Rosalind E Jenkins

Rosalind E Jenkins

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Rosalind E Jenkins

Rosalind E Jenkins

Publications by authors named "Rosalind E Jenkins"

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Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5' AMP-activated protein kinase signalling in malignant cells.

Biochem J 2019 Aug 15;476(15):2255-2269. Epub 2019 Aug 15.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, U.K.

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http://dx.doi.org/10.1042/BCJ20190121DOI Listing
August 2019

Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts.

Chem Res Toxicol 2017 12 22;30(12):2097-2099. Epub 2017 Nov 22.

Department of Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00291DOI Listing
December 2017

Ethanol Stimulates Locomotion via a G-Signaling Pathway in IL2 Neurons in .

Genetics 2017 11 26;207(3):1023-1039. Epub 2017 Sep 26.

The Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, L69 3BX, UK

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http://dx.doi.org/10.1534/genetics.117.300119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676223PMC
November 2017

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients.

Chem Res Toxicol 2017 07 12;30(7):1419-1435. Epub 2017 Jun 12.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, The University of Liverpool , Liverpool L69 3GE, United Kingdom.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00063DOI Listing
July 2017

Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis.

Liver Int 2017 03 6;37(3):377-384. Epub 2016 Aug 6.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.

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http://dx.doi.org/10.1111/liv.13202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243938PMC
March 2017

Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients.

Chem Res Toxicol 2016 10 21;29(10):1762-1772. Epub 2016 Sep 21.

MRC Center for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, United Kingdom.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00253DOI Listing
October 2016

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.

J Med Chem 2016 Mar 8;59(6):2396-409. Epub 2016 Mar 8.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , L69 3GE Liverpool, U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01292DOI Listing
March 2016

Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia.

Mol Cell Proteomics 2015 Apr 2;14(4):933-45. Epub 2015 Feb 2.

From the ‡Department of Molecular and Clinical Cancer Medicine, ¶Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool L7 8XP, UK

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http://dx.doi.org/10.1074/mcp.M114.044479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390271PMC
April 2015

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis.

Toxicol Appl Pharmacol 2015 Mar 28;283(3):168-77. Epub 2015 Jan 28.

Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2015.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361327PMC
March 2015

Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase.

Chem Res Toxicol 2015 Jan 7;28(1):144-54. Epub 2015 Jan 7.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, United Kingdom.

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http://pubs.acs.org/doi/10.1021/tx500458k
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http://dx.doi.org/10.1021/tx500458kDOI Listing
January 2015

Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice.

Liver Transpl 2014 Nov;20(11):1372-82

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS.

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http://dx.doi.org/10.1002/lt.23958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213307PMC
November 2014

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.

J Proteomics 2014 Aug 21;108:171-87. Epub 2014 May 21.

MRC Centre for Drug Safety Science, School of Biomedical Sciences, University of Liverpool, Sherrington Buildings, Liverpool, Merseyside L69 3GE, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115266PMC
August 2014

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients.

J Pharmacol Exp Ther 2014 Aug 5;350(2):387-402. Epub 2014 Jun 5.

Medical Research Council Centre for Drug Safety Science, Institute of Translational Medicine, (T.G.H., X.M., R.E.J., J.L.M., A.S.C., S.L.R., C.J.E., B.K.P., D.P.W.) and Department of Chemistry (A.V.S.), University of Liverpool, Liverpool, United Kingdom; Nottingham Digestive Diseases Centre, NIHR Nottingham Digestive Diseases-Biomedical Research Unit, Nottingham University Hospitals NHS Trust and University of Nottingham (G.P.A.) and Department of Rheumatology, Nottingham University Hospitals NHS Trust (I.P.), Nottingham, United Kingdom; and AstraZeneca U.K. Ltd (S.N.L.B.) and Safety Assessment, AstraZeneca U.K. Ltd (J.G.K.), Alderley Park, Macclesfield, Cheshire, United Kingdom

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http://dx.doi.org/10.1124/jpet.114.215079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109494PMC
August 2014

Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice.

Toxicol Appl Pharmacol 2013 Dec 3;273(3):524-31. Epub 2013 Oct 3.

Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.

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http://dx.doi.org/10.1016/j.taap.2013.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860754PMC
December 2013

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).

Biochem Biophys Res Commun 2013 Oct 31;440(3):364-70. Epub 2013 Aug 31.

Department of Gastroenterology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3GE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2013.08.076DOI Listing
October 2013

Oxidative bioactivation of abacavir in subcellular fractions of human antigen presenting cells.

Chem Res Toxicol 2013 Jul 12;26(7):1064-72. Epub 2013 Jun 12.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Liverpool L69 3GE, United Kingdom.

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http://dx.doi.org/10.1021/tx400041vDOI Listing
July 2013

β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis.

Chem Res Toxicol 2013 Jun 23;26(6):963-75. Epub 2013 May 23.

MRC Centre for Drug Safety Science, Department of Pharmacology, The University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3GE, England.

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http://dx.doi.org/10.1021/tx400124mDOI Listing
June 2013

Detection of drug bioactivation in vivo: mechanism of nevirapine-albumin conjugate formation in patients.

Chem Res Toxicol 2013 Apr 12;26(4):575-83. Epub 2013 Mar 12.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Liverpool, U.K.

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http://dx.doi.org/10.1021/tx4000107DOI Listing
April 2013

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.

Pharmacol Rep 2012 ;64(3):680-97

Department of Pharmacology, University of Liverpool, Sherrington Buildings, Liverpool, Merseyside, L69 3GE, United Kingdom.

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January 2013

PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.

J Neurosci 2012 May;32(20):7042-51

Department of Cellular and Molecular Physiology, The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.4029-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374327PMC
May 2012

Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients.

J Pharmacol Exp Ther 2011 Sep 16;338(3):841-9. Epub 2011 Jun 16.

Medical Research Council Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1124/jpet.111.183871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164351PMC
September 2011

Tetracycline-inducible protein expression in pancreatic cancer cells: effects of CapG overexpression.

World J Gastroenterol 2011 Apr;17(15):1947-60

Liverpool CR-UK Centre, Department of Molecular and Therapeutic Cancer Medicine, University of Liverpool, Liverpool, L69 3GA, UK.

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http://www.wjgnet.com/1007-9327/full/v17/i15/1947.htm
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http://dx.doi.org/10.3748/wjg.v17.i15.1947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082747PMC
April 2011

Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.

J Proteome Res 2010 May;9(5):2658-68

MRC Centre for Drug Safety Science, Department of Pharmacology & Therapeutics, Sherrington Building, Ashton Street, The University of Liverpool, Liverpool L69 3GE, United Kingdom.

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http://dx.doi.org/10.1021/pr1001687DOI Listing
May 2010

Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway.

J Biol Chem 2010 May 8;285(22):16782-8. Epub 2010 Apr 8.

Medical Research Council Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, the University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.096545
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http://dx.doi.org/10.1074/jbc.M109.096545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878012PMC
May 2010

Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein.

J Invest Dermatol 2010 Mar 27;130(3):732-42. Epub 2009 Aug 27.

Department of Pharmacology, The MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1038/jid.2009.271DOI Listing
March 2010

A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ.

J Proteomics 2009 Dec 3;73(2):352-6. Epub 2009 Aug 3.

Royal Liverpool University Hospital, University of Liverpool, United Kingdom.

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http://dx.doi.org/10.1016/j.jprot.2009.07.009DOI Listing
December 2009

High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.

Toxicol Sci 2009 Dec 25;112(2):521-31. Epub 2009 Sep 25.

MRC Centre for Drug Safety Science, Department of Pharmacology & Therapeutics, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L693GE, UK.

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http://dx.doi.org/10.1093/toxsci/kfp235DOI Listing
December 2009

A mechanistic investigation into the irreversible protein binding and antigenicity of p-phenylenediamine.

Chem Res Toxicol 2009 Jun;22(6):1172-80

MRC Centre for Drug Safety Science, Department of Pharmacology, Sherrington Building, Ashton Street, The University of Liverpool, Liverpool, L69 3GE England.

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http://dx.doi.org/10.1021/tx900095rDOI Listing
June 2009

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo.

Proteomics Clin Appl 2009 Jun;3(6):720-9

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, UK.

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http://doi.wiley.com/10.1002/prca.200800222
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http://dx.doi.org/10.1002/prca.200800222DOI Listing
June 2009

Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 May 14;877(13):1229-39. Epub 2008 Nov 14.

MRC Centre for Drug Safety Science, Department of Pharmacology, University of Liverpool, The Sherrington Building, Ashton Street, Liverpool, UK.

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http://dx.doi.org/10.1016/j.jchromb.2008.11.013DOI Listing
May 2009

Multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: implications for hapten formation.

Chem Res Toxicol 2009 May;22(5):937-48

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, School of Biomedical Sciences, The University of Liverpool, Liverpool L69 3GE, United Kingdom.

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http://pubs.acs.org/doi/abs/10.1021/tx900034r
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http://dx.doi.org/10.1021/tx900034rDOI Listing
May 2009

Phosphorylation of cysteine string protein on Serine 10 triggers 14-3-3 protein binding.

Biochem Biophys Res Commun 2008 Dec 23;377(3):809-14. Epub 2008 Oct 23.

The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.

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http://dx.doi.org/10.1016/j.bbrc.2008.10.069DOI Listing
December 2008

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.

Hepatology 2008 Oct;48(4):1292-301

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, The University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1002/hep.22472DOI Listing
October 2008

Albumin and immunoglobulin depletion of human plasma.

Methods Mol Biol 2008 ;425:15-25

University of Liverpool, Liverpool, Great Britain.

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http://dx.doi.org/10.1007/978-1-60327-210-0_2DOI Listing
June 2008

Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.

Proteomics 2008 Jan;8(2):301-15

Department of Pharmacology and Therapeutics, School of Biomedical Sciences, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1002/pmic.200700843DOI Listing
January 2008

Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblasts.

J Biol Chem 2007 Nov 21;282(44):32112-20. Epub 2007 Aug 21.

Department of Human Anatomy and Cell Biology, School of Biomedical Sciences, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M705067200DOI Listing
November 2007

Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.

J Med Chem 2007 Nov 7;50(24):6165-76. Epub 2007 Nov 7.

The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1021/jm0706766DOI Listing
November 2007

A method for the rapid depletion of albumin and immunoglobulin from human plasma.

Proteomics 2004 Oct;4(10):3107-11

Department of Pharmacology, University of Liverpool, UK.

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http://dx.doi.org/10.1002/pmic.200300815DOI Listing
October 2004