Maier Adam S Kibel Cezary Cybulski Lisa Cannon-Albright Katja Butterbach Jong Park Radka Kaneva Jyotsna Batra Manuel R Teixeira Zsofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Stefan P Renner Arndt Hartmann Alexander Hein Matthias Ruebner Diether Lambrechts Els Van Nieuwenhuysen Ignace Vergote Sandrina Lambretchs Jennifer A Doherty Mary Anne Rossing Stefan Nickels Ursula Eilber Shan Wang-Gohrke Kunle Odunsi Lara E Sucheston-Campbell Grace Friel Galina Lurie Jeffrey L Killeen Lynne R Wilkens Marc T Goodman Ingo Runnebaum Peter A Hillemanns Liisa M Pelttari Ralf Butzow Francesmary Modugno Robert P Edwards Roberta B Ness Kirsten B Moysich Andreas du Bois Florian Heitz Philipp Harter Stefan Kommoss Beth Y Karlan Christine Walsh Jenny Lester Allan Jensen Susanne Krüger Kjaer Estrid Høgdall Bernard Peissel Bernardo Bonanni Loris Bernard Ellen L Goode Brooke L Fridley Robert A Vierkant Julie M Cunningham Melissa C Larson Zachary C Fogarty Kimberly R Kalli Dong Liang Karen H Lu Michelle A T Hildebrandt Xifeng Wu Douglas A Levine Fanny Dao Maria Bisogna Andrew Berchuck Edwin S Iversen Jeffrey R Marks Lucy Akushevich Daniel W Cramer Joellen Schildkraut Kathryn L Terry Elizabeth M Poole Meir Stampfer Shelley S Tworoger Elisa V Bandera Irene Orlow Sara H Olson Line Bjorge Helga B Salvesen Anne M van Altena Katja K H Aben Lambertus A Kiemeney Leon F A G Massuger Tanja Pejovic Yukie Bean Angela Brooks-Wilson Linda E Kelemen Linda S Cook Nhu D Le Bohdan Górski Jacek Gronwald Janusz Menkiszak Claus K Høgdall Lene Lundvall Lotte Nedergaard Svend Aage Engelholm Ed Dicks Jonathan Tyrer Ian Campbell Iain McNeish James Paul Nadeem Siddiqui Rosalind Glasspool Alice S Whittemore Joseph H Rothstein Valerie McGuire Weiva Sieh Hui Cai Xiao-Ou Shu Rachel T Teten Rebecca Sutphen John R McLaughlin Steven A Narod Catherine M Phelan Alvaro N Monteiro David Fenstermacher Hui-Yi Lin Jennifer B Permuth Thomas A Sellers Y Ann Chen Ya-Yu Tsai Zhihua Chen Aleksandra Gentry-Maharaj Simon A Gayther Susan J Ramus Usha Menon Anna H Wu Celeste L Pearce David Van Den Berg Malcolm C Pike Agnieszka Dansonka-Mieszkowska Joanna Plisiecka-Halasa Joanna Moes-Sosnowska Jolanta Kupryjanczyk Paul Dp Pharoah Honglin Song Ingrid Winship Georgia Chenevix-Trench Graham G Giles Sean V Tavtigian Doug F Easton Roger L Milne

J Med Genet 2016 12 5;53(12):800-811. Epub 2016 Sep 5.

Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1136/jmedgenet-2016-103839	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200636	PMC

December 2016

Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status.

Hum Mol Genet 2016 12;25(24):5490-5499

Institute of Human Genetics, University of Ulm, Ulm, Germany.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/hmg/ddw349	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418832	PMC

December 2016

Uterine Cancer After Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations.

JAMA Oncol 2016 Nov;2(11):1434-1440

Clinical Cancer Genetics Program, Duke Cancer Institute, Duke University Health System, Durham, North Carolina.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1001/jamaoncol.2016.1820	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594920	PMC

November 2016

Reducing GWAS Complexity.

Authors:

Dennis J Hazelett David V Conti Ying Han Ali Amin Al Olama Doug Easton Rosalind A Eeles Zsofia Kote-Jarai Christopher A Haiman Gerhard A Coetzee

Cell Cycle 2016 ;15(1):22-4

b Departments of Preventive Medicine and Urology , USC/Norris Cancer Center , USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1080/15384101.2015.1120928	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825730	PMC

October 2016

Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels.

Int J Cancer 2016 10 23;139(7):1520-33. Epub 2016 Jun 23.

NIHR Bristol Biomedical Research Unit in Nutrition, Bristol, United Kingdom.

View Article

Download full-text PDF	Source
http://doi.wiley.com/10.1002/ijc.30206	Publisher Site
http://dx.doi.org/10.1002/ijc.30206	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957617	PMC

October 2016

REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants.

Am J Hum Genet 2016 Oct 22;99(4):877-885. Epub 2016 Sep 22.

Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.ajhg.2016.08.016	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065685	PMC

October 2016

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

Authors:

Gordon Fehringer Peter Kraft Paul D Pharoah Rosalind A Eeles Nilanjan Chatterjee Fredrick R Schumacher Joellen M Schildkraut Sara Lindström Paul Brennan Heike Bickeböller Richard S Houlston Maria Teresa Landi Neil Caporaso Angela Risch Ali Amin Al Olama Sonja I Berndt Edward L Giovannucci Henrik Grönberg Zsofia Kote-Jarai Jing Ma Kenneth Muir Meir J Stampfer Victoria L Stevens Fredrik Wiklund Walter C Willett Ellen L Goode Jennifer B Permuth Harvey A Risch Brett M Reid Stephane Bezieau Hermann Brenner Andrew T Chan Jenny Chang-Claude Thomas J Hudson Jonathan K Kocarnik Polly A Newcomb Robert E Schoen Martha L Slattery Emily White Muriel A Adank Habibul Ahsan Kristiina Aittomäki Laura Baglietto Carl Blomquist Federico Canzian Kamila Czene Isabel Dos-Santos-Silva A Heather Eliassen Jonine D Figueroa Dieter Flesch-Janys Olivia Fletcher Montserrat Garcia-Closas Mia M Gaudet Nichola Johnson Per Hall Aditi Hazra Rebecca Hein Albert Hofman John L Hopper Astrid Irwanto Mattias Johansson Rudolf Kaaks Muhammad G Kibriya Peter Lichtner Jianjun Liu Eiliv Lund Enes Makalic Alfons Meindl Bertram Müller-Myhsok Taru A Muranen Heli Nevanlinna Petra H Peeters Julian Peto Ross L Prentice Nazneen Rahman Maria Jose Sanchez Daniel F Schmidt Rita K Schmutzler Melissa C Southey Rulla Tamimi Ruth C Travis Clare Turnbull Andre G Uitterlinden Zhaoming Wang Alice S Whittemore Xiaohong R Yang Wei Zheng Daniel D Buchanan Graham Casey David V Conti Christopher K Edlund Steven Gallinger Robert W Haile Mark Jenkins Loïc Le Marchand Li Li Noralene M Lindor Stephanie L Schmit Stephen N Thibodeau Michael O Woods Thorunn Rafnar Julius Gudmundsson Simon N Stacey Kari Stefansson Patrick Sulem Y Ann Chen Jonathan P Tyrer David C Christiani Yongyue Wei Hongbing Shen Zhibin Hu Xiao-Ou Shu Kouya Shiraishi Atsushi Takahashi Yohan Bossé Ma'en Obeidat David Nickle Wim Timens Matthew L Freedman Qiyuan Li Daniela Seminara Stephen J Chanock Jian Gong Ulrike Peters Stephen B Gruber Christopher I Amos Thomas A Sellers Douglas F Easton David J Hunter Christopher A Haiman Brian E Henderson Rayjean J Hung

Cancer Res 2016 09 20;76(17):5103-14. Epub 2016 Apr 20.

Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/0008-5472.CAN-15-2980	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010493	PMC

September 2016

Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies.

Genet Epidemiol 2016 09 17;40(6):461-9. Epub 2016 Jun 17.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.

View Article

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063501	PMC
http://dx.doi.org/10.1002/gepi.21983	DOI Listing

September 2016

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.

Authors:

Siddhartha P Kar Jonathan Beesley Ali Amin Al Olama Kyriaki Michailidou Jonathan Tyrer ZSofia Kote-Jarai Kate Lawrenson Sara Lindstrom Susan J Ramus Deborah J Thompson Adam S Kibel Agnieszka Dansonka-Mieszkowska Agnieszka Michael Aida K Dieffenbach Aleksandra Gentry-Maharaj Alice S Whittemore Alicja Wolk Alvaro Monteiro Ana Peixoto Andrzej Kierzek Angela Cox Anja Rudolph Anna Gonzalez-Neira Anna H Wu Annika Lindblom Anthony Swerdlow Argyrios Ziogas Arif B Ekici Barbara Burwinkel Beth Y Karlan Børge G Nordestgaard Carl Blomqvist Catherine Phelan Catriona McLean Celeste Leigh Pearce Celine Vachon Cezary Cybulski Chavdar Slavov Christa Stegmaier Christiane Maier Christine B Ambrosone Claus K Høgdall Craig C Teerlink Daehee Kang Daniel C Tessier Daniel J Schaid Daniel O Stram Daniel W Cramer David E Neal Diana Eccles Dieter Flesch-Janys Digna R Velez Edwards Dominika Wokozorczyk Douglas A Levine Drakoulis Yannoukakos Elinor J Sawyer Elisa V Bandera Elizabeth M Poole Ellen L Goode Elza Khusnutdinova Estrid Høgdall Fengju Song Fiona Bruinsma Florian Heitz Francesmary Modugno Freddie C Hamdy Fredrik Wiklund Graham G Giles Håkan Olsson Hans Wildiers Hans-Ulrich Ulmer Hardev Pandha Harvey A Risch Hatef Darabi Helga B Salvesen Heli Nevanlinna Henrik Gronberg Hermann Brenner Hiltrud Brauch Hoda Anton-Culver Honglin Song Hui-Yi Lim Iain McNeish Ian Campbell Ignace Vergote Jacek Gronwald Jan Lubiński Janet L Stanford Javier Benítez Jennifer A Doherty Jennifer B Permuth Jenny Chang-Claude Jenny L Donovan Joe Dennis Joellen M Schildkraut Johanna Schleutker John L Hopper Jolanta Kupryjanczyk Jong Y Park Jonine Figueroa Judith A Clements Julia A Knight Julian Peto Julie M Cunningham Julio Pow-Sang Jyotsna Batra Kamila Czene Karen H Lu Kathleen Herkommer Kay-Tee Khaw Keitaro Matsuo Kenneth Muir Kenneth Offitt Kexin Chen Kirsten B Moysich Kristiina Aittomäki Kunle Odunsi Lambertus A Kiemeney Leon F A G Massuger Liesel M Fitzgerald Linda S Cook Lisa Cannon-Albright Maartje J Hooning Malcolm C Pike Manjeet K Bolla Manuel Luedeke Manuel R Teixeira Marc T Goodman Marjanka K Schmidt Marjorie Riggan Markus Aly Mary Anne Rossing Matthias W Beckmann Matthieu Moisse Maureen Sanderson Melissa C Southey Michael Jones Michael Lush Michelle A T Hildebrandt Ming-Feng Hou Minouk J Schoemaker Montserrat Garcia-Closas Natalia Bogdanova Nazneen Rahman Nhu D Le Nick Orr Nicolas Wentzensen Nora Pashayan Paolo Peterlongo Pascal Guénel Paul Brennan Paula Paulo Penelope M Webb Per Broberg Peter A Fasching Peter Devilee Qin Wang Qiuyin Cai Qiyuan Li Radka Kaneva Ralf Butzow Reidun Kristin Kopperud Rita K Schmutzler Robert A Stephenson Robert J MacInnis Robert N Hoover Robert Winqvist Roberta Ness Roger L Milne Ruth C Travis Sara Benlloch Sara H Olson Shannon K McDonnell Shelley S Tworoger Sofia Maia Sonja Berndt Soo Chin Lee Soo-Hwang Teo Stephen N Thibodeau Stig E Bojesen Susan M Gapstur Susanne Krüger Kjær Tanja Pejovic Teuvo L J Tammela Thilo Dörk Thomas Brüning Tiina Wahlfors Tim J Key Todd L Edwards Usha Menon Ute Hamann Vanio Mitev Veli-Matti Kosma Veronica Wendy Setiawan Vessela Kristensen Volker Arndt Walther Vogel Wei Zheng Weiva Sieh William J Blot Wojciech Kluzniak Xiao-Ou Shu Yu-Tang Gao Fredrick Schumacher Matthew L Freedman Andrew Berchuck Alison M Dunning Jacques Simard Christopher A Haiman Amanda Spurdle Thomas A Sellers David J Hunter Brian E Henderson Peter Kraft Stephen J Chanock Fergus J Couch Per Hall Simon A Gayther Douglas F Easton Georgia Chenevix-Trench Rosalind Eeles Paul D P Pharoah Diether Lambrechts

Cancer Discov 2016 09 17;6(9):1052-67. Epub 2016 Jul 17.

VIB Vesalius Research Center, KU Leuven, Leuven, Belgium.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/2159-8290.CD-15-1227	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010513	PMC

September 2016

Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses.

PLoS Med 2016 Sep 6;13(9):e1002118. Epub 2016 Sep 6.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1371/journal.pmed.1002118	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012582	PMC

September 2016

Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21.

Hum Genet 2016 08 4;135(8):923-38. Epub 2016 Jun 4.

Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84108, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1007/s00439-016-1690-6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020907	PMC

August 2016

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.

N Engl J Med 2016 Aug 6;375(5):443-53. Epub 2016 Jul 6.

From the University of Washington (C.C.P., M. Beightol, C.M., B.N., H.H.C., B.M., T.W., S. Casadei, P.S.N.) and Fred Hutchinson Cancer Research Center (N.D.S., R.G., P.S.N.) - both in Seattle; the Institute of Cancer Research and Royal Marsden Hospital, London (J.M., S. Carreira, R.E., J.B.); Memorial Sloan Kettering Cancer Center (M.F.W., W.A., M. Berger, L.Z., A.Z., J. Vijai, H.I.S., C.S., N.S., P.W.K., D.S., M.R., K.O.), Weill Cornell Medical College (H.B., O.E., M.A.R.), and the Prostate Cancer Clinical Trials Consortium (J. Vinson, J.F.) - all in New York; the University of Michigan, Ann Arbor (D.R., R.L., M.H., A.C.); Howard Hughes Medical Institute, Chevy Chase, MD (A.C., C.S.); and Dana-Farber Cancer Institute, Boston (A.G., L.G., M.-E.T., S.A., G.C.H., E.M.V.A.).

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1056/NEJMoa1603144	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986616	PMC

August 2016

Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium.

Br J Cancer 2016 08 4;115(5):624-31. Epub 2016 Aug 4.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/bjc.2016.228	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997551	PMC

August 2016

Diagnosis and Management of Hereditary Carcinoids.

Authors:

Sarah Benafif Rosalind Eeles

Recent Results Cancer Res 2016 ;205:149-68

The Institute of Cancer Research, Sutton, Surrey, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1007/978-3-319-29998-3_9	DOI Listing

July 2016

Blood lipids and prostate cancer: a Mendelian randomization analysis.

Cancer Med 2016 06 19;5(6):1125-36. Epub 2016 Mar 19.

School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1002/cam4.695	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924371	PMC

June 2016

Reply to S. Kilickap et al, Y. Karakas et al, and I.A. Voutsadakis.

Authors:

James P Morden Rosalind A Eeles Judith M Bliss

J Clin Oncol 2016 06 21;34(17):2071-2. Epub 2016 Mar 21.

The Institute of Cancer Research, Sutton, London, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1200/JCO.2016.66.7709	DOI Listing

June 2016

The PROFILE Feasibility Study: Targeted Screening of Men With a Family History of Prostate Cancer.

Oncologist 2016 06 5;21(6):716-22. Epub 2016 May 5.

Oncogenetics Team, The Institute of Cancer Research, London, United Kingdom Academic Urology Unit, The Royal Marsden National Health Service Foundation Trust, London, United Kingdom

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1634/theoncologist.2015-0336	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912360	PMC

June 2016

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.

Authors:

Robert A Scott Daniel F Freitag Li Li Audrey Y Chu Praveen Surendran Robin Young Niels Grarup Alena Stancáková Yuning Chen Tibor V Varga Hanieh Yaghootkar Jian'an Luan Jing Hua Zhao Sara M Willems Jennifer Wessel Shuai Wang Nisa Maruthur Kyriaki Michailidou Ailith Pirie Sven J van der Lee Christopher Gillson Ali Amin Al Olama Philippe Amouyel Larraitz Arriola Dominique Arveiler Iciar Aviles-Olmos Beverley Balkau Aurelio Barricarte Inês Barroso Sara Benlloch Garcia Joshua C Bis Stefan Blankenberg Michael Boehnke Heiner Boeing Eric Boerwinkle Ingrid B Borecki Jette Bork-Jensen Sarah Bowden Carlos Caldas Muriel Caslake L Adrienne Cupples Carlos Cruchaga Jacek Czajkowski Marcel den Hoed Janet A Dunn Helena M Earl Georg B Ehret Ele Ferrannini Jean Ferrieres Thomas Foltynie Ian Ford Nita G Forouhi Francesco Gianfagna Carlos Gonzalez Sara Grioni Louise Hiller Jan-Håkan Jansson Marit E Jørgensen J Wouter Jukema Rudolf Kaaks Frank Kee Nicola D Kerrison Timothy J Key Jukka Kontto Zsofia Kote-Jarai Aldi T Kraja Kari Kuulasmaa Johanna Kuusisto Allan Linneberg Chunyu Liu Gaëlle Marenne Karen L Mohlke Andrew P Morris Kenneth Muir Martina Müller-Nurasyid Patricia B Munroe Carmen Navarro Sune F Nielsen Peter M Nilsson Børge G Nordestgaard Chris J Packard Domenico Palli Salvatore Panico Gina M Peloso Markus Perola Annette Peters Christopher J Poole J Ramón Quirós Olov Rolandsson Carlotta Sacerdote Veikko Salomaa María-José Sánchez Naveed Sattar Stephen J Sharp Rebecca Sims Nadia Slimani Jennifer A Smith Deborah J Thompson Stella Trompet Rosario Tumino Daphne L van der A Yvonne T van der Schouw Jarmo Virtamo Mark Walker Klaudia Walter Jean E Abraham Laufey T Amundadottir Jennifer L Aponte Adam S Butterworth Josée Dupuis Douglas F Easton Rosalind A Eeles Jeanette Erdmann Paul W Franks Timothy M Frayling Torben Hansen Joanna M M Howson Torben Jørgensen Jaspal Kooner Markku Laakso Claudia Langenberg Mark I McCarthy James S Pankow Oluf Pedersen Elio Riboli Jerome I Rotter Danish Saleheen Nilesh J Samani Heribert Schunkert Peter Vollenweider Stephen O'Rahilly Panos Deloukas John Danesh Mark O Goodarzi Sekar Kathiresan James B Meigs Margaret G Ehm Nicholas J Wareham Dawn M Waterworth

Sci Transl Med 2016 06;8(341):341ra76

Genetics, PCPS, GlaxoSmithKline, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1126/scitranslmed.aad3744	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219001	PMC

June 2016

Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

Genome Res 2016 05;26(5):717.2

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1101/gr.206557.116	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864453	PMC

May 2016

A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population.

Oncotarget 2016 Apr;7(16):21393-403

Centre for Molecular Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.18632/oncotarget.7250	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008293	PMC

April 2016

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.

Br J Cancer 2016 Apr;114(8):945-52

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/bjc.2016.50	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379914	PMC

April 2016

Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.

BMC Med 2016 Apr 4;14:66. Epub 2016 Apr 4.

School of Social and Community Medicine, University of Bristol, Bristol, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1186/s12916-016-0602-x	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820939	PMC

April 2016

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.

Authors:

Alexander Gusev Huwenbo Shi Gleb Kichaev Mark Pomerantz Fugen Li Henry W Long Sue A Ingles Rick A Kittles Sara S Strom Benjamin A Rybicki Barbara Nemesure William B Isaacs Wei Zheng Curtis A Pettaway Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam Esther M John Adam B Murphy Lisa B Signorello John Carpten M Cristina Leske Suh-Yuh Wu Anslem J M Hennis Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein John S Witte Graham Casey Sam Kaggwa Michael B Cook Daniel O Stram William J Blot Rosalind A Eeles Douglas Easton Zsofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Kenneth Muir Graham G Giles Melissa C Southey Liesel M Fitzgerald Henrik Gronberg Fredrik Wiklund Markus Aly Brian E Henderson Johanna Schleutker Tiina Wahlfors Teuvo L J Tammela Børge G Nordestgaard Tim J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Dominika Wokolorczyk Wojciech Kluzniak Lisa Cannon-Albright Craig Teerlink Hermann Brenner Aida K Dieffenbach Volker Arndt Jong Y Park Thomas A Sellers Hui-Yi Lin Chavdar Slavov Radka Kaneva Vanio Mitev Jyotsna Batra Amanda Spurdle Judith A Clements Manuel R Teixeira Hardev Pandha Agnieszka Michael Paula Paulo Sofia Maia Andrzej Kierzek David V Conti Demetrius Albanes Christine Berg Sonja I Berndt Daniele Campa E David Crawford W Ryan Diver Susan M Gapstur J Michael Gaziano Edward Giovannucci Robert Hoover David J Hunter Mattias Johansson Peter Kraft Loic Le Marchand Sara Lindström Carmen Navarro Kim Overvad Elio Riboli Afshan Siddiq Victoria L Stevens Dimitrios Trichopoulos Paolo Vineis Meredith Yeager Gosia Trynka Soumya Raychaudhuri Frederick R Schumacher Alkes L Price Matthew L Freedman Christopher A Haiman Bogdan Pasaniuc

Nat Commun 2016 Apr 7;7:10979. Epub 2016 Apr 7.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/ncomms10979	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829663	PMC

April 2016

LocusExplorer: a user-friendly tool for integrated visualization of human genetic association data and biological annotations.

Authors:

Tokhir Dadaev Daniel A Leongamornlert Edward J Saunders Rosalind Eeles Zsofia Kote-Jarai

Bioinformatics 2016 03 20;32(6):949-51. Epub 2015 Nov 20.

The Institute of Cancer Research, London, UK and.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/bioinformatics/btv690	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939893	PMC

March 2016

Germline genetic profiling in prostate cancer: latest developments and potential clinical applications.

Authors:

Mahbubl Ahmed Rosalind Eeles

Future Sci OA 2016 Mar 18;2(1):FSO87. Epub 2015 Dec 18.

The Institute of Cancer Research, London SM2 5NG, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.4155/fso.15.87	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137984	PMC

March 2016

The contribution of rare variation to prostate cancer heritability.

Nat Genet 2016 Jan 16;48(1):30-5. Epub 2015 Nov 16.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF	Source
http://www.nature.com/articles/ng.3446	Publisher Site
http://dx.doi.org/10.1038/ng.3446	DOI Listing

January 2016

Risk Analysis of Prostate Cancer in PRACTICAL Consortium--Response.

Authors:

Ali Amin Al Olama Rosalind A Eeles Zsofia Kote-Jarai Douglas F Easton

Cancer Epidemiol Biomarkers Prev 2016 Jan;25(1):223

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/1055-9965.EPI-15-1005	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717513	PMC

January 2016

Adjuvant Hormone Therapy May Improve Survival in Epithelial Ovarian Cancer: Results of the AHT Randomized Trial.

Authors:

Rosalind A Eeles James P Morden Martin Gore Janine Mansi John Glees Miklos Wenczl Christopher Williams Henry Kitchener Richard Osborne David Guthrie Peter Harper Judith M Bliss

J Clin Oncol 2015 Dec 28;33(35):4138-44. Epub 2015 Sep 28.

Rosalind A. Eeles, James P. Morden, and Judith M. Bliss, The Institute of Cancer Research; Martin Gore, The Royal Marsden Hospital; Janine Mansi, St George's Hospital; Peter Harper, Guy's Hospital, London; John Glees, Epsom Hospital, Epsom, and The Royal Marsden Hospital, Sutton; Christopher Williams, Southampton General Hospital, Southampton; Henry Kitchener, Aberdeen Royal Infirmary, Aberdeen; Richard Osborne, Addenbrookes Hospital, Cambridge; David Guthrie, Derbyshire Royal Infirmary, Derby, United Kingdom; and Miklos Wenczl, Markusovszky Teaching Hospital, Szombathely, Hungary.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1200/JCO.2015.60.9719	DOI Listing

December 2015

Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions.

Hum Mol Genet 2015 Dec 19;24(25):7406-20. Epub 2015 Oct 19.

Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA,

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/hmg/ddv440	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664175	PMC

December 2015

The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer.

Authors:

Elizabeth K Bancroft Elena Castro Gordon A Bancroft Audrey Ardern-Jones Clare Moynihan Elizabeth Page Natalie Taylor Rosalind A Eeles Emma Rowley Karen Cox

Psychooncology 2015 Nov 14;24(11):1492-9. Epub 2015 Apr 14.

School of Health Sciences, University of Nottingham, Nottingham, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1002/pon.3814	DOI Listing

November 2015

Genome-wide association study of prostate cancer-specific survival.

Authors:

Robert Szulkin Robert Karlsson Thomas Whitington Markus Aly Henrik Gronberg Rosalind A Eeles Douglas F Easton Zsofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Kenneth Muir Graham G Giles Melissa C Southey Liesel M FitzGerald Brian E Henderson Fredrick R Schumacher Christopher A Haiman Csilla Sipeky Teuvo L J Tammela Børge G Nordestgaard Timothy J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul D P Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Jan Lubiński Wojciech Kluźniak Lisa Cannon-Albright Hermann Brenner Volker Herrmann Bernd Holleczek Jong Y Park Thomas A Sellers Hui-Yi Lim Chavdar Slavov Radka P Kaneva Vanio I Mitev Amanda Spurdle Manuel R Teixeira Paula Paulo Sofia Maia Hardev Pandha Agnieszka Michael Andrzej Kierzek Jyotsna Batra Judith A Clements Demetrius Albanes Gerald L Andriole Sonja I Berndt Stephen Chanock Susan M Gapstur Edward L Giovannucci David J Hunter Peter Kraft Loic Le Marchand Jing Ma Alison M Mondul Kathryn L Penney Meir J Stampfer Victoria L Stevens Stephanie J Weinstein Antonia Trichopoulou Bas H Bueno-de-Mesquita Anne Tjønneland David G Cox Lovise Maehle Johanna Schleutker Sara Lindström Fredrik Wiklund

Cancer Epidemiol Biomarkers Prev 2015 Nov 25;24(11):1796-800. Epub 2015 Aug 25.

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/1055-9965.EPI-15-0543	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674990	PMC

November 2015

Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer.

J Natl Cancer Inst 2015 Nov 29;107(11). Epub 2015 Aug 29.

: Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, YB, JGP); National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany (CMU, AR); Mayo Clinic, Rochester, MN (ELG, DNR); The University of Warwick, Coventry, UK (KM); Massachusetts General Hospital, Boston, MA (ATC); University of Hawaii Cancer Center, Honolulu, HI (LLM); Duke University, Durham, NC (JS); University of California at San Francisco, San Francisco, CA (JSW); Institute of Cancer Research, London, UK (RE, RH, ZKJ); Mount Sinai School of Medicine, New York, NY (PBo); Baylor College of Medicine, Houston, TX (MRS); Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS (BLF); Moffitt Cancer Center, Tampa, FL (ZC, CP, TAS); University of South California, Los Angeles, CA (CH, FS, GC, SBG, BH); Cambridge University, Cambridge, UK (DFE, AAAO, HS); National Cancer Institute, Bethesda, MD (MTL, SC, SIB, NW); International Agency for Research on Cancer, Lyon, France (PBr); Harvard School of Public Health, Boston, MA (DCC, PK, SL, DJH); University of Liverpool, Liverpool, UK (JKF); University of Göttingen, Medical School, Göttingen, Germany (HB); Karolinska Institutet, Stockholm, Sweden (FW, HG); Fred Hutchinson Cancer Research Center, Seattle, WA (UP); University of Utah Health Sciences Center and Huntsman Cancer Institute, Salt Lake City, UT (CMU, MLS); Geisel School of Medicine, Dartmouth College, Lebanon, NH (CIA).

View Article

Download full-text PDF	Source
http://jnci.oxfordjournals.org/content/107/11/djv246.full.pd	Web Search
http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv24	Publisher Site
http://dx.doi.org/10.1093/jnci/djv246	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675100	PMC

November 2015

The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium.

Cancer Causes Control 2015 Nov 19;26(11):1603-16. Epub 2015 Sep 19.

School of Social and Community Medicine, University of Bristol, Bristol, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1007/s10552-015-0654-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596899	PMC

November 2015

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans.

Authors:

Ali Amin Al Olama Tokhir Dadaev Dennis J Hazelett Qiuyan Li Daniel Leongamornlert Edward J Saunders Sarah Stephens Clara Cieza-Borrella Ian Whitmore Sara Benlloch Garcia Graham G Giles Melissa C Southey Liesel Fitzgerald Henrik Gronberg Fredrik Wiklund Markus Aly Brian E Henderson Fredrick Schumacher Christopher A Haiman Johanna Schleutker Tiina Wahlfors Teuvo L Tammela Børge G Nordestgaard Tim J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Stephen N Thibodeau Shannon K Mcdonnell Daniel J Schaid Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Dominika Wokołorczyk Wojciech Kluzniak Lisa Cannon-Albright Hermann Brenner Katja Butterbach Volker Arndt Jong Y Park Thomas Sellers Hui-Yi Lin Chavdar Slavov Radka Kaneva Vanio Mitev Jyotsna Batra Judith A Clements Amanda Spurdle Manuel R Teixeira Paula Paulo Sofia Maia Hardev Pandha Agnieszka Michael Andrzej Kierzek Koveela Govindasami Michelle Guy Artitaya Lophatonanon Kenneth Muir Ana Viñuela Andrew A Brown Mathew Freedman David V Conti Douglas Easton Gerhard A Coetzee Rosalind A Eeles Zsofia Kote-Jarai

Hum Mol Genet 2015 Oct 29;24(19):5589-602. Epub 2015 May 29.

Division of Genetics and Epidemiology, The Institute of Cancer Research & Royal Marsden NHS Foundation Trust, London, UK,

View Article

Download full-text PDF	Source
http://hmg.oxfordjournals.org/content/24/19/5589.full.pdf	Web Search
http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv	Publisher Site
http://dx.doi.org/10.1093/hmg/ddv203	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572072	PMC

October 2015

Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions.

Authors:

Ying Han Dennis J Hazelett Fredrik Wiklund Fredrick R Schumacher Daniel O Stram Sonja I Berndt Zhaoming Wang Kristin A Rand Robert N Hoover Mitchell J Machiela Merideth Yeager Laurie Burdette Charles C Chung Amy Hutchinson Kai Yu Jianfeng Xu Ruth C Travis Timothy J Key Afshan Siddiq Federico Canzian Atsushi Takahashi Michiaki Kubo Janet L Stanford Suzanne Kolb Susan M Gapstur W Ryan Diver Victoria L Stevens Sara S Strom Curtis A Pettaway Ali Amin Al Olama Zsofia Kote-Jarai Rosalind A Eeles Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam William B Isaacs Constance Chen Sara Lindstrom Loic Le Marchand Edward L Giovannucci Mark Pomerantz Henry Long Fugen Li Jing Ma Meir Stampfer Esther M John Sue A Ingles Rick A Kittles Adam B Murphy William J Blot Lisa B Signorello Wei Zheng Demetrius Albanes Jarmo Virtamo Stephanie Weinstein Barbara Nemesure John Carpten M Cristina Leske Suh-Yuh Wu Anselm J M Hennis Benjamin A Rybicki Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein S Lilly Zheng John S Witte Graham Casey Elio Riboli Qiyuan Li Matthew L Freedman David J Hunter Henrik Gronberg Michael B Cook Hidewaki Nakagawa Peter Kraft Stephen J Chanock Douglas F Easton Brian E Henderson Gerhard A Coetzee David V Conti Christopher A Haiman

Hum Mol Genet 2015 Oct 10;24(19):5603-18. Epub 2015 Jul 10.

Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center,

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1093/hmg/ddv269	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572069	PMC

October 2015

Identification of four new susceptibility loci for testicular germ cell tumour.

Authors:

Kevin Litchfield Amy Holroyd Amy Lloyd Peter Broderick Jérémie Nsengimana Rosalind Eeles Douglas F Easton Darshna Dudakia D Timothy Bishop Alison Reid Robert A Huddart Tom Grotmol Fredrik Wiklund Janet Shipley Richard S Houlston Clare Turnbull

Nat Commun 2015 Oct 27;6:8690. Epub 2015 Oct 27.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London SM2 5NG, UK.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/ncomms9690	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846317	PMC

October 2015

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.

N Engl J Med 2015 Oct;373(18):1697-708

From the Institute of Cancer Research (J.M., S.C., S.S., S.M., H.M., R.P.-L., D.N.R., A.O., N.T., G.B., N.P., P.F., A.G., I.F., C.P., G.S., D.B., J.G., Z.Z., C.T.W., R.F., R.R., B.E., G.F., D. Roda, W.Y., R.B., H.P., R.A., A.S., R.E., G.A., C.J.L., A.A., E.H., J.S.B.), the Royal Marsden NHS Foundation Trust (J.M., S.S., R.P.-L., A.O., N.T., D.B., Z.Z., R.F., D. Roda, R.E., G.A., J.S.B.), and University College London Hospital (U.M.), London, Queen's University, Belfast (S.J.), University of Leeds, Leeds (C.R.), Churchill Hospital, Oxford (A.P.), University of Liverpool, Liverpool (S.H.), Beatson West of Scotland Cancer Centre, Glasgow (R.J.), and Christie Hospital, Manchester (T.E.) - all in the United Kingdom; the University of Michigan, Ann Arbor (D. Robinson, Y.-M.W., X.C., L.P.K., F.Y.F., A.M.C.); Weill Cornell Medical College, New York (M.A.R.); and Thomas Jefferson University, Philadelphia (K.E.K.).

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1056/NEJMoa1506859	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228595	PMC

October 2015

Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study.

Authors:

Chenan Zhang Jennifer A Doherty Stephen Burgess Rayjean J Hung Sara Lindström Peter Kraft Jian Gong Christopher I Amos Thomas A Sellers Alvaro N A Monteiro Georgia Chenevix-Trench Heike Bickeböller Angela Risch Paul Brennan James D Mckay Richard S Houlston Maria Teresa Landi Maria N Timofeeva Yufei Wang Joachim Heinrich Zsofia Kote-Jarai Rosalind A Eeles Ken Muir Fredrik Wiklund Henrik Grönberg Sonja I Berndt Stephen J Chanock Fredrick Schumacher Christopher A Haiman Brian E Henderson Ali Amin Al Olama Irene L Andrulis John L Hopper Jenny Chang-Claude Esther M John Kathleen E Malone Marilie D Gammon Giske Ursin Alice S Whittemore David J Hunter Stephen B Gruber Julia A Knight Lifang Hou Loic Le Marchand Polly A Newcomb Thomas J Hudson Andrew T Chan Li Li Michael O Woods Habibul Ahsan Brandon L Pierce

Hum Mol Genet 2015 Sep 2;24(18):5356-66. Epub 2015 Jul 2.

Department of Public Health Sciences, Center for Cancer Epidemiology and Prevention, Department of Human Genetics, The University of Chicago, Chicago, IL, USA,

View Article

Download full-text PDF	Source
https://www.repository.cam.ac.uk/bitstream/handle/1810/24890	Web Search
http://hmg.oxfordjournals.org/content/early/2015/07/24/hmg.d	Web Search
http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv	Publisher Site
http://dx.doi.org/10.1093/hmg/ddv252	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550826	PMC

September 2015

Prediction of individual genetic risk to prostate cancer using a polygenic score.

Authors:

Robert Szulkin Thomas Whitington Martin Eklund Markus Aly Rosalind A Eeles Douglas Easton Z Sofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Kenneth Muir Graham G Giles Melissa C Southey Liesel M Fitzgerald Brian E Henderson Fredrick Schumacher Christopher A Haiman Johanna Schleutker Tiina Wahlfors Teuvo L J Tammela Børge G Nordestgaard Tim J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Jan Lubiński Wojciech Kluźniak Lisa Cannon-Albright Hermann Brenner Katja Butterbach Christa Stegmaier Jong Y Park Thomas Sellers Hui-Yi Lin Hui-Yi Lim Chavdar Slavov Radka Kaneva Vanio Mitev Jyotsna Batra Judith A Clements Amanda Spurdle Manuel R Teixeira Paula Paulo Sofia Maia Hardev Pandha Agnieszka Michael Andrzej Kierzek Henrik Gronberg Fredrik Wiklund

Prostate 2015 Sep 14;75(13):1467-74. Epub 2015 Jul 14.

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1002/pros.23037	DOI Listing

September 2015

Reducing overdiagnosis by polygenic risk-stratified screening: findings from the Finnish section of the ERSPC.

Authors:

Nora Pashayan Paul Dp Pharoah Johanna Schleutker Kirsi Talala Teuvo Lj Tammela Liisa Määttänen Patricia Harrington Jonathan Tyrer Rosalind Eeles Stephen W Duffy Anssi Auvinen

Br J Cancer 2015 Sep 20;113(7):1086-93. Epub 2015 Aug 20.

School of Health Sciences, University of Tampere, Tampere FI 33014, Finland.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/bjc.2015.289	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651137	PMC

September 2015

Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.

Authors:

Ali Amin Al Olama Sara Benlloch Antonis C Antoniou Graham G Giles Gianluca Severi David E Neal Freddie C Hamdy Jenny L Donovan Kenneth Muir Johanna Schleutker Brian E Henderson Christopher A Haiman Fredrick R Schumacher Nora Pashayan Paul D P Pharoah Elaine A Ostrander Janet L Stanford Jyotsna Batra Judith A Clements Suzanne K Chambers Maren Weischer Børge G Nordestgaard Sue A Ingles Karina D Sorensen Torben F Orntoft Jong Y Park Cezary Cybulski Christiane Maier Thilo Doerk Joanne L Dickinson Lisa Cannon-Albright Hermann Brenner Timothy R Rebbeck Charnita Zeigler-Johnson Tomonori Habuchi Stephen N Thibodeau Kathleen A Cooney Pierre O Chappuis Pierre Hutter Radka P Kaneva William D Foulkes Maurice P Zeegers Yong-Jie Lu Hong-Wei Zhang Robert Stephenson Angela Cox Melissa C Southey Amanda B Spurdle Liesel FitzGerald Daniel Leongamornlert Edward Saunders Malgorzata Tymrakiewicz Michelle Guy Tokhir Dadaev Sarah J Little Koveela Govindasami Emma Sawyer Rosemary Wilkinson Kathleen Herkommer John L Hopper Aritaya Lophatonanon Antje E Rinckleb Zsofia Kote-Jarai Rosalind A Eeles Douglas F Easton

Cancer Epidemiol Biomarkers Prev 2015 Jul 2;24(7):1121-9. Epub 2015 Apr 2.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1158/1055-9965.EPI-14-0317	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491026	PMC

July 2015

Spatial genomic heterogeneity within localized, multifocal prostate cancer.

Authors:

Paul C Boutros Michael Fraser Nicholas J Harding Richard de Borja Dominique Trudel Emilie Lalonde Alice Meng Pablo H Hennings-Yeomans Andrew McPherson Veronica Y Sabelnykova Amin Zia Natalie S Fox Julie Livingstone Yu-Jia Shiah Jianxin Wang Timothy A Beck Cherry L Have Taryne Chong Michelle Sam Jeremy Johns Lee Timms Nicholas Buchner Ada Wong John D Watson Trent T Simmons Christine P'ng Gaetano Zafarana Francis Nguyen Xuemei Luo Kenneth C Chu Stephenie D Prokopec Jenna Sykes Alan Dal Pra Alejandro Berlin Andrew Brown Michelle A Chan-Seng-Yue Fouad Yousif Robert E Denroche Lauren C Chong Gregory M Chen Esther Jung Clement Fung Maud H W Starmans Hanbo Chen Shaylan K Govind James Hawley Alister D'Costa Melania Pintilie Daryl Waggott Faraz Hach Philippe Lambin Lakshmi B Muthuswamy Colin Cooper Rosalind Eeles David Neal Bernard Tetu Cenk Sahinalp Lincoln D Stein Neil Fleshner Sohrab P Shah Colin C Collins Thomas J Hudson John D McPherson Theodorus van der Kwast Robert G Bristow

Nat Genet 2015 Jul 25;47(7):736-45. Epub 2015 May 25.

1] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [2] Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [3] Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/ng.3315	DOI Listing

July 2015

Corrigendum to "Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study" [Eur Urol 2014;66:489-99].

Authors:

Elizabeth K Bancroft Rosalind A Eeles

Eur Urol 2015 Jun 18;67(6):e126. Epub 2014 Dec 18.

Oncogenetics Team, Institute of Cancer Research, London, UK; Cancer Genetics Unit and Academic Urology Unit, Royal Marsden NHS Foundation Trust, London, UK. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.eururo.2014.12.001	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597558	PMC

June 2015

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

Genome Res 2015 06 11;25(6):814-24. Epub 2015 May 11.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1101/gr.190470.115	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448678	PMC

June 2015

Corrigendum: analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Authors:

Colin S Cooper Rosalind Eeles David C Wedge Peter Van Loo Gunes Gundem Ludmil B Alexandrov Barbara Kremeyer Adam Butler Andrew G Lynch Niedzica Camacho Charlie E Massie Jonathan Kay Hayley J Luxton Sandra Edwards Zsofia Kote-Jarai Nening Dennis Sue Merson Daniel Leongamornlert Jorge Zamora Cathy Corbishley Sarah Thomas Serena Nik-Zainal Manasa Ramakrishna Sarah O'Meara Lucy Matthews Jeremy Clark Rachel Hurst Richard Mithen Robert G Bristow Paul C Boutros Michael Fraser Susanna Cooke Keiran Raine David Jones Andrew Menzies Lucy Stebbings Jon Hinton Jon Teague Stuart McLaren Laura Mudie Claire Hardy Elizabeth Anderson Olivia Joseph Victoria Goody Ben Robinson Mark Maddison Stephen Gamble Christopher Greenman Dan Berney Steven Hazell Naomi Livni Cyril Fisher Christopher Ogden Pardeep Kumar Alan Thompson Christopher Woodhouse David Nicol Erik Mayer Tim Dudderidge Nimish C Shah Vincent Gnanapragasam Thierry Voet Peter Campbell Andrew Futreal Douglas Easton Anne Y Warren Christopher S Foster Michael R Stratton Hayley C Whitaker Ultan McDermott Daniel S Brewer David E Neal

Nat Genet 2015 Jun;47(6):689

View Article

Download full-text PDF	Source
http://www.nature.com/articles/ng0615-689b	Publisher Site
http://dx.doi.org/10.1038/ng0615-689b	DOI Listing

June 2015

The role of the prostate cancer gene 3 urine test in addition to serum prostate-specific antigen level in prostate cancer screening among breast cancer, early-onset gene mutation carriers.

Authors:

Ruben G Cremers Rosalind A Eeles Elizabeth K Bancroft Janneke Ringelberg-Borsboom Hans F Vasen Christi J Van Asperen Jack A Schalken Gerald W Verhaegh Lambertus A Kiemeney

Urol Oncol 2015 May 5;33(5):202.e19-28. Epub 2015 Mar 5.

Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.urolonc.2015.01.018	DOI Listing

May 2015

The evolutionary history of lethal metastatic prostate cancer.

Nature 2015 Apr 1;520(7547):353-357. Epub 2015 Apr 1.

Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital, Tampere, Finland.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1038/nature14347	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413032	PMC

April 2015

Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

Authors:

Timothy R Rebbeck Nandita Mitra Fei Wan Olga M Sinilnikova Sue Healey Lesley McGuffog Sylvie Mazoyer Georgia Chenevix-Trench Douglas F Easton Antonis C Antoniou Katherine L Nathanson Yael Laitman Anya Kushnir Shani Paluch-Shimon Raanan Berger Jamal Zidan Eitan Friedman Hans Ehrencrona Marie Stenmark-Askmalm Zakaria Einbeigi Niklas Loman Katja Harbst Johanna Rantala Beatrice Melin Dezheng Huo Olufunmilayo I Olopade Joyce Seldon Patricia A Ganz Robert L Nussbaum Salina B Chan Kunle Odunsi Simon A Gayther Susan M Domchek Banu K Arun Karen H Lu Gillian Mitchell Beth Y Karlan Christine Walsh Jenny Lester Andrew K Godwin Harsh Pathak Eric Ross Mary B Daly Alice S Whittemore Esther M John Alexander Miron Mary Beth Terry Wendy K Chung David E Goldgar Saundra S Buys Ramunas Janavicius Laima Tihomirova Nadine Tung Cecilia M Dorfling Elizabeth J van Rensburg Linda Steele Susan L Neuhausen Yuan Chun Ding Bent Ejlertsen Anne-Marie Gerdes Thomas v O Hansen Teresa Ramón y Cajal Ana Osorio Javier Benitez Javier Godino Maria-Isabel Tejada Mercedes Duran Jeffrey N Weitzel Kristie A Bobolis Sharon R Sand Annette Fontaine Antonella Savarese Barbara Pasini Bernard Peissel Bernardo Bonanni Daniela Zaffaroni Francesca Vignolo-Lutati Giulietta Scuvera Giuseppe Giannini Loris Bernard Maurizio Genuardi Paolo Radice Riccardo Dolcetti Siranoush Manoukian Valeria Pensotti Viviana Gismondi Drakoulis Yannoukakos Florentia Fostira Judy Garber Diana Torres Muhammad Usman Rashid Ute Hamann Susan Peock Debra Frost Radka Platte D Gareth Evans Rosalind Eeles Rosemarie Davidson Diana Eccles Trevor Cole Jackie Cook Carole Brewer Shirley Hodgson Patrick J Morrison Lisa Walker Mary E Porteous M John Kennedy Louise Izatt Julian Adlard Alan Donaldson Steve Ellis Priyanka Sharma Rita Katharina Schmutzler Barbara Wappenschmidt Alexandra Becker Kerstin Rhiem Eric Hahnen Christoph Engel Alfons Meindl Stefanie Engert Nina Ditsch Norbert Arnold Hans Jörg Plendl Christoph Mundhenke Dieter Niederacher Markus Fleisch Christian Sutter C R Bartram Nicola Dikow Shan Wang-Gohrke Dorothea Gadzicki Doris Steinemann Karin Kast Marit Beer Raymonda Varon-Mateeva Andrea Gehrig Bernhard H Weber Dominique Stoppa-Lyonnet Olga M Sinilnikova Sylvie Mazoyer Claude Houdayer Muriel Belotti Marion Gauthier-Villars Francesca Damiola Nadia Boutry-Kryza Christine Lasset Hagay Sobol Jean-Philippe Peyrat Danièle Muller Jean-Pierre Fricker Marie-Agnès Collonge-Rame Isabelle Mortemousque Catherine Nogues Etienne Rouleau Claudine Isaacs Anne De Paepe Bruce Poppe Kathleen Claes Kim De Leeneer Marion Piedmonte Gustavo Rodriguez Katie Wakely John Boggess Stephanie V Blank Jack Basil Masoud Azodi Kelly-Anne Phillips Trinidad Caldes Miguel de la Hoya Atocha Romero Heli Nevanlinna Kristiina Aittomäki Annemarie H van der Hout Frans B L Hogervorst Senno Verhoef J Margriet Collée Caroline Seynaeve Jan C Oosterwijk Johannes J P Gille Juul T Wijnen Encarna B Gómez Garcia Carolien M Kets Margreet G E M Ausems Cora M Aalfs Peter Devilee Arjen R Mensenkamp Ava Kwong Edith Olah Janos Papp Orland Diez Conxi Lazaro Esther Darder Ignacio Blanco Mónica Salinas Anna Jakubowska Jan Lubinski Jacek Gronwald Katarzyna Jaworska-Bieniek Katarzyna Durda Grzegorz Sukiennicki Tomasz Huzarski Tomasz Byrski Cezary Cybulski Aleksandra Toloczko-Grabarek Elżbieta Złowocka-Perłowska Janusz Menkiszak Adalgeir Arason Rosa B Barkardottir Jacques Simard Rachel Laframboise Marco Montagna Simona Agata Elisa Alducci Ana Peixoto Manuel R Teixeira Amanda B Spurdle Min Hyuk Lee Sue K Park Sung-Won Kim Tara M Friebel Fergus J Couch Noralane M Lindor Vernon S Pankratz Lucia Guidugli Xianshu Wang Marc Tischkowitz Lenka Foretova Joseph Vijai Kenneth Offit Mark Robson Rohini Rau-Murthy Noah Kauff Anneliese Fink-Retter Christian F Singer Christine Rappaport Daphne Gschwantler-Kaulich Georg Pfeiler Muy-Kheng Tea Andreas Berger Mark H Greene Phuong L Mai Evgeny N Imyanitov Amanda Ewart Toland Leigha Senter Anders Bojesen Inge Sokilde Pedersen Anne-Bine Skytte Lone Sunde Mads Thomassen Sanne Traasdahl Moeller Torben A Kruse Uffe Birk Jensen Maria Adelaide Caligo Paolo Aretini Soo-Hwang Teo Christina G Selkirk Peter J Hulick Irene Andrulis

JAMA 2015 Apr;313(13):1347-61

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF	Source
http://dx.doi.org/10.1001/jama.2014.5985	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537700	PMC

April 2015

Rosalind Eeles

Rosalind Eeles

Publications by authors named "Rosalind Eeles"

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors:

Download full-text PDF

Authors: